Abstract: Disclosed are methods of treating cancer, which include administering a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt or ester thereof, to a subject in need thereof. Also disclosed are methods of inhibiting growth and proliferation of cancer cells in vitro or in vivo, which include contacting the cells with an amount of the compound of formula (I) effective to inhibit the growth or proliferation of the cancer cells. Further disclosed are methods of inhibiting tumor growth, which include contacting the tumor with an amount of the compound of formula (I) effective to inhibit the growth of the tumor.

Abstract: Embodiments of the disclosure relate generally to formulations, methods of treatment, kits, and dosage forms for treating inflammatory disorders, including atopic dermatitis, or cancer, the formulations comprising an active pharmaceutical ingredient. The formulation provided comprises granules, wherein the granules comprise: micronized active ingredient; one or more granulation binders; one or more fillers; one or more disintegrants; and one or more antioxidants. In one embodiment, the methods of treatment include orally administering the active ingredient to a subject suffering from atopic dermatitis, where the active ingredient is in an amount of about 20 mg to about 80 mg.

Abstract: Techniques are disclosed relating to set-associative caches in processors. In one embodiment, an integrated circuit is disclosed that includes a set-associative cache configured to receive a request for a data block stored in one of a plurality of ways within the cache, the request specifying an address, a portion of which is a tag value. In such an embodiment, the integrated circuit includes a way prediction circuit configured to predict, based on the tag value, a way in which the requested data block is stored. The integrated circuit further includes a tag array circuit configured to perform a comparison of a portion of the tag value with a set of previously stored tag portions corresponding to the plurality of ways. The tag array circuit is further configured to determine whether the request hits in the cache based on the predicted way and an output of the comparison.

Abstract: Techniques are disclosed relating to managing data-request dependencies for a cache. In one embodiment, an integrated circuit is disclosed that includes a plurality of requesting agents and a cache. The cache is configured to receive read and write requests from the plurality of requesting agents including a first request and a second request. The cache is configured to detect that the first and second requests specify addresses that correspond to different portions of the same cache line, and to determine whether to delay processing one of the first and second requests based on whether the first and second requests are from the same requesting agent. In some embodiments, the cache is configured to service the first and second requests in parallel in response to determining that the first and second requests are from the same requesting agent.

Abstract: An electronic device, a method of an electronic device authenticating a user and a computer readable recording medium are provided, The electronic device includes a storage configured to store an identifier and attributes of a first object as authentication information, a display configured to display a plurality of authentication objects comprising a second object that has one or more of the attributes of the first object and has a form different from a form of the first object, in response to a request to perform an authentication procedure, and a controller configured to authenticate a user based on an attribute of an authentication object selected by the user from among the plurality of displayed authentication objects and the stored authentication information.

Abstract: Systems and methods are described for facilitating non-verbal communication. An electronic processor receives data from the hand-gesture sensor indicative of one or more gestures performed by a user, determines at least one word or phrase corresponding to the data from the hand-gestures sensor, and outputs a text representation of the at least one word or phrase on the display screen. Some systems output the text representation as a natural language sentence based on the data from the hand-gesture sensor and linguistic prosody information determined based, at least in part, on image data of the user captured while performing the one or more gesture. Some systems also includes at least one brain sensor and generate an alternative natural language text sentence in response to detecting a signal from the brain sensor indicative of a contradiction response after displaying the natural language text sentence on the display screen.

Abstract: Systems and methods are described for automatically identifying a food item. A color image and a thermal image are received by an electronic processor with a first food item in the field of view of both the color image and the thermal image. The electronic processor identifies a region of pixels in the color image that corresponds to the first food item based at least in part on a temperature intensity of the pixels in the identified region of pixels relative to other pixels in the thermal image. At least one feature is extracted from the identified region of pixels in the color image corresponding to the first food item and the electronic processor automatically identifies a type of food corresponding to the first food item based at least in part on the at least extracted feature.

Abstract: The present disclosure envisages a system for evaluating the feasibility of introducing a new node in a blockchain infrastructure. The blockchain dimension queries and the transaction dimension queries are presented to a user. The user provides responses to the blockchain dimension queries and transaction dimension queries. A feature detector module detects features from the blockchain dimension responses and the transaction dimension responses. A feature value assignor assigns feature values to the detected features. A criticality assignor assigns criticality scores to the detected features. A weightage assignor assigns weightage scores to the blockchain dimension queries and the transaction dimension queries. The feasibility evaluator receives the feature values, the criticality scores, and the weightage scores, and calculates a feasibility score, thereby evaluating the feasibility of introducing the new node.

Abstract: A global cross-carrier system for distributing mobile data. A sharer utilizes a mobile application to access the data share server to enable sharing of any unused data in the sharer's data plan with a wireless network carrier. A borrower associated with another carrier can utilize a mobile application to access the data share server to enable borrowing of any available data shared by other users. A data share server might optionally purchase data from one or more carriers, the one or more carriers need not be located within the same country. The sharer has an option of purchasing a data plan from the data share server. A borrower has the option of purchasing on-demand data in the form of a session if there are no sharers in the data pool.

Abstract: A Brain-Mobile Interface (BMoI) system is provided. A control circuit is configured to execute a predictive model to generate a defined number of predicted signal features in future time based on a number of signal features extracted from a first type sensory data (e.g., electroencephalogram (EEG) data). A predicted future mental state(s) can thus be generated based on the number of predicted signal features and used to trigger a corresponding action(s) in a BMoI application(s). In a non-limiting example, a second type sensory data (e.g., electrocardiogram (ECG) data) can be used to improve accuracy of the predictive model. By using the predicted signal features to generate the predicted future mental state(s) to control the BMoI application(s), it is possible to duty-cycle the BMoI system to help reduce power consumption and processing latency, thus allowing the BMoI application(s) to operate in real-time with improved accuracy and power consumption.

Abstract: This disclosure involves development and deployment platforms for decision algorithms. For example, a computing system provides software development interface to a client device. The system sets, based on an input from the client device via the interface, a decision engine to a test mode that causes the decision engine to operate on test data stored in a first database and that prevents the decision engine from applying operations from the client device to production data stored in a second database. The system also configures the decision engine in the test mode to execute a different decision algorithms on the test data. The system also sets, based on another input via the interface, the decision engine to a deployment mode that causes the decision engine to operate on the production data. The system configures the decision engine in the deployment mode to execute one or more of the tested decision algorithms.

Abstract: A method is provided to operate a computer to interoperate with a portable media player. The method includes processing signals provided from the portable media player to the computer that are indicative of whether an accessory has been connected to the portable media player, to determine whether the accessory has been connected to the portable media player. Based on a determination that the accessory has been connected to the portable media player, physiologic data of a user that was provided to the portable media player from a wireless physiologic data gathering device, is received from the portable media player, into the computer, via the accessory.

Abstract: Methods and systems are described for sensing and recovery of a biological signal using generative-model-based compressive sensing. A transformation is applied to sparsify the quasi-periodic signal removing morphology parameters and leaving temporal parameters. The sparsified signal is sampled and the sampled signal data is transmitted to a base station. A homotopy recovery algorithm is applied to the received sampled signal data by the base station to recover the temporal parameters of the biological signal. Generative modelling is applied using previously captured morphology parameters to generate a reconstructed signal. Finally, the reconstructed signal is adjusted and scaled based on the recovered temporal parameters to provide a reconstructed signal that is diagnostically equivalent to the original biological signal.

Abstract: The present disclosure is directed to a system and method for estimating an overall wind coherence acting on a wind turbine and using same to dynamically adapt the gain or bandwidth of pitch or torque or yaw control logic within a wind turbine. The method includes generating, via sensors, a plurality of sensor signals reflective of wind conditions near the wind turbine. The method also includes filtering, via at least one filter, the sensor signals at a predetermined frequency range considered damaging for turbine sub-system loading. Thus, the method also includes estimating an overall damaging wind coherence acting on the wind turbine as a function of distance-normalized wind coherences, which themselves are derived from auto and cross-covariances of pairs of filtered signals. The distance normalization uses a model of natural coherence dissipation with distance.

Abstract: The present disclosure is directed to a system and method for estimating an overall wind coherence acting on a wind turbine and using same to dynamically adapt the gain or bandwidth of pitch or torque or yaw control logic within a wind turbine. The method includes generating, via sensors, a plurality of sensor signals reflective of wind conditions near the wind turbine. The method also includes filtering, via at least one filter, the sensor signals at a predetermined frequency range considered damaging for turbine sub-system loading. Thus, the method also includes estimating an overall damaging wind coherence acting on the wind turbine as a function of distance-normalized wind coherences, which themselves are derived from auto and cross-covariances of pairs of filtered signals. The distance normalization uses a model of natural coherence dissipation with distance.

Abstract: A method is provided to operate a computer to interoperate with a portable media player. The method includes processing signals provided from the portable media player to the computer that are indicative of whether an accessory has been connected to the portable media player, to determine whether the accessory has been connected to the portable media player. Based on a determination that the accessory has been connected to the portable media player, physiologic data of a user that was provided to the portable media player from a wireless physiologic data gathering device, is received from the portable media player, into the computer, via the accessory.

Abstract: The present invention relates to the use of the compound 1-(2-(4-fluorophenyl)thiazol-5-yl)-1-(pyridin-4-yl)ethanol (“ASNOO1”) in treatments without concomitant use of a steroid and/or in the form of a racemic mixture, e.g. in prostate cancer treatment. It also relates to its use in methods that are food indifferent.

Abstract: Methods and apparatus to provide a distributed firewall in a network are disclosed. An example method includes identifying, at a control plane, a network traffic rule to implement in a network, and determining a first firewall of a distributed firewall in the network to enforce the network traffic rule. Example methods also configure a first software-defined network node to route network traffic to the first firewall. The first firewall is instantiated by a first firewall instance at a second software-defined network node and by a second firewall instance at a third software-defined network node. In response to determining at least some of the network traffic forwarded by the first software-defined network node to the second and third software-defined network nodes is being dropped at the first and second firewall instances, example methods also cause the first software-defined network node to implement a third firewall instance.

Abstract: A heterogeneous multiple core control system for predictive medical monitoring is provided. The system includes a first processor platform that is optimized for serialized computation and a second processor platform that is optimized for parallelized computation. A memory stores instructions that are executed by either the first processor platform or the second processor platform to provide the functionality of the system. By executing the instructions, the system determines whether a condition of a first patient is to be monitored using a primarily parallelized model or a primarily serialized model. The predicted condition is calculated using the primarily parallelized model by executing the primarily parallelized model on the second processor platform. The predicted condition is calculated using the primarily serialized model by executing the primarily serialized model on the first processor platform.

Abstract: Systems, methods, and apparatuses for reducing the load to load/store address latency in an out-of-order processor. When a producer load is detected in the processor pipeline, the processor predicts whether the producer load is going to hit in the store queue. If the producer load is predicted not to hit in the store queue, then a dependent load or store can be issued early. The result data of the producer load is then bypassed forward from the data cache directly to the address generation unit. This result data is then used to generate an address for the dependent load or store, reducing the latency of the dependent load or store by one clock cycle.