Abstract: The present invention provides a method of selecting a mRNA for production of a polypeptide of interest comprising: a) producing an array of individual mRNA sequences comprising different nucleotide sequences encoding the polypeptide of interest; b) determining one or more or two or more of the following parameters for each individual mRNA sequence of (a): (i) minimum free energy (MFE) RNA secondary structure; (ii) ensemble free energy (EFE); (iii) frequency of the minimum free energy (FMFE) RNA secondary structure in a thermodynamic ensemble; and (iv) ensemble diversity (ED); c) ranking the individual mRNA sequences of the array according the parameters determined in step (b); and d) selecting a mRNA sequence from the ranked array of step (c), wherein the selected mRNA produces the polypeptide of interest. The present invention further provides a method of selecting a mRNA for enhanced and reduced production of a polypeptide of interest.

Abstract: A power converting circuit includes a converter. The converter receives and converts an input power to provide power for a load. The converter includes a power storage unit, a switch unit, a capacitor unit, and a current sampling unit. The power storage unit includes input and output terminals. The switch unit includes first and second switches, which are series connected at a common terminal, and the common terminal is coupled to the output terminal of the power storage unit. The capacitor unit includes first and second capacitors. The first capacitor and the switch unit are parallel connected to form a capacitor-switch parallel structure. The second capacitor capacitance is more than ten times larger than the first capacitor capacitance. The current sampling unit and the capacitor-switch parallel structure are series connected to form a capacitor-sampling unit series structure. The capacitor-sampling unit series structure and the second capacitor are parallel connected.

Abstract: An oral care implement including at least one spiral bristle. In one aspect, the invention can be an oral care implement having a handle; a head coupled to the handle; at least one bristle tuft extending from the head, the at least one bristle tuft comprising at least one spiral bristle comprising coextruded first and second strand components that are intertwined together to form the at least one spiral bristle; the first strand component comprising a first plastic and a first oral care additive; and the second strand component comprising a second plastic and a second oral care additive, Tine rein the first oral care additive is different than the second oral care additive.

Abstract: An oral care implement (100) including at least multi-component bristle. The oral care implement (100) comprises a handle (120); a head (110) coupled to the handle (120); at least one bristle tuft extending from the head, the at least one bristle tuft comprises at least one multi-component bristle (200) comprising coextruded core (210) and sheath components (220), the sheath component (220) surrounding a first portion (215) of the core component (210), and a second portion (216) of the core component (210) protruding from the sheath component (220) at a tip portion (230) of the multi-component bristle (200); the sheath component (220) comprises a first plastic and a first oral care additive; the core component (210) comprises a second plastic and a second oral care additive, wherein the first oral care additive is different than the second oral care additive.

Abstract: An oral implement comprises a head (10) and a handle (12). The head (10) comprises a first face (14) and a plurality of cleaning elements (34, 36) extending therefrom, a proximal section (16) adjacent to the handle (12) and a distal section (18) remote from the handle (12). The head (10) further comprises a flexible bridge (20) coupling the distal section (18) to the proximal section (16), so that the distal section (18) is flexibly moveable relative to the proximal section (16). The flexible bridge (20) further comprises at least one elastomeric cleaning element extending from the first face (14); wherein the at least one elastomeric cleaning element extends along the flexible bridge (20) in a direction perpendicular to a longitudinal axis of the head (10).

Abstract: A control circuit, control method used in a PFC circuit and the power source system thereof are disclosed herein. The control circuit comprises: a zero current detection circuit having a polarity detection circuit for outputting a first and a second digital signals and a signal conversion circuit for generating an analog signal; a feedback circuit for generating a driving pulse signal; and a pulse distribution circuit for distributing the driving pulse signal to a first and a second switches according to the first and the second digital signal. After a switch cycle, one of the first and the second switch performs an ON operation for the next switch cycle when the current flowing through the inductor decreases to a predetermined threshold value, wherein an ON time of the first switch is equal in each switch cycle, and an ON time of the second switch is equal in each switch cycle.

Abstract: An exemplary flat heat pipe includes a hollow, flattened casing and a first wick structure and a second wick structure received in the casing. The casing includes a top plate and a bottom plate opposite to the top plate. The first wick structure is formed by weaving wires, and the second wick structure is made of sintered metal powder. The first and second wick structures are disposed at inner sides of the bottom and top plates of the casing, respectively. The first and second wick structures contact each other. The casing defines two vapor channels at opposite lateral sides of the combined first and second wick structures, respectively.

Abstract: A heat sink includes a base and a removable air guide member. The base includes a thermal plate and two air guide plates fixed to opposite two sides of the thermal plate. An air guide channel is formed between the thermal plate and the two air guide plates. The fins are connected to the thermal plate. One end of each air guide plate bends and extends to form a windshield while another end has a connection portion. The removable air guide member is detachably connected to the base. The removable air guide member includes two vertical plates. One end of each vertical plate is connected to the connection portion while another end bends outward and extends to form a horizontal plate. Thereby, the cooling module and the heat sink can be installed on a motherboard with electronic components arranged densely and may receive maximum airflow.

Abstract: Gene expression signature predictive of cancer patient response to multi-kinase inhibitor is disclosed. Also disclosed are methods predicting the efficacy of the multi-kinase inhibitor for treating cancer in a patient. Also disclosed are methods for distinguishing responders from non-responders to a multi-kinase inhibitor in treating cancer. Also disclosed are methods for treating a cancer patient with a multi-kinase inhibitor.

Abstract: The present invention provides a method of selecting a mRNA for production of a polypeptide of interest comprising: a) producing an array of individual mRNA sequences comprising different nucleotide sequences encoding the polypeptide of interest; b) determining one or more or two or more of the following parameters for each individual mRNA sequence of (a): (i) minimum free energy (MFE) RNA secondary structure; (ii) ensemble free energy (EFE); (iii) frequency of the minimum free energy (FMFE) RNA secondary structure in a thermodynamic ensemble; and (iv) ensemble diversity (ED); c) ranking the individual mRNA sequences of the array according the parameters determined in step (b); and d) selecting a mRNA sequence from the ranked array of step (c), wherein the selected mRNA produces the polypeptide of interest. The present invention further provides a method of selecting a mRNA for enhanced and reduced production of a polypeptide of interest.

Abstract: A power converting circuit includes a converter. The converter receives and converts an input power to provide power for a load. The converter includes a power storage unit, a switch unit, a capacitor unit, and a current sampling unit. The power storage unit includes input and output terminals. The switch unit includes first and second switches, which are series connected at a common terminal, and the common terminal is coupled to the output terminal of the power storage unit. The capacitor unit includes first and second capacitors. The first capacitor and the switch unit are parallel connected to form a capacitor-switch parallel structure. The second capacitor capacitance is more than ten times larger than the first capacitor capacitance. The current sampling unit and the capacitor-switch parallel structure are series connected to form a capacitor-sampling unit series structure. The capacitor-sampling unit series structure and the second capacitor are parallel connected.

Abstract: A control method for a power converter is provided. The power converter includes an inductor, and a switch selectively turned on according to a control signal. The control method includes determining an on-time and a falling time according to a voltage information or a current information of the power converter; determining a switching period of the control signal according to the on-time, the falling time, and a resonant period corresponding to the inductor and a parasitic capacitance of the switch; adjusting the switching period by comparing the switching period with a first threshold period and a second threshold period; generating the control signal having the switching period when the switching period is greater than the first threshold period and less than the second threshold period or when the switching period is greater than the second threshold period and the power converter operates at over 50% of a rated power.