Abstract: The present invention discloses a low-B rare earth magnet. The rare earth magnet contains a main phase of R2T14B and comprises the following raw material components: 13.5 at %˜4.5 at % of R, 5.2 at %˜5.8 at % of B, 0.3 at %˜0.8 at % of Cu, 0.3 at %˜3 at % of Co, and the balance being T and inevitable impurities, the R being at least one rare earth element comprising Nd, and the T being an element mainly comprising Fe. 0.3˜0.8 at % of Cu and an appropriate amount of Co are co-added into the rare earth magnet, so that three Cu-rich phases formed in the grain boundary, and the magnetic effect of the three Cu-rich phases existing in the grain boundary and the solution of the problem of insufficient B in the grain boundary can obviously improve the squareness and heat-resistance of the magnet.

Abstract: The invention provides novel poly-substituted 5-membered heterocyclic compounds represented by Formula (IV), or a pharmaceutically acceptable salt, solvate, metabolite, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as selective irreversible bruton's tyrosine kinase (Btk) inhibitors and are further useful to treat inflammatory, auto immune diseases associated with aberrant B-cell proliferation such as RA (rheumatoid arthritis) and cancers. This invention also provides the preparation of a medicament using of Formula (IV), and methods of preventing or treating diseases associated with excessive Btk activity in mammals, especially humans.

Abstract: The present invention is related to an improved method for HER2 gene test by using quantitative real-time PCR (Polymerase Chain Reaction) technique. Our invention streamlines test process, and incorporates quality control for each major step, including sample, reagent, operation, and data report. We eliminate the need for reference genes which is hard to standardize in HER2 PCR test. We develop a cutoff reference point by using the statistical mean of tumor tissue population, and adopt a simplified scoring scheme for evaluation of HER2 status. Our invention produces consistent result across machines and labs, and has proven to be clinically successful in HER2 test.

Abstract: A method for forming a semiconductor device structure is provided. The method includes forming a spacer layer and a dielectric layer over a substrate. The spacer layer has an opening exposing the substrate, and the dielectric layer surrounds the spacer layer. The method includes forming a metal silicon nitride layer over a sidewall and a bottom surface of the opening. The method includes forming a first work function metal layer over the metal silicon nitride layer. The method includes removing a first top portion of the first work function metal layer. The method includes, after the removal of the first top portion, removing a second top portion of the metal silicon nitride layer. The method includes forming a conductive layer in the opening. The method includes removing a third top portion of the conductive layer and a fourth top portion of the metal silicon nitride layer.

Abstract: Described are techniques for processing a data operation in a data storage system. A front-end component of the data storage system receives the data operation. In response to receiving the data operation, the front-end component performs first processing. The first processing includes determining whether the data operation is a read operation requesting to read a data portion which results in a cache miss; and if said determining determines that the data operation is a read operation resulting in a cache miss, performing read miss processing. Read miss processing includes sequential stream recognition processing performed by the front-end component to determine whether the data portion is included in a sequential stream.

Abstract: Described are techniques for destaging data. Write data for write operations are stored in cache page(s). The cache may be partitioned into cache pages and write data stored thereon may be marked as write pending denoting that write data needs to be written out to physical storage. Weight values may be determined for the cache pages in accordance with factors. A first cache page may be selected having a highest such weight value where the selected first cache page includes at least some write data marked as write pending. The write data of the selected first cache page may be destaged to physical storage.

Abstract: Example embodiments of the present invention relate to methods, systems, and computer program products for reducing I/O latency in a storage system. The method include polling a storage system for values related to caching of I/Os in global memory for subsequent destaging to disk. The host then may determine respective write delay values for I/Os to be sent from a host communicatively coupled with the storage system according to the values related to caching of I/Os. The write delay values then may be applied to the I/Os at the host to delay sending of the I/Os by respective delay times from the host to the storage system.

Abstract: A stapler includes a main body, a magazine, a striker, and a driving portion. The main body encloses a receiving space and has an opening at the bottom of the front end thereof The opening communicates with the receiving space. The magazine is arranged in the main body for receiving nails. The striker is arranged at the front end of the main body and is linearly slidable above the opening vertically. The driving portion is disposed on the main body and is connected to the striker to drive it to move downward to strike the nail out. The striker has a bottom face oriented frontward and downward so that an angle ranged from 3-15 degrees is defined between the bottom face and the horizontal plane.

Abstract: The invention is directed to a method of preparing B-cells that produce interleukin-10 (IL-10), or IL-10 per se, which comprises contacting one or more B-cells ex vivo with an isolated interleukin-35 (IL-35) protein, and culturing the one or more B-cells under conditions to provide one or more B-cells that produce IL-10. The invention also is directed to a method of suppressing the proliferation of lymphocytes in vitro or in vivo by contacting lymphocytes with an isolated IL-35 protein. The invention further is directed to a method of suppressing autoimmunity in a mammal by administering to the mammal an IL-35 protein or IL-10-producing B-cells.

Abstract: The invention provides novel substituted 6-arylamino pyridone carboxamides represented by Formula I, or a pharmaceutically acceptable salt, solvate, poly-morph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans.

Abstract: A clamping device for a sprayer can is provided, including a shell body. The shell body includes a grip portion and a clamping portion for clamping one end of a sprayer can. The sprayer can is provided with a dispenser valve. The clamping portion includes a circumferential wall, and the circumferential wall defines a space for receiving the dispenser valve and a receiving opening communicating with the space. The circumferential wall is further formed with a window which communicates with the space, and the dispenser valve can spray through the window. The circumferential wall includes first flexible portions and at least one second flexible portion. At least one said second flexible portion is connected between every two adjacent first flexible portions. The second flexible portion is greater than the first flexible portion in flexibility.

Abstract: The present invention discloses a W-containing R—Fe—B—Cu serial sintered magnet and quenching alloy. The sintered magnet contains an R2Fe14B-type main phase, the R being at least one rare earth element comprising Nd or Pr; the crystal grain boundary of the rare earth magnet contains a W-rich area above 0.004 at % and below 0.26 at %, and the W-rich area accounts for 5.0 vol %˜11.0 vol % of the sintered magnet. The sintered magnet uses a minor amount of W pinning crystal to segregate the migration of the pinned grain boundary in the crystal grain boundary to effectively prevent abnormal grain growth and obtain significant improvement. The crystal grain boundary of the quenching alloy contains a W-rich area above 0.004 at % and below 0.26 at %, and the W-rich area accounts for at least 50 vol % of the crystal grain boundary.

Abstract: The present invention discloses a low-B rare earth magnet. The rare earth magnet contains a main phase of R2T14B and comprises the following raw material components: 13.5 at %˜4.5 at % of R, 5.2 at %˜5.8 at % of B, 0.3 at %˜0.8 at % of Cu, 0.3 at %˜3 at % of Co, and the balance being T and inevitable impurities, the R being at least one rare earth element comprising Nd, and the T being an element mainly comprising Fe. 0.3˜0.8 at % of Cu and an appropriate amount of Co are co-added into the rare earth magnet, so that three Cu-rich phases formed in the grain boundary, and the magnetic effect of the three Cu-rich phases existing in the grain boundary and the solution of the problem of insufficient B in the grain boundary can obviously improve the squareness and heat-resistance of the magnet.

Abstract: The present disclosure relates to an advertisement providing server and an advertisement schedule generating method performed by the advertisement providing server. Specifically, the advertisement schedule generating method collects an advertisement viewing history of a user and schedules an advertisement suitable for the user by time based on the advertisement viewing history.

Abstract: The present invention is related to an improved method for HER2 gene test by using quantitative real-time PCR (Polymerase Chain Reaction) technique. Our invention streamlines test process, and incorporates quality control for each major step, including sample, reagent, operation, and data report. We eliminate the need for reference genes which is hard to standardize in HER2 PCR test. We develop a cutoff reference point by using the statistical mean of tumor tissue population, and adopt a simplified scoring scheme for evaluation of HER2 status. Our invention produces consistent result across machines and labs, and has proven to be clinically successful in HER2 test.

Abstract: An apparatus and method for recognizing an object using correlation information about an object and content-related information which is generated based on the content-related information. The apparatus includes a data classifier, a data analyzer, a correlation manager, and an object identifier.

Abstract: The invention provides novel ethylene derivatives represented by Formula I, which may be used as selective estrogen receptor modulators (SERMs) and useful in the prophylaxis and/or treatment of estrogen-dependent conditions or conditions.

Abstract: A clamping device for a sprayer can is provided, including a shell body. The shell body includes a grip portion and a clamping portion for clamping one end of a sprayer can. The sprayer can is provided with a dispenser valve. The clamping portion includes a circumferential wall, and the circumferential wall defines a space for receiving the dispenser valve and a receiving opening communicating with the space. The circumferential wall is further formed with a window which communicates with the space, and the dispenser valve can spray through the window. The circumferential wall includes first flexible portions and at least one second flexible portion. At least one said second flexible portion is connected between every two adjacent first flexible portions. The second flexible portion is greater than the first flexible portion in flexibility.

Abstract: The present invention provides a nail guider including a guiding board, at least an assisting member. The guiding board positioned in front of the nail track vertically has a first surface and a second surface. The first surface faces the nail track. The guiding board has at least a vertical penetrating slot thereon. The penetrating slot penetrates the first surface and the second surface of the guiding board. The assisting member includes an assisting end and a pushing end, slides forwardly and backwardly in the penetrating slot. The assisting end protrudes out of the first surface selectively, and the pushing end is located at the second surface. The assisting member used for straightening up nails further comprises at least an assisting surface parallel to the nailing track. The pushing end can be pushed so that the assisting surface can assist and straighten up nails.

Abstract: The invention provides novel poly-substituted 5-membered heterocyclic compounds represented by Formula (IV), or a pharmaceutically acceptable salt, solvate, metabolites, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as selective irreversible bruton's tyrosine kinase (Btk) inhibitors and is further useful to treat inflammatory, auto immune diseases associated with aberrant B-cell proliferation such as RA (rheumatoid arthritis) and cancers. This invention also provided the preparation of a medicament using of Formula (IV), and methods of preventing or treating diseases associated with excessive Btk activity in mammals, especially humans.