Patents by Inventor Robert Graham

Robert Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ZERO VOLTAGE MASS SPECTROMETRY PROBES AND SYSTEMS
    Publication number: 20190237315
    Abstract: The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.
    Type: Application
    Filed: February 20, 2019
    Publication date: August 1, 2019
    Inventors: Robert Graham Cooks, Michael Stanley Wleklinski, Soumabha Bag, Yafeng Li
  • Synchronization of ion generation with cycling of a discontinuous atmospheric interface
    Patent number: 10361073
    Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: July 23, 2019
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Jason Duncan, Guangming Huang, Guangtao Li, Xin Yan, Ewa Sokol, Xin Li
  • METHODS FOR ANALYZING STABILITY OF AN ACTIVE PHARMACEUTICAL INGREDIENT
    Publication number: 20190219555
    Abstract: The invention generally relates to methods for analyzing stability of an active pharmaceutical agent. In certain aspects, the methods involve obtaining an active pharmaceutical agent, and distributing the active pharmaceutical agent into one or more microdroplets. The one or more microdroplets including the active pharmaceutical agent are then subjected to one or more conditions that force degradation of the active pharmaceutical agent in each of the one or more microdroplets. The one or more microdroplets are then analyzed to determine a ratio of the active pharmaceutical agent to that of a degradation product of the active pharmaceutical agent, thereby analyzing stability of an active pharmaceutical agent.
    Type: Application
    Filed: January 11, 2019
    Publication date: July 18, 2019
    Inventors: Robert Graham Cooks, Roy Helmy, Yangjie Li, Yong Liu
  • MASS SPECTROMETRY ANALYSIS OF MICROORGANISMS IN SAMPLES
    Publication number: 20190206668
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Application
    Filed: December 18, 2018
    Publication date: July 4, 2019
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • Systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions
    Patent number: 10329679
    Abstract: The invention generally relates to systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions. In certain aspects, the invention provides methods that involve providing a metal and a solvent. The methods additionally involve applying voltage to the solvated metal to thereby produce solvent droplets including ions of the metal containing compound, and directing the solvent droplets including the metal ions to a target. In certain embodiments, once at the target, the metal ions can react directly or catalyze reactions.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: June 25, 2019
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Anyin Li, Thalappil Pradeep, Zane Baird
  • SYNCHRONIZATION OF ION GENERATION WITH CYCLING OF A DISCONTINUOUS ATMOSPHERIC INTERFACE
    Publication number: 20190189415
    Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
    Type: Application
    Filed: January 29, 2019
    Publication date: June 20, 2019
    Inventors: Robert Graham Cooks, Guangtao Li, Guangming Huang, Jason Duncan, Xin Li, Ewa Sokol, Xin Yan
  • SYSTEMS AND METHODS FOR RELAY IONIZATION
    Publication number: 20190180995
    Abstract: The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.
    Type: Application
    Filed: February 1, 2019
    Publication date: June 13, 2019
    Inventors: Robert Graham Cooks, Anyin Li, Adam Hollerbach
  • ENCLOSED DESORPTION ELECTROSPRAY IONIZATION PROBES AND METHOD OF USE THEREOF
    Publication number: 20190167164
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Application
    Filed: January 15, 2019
    Publication date: June 6, 2019
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • Systems and methods for transfer of ions for analysis
    Patent number: 10290483
    Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: May 14, 2019
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Robert Graham Cooks, Sandilya Venkata Garimella, Jason David Harper, Nicholas Alan Charipar
  • METHODS OF ANALYZING CRUDE OIL
    Publication number: 20190137473
    Abstract: The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps.
    Type: Application
    Filed: December 26, 2018
    Publication date: May 9, 2019
    Inventors: Robert Graham Cooks, Fred Paul Mark Jjunju, Anyin Li, Iman S. Roqan
  • CHARGED MASS LABELING SYSTEM
    Publication number: 20190128897
    Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.
    Type: Application
    Filed: January 20, 2017
    Publication date: May 2, 2019
    Inventors: Robert Graham Cooks, Zane Baird, Michael Pugia, Adam Hollerbach, Stephen Ayrton
  • Implant heat protection
    Patent number: 10265533
    Abstract: Presented herein are techniques for protecting an implantable component of a medical device from the buildup of excessive heat following a charging process. In one embodiment, the implantable component includes a resonant tank circuit that includes an implantable coil that receives power from the external charging device via an inductive link. The implantable component includes a rechargeable battery that is electrically connected to the resonant tank circuit and that can be recharged using the power received from the external charging device. A controller in the implantable component is configured to determine when charging of the rechargeable battery should be terminated and, in response, detune the resonant tank circuit in accordance with a predetermined pattern to signal to the external charging device that charging of the rechargeable battery should be terminated.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: April 23, 2019
    Assignee: COCHLEAR LIMITED
    Inventors: Werner Meskens, Oliver John Ridler, Robert Graham Bennett
  • Zero voltage mass spectrometry probes and systems
    Patent number: 10256085
    Abstract: The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: April 9, 2019
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Michael Stanley Wleklinski, Soumabha Bag, Yafeng Li
  • Systems and methods for relay ionization
    Patent number: 10242856
    Abstract: The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: March 26, 2019
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Robert Graham Cooks, Anyin Li, Adam Hollerbach
  • PRECURSOR AND NEUTRAL LOSS SCAN IN AN ION TRAP
    Publication number: 20190066989
    Abstract: The invention generally relates to systems and methods for precursor and neutral loss scan in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to excite a precursor ion and eject a product ion in the single ion trap.
    Type: Application
    Filed: November 2, 2016
    Publication date: February 28, 2019
    Applicant: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Dalton Snyder, Christopher Pulliam
  • SYSTEMS AND METHODS FOR SAMPLE ANALYSIS USING SWABS
    Publication number: 20190066991
    Abstract: The invention generally relates to systems and methods for sample analysis using swabs. In certain aspects, the invention provides systems that include a probe having a conductive proximal portion coupled to a porous material at a distal portion of the probe that is configured to retain a portion of a sample that has contacted the porous material, and a mass spectrometer having an inlet. The system is configured such that the porous material at a distal portion of the probe is aligned over the inlet of the mass spectrometer.
    Type: Application
    Filed: August 13, 2018
    Publication date: February 28, 2019
    Inventors: Robert Graham Cooks, Alan Keith Jarmusch, Valentina Pirro
  • Enclosed desorption electrospray ionization probes and method of use thereof
    Patent number: 10213143
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: February 26, 2019
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-Hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • ION TRAPS THAT APPLY AN INVERSE MATHIEU Q SCAN
    Publication number: 20190057856
    Abstract: The invention generally relates to ion traps and methods of use thereof. In certain embodiments, the invention provides a system that includes a mass spectrometer including an ion trap, and a central processing unit (CPU). The CPU has storage that is coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a constant radio frequency (RF) signal to the ion trap, and apply a first alternating current (AC) signal to the ion trap the frequency of which varies as a function of time.
    Type: Application
    Filed: October 21, 2016
    Publication date: February 21, 2019
    Applicants: Purdue Research Foundation, Purdue Research Foundation
    Inventors: Robert Graham Cooks, Jason Duncan, Joshua Wiley
  • Mass spectrometry analysis of microorganisms in samples
    Patent number: 10204772
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: February 12, 2019
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • SYSTEMS AND METHODS FOR ISOLATING A TARGET ION IN AN ION TRAP
    Publication number: 20190043706
    Abstract: The invention generally relates to systems and methods for isolating a target ion in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a dual frequency waveform to the ion trap that ejects non-target ions from the ion trap while retaining a target ion in the ion trap.
    Type: Application
    Filed: April 13, 2017
    Publication date: February 7, 2019
    Inventors: Robert Graham Cooks, Dalton Snyder