Patents by Inventor Robert G. Matheny

Robert G. Matheny has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extracellular Matrix Constructs for Treating Damaged Biological Tissue
    Publication number: 20150359622
    Abstract: Extracellular matrix (ECM) constructs having a biodegradable support scaffold and an anchoring mechanism, which includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein. In a preferred embodiment, the support scaffold and anchoring mechanism comprise an ECM material. In some embodiments, the microneedles are also capable of administering a biologically active agent and/or a pharmacological composition to the engaged tissue.
    Type: Application
    Filed: August 21, 2015
    Publication date: December 17, 2015
    Inventor: Robert G. Matheny
  • Articles for Tissue Regeneration with Biodegradable Polymer
    Publication number: 20150359934
    Abstract: The invention is also directed to particulate articles comprising extracellular matrix components that are encased in a biodegradable polymer composition. Methods of for treating damaged tissue and regenerating new tissue at sites of the damaged tissue by placing a particulate article in mammals are claimed.
    Type: Application
    Filed: August 21, 2015
    Publication date: December 17, 2015
    Inventor: Robert G Matheny
  • Extracellular Matrix Encasement Structures and Methods
    Publication number: 20150359936
    Abstract: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
    Type: Application
    Filed: August 24, 2015
    Publication date: December 17, 2015
    Inventor: Robert G. Matheny
  • Method and System for Treatment of Damaged Biological Tissue
    Publication number: 20150352145
    Abstract: Biomaterial compositions and articles comprising extracellular matrix (ECM) and an ECM-mimicking biomaterial, such as poly(glycerol sebacate) (PGS), for treating damaged biological tissue; particularly, damaged cardiovascular tissue. The biomaterial compositions and articles can also include additional biologically active agents, such as growth factors, and polymeric materials, such as polyepsilon-caprolactone (PCL).
    Type: Application
    Filed: August 21, 2015
    Publication date: December 10, 2015
    Inventor: Robert G. Matheny
  • Extracellular Matrix Prostheses for Treating Damaged Biological Tissue
    Publication number: 20150352254
    Abstract: Particulate structures comprising a particulate extracellular matrix (ECM) component encased in a biomaterial composition, which, when administered to damaged cardiovascular tissue, induce modulated healing.
    Type: Application
    Filed: August 21, 2015
    Publication date: December 10, 2015
    Inventor: Robert G Matheny
  • Compositions for regenerating defective or absent myocardium
    Patent number: 9199001
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: December 1, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Extracellular Matrix Encasement Structures and Methods
    Publication number: 20150335792
    Abstract: A remodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region and at least one lead conduit, the internal region being configured to receive a device therein, the lead conduit being configures to receive at least one device lead therein, the bioremodelable material comprising an extracellular matrix (ECM) composition that includes an ECM component derived from a mammalian source.
    Type: Application
    Filed: August 5, 2015
    Publication date: November 26, 2015
    Inventor: Robert G. Matheny
  • Extracellular Matrix Encasement Structures and Methods
    Publication number: 20150335787
    Abstract: A bioremodelable pouch formed from at least one sheet of bioremodelable extracellular matrix (ECM) material, the pouch including an internal region that is configured to receive a medical device, the pouch including an outer coating comprising a pharmacological agent or ECM-mimicking biomaterial composition comprising poly(glycerol sebacate) (PGS).
    Type: Application
    Filed: August 6, 2015
    Publication date: November 26, 2015
    Inventor: Robert G. Matheny
  • Method for treatment of cardiovascular disorders
    Patent number: 9161952
    Abstract: Methods for treating a cardiovascular disorder comprising concomitant administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance. In a preferred embodiment, the ECM based compositions include an ECM material derived from a mammalian source.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: October 20, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventors: Robert G Matheny, Anna Fallon
  • Reinforced Prosthetic Tissue Valves
    Publication number: 20150289974
    Abstract: A prosthetic atrioventricular valve that includes a continuous tubular member having proximal and distal ends, the tubular member comprising an extracellular matrix (ECM) material, and a reinforcement member disposed in the tubular member lumen and attached to the distal end of the tubular member, the reinforcement member comprising at least two elongated linear members that are configured to connect the joined tubular and reinforcement members to a cardiovascular structure.
    Type: Application
    Filed: June 24, 2015
    Publication date: October 15, 2015
    Inventor: Robert G Matheny
  • ECM Constructs for treating damaged biological tissue
    Patent number: 9149496
    Abstract: Extracellular matrix (ECM) constructs having a biodegradable support scaffold and an anchoring mechanism, which includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein. In a preferred embodiment, the support scaffold and anchoring mechanism comprise an ECM material. In some embodiments, the microneedles are also capable of administering a biologically active agent and/or a pharmacological composition to the engaged tissue.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: October 6, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Sternal Closure Apparatus, System and Method
    Publication number: 20150265325
    Abstract: A bioresorbable closure member having integral first and second elongated projection members comprising first extracellular matrix (ECM) from a first mammalian tissue source, the first and second elongated projection members being configured wherein the longitudinal axes of the members intersect and form an angle with respect to said first and second members. The ECM can include one or more exogenously added biologically active agents, including osteogenic agents, bone morphogenic proteins, growth factors and cells.
    Type: Application
    Filed: March 24, 2014
    Publication date: September 24, 2015
    Inventor: Robert G Matheny
  • Artificial Skeletal Material and Constructs Formed Therefrom
    Publication number: 20150265653
    Abstract: A bioresorbable skeletal construct member formed from an osteoinductive composition comprising autogenic bone and an extracellular matrix (ECM) material, the construct member being configured to induce osteoanagenesis and angiogenesis when implanted proximate endogenous bone and tissue.
    Type: Application
    Filed: March 24, 2014
    Publication date: September 24, 2015
    Inventor: Robert G. Matheny
  • Compositions and methods for treating organ dysfunction
    Patent number: 9132172
    Abstract: A method of retarding cellular senescence comprising (i) providing an extracellular matrix (ECM) composition comprising ECM from an adolescent tissue source, the ECM comprising an exogenously added cytokine, and (ii) administering ECM composition to an organ with cells exhibiting cellular senescence, wherein, the cytokine interacts with at least one molecule in the ECM composition and modulates ROS production of the cells, whereby, the cellular senescence is abated.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: September 15, 2015
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Compositions for regenerating defective or absent myocardium
    Patent number: 9125972
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: September 8, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Compositions for Regenerating Defective or Absent Myocardium
    Publication number: 20150246161
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Application
    Filed: February 28, 2014
    Publication date: September 3, 2015
    Inventor: Robert G. Matheny
  • Compositions for Regenerating Defective or Absent Myocardium
    Publication number: 20150246159
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Application
    Filed: February 28, 2014
    Publication date: September 3, 2015
    Inventor: Robert G. Matheny
  • Compositions for Regenerating Defective or Absent Myocardium
    Publication number: 20150246160
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Application
    Filed: February 28, 2014
    Publication date: September 3, 2015
    Inventor: Robert G. Matheny
  • Extracellular Matrix Material Valve Conduit and Methods of Making Thereof
    Publication number: 20150245907
    Abstract: Methods for forming extracellular matrix valve conduits are disclosed. Extracellular matrix valve conduits produced using the disclosed methods are also disclosed. Methods of sterilizing and decellularizing extracellular matrix materials are also disclosed.
    Type: Application
    Filed: March 3, 2014
    Publication date: September 3, 2015
    Inventors: Robert G. Matheny, Christian L. Gilbert
  • Compositions and methods for preventing cardiac arrhythmia
    Patent number: 9119841
    Abstract: Disclosed herein are compositions and methods for treating or preventing cardiac arrhythmia in a subject.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: September 1, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny