Patents by Inventor Robert H. Grubbs

Robert H. Grubbs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10214494
    Abstract: Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: Wherein R1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R3 and R4 are each an aliphatic group; and X is an anion; the method comprises cyclization of a halogenated acrylate with Hünig's base in a solvent.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: February 26, 2019
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Rusty L. Blanski, Robert H. Grubbs
  • Publication number: 20190048030
    Abstract: The present disclosure describes novel silylated heteroaromatic derivatives, including those prepared by methods comprising the use of hydrosilanes and at least one strong base, the definition of strong base now also including hydroxide, especially KOH.
    Type: Application
    Filed: October 12, 2018
    Publication date: February 14, 2019
    Inventors: Anton Toutov, Kerry Betz, Alexey Fedorov, Brian M. Stoltz, Wenbo Liu, Robert H. Grubbs
  • Publication number: 20190038749
    Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
    Type: Application
    Filed: October 8, 2018
    Publication date: February 7, 2019
    Inventors: Robert H. Grubbs, Marshall L. Stoller, Hoyong Chung, Alissa M. Fitzgerald, Thomas W. Kenny, Renee M. Thomas
  • Patent number: 10188769
    Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: January 29, 2019
    Assignees: UNIVERSITY OF SOUTHERN CALIFORNIA, CALIFORNIA INSTITUTE OF TECHNOLOGY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Mark S. Humayun, Ashish Ahuja, Yu-Chong Tai, David R. Hinton, Robert H. Grubbs, Dennis O. Clegg, Lincoln Vallance Johnson, Sherry T. Hikita
  • Publication number: 20190001024
    Abstract: This disclosure relates compositions comprising upconverting core-shell nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable intraocular lenses.
    Type: Application
    Filed: June 27, 2018
    Publication date: January 3, 2019
    Inventors: Robert H. Grubbs, Christopher B. Marotta
  • Patent number: 10166731
    Abstract: A method for adjusting a light adjustable lens in an optical system includes providing a light adjustable lens in an optical system; providing an ultraviolet light source to generate an ultraviolet light; and irradiating the generated ultraviolet light with a light delivery system onto the light adjustable lens with a center wavelength and with a spatial irradiance profile to change a dioptric power of the light adjustable lens by changing a refraction of the light adjustable lens in a refraction-change zone, thereby causing a wavefront sag, defined as half of a product of the change of the dioptric power and the square of a radius of the refraction-change zone, to be within 28% of its maximum over an ultraviolet spectrum.
    Type: Grant
    Filed: April 22, 2018
    Date of Patent: January 1, 2019
    Assignee: RxSight, Inc.
    Inventors: Robert H. Grubbs, Christian A. Sandstedt
  • Publication number: 20180370920
    Abstract: Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: Wherein R1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R3 and R4 are each selected from the group consisting of a C1-C20 alkyl group, C1-C20 partially fluorinated alkyl group, an aryl group, an aryl group with para CF3 functionality, an aryl group having C1-C20 partially fluorinated alkyl groups or partially fluorinated alkoxy groups, and a C1-C20 partially fluorinated aliphatic group, and a C1-C20 aryl group; and X is an anion. The method comprises cyclization of a halogenated acrylate with a formamidine with Hünig's base in a solvent.
    Type: Application
    Filed: August 14, 2018
    Publication date: December 27, 2018
    Applicant: Government of the United States as Represented by the Secretary of the Air Force
    Inventors: Rusty L. Blanski, Robert H. Grubbs
  • Publication number: 20180362714
    Abstract: The disclosure provides methods and materials suitable for preparing coating layers on substrates. The coatings comprise quaternary amine groups and therefore impart anti-bacterial properties to the substrate. In one embodiment, for example, there is provided a quaternary amine-containing polymeric coating comprising propylene and ethylene repeat units.
    Type: Application
    Filed: May 22, 2018
    Publication date: December 20, 2018
    Inventors: Robert H. GRUBBS, Choon Woo LEE
  • Publication number: 20180361371
    Abstract: This invention relates generally to metathesis catalysts and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in Z and E selective olefin metathesis reactions. The invention has utility in the fields of organometallics and organic synthesis.
    Type: Application
    Filed: December 9, 2016
    Publication date: December 20, 2018
    Inventors: Adam M. JOHNS, T. Patric MONTGOMERY, Tonia S. AHMED, Robert H. GRUBBS, Richard L. PEDERSON
  • Patent number: 10150738
    Abstract: Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: Wherein R1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R3 and R4 are each an aliphatic group; and X is an anion; the method comprises cyclization of a halogenated acrylate with Hünig's base in a solvent.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: December 11, 2018
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Rusty L. Blanski, Robert H. Grubbs
  • Patent number: 10149906
    Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: December 11, 2018
    Assignees: California Institute of Technology, The Regents of the University of California
    Inventors: Robert H. Grubbs, Marshall L. Stoller, Hoyong Chung, Alissa M. Fitzgerald, Thomas W. Kenny, Renee M. Thomas
  • Patent number: 10153513
    Abstract: Provided herein is a class of copolymers, including triblock brush copolymers having specific block configurations, for example, ABC triblock brush copolymers and ABA triblock brush copolymers. In an embodiment, for example, copolymers of the invention incorporate various polymer side chain groups which contribute beneficial physical, chemical, or electronic properties such as increased mechanical or elastic strength, improved ionic or electric conductivity. In some embodiments, the provided copolymers exhibit advantageous steric properties allowing for rapid self-assembly into a variety of morphologies that are substantially different than non-brush, block copolymers.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: December 11, 2018
    Assignee: California Institute of Technology
    Inventors: Robert H. Grubbs, Christopher M. Bates, Alice Chang, Brendon McNicholas, Simon C. Jones
  • Publication number: 20180346491
    Abstract: The present invention includes novel compounds and compositions including heteroaromatic Silicon-Fluoride-Acceptors, which are useful for PET scanning. The present invention further includes a novel method of 18F imaging for PET scanning, the method comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic SiFAs. In one embodiment the invention is practiced in the form of a kit.
    Type: Application
    Filed: May 24, 2016
    Publication date: December 6, 2018
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, CALIFORNIA INSTITUTE OF THCHNOLOGY
    Inventors: Christopher Martin WALDMANN, Anton A TOUTOV, Jennifer Marie MURPHY, Robert H GRUBBS
  • Publication number: 20180333256
    Abstract: A color-apodized intraocular lens includes a lens center, with a center-transmittance to transmit an incident light; a lens annul us, surrounding the lens center, configured to selectively attenuate the incident light according to a radius- and wavelength-dependent annulus-transmittance, wherein the annulus-transmittance is less than the center-transmittance, in a short wavelength spectral range; and haptics, extending from the lens annulus.
    Type: Application
    Filed: May 22, 2017
    Publication date: November 22, 2018
    Applicant: RxSight, Inc.
    Inventors: Matt Haller, Christian A. Sandstedt, Robert H. Grubbs
  • Patent number: 10125153
    Abstract: The present invention describes chemical systems and methods for silylating N—H bonds of aliphatic amines, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one hydroxide, especially KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to replace an N—H bond with a silyl N—Si bond.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: November 13, 2018
    Assignee: California Institute of Technology
    Inventors: Anton Toutov, Kerry Betz, Alexey Fedorov, Brian M. Stoltz, Wenbo Liu, Robert H. Grubbs
  • Patent number: 10118976
    Abstract: Anion-coordinating polymers comprising one or more anion-coordinating unit of Formula (I), optionally in combination with one or more cation-coordinating unit of Formula (II) and/or a linking unit of Formula (III) and related electrolytes, batteries, methods and system.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: November 6, 2018
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, CORNELL UNIVERSITY
    Inventors: Brett M. Savoie, Michael A. Webb, Robert H. Grubbs, Thomas F. Miller, III, Geoffrey W. Coates, Qi Zheng
  • Patent number: 10081705
    Abstract: The invention provides a class of wedge-type block copolymers having a plurality of chemically different blocks, at least a portion of which incorporates a wedge group-containing block providing useful properties. For example, use of one or more wedge group-containing blocks in some block copolymers of the invention significantly inhibits chain entanglement and, thus, the present block copolymers materials provide a class of polymer materials capable of efficient molecular self-assembly to generate a range of structures, such as periodic nanostructures and microstructures. Materials of the present invention include copolymers having one or more wedge group-containing blocks, and optionally for some applications copolymers also incorporating one or more polymer side group-containing blocks. The present invention also provides useful methods of making and using wedge-type block copolymers.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: September 25, 2018
    Assignee: California Institute of Technology
    Inventors: Yan Xia, Benjamin R. Sveinbjornsson, Robert H. Grubbs, Raymond Weitekamp, Garret M. Miyake, Victoria Piunova, Christopher Scot Daeffler
  • Publication number: 20180265547
    Abstract: The invention relates generally to the synthesis of modified amino acids and modified peptides in the presence of cyclometalated catalysts. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.
    Type: Application
    Filed: March 14, 2018
    Publication date: September 20, 2018
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Shane L. MANGOLD, Robert H. GRUBBS
  • Publication number: 20180258230
    Abstract: In an aspect, a method of synthesizing a graft copolymer comprises the steps of: copolymerizing a first macromonomer and a first reactive diluent; wherein said first macromonomer comprises a first backbone precursor directly or indirectly covalently linked to a first polymer side chain group; wherein said reactive diluent is provided in the presence of the first macromonomer at an amount selected so as to result in formation said graft copolymer having a first backbone incorporating said diluent and said first macromonomer in a first polymer block characterized by a preselected first graft density or a preselected first graft distribution of said first macromonomer. In some embodiments of this aspect, said preselected first graft density is any value selected from the range of 0.05 to 0.75. In some methods, the composition and amount of said diluent is selected to provide both a first preselected first graft density and a first preselected first graft distribution.
    Type: Application
    Filed: March 7, 2018
    Publication date: September 13, 2018
    Inventors: Robert H. GRUBBS, Tzu-Pin LIN, Alice CHANG, Hsiang-Yun CHEN, Christopher M. BATES
  • Patent number: 10072030
    Abstract: The present invention is directed to a mild, efficient, and general direct C(sp)-H bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal alkynyl C—H bond, with a mixture of at least one organosilane and an alkali metal hydroxide, alkali metal alkoxide, or alkali metal hydride under conditions sufficient to form a silylated terminal alkynyl moiety. The methods are operable in the presence or substantially absence of transition-metal compounds. The systems associated with these methods are also disclosed.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: September 11, 2018
    Assignee: California Institute of Technology
    Inventors: Anton Toutov, Kerry Betz, Brian M. Stoltz, Wenbo Liu, Robert H. Grubbs