Patents by Inventor Robert Graham

Robert Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MASS SPECTROMETRY ANALYSIS OF MICROORGANISMS IN SAMPLES
    Publication number: 20200294781
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Application
    Filed: March 4, 2020
    Publication date: September 17, 2020
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • Ion focusing
    Patent number: 10777400
    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: September 15, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
  • Conducting reactions in Leidenfrost-levitated droplets
    Patent number: 10774044
    Abstract: The invention generally relates to conducting reactions in Leidenfrost-levitated droplets.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: September 15, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Christopher Pulliam, Ryan M. Bain
  • Sample dispenser including an internal standard and methods of use thereof
    Patent number: 10761083
    Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: September 1, 2020
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, He Wang, Nicholas E. Manicke, Robert Graham Cooks, Qian Yang, Jiangjiang Liu
  • Synchronization of ion generation with cycling of a discontinuous atmospheric interface
    Patent number: 10755910
    Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: August 25, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Guangtao Li, Guangming Huang, Jason Duncan, Xin Li, Ewa Sokol, Xin Yan
  • Unit dose detergent compositions
    Patent number: 10745654
    Abstract: The present invention relates to unit dose detergent compositions comprising a water-soluble container formed from a water-soluble film material enclosing a liquid composition with a relatively high water content. In one embodiment, the unit dose detergent composition comprises a water-soluble container formed from a water-soluble film material enclosing a liquid composition, wherein the liquid composition comprises (a) at least one surfactant, (b) at least one humectant selected from the group consisting of polyols having 3 to 9 carbon atoms, and (c) about 15 wt % to about 35 wt % of water.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: August 18, 2020
    Assignee: Henkel IP & Holding GmbH
    Inventors: Syed Humza Naqvi, Troy Robert Graham, Ryan Bradley Cameron
  • Ion generation using modified wetted porous materials
    Patent number: 10732159
    Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: August 4, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang
  • Systems and methods for separating ions at about or above atmospheric pressure
    Patent number: 10727041
    Abstract: The invention generally relates to systems and methods for separating ions at about or above atmospheric pressure. In certain embodiments, the invention provides systems that include an ionization source that generates ions and an ion trap. The ion trap is maintained at about or above atmospheric pressure and includes a plurality of electrodes and at least one inlet configured to receive a gas flow and at least one outlet. The system is configured such that a combination of a gas flow and one or more electric fields produced by the electrodes separates the ions based on mass-to-charge ratio and sends the separated ions through the at least one outlet of the ion trap.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: July 28, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Dalton Snyder, Amar S. Basu, Wen-Ping Peng
  • Sample analysis systems and methods of use thereof
    Patent number: 10720316
    Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: July 21, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zane Baird, Pu Wei
  • FAILSAFE VALVE ACTUATOR
    Publication number: 20200224785
    Abstract: The present invention relates to a failsafe valve actuator (10) comprising a drive mechanism (12), a drive shaft (42) having a clutch (50) arranged adjacent to a threaded portion (44) of the drive shaft (42), and a clutch actuator (52) coupled to the clutch (50) and arranged to move the clutch (50) between an engaged position in which the clutch (50) engages with the threaded portion (44) of the drive shaft (42) and a disengaged position in which the clutch (50) is disengaged from the drive shaft (42). In response to energisation of the clutch actuator (52) the clutch (50) is moved to the engaged position such that threaded engagement between the drive shaft (42) and clutch (50) transfers rotational movement of the drive shaft (42) by the drive mechanism (12) into axial movement of the drive shaft (42) and holds the drive shaft (42) against a drive shaft bias member when the drive mechanism is inactive.
    Type: Application
    Filed: July 6, 2018
    Publication date: July 16, 2020
    Inventor: Robert Graham HARRIS
  • Zero voltage mass spectrometry probes and systems
    Patent number: 10714323
    Abstract: The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: July 14, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Michael Stanley Wleklinski, Soumabha Bag, Yafeng Li
  • ION FOCUSING
    Publication number: 20200219711
    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.
    Type: Application
    Filed: February 27, 2020
    Publication date: July 9, 2020
    Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
  • Systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions
    Patent number: 10683579
    Abstract: The invention generally relates to systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions. In certain aspects, the invention provides methods that involve providing a metal and a solvent. The methods additionally involve applying voltage to the solvated metal to thereby produce solvent droplets including ions of the metal containing compound, and directing the solvent droplets including the metal ions to a target. In certain embodiments, once at the target, the metal ions can react directly or catalyze reactions.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: June 16, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Anyin Li, Thalappil Pradeep, Zane Baird
  • METHODS OF ANALYZING CRUDE OIL
    Publication number: 20200173976
    Abstract: The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps.
    Type: Application
    Filed: January 17, 2020
    Publication date: June 4, 2020
    Inventors: Robert Graham Cooks, Fred Paul Mark Jjunju, Anyin Li, Iman S. Roqan
  • MASS SPECTROMETRY PROBES AND SYSTEMS FOR IONIZING A SAMPLE
    Publication number: 20200168446
    Abstract: The invention generally relates to mass spectrometry probes and systems for ionizing a sample. In certain embodiments, the invention provides a mass spectrometry probe including a substrate in which a portion of the substrate is coated with a material, a portion of which protrudes from the substrate.
    Type: Application
    Filed: January 2, 2020
    Publication date: May 28, 2020
    Inventors: Robert Graham Cooks, Depanjan Sarkar, Thalappil Pradeep, Rahul Narayanan
  • SYSTEMS AND METHODS FOR CONDUCTING NEUTRAL LOSS SCANS IN A SINGLE ION TRAP
    Publication number: 20200161111
    Abstract: The invention generally relates to systems and methods for conducting neutral loss scans in a single ion trap. In certain aspects, the invention provides systems that include a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a scan function that excites a precursor ion, rejects the precursor ion after its excitation, and ejects a product ion in the single ion trap.
    Type: Application
    Filed: January 24, 2020
    Publication date: May 21, 2020
    Inventors: Robert Graham Cooks, Dalton Snyder
  • Rare event detection using mass tags
    Patent number: 10656157
    Abstract: The invention generally relates to methods for rare event detection using mass tags. In certain embodiments, the invention provides methods for detecting a target analyte in a sample that involve conducting an assay that specifically associates a mass tag with a target analyte in a sample, generating ions of the mass tag, and analyzing the generated ions of the mass tag, thereby detecting the target analyte from the sample.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: May 19, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang
  • ENCLOSED DESORPTION ELECTROSPRAY IONIZATION PROBES AND METHOD OF USE THEREOF
    Publication number: 20200121229
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Application
    Filed: December 19, 2019
    Publication date: April 23, 2020
    Applicants: Purdue Research Foundation, Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • On-Demand Rapid Synthesis of Lomustine Under Continuous Flow Conditions
    Publication number: 20200115330
    Abstract: Disclosed herein is a continuous manufacturing process for lomustine that has a short residence time and 63 percent yield. Major advantages of this process are that the total production cost for lomustine is lower, the product is higher quality, and the manufacturing operation is safer for production personnel.
    Type: Application
    Filed: October 16, 2019
    Publication date: April 16, 2020
    Inventors: David H. Thompson, Robert Graham Cooks, Christina Ramires Ferreira, Zinia Jaman
  • Ion traps that apply an inverse Mathieu q scan
    Patent number: 10622202
    Abstract: The invention generally relates to ion traps that operate by applying an inverse Mathieu q scan. In certain embodiments, the invention provides systems that include a mass spectrometer having an ion trap and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply an inverse Mathieu q scan to the ion trap.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: April 14, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Dalton Snyder