Patents by Inventor Robert Holt
Robert Holt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20100197100Abstract: Semiconductor devices and methods of manufacturing thereof are disclosed. In a preferred embodiment, a method of manufacturing a semiconductor device includes providing a workpiece, and forming a recess in the workpiece. The recess has a depth having a first dimension. A first semiconductive material is formed in the recess to partially fill the recess in a central region to a height having a second dimension. The second dimension is about one-half or greater of the first dimension. A second semiconductive material is formed over the first semiconductive material in the recess to completely fill the recess, the second semiconductive material being different than the first semiconductive material.Type: ApplicationFiled: April 16, 2010Publication date: August 5, 2010Inventors: Jin-Ping Han, Henry Utomo, O. Sung Kwon, Oh Jung Kwon, Judson Robert Holt, Thomas N. Adam
-
Patent number: 7737468Abstract: Semiconductor devices and methods of manufacturing thereof are disclosed. In a preferred embodiment, a method of manufacturing a semiconductor device includes providing a workpiece, and forming a recess in the workpiece. The recess has a depth having a first dimension. A first semiconductive material is formed in the recess to partially fill the recess in a central region to a height having a second dimension. The second dimension is about one-half or greater of the first dimension. A second semiconductive material is formed over the first semiconductive material in the recess to completely fill the recess, the second semiconductive material being different than the first semiconductive material.Type: GrantFiled: May 21, 2007Date of Patent: June 15, 2010Assignees: Infineon Technologies AG, International Business Machines CorporationInventors: Jin-Ping Han, Henry Utomo, O Sung Kwon, Oh Jung Kwon, Judson Robert Holt, Thomas N. Adam
-
Publication number: 20100129802Abstract: A method and computer-program product for sequencing nucleic acid sequences using restriction fragment maps derived from end-sequenced nucleotide fragments. The initial nucleotide sequence can be processed to form a shot-gun-data set. The present teachings employ a technique called Restriction Site Shotgun Sequencing (RSSS.) It can reduce the amount of overlap required between fragment ends while still producing a good assembly. A decrease in overlap can be achieved by using additional information in the fragments to assist in determining that two fragments overlap.Type: ApplicationFiled: July 15, 2009Publication date: May 27, 2010Applicant: APPLIED BIOSYSTEMS, LLCInventors: Daniel P. FASULO, Robert A. HOLT, Cheryl A. EVANS, Jeannine D. GOCAYNE, Peter W. LI
-
Publication number: 20100129903Abstract: Isolated polynucleotides comprising a PITX3 promoter are provided, where a PITX3 regulatory element is operably joined to a PITX3 basal promoter utilizing a non-native spacing between the promoter and regulatory elements. The promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, etc.Type: ApplicationFiled: August 10, 2009Publication date: May 27, 2010Inventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra
-
Patent number: 7718500Abstract: A structure and method for forming raised source/drain structures in a NFET device and embedded SiGe source/drains in a PFET device. We provide a NFET gate structure over a NFET region in a substrate and PFET gate structure over a PFET region. We provide NFET SDE regions adjacent to the NFET gate and provide PFET SDE regions adjacent to the PFET gate. We form recesses in the PFET region in the substrate adjacent to the PFET second spacers. We form a PFET embedded source/drain stressor in the recesses. We form a NFET S/D epitaxial Si layer over the NFET SDE regions and a PFET S/D epitaxial Si layer over PFET embedded source/drain stressor. The epitaxial Si layer over PFET embedded source/drain stressor is consumed in a subsequent salicide step to form a stable and low resistivity silicide over the PFET embedded source/drain stressor.Type: GrantFiled: December 16, 2005Date of Patent: May 18, 2010Assignees: Chartered Semiconductor Manufacturing, Ltd, International Business Machines Corporation (IBM), Samsung Electronics Co., Ltd.Inventors: Yung Fu Chong, Zhijiong Luo, Joo Chan Kim, Judson Robert Holt
-
Patent number: 7696335Abstract: The invention provides methods, kits, and compositions comprising novel mutant loxP sites. Such sites are particularly useful for procedures requiring multiple site-specific recombination reactions, including deletions or insertions of multiple genes or other sequences in the same organism, staged insertions or deletions of genes of the same organism at different times, assembly of large polynucleotide constructs by serial site-specific recombination, and the like. In one aspect, compositions of the invention includes particular mutant spacer oligonucleotides of loxP recombination elements, the recombination elements themselves, and pairs of non-promiscuous mutant loxP sites.Type: GrantFiled: October 12, 2006Date of Patent: April 13, 2010Assignee: BC Cancer AgencyInventors: Robert A. Holt, Perseus I. Missirlis
-
Publication number: 20100081201Abstract: Isolated polynucleotides comprising an OLIG1 promoter are provided, where an OLIG1 regulatory element is operably joined to an OLIG1 basal promoter utilizing a non-native spacing between the promoter and regulatory elements. The promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, etc.Type: ApplicationFiled: July 17, 2009Publication date: April 1, 2010Inventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra
-
Publication number: 20100009524Abstract: A semiconductor fabrication method. The method includes providing a semiconductor substrate, wherein the semiconductor substrate includes a semiconductor material. Next, a top portion of the semiconductor substrate is removed. Next, a first semiconductor layer is epitaxially grown on the semiconductor substrate, wherein a first atom percent of the semiconductor material in the first semiconductor layer is equal to a certain atom percent of the semiconductor material in the semiconductor substrate.Type: ApplicationFiled: July 8, 2008Publication date: January 14, 2010Applicant: INTERNATIONAL BUSINESS MACHINESInventors: Ashima B. Chakravarti, Judson Robert Holt, Jeremy John Kempisty, Suk Hoon Ku, Woo-Hyeong Lee, Amlan Majumdar, Ryan Matthew Mitchell, Renee Tong Mo, Zhibin Ren, Dinkar Singh
-
Publication number: 20090280568Abstract: Isolated polynucleotides comprising an S100B promoter are provided, where an S100B regulatory element is operably joined to an S100B basal promoter utilizing a non-native spacing between the promoter and regulatory elements. The promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, etc.Type: ApplicationFiled: May 7, 2009Publication date: November 12, 2009Inventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra
-
Patent number: 7507631Abstract: A method of forming and a structure of an electronic device. The method including: forming a trench in a single-crystal semiconductor substrate; forming a dopant diffusion barrier layer on sidewalls and a bottom of the trench; and epitaxially growing a single-crystal semiconductor layer in the trench, the single-crystal semiconductor layer filling the trench, the dopant diffusion barrier layer a barrier to diffusion of semiconductor dopants. Also a power transistor formed by the same method.Type: GrantFiled: July 6, 2006Date of Patent: March 24, 2009Assignee: International Business Machines CorporationInventors: Brian Joseph Greene, Judson Robert Holt
-
Publication number: 20080290370Abstract: Semiconductor devices and methods of manufacturing thereof are disclosed. In a preferred embodiment, a method of manufacturing a semiconductor device includes providing a workpiece, and forming a recess in the workpiece. The recess has a depth having a first dimension. A first semiconductive material is formed in the recess to partially fill the recess in a central region to a height having a second dimension. The second dimension is about one-half or greater of the first dimension. A second semiconductive material is formed over the first semiconductive material in the recess to completely fill the recess, the second semiconductive material being different than the first semiconductive material.Type: ApplicationFiled: May 21, 2007Publication date: November 27, 2008Inventors: Jin-Ping Han, Henry Utomo, O Sung Kwon, Oh Jung Kwon, Judson Robert Holt, Thomas N. Adam
-
Publication number: 20080286871Abstract: The invention provides methods and compositions for assembling a modular replacement genome in a host microorganism. After such assembly, the host organism's genome is inactivated or ablated to permit full control of host cellular functions by the replacement genome. A modular replacement genome comprises an assembly of nucleic acid fragments, or segments, derived from one or more natural organisms or from synthetic polynucleotides or from a combination of both. Such an assembly, or set, of segments making up a replacement genome comprises a substantially complete set of genes and regulatory elements for carrying out minimal life functions under predefined culture conditions. The invention provides modular genomes having modules that are amenable to facile replacement, deletion, and/or additions.Type: ApplicationFiled: November 27, 2007Publication date: November 20, 2008Inventor: Robert A. Holt
-
Publication number: 20080009109Abstract: A method of forming and a structure of an electronic device. The method including: forming a trench in a single-crystal semiconductor substrate; forming a dopant diffusion barrier layer on sidewalls and a bottom of the trench; and epitaxially growing a single-crystal semiconductor layer in the trench, the single-crystal semiconductor layer filling the trench, the dopant diffusion barrier layer a barrier to diffusion of semiconductor dopants. Also a power transistor formed by the same method.Type: ApplicationFiled: July 6, 2006Publication date: January 10, 2008Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Brian Joseph Greene, Judson Robert Holt
-
Publication number: 20070258999Abstract: The invention provides, in part, the genomic sequence of a putative coronavirus, the SARS virus, and provides novel nucleic acid and amino acid sequences that may be used, for example, for the diagnosis, prophylaxis, or therapy of a variety of SARS virus related disorders.Type: ApplicationFiled: April 28, 2004Publication date: November 8, 2007Applicant: THE PUBLIC HEALTH AGENCY OF CANADAInventors: Frank Plummer, Heinz Feldmann, Steven Jones, Yan Li, Nathalie Bastien, Robert Brunham, Angela Brooks-Wilson, Robert Holt, Christopher Upton, Rachel Roper, Caroline Astell, Steven Jones
-
Publication number: 20070243617Abstract: The invention provides methods and compositions for assembling a modular replacement genome in a host microorganism. After such assembly, the host organism's genome is inactivated or ablated to permit full control of host cellular functions by the replacement genome. A modular replacement genome comprises an assembly of nucleic acid fragments, or segments, derived from one or more natural organisms or from synthetic polynucleotides or from a combination of both. Such an assembly, or set, of segments making up a replacement genome comprises a substantially complete set of genes and regulatory elements for carrying out minimal life functions under predefined culture conditions. The invention provides modular genomes having modules that are amenable to facile replacement, deletion, and/or additions.Type: ApplicationFiled: October 12, 2006Publication date: October 18, 2007Inventor: Robert Holt
-
Publication number: 20070111163Abstract: A dental implant system comprises a dental implant, a first component, and a second component. The dental implant has a lower section for engaging bone, a middle section for passing through gingiva, and a top section with a first non-rotational feature. The first component has a larger width dimension than the implant such that a first lower portion of the first component surrounds the middle section of the implant. The first lower portion has a first scalloped lowermost end surface assisting to form the gingiva around the middle section of the implant. A second component attaches to the implant after the first component. The second component has a second lowermost portion with a second scalloped lowermost end surface that is substantially similar to the first scalloped lowermost end surface. The system may include a driver mechanism with a scalloped lowermost surface that helps to drive the implant into bone.Type: ApplicationFiled: November 2, 2006Publication date: May 17, 2007Inventors: Theodore Powell, Michael Benner, Robert Holt
-
Publication number: 20070087366Abstract: The invention provides methods, kits, and compositions comprising novel mutant loxP sites. Such sites are particularly useful for procedures requiring multiple site-specific recombination reactions, including deletions or insertions of multiple genes or other sequences in the same organism, staged insertions or deletions of genes of the same organism at different times, assembly of large polynucleotide constructs by serial site-specific recombination, and the like. In one aspect, compositions of the invention includes particular mutant spacer oligonucleotides of loxP recombination elements, the recombination elements themselves, and pairs of non-promiscuous mutant loxP sites.Type: ApplicationFiled: October 12, 2006Publication date: April 19, 2007Inventors: Robert Holt, Perseus Missirlis
-
Publication number: 20060212518Abstract: A method, apparatus, system, and signal-bearing medium that, in an embodiment, determine whether a user at a first client has a chat session already active at a second client with a third client in response to a request for initiation of a chat session for the user at the first client. If the user does already have a chat session active, the third client is notified that the first client replaces the second client in the chat session. Then chat data from the second client is copied to the first client, and a disconnect message is sent to the second client from first client. In various embodiments, the determination may be made by sending a query to a plurality of clients connected via a network or by sending a query to a server that serves the first client, the second client, and the third client. The copied chat data, which may include messages sent between the second client and the third client, is presented at the first client.Type: ApplicationFiled: March 17, 2005Publication date: September 21, 2006Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Byron Bailey, Robert Holt, William Menoyo, Jason Nikolai
-
Publication number: 20060194297Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.Type: ApplicationFiled: April 27, 2006Publication date: August 31, 2006Inventors: Andrew Blacker, Christopher Reeve, Robert Holt
-
Publication number: 20060073493Abstract: A method and computer-program product for sequencing nucleic acid sequences using restriction fragment maps derived from end-sequenced nucleotide fragments. The initial nucleotide sequence can be processed to form a shot-gun-data set. The present teachings employ a technique called Restriction Site Shotgun Sequencing (RSSS.) It can reduce the amount of overlap required between fragment ends while still producing a good assembly. A decrease in overlap can be achieved by using additional information in the fragments to assist in determining that two fragments overlap.Type: ApplicationFiled: June 15, 2005Publication date: April 6, 2006Applicant: Applera CorporationInventors: Daniel Fasulo, Robert Holt, Cheryl Evans, Jeannine Gocayne, Peter Li