Patents by Inventor Robert A. Holton

Robert A. Holton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Taxanes having a C7 carbonate substituent
    Patent number: 7226944
    Abstract: Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: June 5, 2007
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • C7 ester substituted taxanes
    Patent number: 7186849
    Abstract: Taxanes having an ester substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: March 6, 2007
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Taxanes having a C7 heterosubstituted acetate substituent
    Patent number: 7183312
    Abstract: Texanes having a heterosubstituted acetate substituent at C(7), a hydroxy substitutent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: February 27, 2007
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • C7 lactyloxy-substituted taxanes
    Patent number: 7160919
    Abstract: A taxane having the formula: wherein X3 is furyl, X5 is t-butoxycarbonyl, Bz is benzoyl, and Ac is acetyl.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: January 9, 2007
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Robert A. Holton, Hyeong Baik Kim
  • C10 heterosubstituted acetate taxane compositions
    Patent number: 7157474
    Abstract: Compositions comprising a taxane having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: January 2, 2007
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Processes for the production of polycyclic fused ring compounds
    Publication number: 20060281934
    Abstract: The present invention provides processes for the production of polycyclic fused ring compounds. The polycyclic fused ring compounds are produced by protecting a polycyclic fused ring polyol with a bridging silicon-based protecting group and attaching a suitable side chain. Novel polycyclic fused ring compounds and intermediate compounds are also described.
    Type: Application
    Filed: June 8, 2006
    Publication date: December 14, 2006
    Applicant: Florida State University Research Foundation, Inc.
    Inventors: Phong Vu, Robert Holton
  • Resolution of enantiomeric mixtures of beta-lactams
    Publication number: 20060281918
    Abstract: A new process for resolution of an enantiomeric mixture of C3-hydroxyl substituted ?-lactams is disclosed. Generally, the enantiomeric mixture is treated with an optically active proline acylating agent to form a C3-ester substituted ?-lactam diastereomer or a mixture of C3-ester substituted ?-lactam diastereomers followed by selective recovery of the unreacted enantiomer or of one of the diastereomers.
    Type: Application
    Filed: June 8, 2006
    Publication date: December 14, 2006
    Applicant: Florida State University Research Foundation, Inc.
    Inventors: Phong Vu, Robert Holton
  • Processes for the preparation of paclitaxel
    Publication number: 20060281933
    Abstract: The present invention provides processes for the production of paclitaxel. Paclitaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form paclitaxel.
    Type: Application
    Filed: June 8, 2006
    Publication date: December 14, 2006
    Applicant: Florida State University Research Foundation, Inc.
    Inventors: Phong Vu, Robert Holton
  • Processes for the preparation of docetaxel
    Publication number: 20060281932
    Abstract: The present invention provides processes for the production of docetaxel. Docetaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form docetaxel.
    Type: Application
    Filed: June 8, 2006
    Publication date: December 14, 2006
    Applicant: Florida State University Research Foundation, Inc.
    Inventors: Phong Vu, Robert Holton
  • Beta-lactam synthesis
    Publication number: 20060281914
    Abstract: The present invention is directed to a process for the preparation of ?-lactams. Generally, an imine is cyclocondensed with a ketene acetal or enolate to form the ?-lactam product in a “one pot” synthesis, this process is generally performed at a higher temperature than conventional processes.
    Type: Application
    Filed: June 8, 2006
    Publication date: December 14, 2006
    Applicant: Florida State University Research Foundation, Inc.
    Inventors: Phong Vu, Robert Holton
  • C10 cyclopropyl ester substituted taxane compositions
    Publication number: 20060189679
    Abstract: Compositions comprising a taxane having a cyclopropyl ester substituent at C10, a keto substituent at C9, a hydroxy substituent at C7, a 2-furyl substituent at C3? and an isobutoxycarbamate substituent at C3?.
    Type: Application
    Filed: February 13, 2006
    Publication date: August 24, 2006
    Applicant: Florida State University Research Foundation, Inc.
    Inventors: Robert Holton, Ross Longley
  • Metal alkoxide taxane derivatives
    Patent number: 7074945
    Abstract: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reached with a ?-lactam.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: July 11, 2006
    Assignee: Florida State University
    Inventor: Robert A. Holton
  • Radiosensitizing taxanes and their pharmaceutical preparations
    Patent number: 7067552
    Abstract: Taxanes containing electron-affinic radiosensitizing functional groups, their pharmaceutical preparations, and methods of making and using this new class of highly potent radiosensitizers of tumor cells.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: June 27, 2006
    Assignee: Florida State University
    Inventors: Robert A. Holton, Hossain Nadizadeh, Li-Xi Yang
  • Enzymatic process for the resolution for enantiomeric mixtures of ?-lactams
    Patent number: 7067305
    Abstract: A process for the resolution of an enantiomeric mixture of ?-lactams containing an ester, the process comprising selectively hydrolyzing the ester of one of the enantiomers by combining the mixture with homogenized liver.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: June 27, 2006
    Assignee: FSU Research Foundation, Inc.
    Inventors: Robert A. Holton, Phong Vu
  • C10 carbonate taxane compositions
    Patent number: 7056946
    Abstract: Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: November 24, 2003
    Date of Patent: June 6, 2006
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Taxanes having a C10 carbonate substituent
    Publication number: 20060111401
    Abstract: Taxanes having a methylcarbonate or ethylcarbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(13) side chain substituents.
    Type: Application
    Filed: January 12, 2006
    Publication date: May 25, 2006
    Applicant: Florida State University Research Foundation, Inc.
    Inventor: Robert Holton
  • 1-deoxy taxol analogs
    Patent number: 7019150
    Abstract: 1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.
    Type: Grant
    Filed: August 7, 2003
    Date of Patent: March 28, 2006
    Assignee: Florida State University
    Inventors: Robert A. Holton, Suhan Tang, Feng Liang, Carmen Somoza
  • C7 carbonate taxane compositions
    Patent number: 6992104
    Abstract: Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: January 31, 2006
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Process for C7 silylation of hydroxy substituted taxanes and intermediates thereof
    Publication number: 20050272944
    Abstract: Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) hydroxyl and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which the C(10) hydroxyl group is protected or derivatized prior to the C(7) hydroxyl group; and the provision of C(7) and C(10) derivatized 10-DAB compounds.
    Type: Application
    Filed: June 9, 2005
    Publication date: December 8, 2005
    Applicant: Florida State University
    Inventors: Robert Holton, Zhuming Zhang, Paul Clarke
  • C10 cyclopentyl ester substituted taxanes
    Publication number: 20050228037
    Abstract: A taxane having a cyclopentyl ester substituent at C10, a keto substituent at C9, a hydroxy substituent at C2, a 2-thienyl substituent at C3? and an isopropoxycarbamate substituent at C3?.
    Type: Application
    Filed: February 14, 2005
    Publication date: October 13, 2005
    Applicant: Florida State University Research Foundation, Inc.
    Inventors: Robert Holton, Phong Vu