Abstract: The present invention is directed to anti-PVRIG antibodies and methods of using same.

Abstract: Methods, systems, computer-readable media, and apparatuses may provide virtualization of device management services (e.g., device drivers) dedicated managing a particular device and designed under for or under the assumption the particular device and the device management service will be utilized in a single session/user environment, so that virtual instances of the device management services may be used in a multi-session environment. Further, a redirection and/or virtualization layer may be created for each session in the multi-session environment to perform global database redirection, object name translation, and file system translation to ensure session boundaries are maintained and global/shared resources are not inappropriately altered by a session. As an example, the redirection/virtualization layer may redirect communications associated with a session and for a global resource to access a virtual instance of the resource specific to the session.

Abstract: Systems and methods are provided for efficient handling of user requests to access shared resources in a distributed system, which handling may include throttling access to resources on a per-resource basis. A distributed load-balancing system can be logically represented as a hierarchical token bucket cache, where a global cache contains token buckets corresponding to individual resources whose tokens can be dispensed to service hosts each maintaining a local cache with token buckets that limit the servicing of requests to access those resources. Local and global caches can be implemented with a variant of a lazy token bucket algorithm to enable limiting the amount of communication required to manage cache state. High granularity of resource management can thus enable increased throttle limits on user accounts without risking overutilization of individual resources.

Abstract: Compositions and methods are provided for an inducible, high efficiency intra-genomic homologous recombination (IGHR) system in plants, that can be used for non-chimeric, heritable gene targeting. The advantage of IGHR approach to targeted integration is that every cell contains donor DNA and nuclease-encoding sequences, so that there are many potentially homology-directed targeting events that can occur during plant development.

Abstract: The present invention relates to an improved and industrially viable process for the preparation of Acalabrutinib and its Intermediates. The present invention involves less expensive reagents, solvents and the process conditions can be easily adopted for commercial scale. The present invention relates to process for the preparation Acalabrutinib of formula (1) and process for the preparation of Acalabrutinib key starting material.

Abstract: Apparatus and methods disclosed herein provide technical solution for on-demand manufacturing of a payment instrument that includes an integrated circuit chip. Apparatus and methods provide technical solutions for securely validating and activating the manufactured payment instrument. The customer may submit a request to manufacture a payment instrument through an automated teller machine (“ATM”), online banking channel or mobile banking channel. Apparatus and methods allow a customer to manufacture a payment instrument at home using a 3D printer or use a 3D printer installed at an ATM. Using a secure validation methods, the newly manufactured payment instrument may be activated at an ATM.

Abstract: The present invention is directed to triple combination therapies with anti-TIGIT antibodies, anti-PVRIG antibodies, and checkpoint inhibitors, including anti-PD-1 or anti-PD-L1 antibodies.

Abstract: Apparatus and methods disclosed herein provide technical solution for on-demand manufacturing of a payment instrument that includes an integrated circuit chip. Apparatus and methods provide technical solutions for securely validating and activating the manufactured payment instrument. The customer may submit a request to manufacture a payment instrument through an automated teller machine (“ATM”), online banking channel or mobile banking channel. Apparatus and methods allow a customer to manufacture a payment instrument at home using a 3D printer or use a 3D printer installed at an ATM. Using a secure validation methods, the newly manufactured payment instrument may be activated at an ATM.

Abstract: A hemostasis aiding device for use at wound sites associated with venous access procedures.

Abstract: A system includes a first data center that includes a first computing device communicatively coupled to a first database. The first computing device is configured to determine data stored in the first database to be replicated to a second database communicatively coupled to a second computing device of a remote data center. The first computing device is further configured to determine whether a point-to-point data tunnel has been established across a broadband cellular network between the first computing device and the second computing device and to establish the point-to-point data tunnel across the broadband cellular network between the first computing device and the second computing device when it is determined that the point-to-point data tunnel has not been established. The first computing device is further configured to replicate the data to the second database by transmitting the data to the second computing device across the point-to-point data tunnel.

Abstract: A network-on-chip (NoC) system includes a default communication path between a master device and a slave device, and a backup communication path between the master device and the slave device. The default communication path is configured to work in a normal operation state of the chip. The backup communication path is configured to replace the default communication path when a fault arises in the default communication path.

Abstract: A method of accessing a Non-Volatile Memory express over Fabrics (NVMeoF) memory region of a remote target device includes establishing a NVMeoF transport connection with the remote target device and creating an admin queue by sending a NVMeoF connect command to the remote target device. The method includes accessing the NVMeoF memory region of the remote target device by sending PropertyGet/PropertySet commands to an admin submission queue of the remote target device, performing one of (a) receiving PropertyGet/PropertySet completion queue entries from the remote target device when accessing the NVMeoF memory region of the remote target device is completed, or (b) receiving at least one of RDMA write and RDMA read requests from the remote target device in response to PropertyGet/PropertySet submission queue entries, and receiving completion queue entries from the remote target device when the accessing of the NVMeoF memory region of the remote target device is completed.

Abstract: Disclosed herein are novel inhibitors of TGF?1 activation with durable inhibitory effects. Methods directed to the selection of a suitable TGF? inhibitor for various disease conditions and patient populations are also provided.

Abstract: Systems and methods are provided for conducting incremental restore operations on block storage volumes using an object-based snapshot. A full restore from an object-based snapshot can include copying all blocks of a data set from the object-based snapshot to a destination volume. For high capacity volumes, full restores may take large amounts of time. Moreover, full restores may be inefficient where a destination volume already contains some data of the snapshot. Embodiments of the present disclosure provide for incremental restore operations, where a delta data set is transferred from the snapshot to the destination volume, representing data in the snapshot is not known to already exist on the volume or another available volume.

Abstract: A method for applying agency and regulation modeling in a multi-tenant architecture system includes accessing merchant's representation in an identity manager. The merchant is managed via a full representation by an original identity manager. The method includes performing a first service for the merchant via the representation, and determining, based on results of the first service and on policies of the first service provider, that performance of a second service is required for completion of the first service. The second service is provided by a second service provider onboarded into the first service provider, where the second service amends policy requirements of the first service provider. The method includes accessing a first subservice of the second service using the representation to generate second results for use at a second subservice of the second service, the second subservice configured to use transaction resources of the first representation.

Abstract: A testing probe structure for wafer level testing semiconductor IC packaged devices under test (DUT). The structure includes a substrate, through substrate vias, a bump array formed on a first surface of the substrate for engaging a probe card, and at least one probing unit on a second surface of the substrate. The probing unit includes a conductive probe pad formed on one surface of the substrate and at least one microbump interconnected to the pad. The pads are electrically coupled to the bump array through the vias. Some embodiments include a plurality of microbumps associated with the pad which are configured to engage a mating array of microbumps on the DUT. In some embodiments, the DUT may be probed by applying test signals from a probe card through the bump and microbump arrays without direct probing of the DUT microbumps.

Abstract: Systems, computer program products, and methods are described herein for enhanced authentication framework using multi-dimensional hashing. The present invention is configured to electronically receive, from a computing device of a user, a resource transfer request; retrieve, from an authentication database, a multi-dimensional hash for a first set of data files for the user and a user identification artifact; retrieve, from the computing device of the user, a second set of data files matching the user identification artifact; initiate an asynchronous hash processing engine on the second set of data files; generate, using the asynchronous hash processing engine, a multi-dimensional hash for the second set of data files; compare the multi-dimensional hash for the first set of data files with the multi-dimensional hash for the second set of data files to determine a match; and authorize the resource transfer request based on at least determining the match.

Abstract: Aspects of the disclosure relate to isolating and reinstating nodes in a distributed ledger using proof of innocence. In some embodiments, a first plug-in embedded with the blockchain network may monitor consumer-initiated transactions submitted to an enterprise organization node to determine the legitimacy of each consumer-initiated transaction. The first plug-in may identify consumer-initiated transactions associated with malicious activity and may flag the consumer node for further analysis. A second plug-in may identify and analyze the consumer-initiated transactions associated with the consumer node to determine a proof of innocence value associated with the consumer node. The first plug-in may isolate the consumer node from the distributed ledger if the proof of innocence value exceeds a proof of innocence threshold. Alternatively, the first plug-in may permit the consumer node to remain within the distributed ledger if the proof of innocence value falls below the proof of innocence threshold.

Abstract: The present disclosure relates to a method for determining optimal process flow (107) for a process performed by users (101) in a computing system. The method comprises receiving plurality of keystroke level events for each of plurality of process flows associated with the process, performed by plurality of users (101). Further, the method comprises determining one or more subtasks (105) for each of the plurality of process flows (102). A subtask comprises a set of events occurring together in the plurality of keystroke level events (103). Furthermore, the method comprises grouping one or more process flows from the plurality of process flows (102) to form one or more clusters (106), based on the one or more subtasks (105). Each cluster comprises the one or more process flows with similar subtasks. Thereafter, the method comprises determining an optimal process flow (107) in each cluster.

Abstract: The present invention relates to anti-SIRP? (Signal regulatory protein alpha) antibodies and antigen-binding fragments thereof for therapeutic and diagnostic methods and compositions using them.