Patents by Inventor Robert Graham

Robert Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mass spectrometry analysis of microorganisms in samples
    Patent number: 10622198
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: April 14, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • ION focusing
    Patent number: 10615021
    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: April 7, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
  • Systems and methods for relay ionization
    Patent number: 10580634
    Abstract: The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: March 3, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Anyin Li, Adam Hollerbach
  • Systems and methods for conducting neutral loss scans in a single ion trap
    Patent number: 10580633
    Abstract: The invention generally relates to systems and methods for conducting neutral loss scans in a single ion trap. In certain aspects, the invention provides systems that include a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a scan function that excites a precursor ion, rejects the precursor ion after its excitation, and ejects a product ion in the single ion trap.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: March 3, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Dalton Snyder
  • Methods of analyzing crude oil
    Patent number: 10571453
    Abstract: The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: February 25, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Fred Paul Mark Jjunju, Anyin Li, Iman S. Roqan
  • Mass spectrometry probes and systems for ionizing a sample
    Patent number: 10559455
    Abstract: The invention generally relates to mass spectrometry probes and systems for ionizing a sample. In certain embodiments, the invention provides a mass spectrometry probe including a substrate in which a portion of the substrate is coated with a material, a portion of which protrudes from the substrate.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: February 11, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Depanjan Sarkar, Thalappil Pradeep, Rahul Narayanan
  • Enclosed desorption electrospray ionization probes and method of use thereof
    Patent number: 10555694
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: February 11, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • SYSTEMS AND METHODS FOR PRODUCING METAL CLUSTERS; FUNCTIONALIZED SURFACES; AND DROPLETS INCLUDING SOLVATED METAL IONS
    Publication number: 20200024762
    Abstract: The invention generally relates to systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions. In certain aspects, the invention provides methods that involve providing a metal and a solvent. The methods additionally involve applying voltage to the solvated metal to thereby produce solvent droplets including ions of the metal containing compound, and directing the solvent droplets including the metal ions to a target. In certain embodiments, once at the target, the metal ions can react directly or catalyze reactions.
    Type: Application
    Filed: May 17, 2019
    Publication date: January 23, 2020
    Inventors: Robert Graham Cooks, Anyin Li, Thalappil Pradeep, Zane Baird
  • SYSTEMS AND METHODS FOR CONDUCTING REACTIONS AND SCREENING FOR REACTION PRODUCTS
    Publication number: 20200020516
    Abstract: The invention generally relates to systems and methods for conducting reactions and screening for reaction products.
    Type: Application
    Filed: March 22, 2018
    Publication date: January 16, 2020
    Inventor: Robert Graham Cooks
  • AUTOMATED MANUFACTURE OF COMPLEX CONTOURED COMPOSITE PARTS
    Publication number: 20190389150
    Abstract: A method and apparatus for forming a composite object. A first plurality of tows is laid up over a tool according to a first path. A second plurality of tows is laid up over the tool according to a second path. A first portion of the first plurality of tows runs non-parallel to a second portion of the second plurality of tows. First ends of the first portion of the first plurality of tows and second ends of the second portion of the second plurality of tows meet at a merge zone along the tool to form a ply of a composite laminate.
    Type: Application
    Filed: June 20, 2018
    Publication date: December 26, 2019
    Inventors: Michael Kenneth-Que Louie, Jeron D. Moore, Gagandeep Saini, Luis A. Perla, Brice Aaron Johnson, Stewart James Ibbotson, Timothy D. Jackson, Robert G. Meyer, Robert Graham Albers
  • Systems and methods for ejection of ions from an ion trap
    Patent number: 10515792
    Abstract: The invention generally relates to systems and methods for ejection of ions from an ion trap. In certain embodiments, systems and methods of the invention sum two different frequency signals into a single summed signal that is applied to an ion trap. In other embodiments, an amplitude of a single frequency signal is modulated as the single frequency signal is being applied to the ion trap. In other embodiments, a first alternating current (AC) signal is applied to an ion trap that varies as a function of time, while a constant radio frequency (RF) signal is applied to the ion trap.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: December 24, 2019
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Dalton Snyder
  • ENCLOSED DESORPTION ELECTROSPRAY IONIZATION PROBES AND METHOD OF USE THEREOF
    Publication number: 20190374136
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Application
    Filed: August 13, 2019
    Publication date: December 12, 2019
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • MASS SPECTROMETRY PROBES AND SYSTEMS FOR IONIZING A SAMPLE
    Publication number: 20190355567
    Abstract: The invention generally relates to mass spectrometry probes and systems for ionizing a sample. In certain embodiments, the invention provides a mass spectrometry probe including a substrate in which a portion of the substrate is coated with a material, a portion of which protrudes from the substrate.
    Type: Application
    Filed: July 19, 2019
    Publication date: November 21, 2019
    Inventors: Robert Graham Cooks, Depanjan Sarkar, Thalappil Pradeep, Rahul Narayanan
  • SURFACE QUALITY OF COMPOSITE STRUCTURES
    Publication number: 20190344513
    Abstract: An illustrative example of the present disclosure provides a method. A first set of composite plies including a first outer ply of a first composite structure is laid up. A first intermediate surface of the first outer ply is measured to form a first set of measurements. A laydown surface for a tool path of a composite placement machine is modified to form a modified tool path, wherein modifying the laydown surface comprises modifying the laydown surface such that a laydown surface of the modified tool path matches the first set of measurements. A composite ply is laid down using the composite placement machine and the modified tool path.
    Type: Application
    Filed: May 11, 2018
    Publication date: November 14, 2019
    Inventors: Michael Kenneth-Que Louie, Robert Graham Albers, Jeron D. Moore, Luis A. Perla, Gagandeep Saini, Brice A. Johnson, Marcin A. Rabiega
  • SYSTEMS AND METHODS FOR RELAY IONIZATION
    Publication number: 20190348266
    Abstract: The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.
    Type: Application
    Filed: July 22, 2019
    Publication date: November 14, 2019
    Applicant: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Anyin Li, Adam Hollerbach
  • Enclosed desorption electrospray ionization probes and method of use thereof
    Patent number: 10420495
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: September 24, 2019
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • Systems and methods for relay ionization
    Patent number: 10395911
    Abstract: The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: August 27, 2019
    Assignee: Rudue Research Foundation
    Inventors: Robert Graham Cooks, Anyin Li, Adam Hollerbach
  • Mass spectrometry probes and systems for ionizing a sample transport
    Patent number: 10395913
    Abstract: The invention generally relates to mass spectrometry probes and systems for ionizing a sample. In certain embodiments, the invention provides a mass spectrometry probe including a substrate in which a portion of the substrate is coated with a material, a portion of which protrudes from the substrate.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: August 27, 2019
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Depanjan Sarkar, Thalappil Pradeep, Rahul Narayanan
  • Keys for encrypted disk partitions
    Patent number: 10389693
    Abstract: Examples described herein include receiving a key request from a requestor, determining a validity of the key request, and sending the key to the requestor based on the determination of the validity of the key request. In some examples, the key request is for a key to an encrypted disk partition of a protected computing device and comprises a unique identifier associated with the encrypted disk partition.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: August 20, 2019
    Assignee: Hewlett Packard Enterprise Development LP
    Inventors: Robert Graham Clark, Timothy John Kelsey, Bryan Stephenson, Douglas Chivers
  • Structure with feed through
    Patent number: 10370928
    Abstract: A technique provides protection against unwanted conditions in wellhead structures and other structures. According to the technique, a system provides a feed through in a wellhead structure or other type of structure. The feed through may accommodate a communication line routed therethrough. A closing device is positioned in the structure at a location to enable closing of the feed through via the closing device. Additionally, a condition-sensitive device is operatively engaged with the closing device to initiate actuation of the closing device once the condition-sensitive device is exposed to a predetermined condition. Upon exposure to the predetermined condition, the condition-sensitive device initiates closing of the feed through via the closing device.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: August 6, 2019
    Assignee: SCHLUMBERGER TECHNOLOGY CORPORATION
    Inventors: David Noakes, Robert Graham, Colin Wilson