Patents by Inventor Robert Holt
Robert Holt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150166635Abstract: Isolated polynucleotides comprising a GPR88 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, antisense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: September 16, 2014Publication date: June 18, 2015Inventors: Elizabeth M. Simpson, Charles de Leeuw, Wyeth W. Wasserman, Elodie Portales-Casamar, Steven J. Jones, Cletus D'Souza, Robert A. Holt, Vikramjit Chopra, Daniel Goldowitz
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Patent number: 9006413Abstract: Isolated polynucleotides comprising a PCP2 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: GrantFiled: November 21, 2013Date of Patent: April 14, 2015Assignee: The University of British ColumbiaInventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra, Charles de Leeuw
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Patent number: 8987093Abstract: Method of forming multi-gate finFETs with epitaxially-grown merged source/drains. Embodiments of the invention may include forming a plurality of semiconductor fins joined by a plurality of inter-fin semiconductor regions, depositing a sacrificial gate over a center portion of each of the plurality of fins, forming a first merge layer over a first end of each of the plurality of fins to form a first merged fin region, forming a second merge layer over the second end of each of the plurality of fins to form a second merged fin region, etching a portion of the first merged fin region to form a first source/drain base region, etching a portion of the second merged fin region to form a second source/drain base region, forming a first source/drain region on the first source/drain base region, and forming a second source/drain region on the second source/drain base region.Type: GrantFiled: September 20, 2012Date of Patent: March 24, 2015Assignee: International Business Machines CorporationInventors: Eric C. Harley, Judson Robert Holt, Alexander Reznicek, Thomas N. Adam
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Patent number: 8895715Abstract: Isolated polynucleotides comprising an S100B promoter are provided, where an S100B regulatory element is operably joined to an S100B basal promoter utilizing a non-native spacing between the promoter and regulatory elements. The promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, etc.Type: GrantFiled: May 7, 2009Date of Patent: November 25, 2014Assignee: The University of British ColumbiaInventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra
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Publication number: 20140315987Abstract: Isolated polynucleotides comprising a CCKBR mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: April 14, 2014Publication date: October 23, 2014Inventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra, Charles de Leeuw
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Publication number: 20140256800Abstract: Isolated polynucleotides comprising a FEV mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: March 3, 2014Publication date: September 11, 2014Inventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Daniel Goldowitz, Robert A. Holt, Steven J. Jones, Charles de Leeuw, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra
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Publication number: 20140248701Abstract: Isolated polynucleotides comprising a DCX mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: January 23, 2014Publication date: September 4, 2014Inventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra, Charles de Leeuw
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Patent number: 8790980Abstract: Some example embodiments of the invention comprise methods for and semiconductor structures comprised of: a MOS transistor comprised of source/drain regions, a gate dielectric, a gate electrode, channel region; a carbon doped SiGe region that applies a stress on the channel region whereby the carbon doped SiGe region retains stress/strain on the channel region after subsequent heat processing.Type: GrantFiled: February 17, 2014Date of Patent: July 29, 2014Assignees: GLOBALFOUNDRIES Singapore Pte. Ltd.Inventors: Jin Ping Liu, Jundson Robert Holt
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Publication number: 20140159113Abstract: Some example embodiments of the invention comprise methods for and semiconductor structures comprised of: a MOS transistor comprised of source/drain regions, a gate dielectric, a gate electrode, channel region; a carbon doped SiGe region that applies a stress on the channel region whereby the carbon doped SiGe region retains stress/strain on the channel region after subsequent heat processing.Type: ApplicationFiled: February 17, 2014Publication date: June 12, 2014Applicant: GLOBALFOUNDRIES Singapore PTE. Ltd.Inventors: Jin Ping LIU, Judson Robert HOLT
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Publication number: 20140141517Abstract: Isolated polynucleotides comprising a PCP2 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: November 21, 2013Publication date: May 22, 2014Inventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra, Charles de Leeuw
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Publication number: 20140080275Abstract: Method of forming multi-gate finFETs with epitaxially-grown merged source/drains. Embodiments of the invention may include forming a plurality of semiconductor fins joined by a plurality of inter-fin semiconductor regions, depositing a sacrificial gate over a center portion of each of the plurality of fins, forming a first merge layer over a first end of each of the plurality of fins to form a first merged fin region, forming a second merge layer over the second end of each of the plurality of fins to form a second merged fin region, etching a portion of the first merged fin region to form a first source/drain base region, etching a portion of the second merged fin region to form a second source/drain base region, forming a first source/drain region on the first source/drain base region, and forming a second source/drain region on the second source/drain base region.Type: ApplicationFiled: September 20, 2012Publication date: March 20, 2014Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Eric C. Harley, Judson Robert Holt, Alexander Reznicek, Thomas N. Adam
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Patent number: 8672362Abstract: A single piece tag includes a substrate having a first surface and an opposing second surface. A first reactant is applied to the first surface. A first portion of the first reactant is covered by a first release liner. A second reactant is applied to the first release liner which separates the second reactant from the first reactant. A second release liner adjacent the first release liner covers a second portion of the first reactant. The tag is activated by removing the second release liner from the tag to expose the second portion of the adhesive, and the substrate is folded onto itself to contact the second reactant on the first release liner with the first reactant.Type: GrantFiled: August 5, 2008Date of Patent: March 18, 2014Assignee: Brady Worldwide, Inc.Inventors: Robert Holt, David J. Haas
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Patent number: 8652892Abstract: Some example embodiments of the invention comprise methods for and semiconductor structures comprised of: a MOS transistor comprised of source/drain regions, a gate dielectric, a gate electrode, channel region; a carbon doped SiGe region that applies a stress on the channel region whereby the carbon doped SiGe region retains stress/strain on the channel region after subsequent heat processing.Type: GrantFiled: May 23, 2011Date of Patent: February 18, 2014Assignees: Globalfoundries Singapore Pte. Ltd.Inventors: Jin Ping Liu, Judson Robert Holt
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Patent number: 8629261Abstract: Isolated polynucleotides comprising an OLIG1 promoter are provided, where an OLIG1 regulatory element is operably joined to an OLIG1 basal promoter utilizing a non-native spacing between the promoter and regulatory elements. The promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, etc.Type: GrantFiled: July 17, 2009Date of Patent: January 14, 2014Assignee: The University of British ColumbiaInventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra
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Patent number: 8598331Abstract: Isolated polynucleotides comprising a CLDN5 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The mini-promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, etc.Type: GrantFiled: September 28, 2010Date of Patent: December 3, 2013Assignee: The University of British ColumbiaInventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra
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Publication number: 20130274170Abstract: An aqueous viscoelastic composition is provided comprising at least one viscoelastic surfactant, and at least one hydrophobically modified polymer, which is formed from polymerization of ethylenically unsaturated monomers; has a number average molecular weight of from 1,000 to 100,000 Da; and to a level of at least 0.1 mole %, based on the amount of monomer units in the polymer, contains monomeric units each covalently bonded to a pendant, optionally alkoxylated, hydrocarbyl group having from 6 to 40 carbon atoms, said pendant, optionally alkoxylated, hydrocarbyl group being connected to the backbone of said hydrophobically modified polymer via a non-ester containing linking group.Type: ApplicationFiled: December 15, 2011Publication date: October 17, 2013Inventors: Qingwen Wendy Yuan-Huffman, Klin Aloysius Rodrigues, Jian Zhou, Stuart Peter Robert Holt, Elliot Isaac Band
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Publication number: 20130266531Abstract: Personal care compositions, methods for making and uses thereof include an aqueous viscoelastic composition and a personal care active ingredient. The viscoelastic composition includes at least one surfactant and at least one hydrophobically-modified polymers with low molecular weights.Type: ApplicationFiled: December 15, 2011Publication date: October 10, 2013Applicant: Akzo Nobel Chemicals International B.V.Inventors: Qingwen Wendy Yuan-Huffman, Klin A. Rodrigues, Jian Zhou, Stuart Peter Robert Holt, Elliot Isaac Band, JR., Samuel Anthony Vona
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Publication number: 20130259899Abstract: Fusobacterium is a genus of gram-negative, filamentous, anaerobic bacteria found as normal flora in the mouth and large bowel, and often in necrotic tissue. A comparison of microbial ribonucleic acids (RNA) between colorectal carcinoma (CRC) tissue and adjacent normal control tissue found the over-representation of F. nucleatum in CRC tissue. RNA abundance was measured by polymerase chain reaction (PCR)-amplifying RNA from the tissue, constructing libraries, sequencing the RNA in the libraries, pairing sequences from CRC and normal tissue, and quantifying RNA abundance. Detection of Fusobacterium in a gastrointestinal sample is indicative of gastrointestinal cancer.Type: ApplicationFiled: October 4, 2011Publication date: October 3, 2013Applicants: ALLEN-VERCOE, EMMA MOLECULAR AND CELLULAR BIOLOGY UNIVERSITY OF GUELPH, BRITISH COLOMBIA CANCER AGENCY BRANCHInventors: Emma Allen-Vercoe, Robert Holt, Richard Moore, Rene Warren
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Patent number: 8450775Abstract: An example embodiment of a strained channel transistor structure comprises the following: a strained channel region comprising a first semiconductor material with a first natural lattice constant; a gate dielectric layer overlying the strained channel region; a gate electrode overlying the gate dielectric layer; and a source region and drain region oppositely adjacent to the strained channel region, one or both of the source region and drain region are comprised of a stressor region comprised of a second semiconductor material with a second natural lattice constant different from the first natural lattice constant; the stressor region has a graded concentration of a dopant impurity and/or of a stress inducing molecule. Another example embodiment is a process to form the graded impurity or stress inducing molecule stressor embedded S/D region, whereby the location/profile of the S/D stressor is not defined by the recess depth/profile.Type: GrantFiled: September 12, 2011Date of Patent: May 28, 2013Assignees: GLOBALFOUNDRIES Singapore Pte. Ltd.Inventors: Yung Fu Chong, Zhijiong Luo, Judson Robert Holt
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Patent number: 8383800Abstract: Isolated polynucleotides comprising an MKI67 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The mini-promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, etc.Type: GrantFiled: September 28, 2010Date of Patent: February 26, 2013Assignee: The University of British ColumbiaInventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra