Abstract: An ultra-thin elastomer sheet has a maximum film thickness of 3 ?m and composed of a crosslinked silicone polymer in which a silicone polymer configured from unit portions having reactive organic groups and unit portions not having reactive organic groups is crosslinked by a crosslinking agent having a reaction group reacting with the reactive organic groups, the crosslinked silicone polymer is defined by the following mathematical formula: U=(Um+Un)/Ua??(I) where, U is a number of monomer unit portions between crosslinking points of the crosslinked silicone polymer, Um is a number of monomer unit portions of the silicone polymer not having reactive organic groups, Un is a number of monomer unit portions of the silicone polymer having reactive organic groups, and Ua is a number of reaction groups of the crosslinking agent used in crosslinking and the number of monomer unit portions between crosslinking points of the crosslinked silicone polymer is 348-2090.

Abstract: A bioelectrode in which an electrode layer can deform in association with the unevenness of the installation surface of the biological surface so as to adhere to the installation surface, and which can be easily transported and stored, a production method and an installation method for the bioelectrode. It is a bioelectrode in which a flexible electrode that is to directly contact a biological surface is formed from an electrode layer that includes a conductive polymer and deforms in association with an installation surface of the biological surface so as to adhere to the installation surface, and an elastomer layer that is layered on one surface side of the electrode layer and deforms in association with the installation surface and the electrode layer, wherein the flexible electrode is bonded to a water-permeable layer that serves as a support via a water-soluble sacrificial layer that includes a water-soluble material.

Abstract: Provided is a temperature-responsive fluorescent particle comprising at least one type of fluorescent molecule in a molecular assembly comprising and constituted by at least one type of amphiphilic molecule, wherein the fluorescent molecule emits fluorescence when the molecular assembly is in the liquid phase and it is quenched when the molecular assembly is in the solid phase, due to a temperature-responsive solid-liquid phase transition, so that fluorescence emission and quenching of the fluorescent molecule are reversibly switched in a temperature responsive manner. Also provided is a temperature-responsive fluorescent probe comprising the temperature-responsive fluorescent particle the surface of which is modified with a biomolecule recognition element, and methods for detecting and quantitatively determining a biomolecule with the temperature-responsive fluorescent probe.

Abstract: A hemostatic material includes a lipid that can accelerate adhesion or aggregation of platelets even if the lipid does not carry a protein or a peptide involved in adhesion or aggregation of platelets such as GPIb and H12 and, to achieve the object, provides a hemostatic material including a water-insoluble base and a lipid supported on a surface of the base, wherein the lipid includes one or two or more anionic lipids.

Abstract: An extensible electroconductive wiring material includes a flexible electroconductive material and insulating elastic bodies and, wherein the flexible electroconductive material having an electroconductive layer has vent peripheral edge portions in which vent holes and/or vent slits are penetrated and aligned in series and/or in parallel along an energization direction of the electroconductive layer while the vent peripheral edge portions are energizably linked, and the vent peripheral edge portions is sealed and covered by the insulating elastic bodies, so as not to be exposed; and the insulating elastic bodies, have penetration slits, and/or penetration holes which penetrate therethrough while matching the vent peripheral edge portions and are smaller than the vent holes and the vent slits. The extensible electroconductive wiring module has a plurality of these extensible electroconductive wiring materials.

Abstract: A carboxylic acid-type lipid can accelerate adhesion or aggregation of platelets even if the carboxylic acid-type lipid does not carry a protein involved in adhesion or aggregation of platelets or a peptide corresponding to an active site of the protein; a lipid particle and a lipid membrane each include the carboxylic acid-type lipid; and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each include the carboxylic acid-type lipid, the lipid particle or the lipid membrane. A carboxylic acid-type lipid is selected from carboxylic acid-type lipids represented by formulas (I) to (VI), a lipid particle includes the carboxylic acid-type lipid, a lipid membrane includes the carboxylic acid-type lipid, and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each include the carboxylic acid-type lipid, the lipid particle or the lipid membrane.

Abstract: A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-?m-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-?m-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.

Abstract: An extensible electroconductive wiring material includes a flexible electroconductive material and insulating elastic bodies and, wherein the flexible electroconductive material having an electroconductive layer has vent peripheral edge portions in which vent holes and/or vent slits are penetrated and aligned in series and/or in parallel along an energization direction of the electroconductive layer while the vent peripheral edge portions are energizably linked, and the vent peripheral edge portions is sealed and covered by the insulating elastic bodies, so as not to be exposed; and the insulating elastic bodies, have penetration slits, and/or penetration holes which penetrate therethrough while matching the vent peripheral edge portions and are smaller than the vent holes and the vent slits. The extensible electroconductive wiring module has a plurality of these extensible electroconductive wiring materials.

Abstract: A porous ultra-thin polymer film has a film thickness of 10 nm-1000 nm. A method of producing the porous ultra-thin polymer film includes dissolving two types of mutually-immiscible polymers in a first solvent in an arbitrary proportion to obtain a solution; applying the solution onto a substrate and then removing the first solvent from the solution applied onto the substrate to obtain a phase-separated ultra-thin polymer film that has been phase-separated into a sea-island structure; and immersing the ultra-thin polymer film in a second solvent which is a good solvent for the polymer of the island parts but a poor solvent for a polymer other than the island parts to remove the island parts, thereby obtaining a porous ultra-thin polymer film.

Abstract: The present invention relates to a process for the preparation of films of conductive polymers, by the technique so-called roll-to-roll, which allows to obtain freestanding films having advantageous features such as toughness, flexibility, ability to adhere to different substrates, a submicron thickness and a very high ratio surface area/thickness; the present films are suitable for use in several technological applications, in particular for the development of biosensors, and in the production of flexible electronic components with large surface, suitable for wearable devices and also intended for contacting skin.

Abstract: A polymer film has an average film thickness T0 along a straight line D passing through the center of gravity of a two-dimensional projection such that the area of the polymer film is maximized, satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation ? defined by equation (d) satisfies equation (e); and a dispersion liquid and an agglomerate using the same. (a) 10 nm?T0?1000 nm, (b) 0.1 ?m?L?500 ?m, (c) 0.01 GPa?E?4.3 GPa, (d) ?=1?T1/T2, (e) 0.346E×10?9?1.499<?<?0.073E×10?9+0.316.

Abstract: A laminated film includes a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle and, when stuck to an adherend with curved surface, the laminated film has excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. The acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs. The laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.

Abstract: Provided are an electronic device employing a polymer nanosheet, having an electronic element and a conductive wiring that are connected to each other in a solder-free manner, and exhibiting a high conformability and adhesiveness to an object for attaching including a biological tissue such as skin; and a method for manufacturing the same. The electronic device includes the electronic element; and the polymer nanosheet adhering to the electronic element. Specifically, the polymer nanosheet adheres to the electronic element in a manner such that one surface of the electronic element is entirely covered by the polymer nanosheet. It is preferred that the polymer nanosheet have a thickness of smaller than 1 ?m. Further, a conductive wiring capable of being electrically connected to the electronic element; and a power source for supplying power to the electronic element, may also be formed on the polymer nanosheet.

Abstract: A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-?m-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-?m-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.

Abstract: A polymer film can be adjusted to movement or a fine uneven surface of a living body and has excellent ability to adhere to a biological tissue. The polymer film includes a block copolymer having a structure in which branched polyalkylene glycol and polyhydroxyalkanoic acid are bound to each other, wherein the polymer film has a film thickness of 10 to 1000 nm. The branched polyalkylene glycol has at least three terminal hydroxyl groups per molecule, the mass percentage of the branched polyalkylene glycol relative to the total mass of the block copolymer is 1% to 30%, and a value obtained by dividing the average molecular weight of polyhydroxyalkanoic acid in the block copolymer by X that is the number of terminal hydroxyl groups present per a single molecule of the branched polyalkylene glycol is 10000 to 30000.

Abstract: A laminated film includes a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle and, when stuck to an adherend with curved surface, the laminated film has excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. The acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs. The laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.

Abstract: A method for preparing a thin film polymer structure having a functional substance on an A surface and a B surface of the film, the polymer structure being obtained by: (a) adsorbing polyfunctional molecules to a region of an arbitrary shape in an interface between a substrate body and a liquid phase; (b) polymerizing and/or crosslinking the adsorbing polyfunctional molecules to form a polymer thin film; (c) bonding a functional substance to the A surface of the formed thin film and then forming a soluble support film on the A surface; (d) exfoliating the thin film and the soluble support film from the substrate body; and (e) bonding to the B surface of the thin film a functional substance identical to or different from the functional substance bonded to the A surface and then dissolving the soluble support film with a solvent.

Abstract: A porous ultra-thin polymer film has a film thickness of 10 nm-1000 nm. A method of producing the porous ultra-thin polymer film includes dissolving two types of mutually-immiscible polymers in a first solvent in an arbitrary proportion to obtain a solution; applying the solution onto a substrate and then removing the first solvent from the solution applied onto the substrate to obtain a phase-separated ultra-thin polymer film that has been phase-separated into a sea-island structure; and immersing the ultra-thin polymer film in a second solvent which is a good solvent for the polymer of the island parts but a poor solvent for a polymer other than the island parts to remove the island parts, thereby obtaining a porous ultra-thin polymer film.

Abstract: A polymer film has an average film thickness T0 along a straight line D passing through the center of gravity of a two-dimensional projection such that the area of the polymer film is maximized, satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation ? defined by equation (d) satisfies equation (e); and a dispersion liquid and an agglomerate using the same. (a) 10 nm?T0?1000 nm, (b) 0.1 ?m?L?500 ?m, (c) 0.01 GPa?E?4.3 GPa, (d) ?=1?T1/T2, (e) 0.346E×10?9?1.499<?<?0.073E×10?9+0.316.

Abstract: A thin film polymer structure having a functional substance on the face (A surface) and reverse face (B surface) of the film, obtained by the steps of: (a) causing polyfunctional molecules to adsorb to an area of an arbitrary shape in an interface between a substrate body and a liquid phase; (b) polymerizing and/or crosslinking the adsorbing polyfunctional molecules to form a polymer thin film; (c) bonding a functional substance to the A surface of the formed thin film and then (d) forming a soluble support film thereon; exfoliating the thin film and the soluble support film from the substrate body; (e) bonding to the B surface of the thin film a functional substance identical to or different from the abovementioned functional substance and then dissolving the soluble support film with a solvent.