Abstract: A bristle and a tooth brush incorporating the same. A toothbrush (100) having a handle (120), a head (110) coupled to the handle (120), and at least one bristle that comprising a composition including a polymer and fibroin particles.

Abstract: An oral care implement (100) in one embodiment includes an elongated body (101) comprising a head portion (110) supporting plurality of tooth cleaning elements (111) and a handle portion (120) defining an outer surface (127). A grip control component (130) is disposed on the handle portion (120) and includes a pair of transversely spaced apart control surfaces (132) separated by a longitudinally extending channel (133). The control surfaces (132) are elevated above the outer surface (127) of the handle portion (120) and positioned to engage a user's thumb. The control component (130) is operable to tilt the head portion (110) at an upward or downward angle relative to a vertical plane of a user's teeth when the control component (130) is grasped between the user's thumb and forefinger for producing a proper brushing angle at the gum line.

Abstract: A toothbrush (100) having a combination of tapered and non-tapered cleaning elements (50) for enhanced cleaning effects and having a plurality of tapered bristle tufts of differing tuft configurations including, a first tapered bristle tuft (500) having a dome-shaped bristle tip profile (520) toward one end (210) of the head (200), a second tapered bristle tuft (602) having an arcuate-shaped bristle configuration (622) toward an opposite end (222) of the head (200), and a plurality of laterally-extending third tapered bristle tufts (600) arranged in an alternating fashion with non-tapered bristle tufts (630) and disposed between the first and second tapered bristle tufts (500, 602).

Abstract: An oral care system includes an oral care implement and a smart device removably retained in a cavity of the oral care implement. The smart device may have a plurality of sensors for sensing conditions of the oral cavity and/or for sensing various parameters associated with the movement of the oral care implement within the oral cavity during use. The smart device may also include a transmitter for transmitting data/information obtained by the sensors to an electronic device, such as a smart phone.

Abstract: The presently disclosed subject matter relates to tumor infiltrated T cells induced by oncolytic virus (“OV-induced T cells”), methods of making and using said OV-induced T cells for an adoptive T-cell therapy. The presently disclosed subject matter further relates to oncolytic viruses and armed oncolytic viruses, methods of making and using said oncolytic viruses, as well as pharmaceutical compositions and kits comprising said oncolytic viruses.

Abstract: A method for predicting the responsiveness of a cancer cell to an MEK inhibitor, comprising detecting the presence of at least one mutation in one or more genes selected from the group consisting of ADAM12, COL14A1, TNN, and TP53, in the cancer cell, by contacting a nucleic acid sample derived from the cancer cell with at least one oligonucleotide which allows specific detection of the mutation; wherein presence of mutation in ADAM12, COL14A1, TNN, TP53 and/or any combination thereof is indicative of decreased responsiveness of the cancer cell to the ERK inhibitor.

Abstract: An oral care implement including at least one multi-component bristle. In one aspect, the invention can be an oral care implement having a handle; a head coupled to the handle; at least one bristle tuft extending from the head, the at least one bristle tuft comprising at least one multi-component bristle comprising first and second components. The first component may include a first plastic and a first oral care additive and the second component may include a second plastic and a second oral care additive such that the first oral care additive is different than the second oral care additive.

Abstract: In some embodiments, an oral care system includes a toothbrush and a smart device removably retained in the toothbrush and having a plurality of sensors for sensing conditions of the oral cavity. The sensors may include sensors that obtain information while the smart device is retained in the toothbrush and sensors that obtain information while the smart device is separated from the toothbrush.

Abstract: A toothbrush is provided that includes a base component having a gripping region and an oral engaging region defining a longitudinal axis along a length of the oral engaging region and a transverse axis along a width of the oral engaging region. The oral engaging region has bilateral symmetry with respect to the longitudinal axis and can comprise wherein the oral engaging region has bilateral symmetry with respect to the longitudinal axis and comprises a first distal region having an approximately concave contour tapering to a second middle region having an approximately convex contour and widening to a third proximal region having an approximately concave contour. The oral engaging region can support a plurality of cleaning elements along a front side and a plurality of soft cleaning elements along a second side opposite the first.

Abstract: A light regulation device includes a first light guide structure having an incident light, a second light guide structure having a light emitting surface, and a light deflection sheet having a first light deflection layer. All or a portion of the incident light is guided by the first light guide structure toward the light deflection sheet, is then deflected at least by the first light deflection layer to travel to the second light guide structure so as to be guided by the same to emit through the light emitting surface. The other portion of the incident light is guided by the first light guide structure toward the second light guide structure, and is then guided by the second light guide structure to emit through the light emitting surface.

Abstract: An oral care implement (100) including at least multi-component bristle. The oral care implement (100) comprises a handle (120); a head (110) coupled to the handle (120); at least one bristle tuft extending from the head, the at least one bristle tuft comprises at least one multi-component bristle (200) comprising coextruded core (210) and sheath components (220), the sheath component (220) surrounding a first portion (215) of the core component (210), and a second portion (216) of the core component (210) protruding from the sheath component (220) at a tip portion (230) of the multi-component bristle (200); the sheath component (220) comprises a first plastic and a first oral care additive; the core component (210) comprises a second plastic and a second oral care additive, wherein the first oral care additive is different than the second oral care additive.

Abstract: A coupler is presented that has high-directivity and low coupling coefficient variation. The coupler includes a first trace with a first edge substantially parallel to a second edge and substantially equal in length to the second edge. The first trace includes a third edge substantially parallel to a fourth edge. The fourth edge is divided into three segments. The outer segments are a first distance from the third edge. The middle segment is a second distance from the third edge. Further, the coupler includes a second trace, which includes a first edge substantially parallel to a second edge and substantially equal in length to the second edge. The second trace includes a third edge substantially parallel to a fourth edge. The fourth edge is divided into three segments. The outer segments are a first distance from the third edge. The middle segment is a second distance from the third edge.

Abstract: An oral care product array includes a handle component and multiple refill components therefor. The handle component includes a power source. A first refill component includes a first light generating module which emits light in a first spectrum from the first refill component. A second refill component includes a second light generating module which emits light in a second spectrum from the second refill component. Each refill component has a coupled state, when coupled to the handle component, and a decoupled state, when decoupled from the handle component. When the first refill component is in the coupled state, the first light generating module is powered by the power source to emit light in the first spectrum. When the second refill component is in the coupled state, the second light generating module is powered by the power source to emit light in the second spectrum.

Abstract: A light-emitting oral care implement includes a light delivery unit that includes a passageway through a body of the oral care implement and a tuft comprising a plurality of filaments located in the passageway, each of the filaments having a core component and a sheath component. The core component may have a transmittance that is greater than the transmittance of the sheath component. The core component may include a base portion that protrudes from a lower end of the sheath component, the base portion forming an anchor portion of the tuft that anchors the tuft to the body of the oral care implement. Furthermore, the oral care implement may include a light source that transmits lights through the anchor portion of the tuft and through the core components for transmittance from the filaments at a location above a front surface of the body.

Abstract: A spiral bristle (201) includes: a first component (231), a second component (233), and a third component (235), with each of the second and third components (233, 235) wrapping around the first component (231) in a helical and spaced-apart manner, the second and third components (233, 235) isolated from one another by the first component (231). An oral care implement includes the spiral bristle.

Abstract: A bristle and a tooth brush incorporating the same. A toothbrush (100) having a handle (120), a head (110) coupled to the handle (120), and at least one bristle that comprising a composition including a polymer and fibroin particles.

Abstract: A communication system includes at least one transmitting unit and at least one receiving unit. The at least one transmitting unit is configured to transmit at least one input signal after precoding it with at least one precoding matrix. The at least one receiving unit wirelessly coupled with the at least one transmitting unit is configured to receive the at least one precoded input signal, and generate at least one channel quality signal corresponding to the at least one precoded input signal, in which the at least one transmitting unit generates at least one magnitude information estimate or at least one phase information estimate or at least one of both for at least one channel state information according to the at least one channel quality signal, the at least one precoding matrix and at least one noise size signal.

Abstract: The present disclosure provides a diagnostic method based on pairwise comparison of cancers using transcriptome expression data. In one embodiment, the method comprises the steps of: obtaining a first gene expression profile of a first cancer sample having a first cancer type; obtaining a second gene expression profile of a second cancer sample having a second cancer type, wherein the second cancer type is different from the first cancer type; comparing said first gene expression profile with said second gene expression profile; and selecting N genes that are most differentially expressed in the first and the second gene expression profiles to generate pairwise differentially expressed genes (DEGs), wherein N is an integer between 10 and 100.