Patents by Inventor Robert Holt
Robert Holt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190043967Abstract: Methods of forming a graded SiGe percentage PFET channel in a FinFET or FDSOI device by post gate thermal condensation and oxidation of a high Ge percentage channel layer and the resulting devices are provided. Embodiments include forming a gate dielectric layer over a plurality of Si fins; forming a gate over each fin; forming a HM and spacer layer over and on sidewalls of each gate; forming a cavity in each fin adjacent to the gate and spacer layer; epitaxially growing an un-doped high percentage SiGe layer in each cavity and along sidewalls of each fin; thermally condensing the high percentage SiGe layer, an un-doped low percentage SiGe formed underneath in the substrate and fins; and forming a S/D region over the high percentage SiGe layer in each u-shaped cavity, an upper surface of the S/D regions below the gate dielectric layer.Type: ApplicationFiled: July 3, 2018Publication date: February 7, 2019Inventors: George Robert MULFINGER, Ryan SPORER, Timothy J. MCARDLE, Judson Robert HOLT
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Patent number: 10163635Abstract: A method for preventing epitaxial merge between adjacent devices of a semiconductor is provided. Embodiments include forming a protection layer over a spacer formed over a first and second plurality of fins deposited within a substrate; pinching off a portion of the protection layer formed within a space between each of the plurality of fins; forming a planarization layer over the protection layer and the spacer; and etching a portion of the spacer to form inner sidewalls between each of the plurality of fins, outer sidewalls of a height greater than the height of the inner sidewalls for preventing the growth of the epitaxial layer beyond the outer sidewalls, or a combination thereof.Type: GrantFiled: October 30, 2017Date of Patent: December 25, 2018Assignee: GLOBALFOUNDRIES INC.Inventors: Yi Qi, Hui Zang, Hsien-Ching Lo, Jerome Ciavatti, Judson Robert Holt
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Patent number: 10043893Abstract: Methods of forming a graded SiGe percentage PFET channel in a FinFET or FDSOI device by post gate thermal condensation and oxidation of a high Ge percentage channel layer and the resulting devices are provided. Embodiments include forming a gate dielectric layer over a plurality of Si fins formed over a substrate; forming a gate over each fin; forming a HM and spacer layer over and on sidewalls of each gate; forming a u-shaped cavity in each fin adjacent to the gate and spacer layer; epitaxially growing an un-doped high percentage SiGe layer in each u-shaped cavity and along sidewalls of each fin; thermally condensing the high percentage SiGe layer, an un-doped low percentage SiGe formed underneath in the substrate and fins; and forming a S/D region over the high percentage SiGe layer in each u-shaped cavity, an upper surface of the S/D regions below the gate dielectric layer.Type: GrantFiled: August 3, 2017Date of Patent: August 7, 2018Assignee: GLOBALFOUNDRIES INC.Inventors: George Robert Mulfinger, Ryan Sporer, Timothy J. McArdle, Judson Robert Holt
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Publication number: 20180141045Abstract: A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.Type: ApplicationFiled: January 22, 2018Publication date: May 24, 2018Inventors: John A. Verrant, Niten V. Lalpuria, Igor Nikonorov, Darryn W. Unfricht, Benjamin Ports, Stephen C. Wardlaw, Robert A. Levine, Robert Holt, Kyle Hukari
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Publication number: 20180138177Abstract: Formation of band-edge contacts include, for example, providing an intermediate semiconductor structure comprising a substrate and a gate thereon and source/drain regions adjacent the gate, depositing a non-epitaxial layer on the source/drain regions, deposing a metal layer on the non-epitaxial layer, and forming metal alloy contacts from the deposited non-epitaxial layer and metal layer on the source/drain regions by annealing the deposited non-epitaxial layer and metal layer.Type: ApplicationFiled: November 16, 2016Publication date: May 17, 2018Applicant: GLOBALFOUNDRIES Inc.Inventors: Tek Po Rinus LEE, Bharat KRISHNAN, Jinping LIU, Hui ZANG, Judson Robert HOLT
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Publication number: 20180130656Abstract: A method of forming defect-free relaxed SiGe fins is provided. Embodiments include forming fully strained defect-free SiGe fins on a first portion of a Si substrate; forming Si fins on a second portion of the Si substrate; forming STI regions between adjacent SiGe fins and Si fins; forming a cladding layer over top and side surfaces of the SiGe fins and the Si fins and over the STI regions in the second portion of the Si substrate; recessing the STI regions on the first portion of the Si substrate, revealing a bottom portion of the SiGe fins; implanting dopant into the Si substrate below the SiGe fins; and annealing.Type: ApplicationFiled: December 15, 2017Publication date: May 10, 2018Inventors: Judson Robert Holt, Jinping Liu, Jody Fronheiser, Bharat Krishnan, Churamani Gaire, Timothy James Mcardle, Murat Kerem Akarvardar
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Publication number: 20180052176Abstract: The present invention is a method for determining the identity of the epitopes recognized by T-cells. The method consists of expressing an encoded library of candidate epitope sequences in a recipient reporter cell capable of providing a detectable signal upon cytotoxic attack from a single cognate T-cell followed by contacting the reporter cells with T-cells of interest. The reporter cells with a single indicating cytotoxic attack from a T-cell are isolated and then analyzed by next-generation sequencing in order to identify the epitope sequences. Specifically disclosed is a method in which a library of candidate epitope-encoding nucleic acids are expressed in cells which feature a membrane-bound major histocompatibility complex (MHC) protein, said library produced by transfection of plasmids featuring both a nucleotide encoding the candidate epitope and a nucleotide encoding a FRET-based fluorescent protein cleaved by granzyme.Type: ApplicationFiled: March 25, 2015Publication date: February 22, 2018Inventors: Robert Holt, Govinda Sharma
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Patent number: 9873118Abstract: A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.Type: GrantFiled: December 30, 2011Date of Patent: January 23, 2018Assignee: Abbott Point of Care, Inc.Inventors: John A. Verrant, Niten V. Lalpuria, Igor Nikonorov, Darryn W. Unfricht, Benjamin Ports, Stephen C. Wardlaw, Robert A. Levine, Robert Holt, Kyle Hukari
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Publication number: 20170182096Abstract: The invention is directed to methods and compositions for cell-based targeted delivery of predetermined compounds to a population of target cells. In some embodiments, methods of the invention include providing cytotoxic lymphocytes genetically modified to produce and sequester in lytic granules fusion proteins comprising a granzyme, or other effector agent, and a predetermined protein, so that upon specific contact of the cytotoxic lymphocytes with the target cells, the granzyme-perforin pathway of the cytotoxic lymphocytes is activated, leading to the delivery of the fusion protein to the cytosols of the target cells.Type: ApplicationFiled: April 15, 2015Publication date: June 29, 2017Inventors: Robert Holt, Daniel Woodsworth
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Patent number: 9611304Abstract: Isolated polynucleotides comprising a TNNT1 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: GrantFiled: May 28, 2015Date of Patent: April 4, 2017Assignee: The University of British ColumbiaInventors: Elizabeth M. Simpson, Vikramjit Chopra, Cletus D'Souza, Charles de Leeuw, Daniel Goldowitz, Robert A. Holt, Steven J. Jones, Elodie Portales-Casamar, Wyeth W. Wasserman
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Patent number: 9546357Abstract: Isolated polynucleotides comprising a UGT8 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: GrantFiled: March 11, 2015Date of Patent: January 17, 2017Assignee: The University of British ColumbiaInventors: Elizabeth M. Simpson, Cletus D'Souza, Charles de Leeuw, Daniel Goldowitz, Robert A. Holt, Elodie Portales-Casamar, Vikramjit Chopra, Wyeth W. Wasserman, Steven J. Jones
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Patent number: 9349864Abstract: Methods for fabricating integrated circuits including selectively forming layers of increased dopant concentration are provided. In an embodiment, a method for fabricating an integrated circuit includes forming a material layer with a selected facet on a selected plane and a non-selected facet on a non-selected plane. The method further includes performing an epitaxial deposition process with a dopant source to grow an in-situ doped epitaxial material on the material layer. The epitaxial deposition process grows the in-situ doped epitaxial material on the selected facet at a first growth rate and over the non-selected facet at a second growth rate greater than the first growth rate. A layer of increased dopant concentration is selectively formed over the selected facet.Type: GrantFiled: August 14, 2015Date of Patent: May 24, 2016Assignee: GLOBALFOUNDRIES, INC.Inventors: Timothy James Mcardle, Judson Robert Holt, Churamani Gaire
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Publication number: 20160003731Abstract: A biological fluid sample analysis chamber and a method for analyzing a biological fluid sample is provided. The chamber includes a first chamber panel, a second chamber panel, and a plurality of beads disposed between the first chamber panel and the second chamber panel, which beads are configured to not reflect light incident to the beads in an amount that appreciably interferes with a photometric analysis of the biologic fluid.Type: ApplicationFiled: February 19, 2014Publication date: January 7, 2016Inventors: Manav Mehta, Robert Holt
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Publication number: 20150343020Abstract: Isolated polynucleotides comprising a TNNT1 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: May 28, 2015Publication date: December 3, 2015Inventors: Elizabeth M. Simpson, Vikramjit Chopra, Cletus D'Souza, Charles de Leeuw, Daniel Goldowitz, Robert A. Holt, Steven J. Jones, Elodie Portales-Casamar, Wyeth W. Wasserman
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Publication number: 20150315609Abstract: Isolated polynucleotides comprising a SLC6A4 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: May 4, 2015Publication date: November 5, 2015Inventors: Elizabeth M. Simpson, Cletus D'Souza, Charles de Leeuw, Daniel Goldowitz, Robert A. Holt, Steven J. Jones, Elodie Portales-Casamar, Wyeth W. Wasserman, Vikramjit Chopra
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Publication number: 20150259691Abstract: Isolated polynucleotides comprising a UGT8 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: March 11, 2015Publication date: September 17, 2015Inventors: Elizabeth M. Simpson, Cletus D'Souza, Charles de Leeuw, Daniel Goldowitz, Robert A. Holt, Elodie Portales-Casamar, Vikramjit Chopra, Wyeth W. Wasserman, Steven J. Jones
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Publication number: 20150240259Abstract: Isolated polynucleotides comprising a PCP2 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: March 3, 2015Publication date: August 27, 2015Inventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra, Charles de Leeuw
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Patent number: 9080043Abstract: An aqueous viscoelastic composition is provided comprising at least one viscoelastic surfactant, and at least one hydrophobically modified polymer, which is formed from polymerization of ethylenically unsaturated monomers; has a number average molecular weight of from 1,000 to 100,000 Da; and to a level of at least 0.1 mole %, based on the amount of monomer units in the polymer, contains monomeric units each covalently bonded to a pendant, optionally alkoxylated, hydrocarbyl group having from 6 to 40 carbon atoms, said pendant, optionally alkoxylated, hydrocarbyl group being connected to the backbone of said hydrophobically modified polymer via a non-ester containing linking group.Type: GrantFiled: December 15, 2011Date of Patent: July 14, 2015Assignee: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.Inventors: Qingwen Wendy Yuan-Huffman, Klin Aloysius Rodrigues, Jian Zhou, Stuart Peter Robert Holt, Elliot Isaac Band
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Patent number: 9074222Abstract: Isolated polynucleotides comprising a DCX mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: GrantFiled: January 23, 2014Date of Patent: July 7, 2015Assignee: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra, Charles de Leeuw
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Patent number: 9068209Abstract: The invention provides a system and method for synthesizing polynucleotides by solid phase assembly oligonucleotide precursors, in accordance with the method, a polynucleotide is partitioned into an ordered set of subunits, wherein each subunit is assembled in a single reaction from a subset of oligonucleotide precursors that uniquely anneal together to produce the subunit. The subunits are then assembled to form the desired polynucleotide. An important feature of the invention is the selection of subunits that are free of undesired sequence elements, such as palindromes, repetitive sequences, and the like, which would result in more than one subunit product alter ligating a pool of oligonucleotide precursors.Type: GrantFiled: May 12, 2009Date of Patent: June 30, 2015Assignee: British Columbia Cancer Agency BranchInventors: Robin Coope, Daniel Horspool, Robert A. Holt