Patents by Inventor Robert Graham

Robert Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determining whether a peptide comprises aspartate or isoaspartate
    Patent number: 10908165
    Abstract: The invention generally relates to methods for determining whether a peptide includes aspartate or isoaspartate. In certain aspects, methods of the invention involve binding an aspartate/isoaspartate residue in a peptide with a label to produce a labeled peptide. The labeled peptide is then ionized. The ionizing process causes the label to undergo rearrangement in a gas phase at a higher rate if the label is bound to the aspartate residue as compared to if the label is bound to the isoaspartate residue. The methods of the invention then involve performing a mass spectrometry analysis to detect the rearrangement of the label, thereby determining whether the peptide includes aspartate or isoaspartate.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: February 2, 2021
    Assignees: Purdue Research Foundation, AMGEN INC.
    Inventors: Stephen T. Ayrton, Robert Graham Cooks, Tawnya Flick, Da Ren
  • NASAL CANNULA
    Publication number: 20210023322
    Abstract: A nasal cannula comprising: a body portion, having a first end and a second end, the first and second ends being spaced apart from one another by the body portion; a body fluid inlet port formed at the first end, and a body fluid outlet port formed at the second end; and a first nasal inlet port and a first nasal output port each extending from the body portion of the cannula, the first nasal inlet port being in fluid communication with the body fluid outlet port, and the first nasal outlet port being in fluid communication with the body fluid inlet port, wherein the nasal cannula comprises first and second end caps at the first and second ends respectively, which first and second end caps are attachable to the body portion, and wherein the body fluid inlet port is formed in the first end cap, and the body fluid outlet port is formed in the second end cap.
    Type: Application
    Filed: March 27, 2019
    Publication date: January 28, 2021
    Inventor: Robert Graham URIE
  • LOGICAL OPERATIONS IN MASS SPECTROMETRY
    Publication number: 20210013023
    Abstract: The invention generally relates to logical operations in mass spectrometry. The system comprising a mass spectrometer comprising one or more ion traps; and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply one or more scan functions to the one or more ion traps, the scan functions being combine together.
    Type: Application
    Filed: March 18, 2019
    Publication date: January 14, 2021
    Inventors: Robert Graham Cooks, Dalton Snyder, Lucas Szalwinski
  • MASS SPECTROMETRY ANALYSIS OF MICROORGANISMS IN SAMPLES
    Publication number: 20200402786
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Application
    Filed: September 8, 2020
    Publication date: December 24, 2020
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • MULTIPLEXED INDUCTIVE IONIZATION SYSTEMS AND METHODS
    Publication number: 20200381238
    Abstract: The invention generally relates to systems including nanoelectrospray ionization emitters in a movable array format in which the emitters can be loaded, singly or simultaneously, through their narrow ends using a novel dip and go method based on capillary action, taking up sample from an array. The sample solutions in each emitter can be electrophoretically cleaned, singly or simultaneously, by creating an inductive electric field that moves interfering ions away from the narrow end of the capillary. Subsequent to cleaning, the emitters are supplied with an inductive electric field that causes electrospray into a mass spectrometer allowing mass analysis of the contents of the emitter.
    Type: Application
    Filed: May 28, 2020
    Publication date: December 3, 2020
    Inventors: Robert Graham Cooks, Zhenwei Wei, David G. Mclaren
  • ION FOCUSING
    Publication number: 20200381237
    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.
    Type: Application
    Filed: August 7, 2020
    Publication date: December 3, 2020
    Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
  • Systems and methods for conducting neutral loss scans in a single ion trap
    Patent number: 10840074
    Abstract: The invention generally relates to systems and methods for conducting neutral loss scans in a single ion trap. In certain aspects, the invention provides systems that include a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a scan function that excites a precursor ion, rejects the precursor ion after its excitation, and ejects a product ion in the single ion trap.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: November 17, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Dalton Snyder
  • SYNCHRONIZATION OF ION GENERATION WITH CYCLING OF A DISCONTINUOUS ATMOSPHERIC INTERFACE
    Publication number: 20200357620
    Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
    Type: Application
    Filed: July 16, 2020
    Publication date: November 12, 2020
    Inventors: Robert Graham Cooks, Guangtao Li, Guangming Huang, Jason Duncan, Xin Li, Ewa Sokol, Xin Yan
  • SAMPLE DISPENSER INCLUDING AN INTERNAL STANDARD AND METHODS OF USE THEREOF
    Publication number: 20200355671
    Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof.
    Type: Application
    Filed: July 23, 2020
    Publication date: November 12, 2020
    Inventors: Zheng Ouyang, He Wang, Nicholas E. Manicke, Robert Graham Cooks, Qian Yang, Jiangjiang Liu
  • Collapsible fish filleting station systems
    Patent number: 10827761
    Abstract: A collapsible fish filleting station system that relates generally to the field of work-tables and more specifically relates to fish-holding and auxiliary devices in connection with work-tables. The collapsible fish filleting station includes a cutting board comprising a rigid, substantially rectangular, panel and a support assembly configured to support the cutting board in a stable working position over the gunwale of a boat.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: November 10, 2020
    Inventor: Robert Graham
  • ION GENERATION USING MODIFIED WETTED POROUS MATERIALS
    Publication number: 20200340962
    Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 29, 2020
    Inventors: Robert Graham Cooks, Zheng Ouyang
  • Mass spectrometry analysis of microorganisms in samples
    Patent number: 10811241
    Abstract: The invention generally relates to methods for analyzing an analyte in a sample. In certain embodiments, the methods involve providing a capture module, the module configured to capture an analyte in a sample in an ambient environment and generate ions of the analyte, wherein the capture module comprises a cartridge and a porous substrate within the cartridge that is connected to a voltage source, and wherein the porous substrate further comprises an internal standard; capturing the analyte in the sample to the porous substrate of the capture module; generating ions of the analyte and the internal standard held by the porous substrate via the voltage source that is coupled to the porous substrate; and analyzing the generated ions of the analyte and the internal standard in a mass analyzer that is operably coupled to the capture module.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: October 20, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • Enclosed desorption electrospray ionization probes and method of use thereof
    Patent number: 10799165
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: October 13, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • SYSTEMS AND METHODS FOR SEPARATING IONS AT ABOUT OR ABOVE ATMOSPHERIC PRESSURE
    Publication number: 20200321208
    Abstract: The invention generally relates to systems and methods for separating ions at about or above atmospheric pressure. In certain embodiments, the invention provides systems that include an ionization source that generates ions and an ion trap. The ion trap is maintained at about or above atmospheric pressure and includes a plurality of electrodes and at least one inlet configured to receive a gas flow and at least one outlet. The system is configured such that a combination of a gas flow and one or more electric fields produced by the electrodes separates the ions based on mass-to-charge ratio and sends the separated ions through the at least one outlet of the ion trap.
    Type: Application
    Filed: June 22, 2020
    Publication date: October 8, 2020
    Inventors: Robert Graham Cooks, Dalton Snyder, Amar S. Basu, Wen-Ping Peng
  • SAMPLE ANALYSIS SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20200312650
    Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.
    Type: Application
    Filed: June 8, 2020
    Publication date: October 1, 2020
    Inventors: Robert Graham Cooks, Zane Baird, Pu Wei
  • MASS SPECTROMETRY ANALYSIS OF MICROORGANISMS IN SAMPLES
    Publication number: 20200294781
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Application
    Filed: March 4, 2020
    Publication date: September 17, 2020
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • Ion focusing
    Patent number: 10777400
    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: September 15, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
  • Conducting reactions in Leidenfrost-levitated droplets
    Patent number: 10774044
    Abstract: The invention generally relates to conducting reactions in Leidenfrost-levitated droplets.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: September 15, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Christopher Pulliam, Ryan M. Bain
  • Sample dispenser including an internal standard and methods of use thereof
    Patent number: 10761083
    Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: September 1, 2020
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, He Wang, Nicholas E. Manicke, Robert Graham Cooks, Qian Yang, Jiangjiang Liu
  • Synchronization of ion generation with cycling of a discontinuous atmospheric interface
    Patent number: 10755910
    Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: August 25, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Guangtao Li, Guangming Huang, Jason Duncan, Xin Li, Ewa Sokol, Xin Yan