Patents by Inventor Robert A. Holton

Robert A. Holton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C2 substituted taxanes
    Patent number: 6649777
    Abstract: Taxane derivatives having alternative C2 substituents.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: November 18, 2003
    Assignee: Florida State University
    Inventors: Robert A. Holton, Chunlin Tao
  • Taxane formulations
    Patent number: 6638973
    Abstract: The present invention is directed to various formulations of taxanes having improved solubility as compared to paclitaxel, particularly formulations of such taxane derivatives for oral or parenteral administration to a patient.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: October 28, 2003
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Enzymatic process for the resolution of enantiomeric mixtures of beta-lactams
    Publication number: 20030190743
    Abstract: A process for the resolution of an enantiomeric mixture of &bgr;-lactams containing an ester, the process comprising selectively hydrolyzing the ester of one of the enantiomers by combining the mixture with homogenized liver.
    Type: Application
    Filed: April 11, 2003
    Publication date: October 9, 2003
    Applicant: FSU Research Foundation, Inc.
    Inventors: Robert A. Holton, Phong Vu
  • Taxane synthesis method and intermediates
    Patent number: 6630609
    Abstract: A process for the preparation of a composition having the formula: in which a compound having the formula: is treated with a base and a silylating agent.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: October 7, 2003
    Assignee: Florida State University
    Inventors: Robert A. Holton, Phong Vu, Tawfik Gharbaoui, Vincent Reboul
  • Beta-lactams having an alkyl-substituted side chain
    Publication number: 20030187061
    Abstract: Taxane derivatives having an alkyl substituted C13 side chain.
    Type: Application
    Filed: January 27, 2003
    Publication date: October 2, 2003
    Applicant: Florida State University
    Inventors: Robert A. Holton, Ki-Byung Chai, Hamid Idmoumaz, Hossain Nadizadeh, Yukio Suzuki
  • Method for the preparation of 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs
    Patent number: 6620950
    Abstract: 1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: September 16, 2003
    Assignee: Florida State University
    Inventors: Robert A. Holton, Suhan Tang, Feng Liang, Carmen Somoza
  • C7 ester substituted taxanes
    Patent number: 6610860
    Abstract: Taxanes having an ester substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: August 26, 2003
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • C10 carbamoyloxy substituted taxanes
    Patent number: 6596737
    Abstract: Taxanes having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: July 22, 2003
    Assignee: FSU Research Foundation, Inc.
    Inventors: Robert A. Holton, Weishuo Fang
  • Process for the preparation of metal alkoxides
    Publication number: 20030120096
    Abstract: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reacted with a &bgr;-lactam.
    Type: Application
    Filed: November 6, 2002
    Publication date: June 26, 2003
    Applicant: Florida State University
    Inventor: Robert A. Holton
  • C9 hydrido, hydroxy and acyloxy metal alkoxides
    Publication number: 20030114419
    Abstract: Taxane derivatives having alternative C9 substituents.
    Type: Application
    Filed: November 18, 2002
    Publication date: June 19, 2003
    Applicant: Florida State University
    Inventors: Robert A. Holton, Ki-Byung Chai, Yukio Suzuki
  • C10 carbonate substituted taxanes
    Publication number: 20030114493
    Abstract: Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: February 2, 2001
    Publication date: June 19, 2003
    Inventor: Robert A. Holton
  • Taxane synthesis method and intermediates
    Publication number: 20030097024
    Abstract: A process for the preparation of a composition having the formula: 1
    Type: Application
    Filed: July 16, 2002
    Publication date: May 22, 2003
    Applicant: Florida State University
    Inventors: Robert A. Holton, Phong Vu, Tawfik Gharbaoui, Vincent Reboul
  • Preparation of substituted isoserine esters using metal alkoxides and &bgr;-lactams
    Patent number: 6562962
    Abstract: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reacted with a &bgr;-lactam.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: May 13, 2003
    Assignee: Florida State University
    Inventor: Robert A. Holton
  • C10 OXO and hydrido taxane derivatives and pharmaceutical compositions containing them
    Patent number: 6552205
    Abstract: Taxane derivatives having alternative C10 substituents.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: April 22, 2003
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai
  • Enzymatic process for the resolution of enantiomeric mixtures of &bgr;-lactams
    Patent number: 6548293
    Abstract: A process for the resolution of an enantiomeric mixture of &bgr;-lactams containing an ester, the process comprising selectively hydrolyzing the ester of one of the enantiomers by combining the mixture with homogenized liver.
    Type: Grant
    Filed: October 16, 2000
    Date of Patent: April 15, 2003
    Assignee: FSU Research Foundation, Inc.
    Inventors: Robert A. Holton, Phong Vu
  • 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
    Patent number: 6545168
    Abstract: 1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.
    Type: Grant
    Filed: May 5, 1997
    Date of Patent: April 8, 2003
    Assignee: Florida State University
    Inventors: Robert A. Holton, Suhan Tang, Feng Liang, Carmen Somoza
  • Taxanes having T-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
    Publication number: 20030065200
    Abstract: Taxane derivatives having an alkoxy, alkenoxy or aryloxy substituted C13 side chain.
    Type: Application
    Filed: September 17, 2002
    Publication date: April 3, 2003
    Applicant: Florida State University
    Inventors: Robert A. Holton, Ki-Byung Chai, Hamid Idmoumaz, Hossain Nadizadeh, Kasthuri Rengan, Yukio Suzuki, Chunlin Tao
  • C7 carbamate substituted taxanes
    Publication number: 20030060638
    Abstract: Taxanes having a carbamoyloxy substituent at C(7), a hydroxy substituent at C(10, and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: February 6, 2002
    Publication date: March 27, 2003
    Applicant: Florida State University Research Foundation Inc.
    Inventor: Robert A. Holton
  • C7 ACYLOXY METAL ALKOXIDES
    Publication number: 20030055272
    Abstract: Taxane derivatives having alternative C7 substituents.
    Type: Application
    Filed: September 20, 2002
    Publication date: March 20, 2003
    Applicant: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai
  • Tricyclic and tetracyclic taxane intermediates
    Publication number: 20030050485
    Abstract: The synthesis of taxol and other tricyclic and tetracyclic taxanes.
    Type: Application
    Filed: July 12, 2002
    Publication date: March 13, 2003
    Applicant: Florida State University
    Inventors: Robert A. Holton, Carmen Somoza, Hyeong Baik Kim, Mitsuru Shindo, Ronald J. Biediger, P. Douglas Boatman, Chase C. Smith, Feng Liang, Krishna K. Murthi