Patents by Inventor Robert A. Holton

Robert A. Holton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C7 carbamate substituted taxanes
    Patent number: 6750245
    Abstract: Taxanes having a carbamoyloxy substituent at C(7), a hydroxy substituent at C(10, and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: June 15, 2004
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Taxane formulations
    Publication number: 20040097579
    Abstract: The present invention is directed to various formulations of taxanes having improved solubility as compared to paclitaxel, particularly formulations of such taxane derivatives for oral or parenteral administration to a patient.
    Type: Application
    Filed: October 7, 2003
    Publication date: May 20, 2004
    Applicant: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • C7 heterosubstituted acetate taxane compositions
    Publication number: 20040087547
    Abstract: Taxanes having a heterosubstituted acetate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: November 24, 2003
    Publication date: May 6, 2004
    Applicant: FSU Research Foundation Inc.
    Inventor: Robert A. Holton
  • Carbamoyl substituted &bgr;-lactams
    Patent number: 6730782
    Abstract: Taxane derivatives having an amino substituted C13 side chain.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: May 4, 2004
    Assignee: Florida State University
    Inventors: Robert A. Holton, Hossain Nadizadeh, Kasthuri Rengan, Chunlin Tao
  • Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
    Patent number: 6727369
    Abstract: Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C2 substituent other than benzoate and/or a C4 substituent other than acetate in which the C2 benzoate substituent and/or the C4 acetate substituent of a derivative of baccatin III or 10-desacetyl baccatin III is/are selectively reduced to the corresponding hydroxy group(s) and converted to R7COO— and/or R8COO—, respectively, wherein R7 and R8 are independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C8 alkynyl, moncyclic aryl, or monocyclic heteroaryl.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: April 27, 2004
    Assignee: Florida State University
    Inventors: Robert A. Holton, Seokchan Kim, Yukio Suzuki
  • C10 ester substituted taxanes
    Publication number: 20040072872
    Abstract: Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: October 1, 2003
    Publication date: April 15, 2004
    Applicant: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Perparation of substituted isoserine esters using metal alkoxides and beta-lactams
    Publication number: 20040073048
    Abstract: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reached with a &bgr;-lactam.
    Type: Application
    Filed: September 29, 2003
    Publication date: April 15, 2004
    Applicant: Florida State University
    Inventor: Robert A. Holton
  • Preparation of substituted isoserine esters using beta-lactams and metal or ammonium alkoxides
    Publication number: 20040073047
    Abstract: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal or an ammonium alkoxide is reacted with a &bgr;-lactam.
    Type: Application
    Filed: September 29, 2003
    Publication date: April 15, 2004
    Applicant: Florida State University
    Inventor: Robert A. Holton
  • 9&bgr;-hydroxytetracyclic taxanes
    Patent number: 6710191
    Abstract: Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C9 substituent other than keto in which the C9 keto substituent of taxol, a taxol analog, baccatin III or 10-desacetyl baccatin III is selectively reduced to the corresponding hydroxy group.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: March 23, 2004
    Assignee: Florida State University
    Inventors: Robert A. Holton, Carmen Somoza, Yukio Suzuki, Mitsuru Shindo
  • Process for selective derivatization of taxanes
    Patent number: 6706896
    Abstract: Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which the C(10) hydroxyl group is protected or derivatized prior to the C(7) hydroxyl group; and the provision of C(7) and C(10) derivatized 10-DAB compounds.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: March 16, 2004
    Assignee: Florida State University
    Inventors: Robert A. Holton, Zhuming Zhang, Paul A. Clarke
  • C10 carbamoyloxy substituted taxanes
    Publication number: 20040034230
    Abstract: Taxanes having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: July 11, 2003
    Publication date: February 19, 2004
    Applicant: FSU Research Foundation, Inc.
    Inventors: Robert A. Holton, Weishuo Fang
  • 1- Deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
    Publication number: 20040029976
    Abstract: 1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.
    Type: Application
    Filed: August 7, 2003
    Publication date: February 12, 2004
    Applicant: Florida State University
    Inventors: Robert A. Holton, Suhan Tang, Feng Liang, Carmen Somoza
  • C10 heterosubstituted acetate taxanes
    Publication number: 20040024051
    Abstract: Taxanes having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: June 27, 2003
    Publication date: February 5, 2004
    Applicant: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Process for the preparation of metal alkoxides
    Patent number: 6683196
    Abstract: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reacted with a &bgr;-lactam.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: January 27, 2004
    Assignee: Florida State University
    Inventor: Robert A. Holton
  • C7 ester substituted taxanes
    Publication number: 20040014979
    Abstract: Taxanes having an ester substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: June 25, 2003
    Publication date: January 22, 2004
    Applicant: Florida State University
    Inventor: Robert A. Holton
  • C7 heterosubstituted acetate taxanes
    Patent number: 6673833
    Abstract: Taxanes having a heterosubstituted acetate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: January 6, 2004
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • C10 heterosubstituted acetate taxanes
    Patent number: 6664275
    Abstract: Taxanes having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: December 16, 2003
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • C10 carbonate substituted taxanes
    Patent number: 6660866
    Abstract: Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: December 9, 2003
    Assignee: PSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Process for the preparation of ammonium alkoxides
    Patent number: 6653490
    Abstract: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal or an ammonium alkoxide is reacted with a &bgr;-lactam.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: November 25, 2003
    Assignee: Florida State University
    Inventor: Robert A. Holton
  • C10 ester substituted taxanes
    Patent number: 6649632
    Abstract: Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: November 18, 2003
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton