Abstract: This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

Abstract: The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria. The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine for mammals to prevent infection by the Gram negative bacteria. The immunogenic conjugate is also used to raise and subsequently isolate antibodies or binding portions thereof which are capable of recognizing and binding to the autoinducer. The antibodies or binding portions thereof are utilized in a method of treating infections, a method of inhibiting autoinducer activity, and in diagnostic assays which detect the presence of autoinducers or autoinducer antagonists in fluid or tissue samples.

Abstract: There is disclosed an analyte detection system comprising: and analyte analysis stage through which a condensed phase containing the analyte flows; nebuliser means into which the output of the analyte analysis stage is introduced, the nebuliser means producing an analyte containing aerosol; a flame based analyte detector, and means for introducing the analyte containing aerosol into said flame based anylte detector; in which the condensed phase produces no or negligible response from flame based analyte detector, and I) the system can operate at condensed phase flow rates of greater than 20 ?l min?1, preferably greater than 50 ?l min?1, most preferably greater than 100 ?l min?1; and/or ii) the means for introducing the analyte containing aerosol into said flame based detector comprises a spray chamber

Abstract: A digital wideband node (DWN) (28, 48) is coupled to a remote terminal (RT) (22, 42) that in turn is coupled to a subscriber's telephone line (26, 46). The DWN (28, 48) is configured to (1) pass a subscriber's telephone number signal directly to the RT (22, 42) whereupon a test path (25, 45) is formed with the subscriber's telephone line (26, 46), (2) pass POTS test signals directly to the RT (22, 42) for testing the subscriber's telephone line (26, 46) via the test path (25, 45) and (3) process wideband test control signals into wideband test signals which are conveyed to the RT (22, 42) for wideband testing of the subscriber's telephone line (26, 46) via the test path (25, 45).

Abstract: This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.

Abstract: A method of making an identifiable container by providing a molded plastic container that includes at least one layer of material blended with an additive. A mask is provided having a radiation aperture in the form of identifiable indicia, and radiation is directed through the aperture of the mask and onto the container such that the radiation is absorbed by the additive, thereby causing the additive to visibly respond in the form of the identifiable indicia.

Abstract: A method of manufacturing and certifying operation of a system for producing plastic containers using equipment having at least one controllable action that affects quality of containers produced by the equipment includes inspecting raw materials for parameters that affect manufacturability and acceptability of containers produced from such materials, monitoring operation of the equipment including the at least one controllable action, inspecting containers produced by the equipment for variations that affect acceptability of the containers, automatically controlling operation of the equipment to eliminate variations in response to information obtained during the inspecting and monitoring steps, and certifying acceptability of containers produced by the equipment.

Abstract: A method of making an identifiable article such as a container or container preform. A molded plastic container or container preform is provided that includes a wall having at least one layer of matrix resin and at least one layer of barrier resin that is blended with an additive. The wall has at least one localized portion of predetermined geometry in which the barrier layer is thicker than surrounding portions of the wall, and within which the additive is discernable under visible or UV light so as to provide a means to prevent use of counterfeit containers.

Abstract: A bead lock including an insert casing and a bead spacer for providing an air passageway in a vehicle tire to be mounted on a wheel rim on which is located an insert valve and a rim lip for retention of the vehicle tire bead, said insert casing including an insert bead adapted to push against said tire bead and to hold said tire bead firmly against the inner surface of said rim lip, the inner wall of said vehicle tire and the outer surface of said insert casing defining an internal tire space to be pressurized for inflation of said vehicle tire or depressurized for the deflation of said vehicle tire via said insert valve, said tire bead and said insert bead interposed between said internal tire space and said insert valve, said bead spacer extending from said insert bead to an insert valve area corresponding in use to said insert valve location whereby to define at least one air passage for communication of said internal tire space with said insert valve, wherein said bead spacer is made of material sufficien

Abstract: This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.

Abstract: Disclosed are 4-sulfide/sulfoxide/sulfonyl-1H-pyrazolyl derivative compounds of formulas (I) or (II): wherein the variables n, R, R1, R2, R3, R3?, R4, R4?, R5 and R6 are as defined in the specification. The compounds are useful for the treatment or prevention of diseases and/or behaviors involving the 5-HT2C receptor.

Abstract: Disclosed are pyrazolyl derivative compounds or purified stereoisomers or stereoisomer mixtures of said compounds and their salts or prodrug forms thereof which have structural formula (I) or (II): wherein the variables R, R1, R2, R5 and R6 are as defined in the specification. The compounds are useful for the treatment or prevention of diseases and/or behaviors involving the 5-HT2C receptor.

Abstract: A force limiting workpiece holding device for holding a workpiece in a workpiece processing assembly having a spindle and a closer that applies a force, comprises a workpiece holder slidably mounted to the spindle. The workpiece holder includes a plurality of circumferentially-spaced gripping segments that are movable between expanded and contracted positions to grip and release a workpiece. A force limiting coupling structure includes a biasing structure having a spring force. The coupling structure is operatively mountable between the workpiece holder and the closer such that a force applied by the closer to move the gripping segments of the workpiece holder between the expanded and contracted positions is transferred to the workpiece holder through the coupling structure and the biasing structure thereof, whereby a resultant force being applied to the workpiece holder by the closer is limited to the spring force of the biasing structure.

Abstract: An all wheel drive system for a motor vehicle in which wheel slippage is effectively controlled and regenerative energy is effectively stored for subsequent utilization in the system. A hydraulic embodiment of the invention includes a hydraulic motor, a pump, a tank, an accumulator for storing pressurized fluid, and a device for sensing system back pressure. In response to a loss of system back pressure the pressure of the fluid being supplied to the motor is reduced and the motor discharge is directed to the accumulator, and in response to a sensed resumption of system back pressure regenerative energy from the accumulator is directed to the motor to assist in powering the motor. An electric embodiment of the invention includes an electric motor, an electric generator, a device for storing electrical energy such as a battery pack or a capacitor bank, a DC tachometer driven by the motor and operative to sense the motor power requirements, and a directional circuit switch assembly.

Abstract: This invention is directed to an synergistic antimicrobial composition which comprises a mixture of an iodopropynyl compound and a dimethyldithiocarbamate compound, said mixture provided in an amount sufficient to protect a substrate from attack by one or more microbial organisms. The composition can be used broadly in industrial systems and more particularly with substrates such as paints, coatings, plastics, wood and wood composites.

Abstract: This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.

Abstract: This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.

Abstract: A technique is provided for the alignment of an H/D puller for use in a cyclotron. One aspect of the technique comprises magnetically attaching a pair of feeler gages to an alignment tool for use in aligning the H/D puller. The magnetic retention of the feeler gages allows a field engineer to make the desired adjustments to align the H/D puller. Another aspect of the present technique provides for the H/D puller to include a replaceable tip such that the tip may be replaced without removing the H/D puller. Because the H/D puller is not removed and replaced, the alignment of the H/D puller to the ion source is maintained.

Abstract: Faults or degradation of performance of a voice/data communication network (2) are identified without the need to dispatch service personnel by selectively testing isolated sections of the communication network. For some of these tests, the communication network address of a customer's modem under test (106, 114, 60, 66) is retrieved from a database (88) for use in directing these tests to the customer's modem (106, 114, 60, 66) and for emulating the customer's modem (106, 114, 60, 66) during one or more of the tests.

Abstract: This invention relates to pyrrole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.