Abstract: A manufacturing method of a metal bump structure is provided. A driving base is provided. At least one pad and an insulating layer are formed on the driving base. The pad is formed on an arrangement surface of the driving base and has an upper surface. The insulating layer covers the arrangement surface of the driving base and the pad, and exposes a part of the upper surface of the pad. A patterned metal layer is formed on the upper surface of the pad exposed by the insulating layer, and extends to cover a part of the insulating layer. An electro-less plating process is performed to form at least one metal bump on the patterned metal layer. A first extension direction of the metal bump is perpendicular to a second extension direction of the driving base.

Abstract: The present invention relates to a recombinant nonstructural protein 1 (NS 1), a recombinant influenza virus and an immunological composition including the same, as well as a method of treating or preventing a disease or condition caused by or associated with an influenza virus in a subject in need thereof. At least one amino acid residue is mutated or deleted in 4 contiguous amino acid residues of TRAF3-interacting motifs (TIMs) within an effector domain of the recombinant NS 1. A recombinant influenza virus including the recombinant NS1 is comparable to the wild-type influenza virus in virus replication ability, and the recombinant influenza virus can elevate interferon activation of a subject for achieving better immune response and better immunological protection, leading in a method of treating or preventing a disease or condition caused by or associated with an influenza virus in a subject in need thereof.

Abstract: A manufacturing method of a light emitting diode (LED) package structure includes the following steps. A carrier is provided. A redistribution layer is formed on the carrier. A plurality of active devices are formed on the carrier. A plurality of LEDs are transferred on the redistribution layer. The LEDs and the active devices are respectively electrically connected to the redistribution layer. The active devices are adapted to drive the LEDs, respectively. A molding compound is formed on the redistribution layer to encapsulate the LEDs. The carrier is removed to expose a bottom surface of the redistribution layer.

Abstract: A method is disclosed including: generating, based on design information for an integrated circuit, a circuit design that includes an initial power delivery network (PDN) for the integrated circuit; performing a pre-layout simulation to the circuit design that includes the initial power delivery network, to determine whether the circuit design meets a predetermined specification; generating a circuit layout of the integrated circuit when the circuit design meets the predetermined specification; and adding at least one additional conductive pillar or at least one additional power rail in the initial power delivery network according to a relationship of a pillar density of the initial power delivery network and a maximum pillar density when the circuit design does not meet the predetermined specification.

Abstract: Autophagy is the principal catabolic response to nutrient starvation. However, excessive autophagy can be cytotoxic or cytostatic, and contribute to cell death, but its mechanism of induction remains elusive. Here, it was demonstrated that prolonged arginine starvation by ADI-PEG20 induced an autophagy-dependent death of argininosuccinate synthetase 1 (ASS1)-deficient breast cancer cells. Consequently, arginine depleting agents such as ADI-PEG20 may be used in methods for killing one or more argininosuccinate synthetase 1 (ASS1)-deficient breast cancer cells. Further, abundance of ASS1 was either low or absent in more than 60% of 149 random breast cancer biosam pies, which could be exploited as candidates for arginine starvation therapy.

Abstract: Provided are methods of reducing and/or preventing interference by a drug comprising (i) an antibody Fc region and (ii) a moiety that binds to human CD47 in serological assays.

Abstract: A method of identifying a flange specification based on an augmented reality interface includes steps of: providing a first interface, through which an operator picks real-time images of a flange at different viewing angles, and creating a virtual flange surface according to the real-time images; providing a second interface, through which the operator picks three circumferential points corresponding to the flange, and creating a virtual flange model having a virtual outer diameter; providing a third interface, through which the operator adjusts a virtual pitch circle diameter of the virtual flange model; providing a fourth interface, through which the operator adjusts a virtual thickness of the virtual flange model; providing a fifth interface, through which the operator inputs a count of bolts; and searching a database according to the virtual outer diameter, the virtual pitch circle diameter and the virtual thickness of the virtual flange model to obtain searched results.

Abstract: Methods and apparatuses are disclosed herein for performing tone mapping and/or contrast enhancement. In some examples, a block mapping curve is low-pass filtered with block mapping curves of surrounding blocks to form a smoothed block mapping curve. In some examples, overlapped curve mapping of block mapping curves, including smoothed block mapping curves, is performed, including weighting, based on a pixel location, block mapping curves of a group of blocks to generate an interpolated block mapping curve and applying the interpolated block mapping curve to a pixel to perform ton mapping and/or contrast enhancement.

Abstract: Methods and apparatuses are disclosed herein for performing tone mapping and/or contrast enhancement. In some examples, a block mapping curve is low-pass filtered with block mapping curves of surrounding blocks to form a smoothed block mapping curve. In some examples, overlapped curve mapping of block mapping curves, including smoothed block mapping curves, is performed, including weighting, based on a pixel location, block mapping curves of a group of blocks to generate an interpolated block mapping curve and applying the interpolated block mapping curve to a pixel to perform ton mapping and/or contrast enhancement.

Abstract: A micro speaker with amplitude stability, includes a vibrating diaphragm unit, a magnetic unit which is disposed below the vibrating diaphragm unit, and a circuit unit which is disposed between the vibrating diaphragm unit and the magnetic unit. The vibrating diaphragm unit includes a diaphragm which is connected with a voice coil; whereas the diaphragm and the voice coil are connected electrically by an upper fixing arm on the vibrating diaphragm unit, and a pair of flexible circuit board disposed in the circuit unit. The circuit unit also includes plural lower fixing arms to connect and support the flexible circuit boards. Therefore, when an external power source energizes the circuit unit, the voice coil can drive the diaphragm to generate a stable amplitude along the height of the magnetic element, through the upper fixing arm and the lower fixing arms.

Abstract: A display system includes a first display device having an active display region having individually controllable pixels, a sensor to generate information that is useful for determining a position of the first display device relative to a second display device, and a display controller to determine the position of the first display device relative to the second display device based on the information generated by the sensor. The display controller determines an image to be shown on the first display device based on the position of the first display device relative to the second display device.

Abstract: A method for adjusting furnace temperature of a reflow oven by AI, through obtaining product data of the reflow oven, obtaining initial characteristic data of a preceding work station and calculating mean values of temperatures of an upper furnace and a lower furnace, and taking the mean values as initial reflow characteristic data. Data as to first reflow characteristics of each reflow temperature zone and second reflow characteristics data of each zone are obtained, and data of the first and second reflow characteristics data are obtained. The electronic device further combines the characteristic data of the preceding work station with the combined reflow characteristics and combines results into a trained neural network model to output a temperature prediction, the oven temperature being adjusted according to the temperature prediction.

Abstract: A manufacturing method of a light emitting diode (LED) package structure includes the following steps. A carrier is provided. A redistribution layer is formed on the carrier. A plurality of active devices are formed on the carrier. A plurality of LEDs are transferred on the redistribution layer. The LEDs and the active devices are respectively electrically connected to the redistribution layer. The active devices are adapted to drive the LEDs, respectively. A molding compound is formed on the redistribution layer to encapsulate the LEDs. The carrier is removed to expose a bottom surface of the redistribution layer.

Abstract: A control system applicable to a touch device is provided. The touch device includes a touch sensor. The control system comprises a sensing circuit, configured to sense the touch sensor and generate a plurality of sensing values; a processor, configured to generate a sensing image according to the plurality of sensing values; and a convolutional neural network, configured to process the sensing image to generate feature information and generate identification information according to the feature information for determining a status of the touch sensor.

Abstract: Autophagy is the principal catabolic response to nutrient starvation. However, excessive autophagy can be cytotoxic or cytostatic, and contribute to cell death, but its mechanism of induction remains elusive. Here, it was demonstrated that prolonged arginine starvation by ADI-PEG20 induced an autophagy-dependent death of argininosuccinate synthetase 1 (ASS1)-deficient breast cancer cells. Consequently, arginine depleting agents such as ADI-PEG20 may be used in methods for killing one or more argininosuccinate synthetase 1 (ASS1)-deficient breast cancer cells. Further, abundance of ASS1 was either low or absent in more than 60% of 149 random breast cancer biosamples, which could be exploited as candidates for arginine starvation therapy.

Abstract: Disclosed is a method of manufacturing a graphene conductive fabric, which includes mixing a first solvent, a second solvent and nano-graphene sheets, dispersing the nano-graphene sheets with a mechanical force to form a graphene suspension solution; adding at least a curable resin to the graphene suspension solution, dispersing the nano-graphene sheets and the curable resin with the mechanical force to form a graphene resin solution; coating or printing the graphene resin solution on a hydrophobic protective layer, curing the graphene resin solution to form a graphene conductive layer adhered to the hydrophobic protective layer; coating a hot glue layer on the graphene conductive layer; and attaching a fibrous tissue on the hot glue layer, heating and pressing the fibrous tissue to allow the hot glue layer respectively adhere to the graphene conductive layer and the fibrous tissue.

Abstract: Filtration systems and methods for purifying windshield washer fluid to yield methanol pure enough for fueling methanol fuel cell systems. Pumping commercially available windshield washer fluid through filtration systems having one or more filters can remove additives from the windshield washer fluid. The filtration systems include filters, such as activated carbon filters, nanofiltration filters, reverse osmosis filters, and ion exchange resin filters.

Abstract: A method is disclosed including: generating, based on design information for an integrated circuit, a circuit design that includes an initial power delivery network (PDN) for the integrated circuit; performing a pre-layout simulation to the circuit design that includes the initial power delivery network, to determine whether the circuit design meets a predetermined specification; and when the circuit design meets the predetermined specification, generating a power delivery network layout of the integrated circuit, and generating, after the power delivery network layout is generated, a circuit layout of the integrated circuit.

Abstract: The present invention discloses a micro speaker unit with a waterproof effect, including an outer casing which is provided with an accommodation space and a sound hole, and a micro speaker which is installed in the accommodation space. The micro speaker is assembled from a vibrating diaphragm assembly and a magnetic assembly which is inter-assembled with the vibrating diaphragm assembly. The vibrating diaphragm assembly separates the accommodation space into a front chamber and a rear chamber which are not interconnected; whereas, the front chamber is connected with the sound hole. Therefore, water vapor outside the micro speaker unit can be prevented from entering into the rear chamber and the micro speaker by the vibrating diaphragm assembly, thereby improving the waterproof effect of the entire micro speaker unit.

Abstract: Disclosed herein is a method for preparing an aloe extract. The method comprises steps of, mincing a mesophyll of an Aloe in water; heating the minced mixture to 60-80° C.; filtering the mixture to produce a first filtrate; drying the first filtrate; reconstituting the dried first filtrate in water; subjecting the first filtrate or the reconstituent to column chromatography and eluting the column with a first polar solvent; concentrating the eluent; purifying the concentrate with active carbons; filtering the purified concentrate to produce a second filtrate; concentrating the second filtrate; and adding a second polar solvent to the concentrated second filtrate thereby producing the aloe extract. The present disclosure also encompasses the aloe extract prepared by the present method. Said aloe extract has desired contents of O-acetyl groups or polysaccharides, and is useful for manufacturing food, pharmaceutical, or cosmetic products.