Patents by Inventor Robert H. Grubbs

Robert H. Grubbs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180254478
    Abstract: In an aspect, a redox flow battery comprises a catholyte and an anolyte; wherein at least one of said catholyte and said anolyte is a metal-coordination complex, said metal-coordination complex comprising: (i) a metal; (ii) one or more first ligands coordinated with said metal atom, wherein each of said first ligands is independently a Lewis basic ligand; and one or more second ligands associated with said one or more first ligands, wherein each of said second ligands is independently a Lewis acid ligand; and a nonaqueous solvent, wherein said catholyte, said anolyte or both are dissolved in said nonaqueous solvent. One or more first ligands may be provided in a primary coordination sphere of said metal-coordination complex and one or more second ligands may be provided in a secondary coordination sphere of said metal-coordination complex.
    Type: Application
    Filed: February 23, 2018
    Publication date: September 6, 2018
    Inventors: Simon C. Jones, Emmanuelle Despagnet-Ayoub, Brendon McNicholas, Harry B. Gray, Robert H. Grubbs
  • Publication number: 20180244003
    Abstract: A method for adjusting a light adjustable lens in an optical system includes providing a light adjustable lens in an optical system; providing an ultraviolet light source to generate an ultraviolet light; and irradiating the generated ultraviolet light with a light delivery system onto the light adjustable lens with a center wavelength and with a spatial irradiance profile to change a dioptric power of the light adjustable lens by changing a refraction of the light adjustable lens in a refraction-change zone, thereby causing a wavefront sag, defined as half of a product of the change of the dioptric power and the square of a radius of the refraction-change zone, to be within 28% of its maximum over an ultraviolet spectrum.
    Type: Application
    Filed: April 22, 2018
    Publication date: August 30, 2018
    Applicant: RxSight, Inc.
    Inventors: Robert H. Grubbs, Christian A. Sandstedt
  • Patent number: 10059726
    Abstract: The present invention is directed to a mild, efficient, and general direct C(sp2)-H bond silylation of terminal olefins. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal olefinic C—H bond, with a mixture of at least one organosilane, organosilane, or mixture thereof and an alkali metal alkoxide or alkali metal hydroxide, such that the contacting results in the formation of a silylated olefinic product. The systems associated with these methods are also disclosed.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: August 28, 2018
    Assignee: California Institute of Technology
    Inventors: Anton Toutov, Wenbo Liu, Kerry Betz, Alexey Fedorov, Brian M. Stoltz, Robert H. Grubbs
  • Patent number: 10035806
    Abstract: The present invention is directed to derivatized corroles, methods of making and using the same as imaging and therapeutic agents. In certain embodiments, the corroles are compounds having a Structure (I-H) and (I-M): where R1, R2, R3, and R4 are independently —F or —N(H)—(CH2)m—Y, provided that at least one of R1, R2, R3, and R4 is —N(H)—(CH2)m—Y, and m and Y are described herein.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: July 31, 2018
    Assignee: California Institute of Technology
    Inventors: Melanie A. Yen, Harry B. Gray, Robert H. Grubbs, Joshua Palmer
  • Publication number: 20180185272
    Abstract: The present disclosure is directed to fatty-acid glycerol ester derivative compounds containing a targeting bisphosphonate group. The disclosure further include pharmaceutical or biomedical compositions comprising these compounds, and methods of using these compounds and compositions forming microbubbles. The microbubbles have affinity for metal-containing, especially calcium-containing, bodies and/or biological targets. In certain embodiments, these compositions are useful for providing targeted placement of microbubbles capable of cavitation on application of high frequency energy.
    Type: Application
    Filed: June 20, 2016
    Publication date: July 5, 2018
    Inventors: Vanessa M. Marx, Robert H. Grubbs
  • Publication number: 20180177922
    Abstract: This disclosure relates compositions comprising upconverting nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable ocular lenses. Other methods improve the mechanical strength of the sclera directly.
    Type: Application
    Filed: February 12, 2018
    Publication date: June 28, 2018
    Inventors: ROBERT H. GRUBBS, SHANE L. MANGOLD
  • Publication number: 20180155271
    Abstract: The present disclosure describes methods for silylating aromatic organic substrates, and associated chemical systems, said methods comprising or consisting essentially of contacting the aromatic organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.
    Type: Application
    Filed: February 6, 2018
    Publication date: June 7, 2018
    Inventors: ROBERT H. GRUBBS, ALEXEY FEDOROV, ANTON TOUTOV, NICHOLAS A. SWISHER
  • Publication number: 20180127539
    Abstract: This invention relates to methods and compositions for preparing linear and cyclic polyolefins. More particularly, the invention relates to methods and compositions for preparing functionalized linear and cyclic polyolefins via olefin metathesis reactions. Polymer products produced via the olefin metathesis reactions of the invention may be utilized for a wide range of materials applications. The invention has utility in the fields of polymer and materials chemistry and manufacture.
    Type: Application
    Filed: January 3, 2018
    Publication date: May 10, 2018
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Robert TUBA, Robert H. GRUBBS
  • Patent number: 9957383
    Abstract: The present invention is directed to brush block copolymer compositions comprising first and second homopolymers or random copolymers whose presence provides access to photonic bandgaps in the infrared frequency range, their use in this capacity, and methods of making the same. The specific parameters associated with these compositions are described within the specification.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: May 1, 2018
    Assignee: California Institute of Technology
    Inventors: Robert J. MacFarlane, Robert H. Grubbs
  • Patent number: 9950482
    Abstract: A method for adjusting a light adjustable lens in an optical system includes providing a light adjustable lens in an optical system; providing an ultraviolet light source to generate an ultraviolet light; and irradiating the generated ultraviolet light with a light delivery system onto the light adjustable lens with a center wavelength and with a spatial irradiance profile to change a dioptric power of the light adjustable lens by changing a refraction of the light adjustable lens in a refraction-change zone, thereby causing a wavefront sag, defined as half of a product of the change of the dioptric power and the square of a radius of the refraction-change zone, to be within 10% of its maximum over an ultraviolet spectrum.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: April 24, 2018
    Assignee: RxSight, Inc.
    Inventors: Robert H. Grubbs, Christian A. Sandstedt
  • Publication number: 20180072681
    Abstract: Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: Wherein R1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R3 and R4 are each an aliphatic group; and X is an anion; the method comprises cyclization of a halogenated acrylate with Hünig's base in a solvent.
    Type: Application
    Filed: October 5, 2017
    Publication date: March 15, 2018
    Applicant: Government of the United States as Represented by the Secretary of the Air Force
    Inventors: Rusty L. Blanski, Robert H. Grubbs
  • Publication number: 20180064747
    Abstract: This disclosure is directed to structured compositions, including DNA-functionalized scaffolds, for drug capture, and methods and devices for sequestering chemotherapeutics from physiological fluids using the functionalized scaffolds.
    Type: Application
    Filed: September 6, 2017
    Publication date: March 8, 2018
    Inventors: MICHAEL D. SCHULZ, CARL M. BLUMENFELD, ROBERT H. GRUBBS, JULIA R. GREER, DARYL WEI LIANG YEE
  • Patent number: 9908840
    Abstract: The present invention describes chemical systems and methods for reducing C—O, C—N, and C—S bonds, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said system optionally comprising at least one molecular hydrogen donor compound, molecular hydrogen, or both.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: March 6, 2018
    Assignee: California Institute of Technology
    Inventors: Robert H. Grubbs, Alexey Fedorov, Anton Toutov, Nicholas A. Swisher
  • Publication number: 20180057514
    Abstract: The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one strong base, the definition of strong base now also including hydroxide, especially KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.
    Type: Application
    Filed: November 6, 2017
    Publication date: March 1, 2018
    Inventors: ANTON TOUTOV, KERRY BETZ, ALEXEY FEDOROV, BRIAN M. STOLTZ, WENBO LIU, ROBERT H. GRUBBS
  • Patent number: 9895467
    Abstract: This disclosure relates compositions comprising upconverting nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable ocular lenses. Other methods improve the mechanical strength of the sclera directly.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: February 20, 2018
    Assignee: California Institute of Technology
    Inventors: Robert H. Grubbs, Shane L. Mangold
  • Patent number: 9890239
    Abstract: This invention relates to methods and compositions for preparing linear and cyclic polyolefins. More particularly, the invention relates to methods and compositions for preparing functionalized linear and cyclic polyolefins via olefin metathesis reactions. Polymer products produced via the olefin metathesis reactions of the invention may be utilized for a wide range of materials applications. The invention has utility in the fields of polymer and materials chemistry and manufacture.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: February 13, 2018
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Robert Tuba, Robert H. Grubbs
  • Patent number: 9828347
    Abstract: Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: Wherein R1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R3 and R4 are each an aliphatic group; and X is an anion; the method comprises cyclization of a halogenated acrylate with Hünig's base in a solvent.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: November 28, 2017
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Rusty L Blanski, Robert H Grubbs
  • Patent number: 9809607
    Abstract: The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one strong base, the definition of strong base now also including KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: November 7, 2017
    Assignee: California Institute of Technology
    Inventors: Anton Toutov, Kerry Betz, Alexey Fedorov, Brian M. Stoltz, Wenbo Liu, Robert H. Grubbs
  • Publication number: 20170275399
    Abstract: Anion-coordinating polymers comprising one or more anion-coordinating unit of Formula (I), optionally in combination with one or more cation-coordinating unit of Formula (II) and/or a linking unit of Formula (III) and related electrolytes, batteries, methods and system.
    Type: Application
    Filed: January 4, 2017
    Publication date: September 28, 2017
    Inventors: Brett M. SAVOIE, Michael A. WEBB, Robert H. GRUBBS, Thomas F. MILLER, III, Geoffrey W. COATES, Qi ZHENG
  • Patent number: 9764995
    Abstract: The present invention describes chemical systems and methods for silylating heteroaromatic organic substrates using at least alkoxide base, preferably a potassium alkoxide base and at least one organodisilane and (b) at least one alkoxide base. Both methods and compositions for affecting these transformations are disclosed.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: September 19, 2017
    Assignee: California Institute of Technology
    Inventors: Anton Toutov, Wenbo Liu, Brian M. Stoltz, Robert H. Grubbs, Kerry Betz, David P. Schuman