Patents by Inventor Robert H. Grubbs

Robert H. Grubbs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11866398
    Abstract: This invention relates generally to the synthesis of ?12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. ?12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: January 9, 2024
    Assignee: California Institute of Technology
    Inventors: Jiaming Li, Xu Chen, Tonia S. Ahmed, Brian M. Stoltz, Robert H. Grubbs
  • Patent number: 11844724
    Abstract: A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: December 19, 2023
    Assignees: California Institute of Technology, The Regents of the University of California, United States Government represented by the Department of Veterans Affairs
    Inventors: Robert H. Grubbs, Marshall L Stoller, Ying Han, Frank L. Brodie
  • Patent number: 11830983
    Abstract: Electrolyte solutions including at least one anhydrous fluoride salt and at least one non-aqueous solvent are presented. The fluoride salt includes an organic cation having a charge center (e.g., N, P, S, or O) that does not possess a carbon in the ?-position or does not possess a carbon in the ?-position having a bound hydrogen. This salt structure facilitates its ability to be made anhydrous without decomposition. Example anhydrous fluoride salts include (2,2-dimethylpropyl)trimethylammonium fluoride and bis(2,2-dimethylpropyl)dimethylammonium fluoride. Combining these fluoride salts with at least one fluorine-containing non-aqueous solvent (e.g., bis(2,2,2-trifluoroethyl)ether; (BTFE)) promotes solubility of the salt within the non-aqueous solvents. The solvent may be a mixture of at least one non-aqueous, fluorine-containing solvent and at least one other non-aqueous, fluorine or non-fluorine containing solvent (e.g., BTFE and propionitrile or dimethoxyethane).
    Type: Grant
    Filed: March 30, 2021
    Date of Patent: November 28, 2023
    Assignees: California Institute of Technology, Honda Motor Co., Ltd.
    Inventors: Simon C. Jones, Victoria K. Davis, Christopher M. Bates, Nebojsa Momcilovic, Brett M. Savoie, Michael A. Webb, Thomas F. Miller, III, Robert H. Grubbs, Christopher Brooks, Kaoru Omichi
  • Publication number: 20230355242
    Abstract: Aspects disclosed herein include an implantable, detachable, and removable medical device comprising: a therapeutic balloon configured to perform a therapeutic activity inside a living subject; and a focused-ultrasound activatable actuator operably connected to the therapeutic balloon; wherein the actuator is capable of being activated between a closed state and an open state remotely via a focused ultrasound beam; wherein the device is configured to be in an implantation state to facilitate implantation of the device in the living subject, in a therapeutic state to facilitate performance of the therapeutic activity, and subsequently in an expulsion state to facilitate expulsion of the medical device from the living subject; and wherein the implantation state, therapeutic state, and expulsion state are different from each other
    Type: Application
    Filed: January 12, 2023
    Publication date: November 9, 2023
    Inventors: Max KUDISCH, Jeong Hoon KO, Chiara DARAIO, Mikhail G. SHAPIRO, Di WU, Gunho KIM, Robert H. GRUBBS, Michael R. HARRISON, Sunghoon KIM
  • Patent number: 11807617
    Abstract: A highly efficient, Z-selective ring-closing metathesis system for the formation of macrocycles using a stereoretentive, ruthenium-based catalyst supported by a dithiolate ligand is reported. This catalyst is demonstrated to be remarkably active as observed in initiation experiments showing complete catalyst initiation at ?20° C. within 10 min. Using easily accessible diene starting materials bearing a Z-olefin moiety, macrocyclization reactions generated products with significantly higher Z-selectivity in appreciably shorter reaction times, in higher yield, and with much lower catalyst loadings than in previously reported systems. Macrocyclic lactones ranging in size from twelve-membered to seventeen-membered rings are synthesized in moderate to high yields (68-79% yield) with excellent Z-selectivity (95%-99% Z).
    Type: Grant
    Filed: June 2, 2021
    Date of Patent: November 7, 2023
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Tonia S. Ahmed, Robert H. Grubbs
  • Publication number: 20230346886
    Abstract: Disclosed herein include methods, kits, formulations, and compositions for increasing choroidal or retinal perfusion or promoting non-leaking or minimally-leaking choroidal or retinal revascularization in a subject in need thereof. An effective amount of an angiogenesis factor (e.g., a pro-angiogenic factor and/or a vascular maturation factor) can be administered to the subject.
    Type: Application
    Filed: December 7, 2022
    Publication date: November 2, 2023
    Inventors: Robert H. Grubbs, Daniel M. Schwartz
  • Patent number: 11779912
    Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, articles of manufacture comprising such compounds, and the use of such compounds in the metathesis of olefins and olefin compounds. The invention has utility in the fields of catalysts, organic synthesis, polymer chemistry, and industrial and fine chemicals industry.
    Type: Grant
    Filed: August 27, 2021
    Date of Patent: October 10, 2023
    Assignees: UMICORE AG & Co. KG, CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Adam M. Johns, Jessica R. Herron, Richard L. Pederson, Bryan A. Fiamengo, Jennifer A. Beerman, Tzu-Pin Lin, Crystal K. Chu, Robert H. Grubbs
  • Patent number: 11773116
    Abstract: The present disclosure is directed to hydrosilyl amines and fluorosilyl amines and methods of making the same.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: October 3, 2023
    Assignee: California Institute of Technology
    Inventors: Anton A. Toutov, Kerry N. Betz, Andrew M. Romine, Robert H. Grubbs
  • Publication number: 20230285561
    Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
    Type: Application
    Filed: March 22, 2023
    Publication date: September 14, 2023
    Inventors: Robert H. GRUBBS, Marshall L. STOLLER, Hoyong CHUNG, Alissa M. FITZGERALD, Thomas W. KENNY, Renee M. THOMAS
  • Patent number: 11753421
    Abstract: The present disclosure describes methods for silylating aromatic derivatives, comprising the use of hydrosilanes and potassium hydroxide.
    Type: Grant
    Filed: March 7, 2022
    Date of Patent: September 12, 2023
    Assignee: California Institute of Technology
    Inventors: Anton Toutov, Kerry Betz, Alexey Fedorov, Brian M. Stoltz, Wenbo Liu, Robert H. Grubbs
  • Publication number: 20230219282
    Abstract: Aspects disclosed herein include a composite material comprising: one or more shape memory polymers; and a first additive provided in the shape memory polymer(s); wherein: the first additive increases one or more ultrasound-absorption characteristics of the composite material compared to that of the same shape memory polymer(s) free of said first additive; the composite material is characterized by a composite transition temperature (Tcm,trans); and the composite material or one or more portions thereof undergo a shape change from a temporary shape to a permanent shape when the composite material or said one or more portions thereof are heated to within 35° C. of Tcm,trans or a temperature approximately equal to or greater than Tcm,trans.
    Type: Application
    Filed: January 12, 2023
    Publication date: July 13, 2023
    Inventors: Max KUDISCH, Jeong Hoon KO, Chiara DARAIO, Mikhail G. SHAPIRO, Di WU, Gunho KIM, Robert H. GRUBBS, Ki-Young YOON
  • Publication number: 20230173071
    Abstract: This current disclosure is directed to compositions based on certain heptamethine dyes useful for generating singlet oxygen using NIR radiation, optionally comprising additives and solvents that enhance the performance of these dyes, and procedures using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near-infrared irradiation to improve the mechanical strength of the sclera.
    Type: Application
    Filed: December 16, 2022
    Publication date: June 8, 2023
    Inventors: John B. JARMAN, Dennis A. DOUGHERTY, Robert H. GRUBBS, Christopher B. MAROTTA, Daniel M. SCHWARTZ
  • Patent number: 11642410
    Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: May 9, 2023
    Assignees: California Institute of Technology, The Regents of the University of California
    Inventors: Robert H. Grubbs, Marshall L. Stoller, Hoyong Chung, Alissa M. Fitzgerald, Thomas W. Kenny, Renee M. Thomas
  • Publication number: 20230135901
    Abstract: The present disclosure relates to fluoride ion batteries and structures of metal based electrode materials for various fluoride ion batteries. The structures of the metal based electrode materials comprise one or more shells or interfaces, enabling the electrodes to operate at room temperature with a liquid electrolyte.
    Type: Application
    Filed: December 28, 2022
    Publication date: May 4, 2023
    Inventors: Qingmin XU, Christopher J. BROOKS, Kaoru OMICHI, Ryan K. MCKENNEY, Simon JONES, Victoria DAVIS, Stephen MUNOZ, Jeongmin KIM, Keith BILLINGS, Thomas MILLER, III, Robert H. GRUBBS, William WOLF, Nam Hawn CHOU
  • Publication number: 20230114064
    Abstract: The present disclosure sets forth novel compounds and compositions including heteroaromatic silicon-fluoride-acceptors, which are useful for PET scanning. The present disclosure further includes novel methods of 8F imaging for PET scanning, the methods comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic silicon-fluoride-acceptors. In certain embodiments the invention is practiced in the form of a kit.
    Type: Application
    Filed: September 19, 2022
    Publication date: April 13, 2023
    Inventors: Christopher Martin Waldmann, Anton A. Toutov, Jennifer Marie Murphy, Robert H. Grubbs
  • Patent number: 11621438
    Abstract: The present disclosure is directed to fluoride (F) ion batteries and F shuttle batteries comprising an anode with a solid electrolyte interphase (SEI) layer, a cathode comprising a core shell structure, and a liquid fluoride battery electrolyte. According to some aspects, the components therein enable discharge and recharge at room-temperature.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: April 4, 2023
    Assignees: HONDA MOTOR CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Qingmin Xu, Christopher J. Brooks, Kaoru Omichi, Simon Jones, Victoria Davis, Stephen Munoz, Jeongmin Kim, Keith Billings, Thomas Miller, III, Robert H. Grubbs, William Wolf
  • Patent number: 11581582
    Abstract: The present disclosure relates to fluoride ion batteries and structures of metal based electrode materials for various fluoride ion batteries. The structures of the metal based electrode materials comprise one or more shells or interfaces, enabling the electrodes to operate at room temperature with a liquid electrolyte.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: February 14, 2023
    Assignees: HONDA MOTOR CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Qingmin Xu, Christopher J. Brooks, Kaoru Omichi, Ryan K. McKenney, Simon Jones, Victoria Davis, Stephen Munoz, Jeongmin Kim, Keith Billings, Thomas Miller, III, Robert H. Grubbs, William Wolf, Nam Hawn Chou
  • Patent number: 11554094
    Abstract: The present disclosure is directed to fatty-acid glycerol ester derivative compounds containing a targeting bisphosphonate group. The disclosure further includes pharmaceutical or biomedical compositions comprising these compounds, and methods of using these compounds and compositions forming microbubbles. The microbubbles have affinity for metal-containing, especially calcium-containing, bodies and/or biological targets. In certain embodiments, these compositions are useful for providing targeted placement of microbubbles capable of cavitation on application of high frequency energy.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: January 17, 2023
    Assignee: California Institute of Technology
    Inventors: Vanessa M. Marx, Robert H. Grubbs
  • Patent number: 11447508
    Abstract: The present disclosure sets forth novel compounds and compositions including heteroaromatic silicon-fluoride-acceptors, which are useful for PET scanning. The present disclosure further includes novel methods of 18F imaging for PET scanning, the methods comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic silicon-fluoride-acceptors. In certain embodiments the invention is practiced in the form of a kit.
    Type: Grant
    Filed: August 19, 2020
    Date of Patent: September 20, 2022
    Assignees: California Institute of Technology, The Regents of the University of California
    Inventors: Christopher Martin Waldmann, Anton A. Toutov, Jennifer Marie Murphy, Robert H. Grubbs
  • Patent number: 11407726
    Abstract: This invention relates generally to the synthesis of E-macrocycles using stereoretentive ruthenium olefin metathesis catalysts supported by dithioiate ligands. Macrocycles were generated with excellent selectivity (>99% E) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield) from diene starting materials bearing two E-olefins or bearing one E-olefin and one terminal olefin, A variety of rings were constructed, ranging from 12- to 18-membered macrocycles, including the antibiotic recifeiolide. The invention has utility in the fields of organometallics and organic synthesis.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: August 9, 2022
    Assignee: California Institute of Technology
    Inventors: Tonia S. Ahmed, T. Patrick Montgomery, Robert H. Grubbs