Abstract: The present disclosure provides a diagnostic method based on pairwise comparison of cancers using transcriptome expression data. In one embodiment, the method comprises the steps of: obtaining a first gene expression profile of a first cancer sample having a first cancer type; obtaining a second gene expression profile of a second cancer sample having a second cancer type, wherein the second cancer type is different from the first cancer type; comparing said first gene expression profile with said second gene expression profile; and selecting N genes that are most differentially expressed in the first and the second gene expression profiles to generate pairwise differentially expressed genes (DEGs), wherein N is an integer between 10 and 100.

Abstract: Embodiments of the present application are directed to an automation process method to generate a set of wetland predictive variables using Light Detection and Ranging (“LiDAR”) data within a geographic information system (“GIS”) software platform, according to some embodiments, and to model and predict wetland in ArcGIS platform using the generated variable set. The automatic process also can run analysis on and display of the predicted wetland. The process is built by developing modules and connection in GIS. The above mentioned processes are automatically run and may just be run by one-button press, or on click, or separate buttons press, or separate clicks.

Abstract: A monofilament bristle (200) is disclosed that comprises coextruded core (210) and sheath components (220). The sheath component (220) has an outer surface (218) and surrounds a first portion (215) of the core component (210). A second portion (216) of the core component (210) protrudes from a top terminal end (203) of the sheath component (220) to form an exposed tip portion (203). In one embodiment, the exposed tip portion (203) of the core component (210) has an outer surface (217) that includes friction-enhancing features. In another embodiment, the exposed tip portion (203) is tapered and has an outer surface (217) with a first roughness and the outer surface (218) of the sheath component (220) has a second roughness, the second roughness being greater than the first roughness In a further embodiment, the core component (210) has an outer surface (217) configured to have higher coefficient of friction than the outer surface (218) of the sheath component (220).

Abstract: A coupler is presented that has high-directivity and low coupling coefficient variation. The coupler includes a first trace with a first edge substantially parallel to a second edge and substantially equal in length to the second edge. The first trace includes a third edge substantially parallel to a fourth edge. The fourth edge is divided into three segments. The outer segments are a first distance from the third edge. The middle segment is a second distance from the third edge. Further, the coupler includes a second trace, which includes a first edge substantially parallel to a second edge and substantially equal in length to the second edge. The second trace includes a third edge substantially parallel to a fourth edge. The fourth edge is divided into three segments. The outer segments are a first distance from the third edge. The middle segment is a second distance from the third edge.

Abstract: A toothbrush is provided that includes a base component having a gripping region and an oral engaging region defining a longitudinal axis along a length of the oral engaging region and a transverse axis along a width of the oral engaging region. The oral engaging region has bilateral symmetry with respect to the longitudinal axis and can comprise wherein the oral engaging region has bilateral symmetry with respect to the longitudinal axis and comprises a first distal region having an approximately concave contour tapering to a second middle region having an approximately convex contour and widening to a third proximal region having an approximately concave contour. The oral engaging region can support a plurality of cleaning elements along a front side and a plurality of soft cleaning elements along a second side opposite the first.

Abstract: A coupler is presented that has high-directivity and low coupling coefficient variation. The coupler includes a first trace with a first edge substantially parallel to a second edge and substantially equal in length to the second edge. The first trace includes a third edge substantially parallel to a fourth edge. The fourth edge is divided into three segments. The outer segments are a first distance from the third edge. The middle segment is a second distance from the third edge. Further, the coupler includes a second trace, which includes a first edge substantially parallel to a second edge and substantially equal in length to the second edge. The second trace includes a third edge substantially parallel to a fourth edge. The fourth edge is divided into three segments. The outer segments are a first distance from the third edge. The middle segment is a second distance from the third edge.

Abstract: A communication system includes at least one transmitting unit and at least one receiving unit. The at least one transmitting unit is configured to transmit at least one input signal after precoding it with at least one precoding matrix. The at least one receiving unit wirelessly coupled with the at least one transmitting unit is configured to receive the at least one precoded input signal, and generate at least one channel quality signal corresponding to the at least one precoded input signal, in which the at least one transmitting unit generates at least one magnitude information estimate or at least one phase information estimate or at least one of both for at least one channel state information according to the at least one channel quality signal, the at least one precoding matrix and at least one noise size signal.

Abstract: A toothbrush (100) having a combination of tapered and non-tapered cleaning elements (50) for enhanced cleaning effects and having a plurality of tapered bristle tufts of differing tuft configurations including, a first tapered bristle tuft (500) having a dome-shaped bristle tip profile (520) toward one end (210) of the head (200), a second tapered bristle tuft (602) having an arcuate-shaped bristle configuration (622) toward an opposite end (222) of the head (200), and a plurality of laterally-extending third tapered bristle tufts (600) arranged in an alternating fashion with non-tapered bristle tufts (630) and disposed between the first and second tapered bristle tufts (500, 602).

Abstract: An oral care implement including at least one multi-component bristle. In one aspect, the invention can be an oral care implement having a handle; a head coupled to the handle; at least one bristle tuft extending from the head, the at least one bristle tuft comprising at least one multi-component bristle comprising first and second components. The first component may include a first plastic and a first oral care additive and the second component may include a second plastic and a second oral care additive such that the first oral care additive is different than the second oral care additive.

Abstract: The present invention provides a method of selecting a mRNA for production of a polypeptide of interest comprising: a) producing an array of individual mRNA sequences comprising different nucleotide sequences encoding the polypeptide of interest; b) determining one or more or two or more of the following parameters for each individual mRNA sequence of (a): (i) minimum free energy (MFE) RNA secondary structure; (ii) ensemble free energy (EFE); (iii) frequency of the minimum free energy (FMFE) RNA secondary structure in a thermodynamic ensemble; and (iv) ensemble diversity (ED); c) ranking the individual mRNA sequences of the array according the parameters determined in step (b); and d) selecting a mRNA sequence from the ranked array of step (c), wherein the selected mRNA produces the polypeptide of interest. The present invention further provides a method of selecting a mRNA for enhanced and reduced production of a polypeptide of interest.

Abstract: In some embodiments, an oral care system includes a toothbrush and a smart device removably retained in the toothbrush and having a plurality of sensors for sensing conditions of the oral cavity. The sensors may include sensors that obtain information while the smart device is retained in the toothbrush and sensors that obtain information while the smart device is separated from the toothbrush.

Abstract: An oral care implement including at least one spiral bristle. In one aspect, the invention can be an oral care implement having a handle; a head coupled to the handle; at least one bristle tuft extending from the head, the at least one bristle tuft comprising at least one spiral bristle comprising coextruded first and second strand components that are intertwined together to form the at least one spiral bristle; the first strand component comprising a first plastic and a first oral care additive; and the second strand component comprising a second plastic and a second oral care additive, Tine rein the first oral care additive is different than the second oral care additive.

Abstract: An oral care implement (100) in one embodiment includes an elongated body (101) comprising a head portion (110) supporting plurality of tooth cleaning elements (111) and a handle portion (120) defining an outer surface (127). A grip control component (130) is disposed on the handle portion (120) and includes a pair of transversely spaced apart control surfaces (132) separated by a longitudinally extending channel (133). The control surfaces (132) are elevated above the outer surface (127) of the handle portion (120) and positioned to engage a user's thumb. The control component (130) is operable to tilt the head portion (110) at an upward or downward angle relative to a vertical plane of a user's teeth when the control component (130) is grasped between the user's thumb and forefinger for producing a proper brushing angle at the gum line.

Abstract: Disclosed is an oral care implement, comprising: an elongate handle having a proximal end, a distal end and a longitudinal axis; and a head at the distal end of the handle, the head comprising one or more oral care elements on a first side of the oral care implement; wherein the handle comprises first and second visibly demarcated grip regions on the first side of the oral care implement, wherein the first grip region is between the second grip region and the proximal end of the handle, wherein the first grip region is between 60 and 100 millimeters from the proximal end of the handle, and wherein the first and second grip regions are spaced apart by between 50 and 100 millimeters in a direction parallel to the longitudinal axis.

Abstract: A method for predicting the responsiveness of a cancer cell to an MEK inhibitor, comprising detecting the presence of at least one mutation in one or more genes selected from the group consisting of ADAM12, COL14A1, TNN, and TP53, in the cancer cell, by contacting a nucleic acid sample derived from the cancer cell with at least one oligonucleotide which allows specific detection of the mutation; wherein presence of mutation in ADAM12, COL14A1, TNN, TP53 and/or any combination thereof is indicative of decreased responsiveness of the cancer cell to the ERK inhibitor.

Abstract: A control method for a power converter is provided. The power converter includes an inductor, and a switch selectively turned on according to a control signal. The control method includes determining an on-time and a falling time according to a voltage information or a current information of the power converter; determining a switching period of the control signal according to the on-time, the falling time, and a resonant period corresponding to the inductor and a parasitic capacitance of the switch; adjusting the switching period by comparing the switching period with a first threshold period and a second threshold period; generating the control signal having the switching period when the switching period is greater than the first threshold period and less than the second threshold period or when the switching period is greater than the second threshold period and the power converter operates at over 50% of a rated power.