Patents by Inventor Robert Graham

Robert Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of analyzing crude oil
    Patent number: 10197547
    Abstract: The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: February 5, 2019
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Fred Paul Mark Jjunju, Anyin Li, Iman S. Roqan
  • SYSTEMS AND METHODS FOR COLLISION INDUCED DISSOCIATION OF IONS IN AN ION TRAP
    Publication number: 20190035619
    Abstract: The invention generally relates to systems and methods for collision induced dissociation of ions in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to generate one or more signals, and apply the one or more signals to the ion trap in a manner that all ions within the ion trap are fragmented at a same Mathieu q value.
    Type: Application
    Filed: April 6, 2017
    Publication date: January 31, 2019
    Inventors: Robert Graham Cooks, Dalton Snyder
  • SYSTEMS AND METHODS FOR PERFORMING MULTIPLE PRECURSER, NEUTRAL LOSS AND PRODUCT ION SCANS IN A SINGLE ION TRAP
    Publication number: 20190035614
    Abstract: The invention generally relates to systems and methods for performing multiple precursor, neutral loss and product ion scans in a single ion trap. In certain aspects, the invention provides systems including a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply at least one of the following ion scans to a single ion population in the single ion trap: multiple precursor ion scans, a plurality of segmented neutral loss scans, or multiple simultaneous neutral loss scans.
    Type: Application
    Filed: July 27, 2018
    Publication date: January 31, 2019
    Inventors: Robert Graham Cooks, Dalton Snyder
  • System and method for retaining memory modules
    Patent number: 10193248
    Abstract: The present invention is an apparatus and method for allowing for the use of commercial dual inline memory module (DIMM) in high shock and vibration environments while preserving serviceability. This system extends the performance of the standard Joint Electron Device Engineering (JEDEC) memory connectors in said environments without sacrificing high speed electrical performance. The system provides a simple clip which locks the module in place using the standard connector latches preventing relative motion of the connector and the DIMM thereby insuring uninterrupted computational performance. The clip may be formed with resilient ends that snap onto pivotal latching devices to prevent inadvertent opening of these latching devices. The clips may also include bumper spacers (205) on their opposite faces to engage bumper spacers of adjacent clips to maintain the modules in proper orientation.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: January 29, 2019
    Assignee: Crystal Group, Inc.
    Inventors: James E Shaw, Rachel Manson, Chase Marsden, Robert Graham, Brent Sievers, Shawn Castillo
  • SYSTEMS AND METHODS FOR PRODUCING METAL CLUSTERS; FUNCTIONALIZED SURFACES; AND DROPLETS INCLUDING SOLVATED METAL IONS
    Publication number: 20190024250
    Abstract: The invention generally relates to systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions. In certain aspects, the invention provides methods that involve providing a metal and a solvent. The methods additionally involve applying voltage to the solvated metal to thereby produce solvent droplets including ions of the metal containing compound, and directing the solvent droplets including the metal ions to a target. In certain embodiments, once at the target, the metal ions can react directly or catalyze reactions.
    Type: Application
    Filed: September 21, 2018
    Publication date: January 24, 2019
    Inventors: Robert Graham Cooks, Anyin Li, Thalappil Pradeep, Zane Baird
  • SYSTEMS AND METHODS FOR SEPARATING IONS AT ABOUT OR ABOVE ATMOSPHERIC PRESSURE
    Publication number: 20190027356
    Abstract: The invention generally relates to systems and methods for separating ions at about or above atmospheric pressure. In certain embodiments, the invention provides systems that include an ionization source that generates ions and an ion trap. The ion trap is maintained at about or above atmospheric pressure and includes a plurality of electrodes and at least one inlet configured to receive a gas flow and at least one outlet. The system is configured such that a combination of a gas flow and one or more electric fields produced by the electrodes separates the ions based on mass-to-charge ratio and sends the separated ions through the at least one outlet of the ion trap.
    Type: Application
    Filed: January 27, 2017
    Publication date: January 24, 2019
    Inventors: Robert Graham Cooks, Dalton Snyder, Amar S. Basu, Wen-Ping Peng
  • ELECTROPHORETIC MASS SPECTROMETRY PROBES AND SYSTEMS AND USES THEREOF
    Publication number: 20190019662
    Abstract: The invention generally relates to electrophoretic mass spectrometry probes and systems and methods of uses thereof. In certain aspects, the invention provides a mass spectrometry probe having a hollow body with a distal tip, an electrically conductive hollow conduit, and an electrode. The electrically conductive hollow conduit may be operably coupled to a reservoir and a power source, and the electrically conductive hollow conduit may be configured to transport a liquid sample into the hollow body and polarize the liquid sample as it flows through the electrically conductive hollow conduit and into in the hollow body. The electrode and the electrically conductive hollow conduit are disposed within the hollow body (e.g., at different heights within the hollow body).
    Type: Application
    Filed: June 27, 2018
    Publication date: January 17, 2019
    Inventors: Robert Graham Cooks, Tawnya Flick
  • Power supply disconnect current measurement for an implantable medical device
    Patent number: 10173064
    Abstract: An implantable medical device (IMD) is disclosed having measurement circuitry for measuring one or more currents in the IMD, such as the currents drawn from various power supply voltages. Such currents are measured without disrupting normal IMD operation, and can be telemetered from the IMD for review. Switching circuitry in line with the current being measured is temporarily opened for a time period to disconnect the power supply voltage from the circuitry being powered. A voltage across a capacitance in parallel with the circuitry is measured when the switching circuitry is opened and again closed at the end of the time period, with the circuitry drawing power from the charged capacitance during this time period. The average current drawn by the power supply voltage is determined using the difference in the measured voltages, the known capacitance, and the time period between the measurements.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: January 8, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Robert Graham Lamont, Damon Moazen, Robert D. Ozawa, Thomas W. Stouffer
  • SAMPLE ANALYSIS SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20190006167
    Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.
    Type: Application
    Filed: August 14, 2018
    Publication date: January 3, 2019
    Inventors: Robert Graham Cooks, Zane Baird, Pu Wei
  • Systems and methods for screening a sample based on multiple reaction monitoring mass spectrometry
    Patent number: 10168312
    Abstract: The invention generally relates to systems methods for screening a sample based on multiple reaction monitoring mass spectrometry. In certain embodiments, the invention provides methods for screening a sample that involve ionizing a sample. Mass spectrometry is then used in order to monitor specific transitions connecting one or more ion pairs within the sample in order to generate a multidimensional chemical profile of the sample. Then, the multidimensional chemical profile of the sample is compared to a database of reference multidimensional chemical profiles, thereby screening the sample. Each reference multidimensional chemical profile is produced from a training set of data.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: January 1, 2019
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Robert Graham Cooks, Christina Ramires Ferreira, Tiago Sobreira
  • ION GENERATION USING MODIFIED WETTED POROUS MATERIALS
    Publication number: 20180372699
    Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
    Type: Application
    Filed: August 21, 2018
    Publication date: December 27, 2018
    Inventors: Robert Graham Cooks, Zheng Ouyang
  • SINGLE MASK LEVEL FORMING BOTH TOP-SIDE-CONTACT AND ISOLATION TRENCHES
    Publication number: 20180358258
    Abstract: A method of forming an integrated circuit includes forming ?1 hard mask layer on a device layer on a BOX layer of a SOI substrate. A patterned masking layer is used for a trench etch to simultaneously form larger and smaller area trenches through the hard mask layer, device layer and the BOX layer. A dielectric liner is formed for lining the larger and smaller area trenches. A dielectric layer is deposited for completely filling the smaller area trenches and only partially filling the larger area trenches. The larger area trenches are bottom etched through the dielectric layer to provide a top side contact to the handle portion. The handle portion at a bottom of the larger area trenches is implanted to form a handle contact, and the larger area trenches are completely filled with an electrically conductive layer to form a top side ohmic contact to the handle contact.
    Type: Application
    Filed: June 9, 2017
    Publication date: December 13, 2018
    Inventors: ZACHARY K. LEE, ROBERT GRAHAM SHAW, HIDEAKI KAWAHARA, ASAD MAHMOOD HAIDER, YUJI MIZUGUCHI, HIROSHI YAMASAKI, ABBAS ALI, BRIAN GOODLIN
  • METHOD FOR DETERMINING WHETHER A PEPTIDE COMPRISES ASPARTATE OR ISOASPARTATE
    Publication number: 20180356426
    Abstract: The invention generally relates to methods for determining whether a peptide includes aspartate or isoaspartate. In certain aspects, methods of the invention involve binding an aspartate/isoaspartate residue in a peptide with a label to produce a labeled peptide. The labeled peptide is then ionized. The ionizing process causes the label to undergo rearrangement in a gas phase at a higher rate if the label is bound to the aspartate residue as compared to if the label is bound to the isoaspartate residue. The methods of the invention then involve performing a mass spectrometry analysis to detect the rearrangement of the label, thereby determining whether the peptide includes aspartate or isoaspartate.
    Type: Application
    Filed: June 7, 2018
    Publication date: December 13, 2018
    Applicants: Purdue Research Foundation, AMGEN
    Inventors: Stephen T. Ayrton, Robert Graham Cooks, Tawnya Flick, Da Ren
  • SYSTEMS AND METHODS FOR CONDUCTING NEUTRAL LOSS SCANS IN A SINGLE ION TRAP
    Publication number: 20180342382
    Abstract: The invention generally relates to systems and methods for conducting neutral loss scans in a single ion trap. In certain aspects, the invention provides systems that include a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a scan function that excites a precursor ion, rejects the precursor ion after its excitation, and ejects a product ion in the single ion trap.
    Type: Application
    Filed: May 21, 2018
    Publication date: November 29, 2018
    Inventors: Robert Graham Cooks, Dalton Snyder
  • ION FOCUSING
    Publication number: 20180330934
    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.
    Type: Application
    Filed: June 5, 2018
    Publication date: November 15, 2018
    Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
  • UNIT DOSE DETERGENT COMPOSITIONS
    Publication number: 20180312788
    Abstract: The present invention relates to unit dose detergent compositions comprising a water-soluble container formed from a water-soluble film material enclosing a liquid composition with a relatively high water content. In one embodiment, the unit dose detergent composition comprises a water-soluble container formed from a water-soluble film material enclosing a liquid composition, wherein the liquid composition comprises (a) at least one surfactant, (b) at least one humectant selected from the group consisting of polyols having 3 to 9 carbon atoms, and (c) about 15 wt % to about 35 wt % of water.
    Type: Application
    Filed: July 5, 2018
    Publication date: November 1, 2018
    Applicant: Henkel IP & Holding GmbH
    Inventors: Syed Humza Naqvi, Troy Robert Graham, Ryan Bradley Cameron
  • Systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions
    Patent number: 10113242
    Abstract: The invention generally relates to systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions. In certain aspects, the invention provides methods that involve providing a metal and a solvent. The methods additionally involve applying voltage to the solvated metal to thereby produce solvent droplets including ions of the metal containing compound, and directing the solvent droplets including the metal ions to a target. In certain embodiments, once at the target, the metal ions can react directly or catalyze reactions.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: October 30, 2018
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Michael Stanley Wleklinski, Thalappil Pradeep, Depanjan Sarkar
  • SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS
    Publication number: 20180286651
    Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
    Type: Application
    Filed: May 24, 2018
    Publication date: October 4, 2018
    Inventors: Zheng Ouyang, Robert Graham Cooks, Sandilya Venkata Garimella, Jason David Harper, Nicholas Alan Charipar
  • ENCLOSED DESORPTION ELECTROSPRAY IONIZATION PROBES AND METHOD OF USE THEREOF
    Publication number: 20180279927
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Application
    Filed: May 25, 2018
    Publication date: October 4, 2018
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-Hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • Ion generation using modified wetted porous materials
    Patent number: 10088461
    Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: October 2, 2018
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang