Abstract: The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.

Abstract: A method of performing a scanning sequence for an ultrasound scan includes establishing a number of ultrasound beams to be transmitted during an ultrasound scan, establishing a pulse repetition interval to be used for performing the ultrasound scan, and establishing a number of firings of each of the ultrasound beams to be performed during the ultrasound scan. The method further includes performing a scanning sequence based on a processing of one or more parameters selected from the group consisting of the number of ultrasound beams, the pulse repetition interval, and the number of firings of the ultrasound beams, wherein the processing of the one or more parameters is configured to provide a continuous interleaving in the transmitted beams thereby avoiding a generation of beam interleaving discontinuities and a formation of artifacts in a resulting image.

Abstract: A method of sowing a somatic plant embryo or germinant of a conifer species to facilitate subsequent development of the embryo or germinant into an autotrophic seedling. The method involves the following steps carried out ex vitro in non-sterile conditions: providing a nutrient medium comprising particles of a solid component present within a flowable or semi-solid component containing water and a carbohydrate nutrient for the embryo or germinant, dispensing a quantity of the nutrient medium onto a surface of a porous solid growth substrate for the somatic plant embryo or germinant, to and contacting the plant embryo or germinant with the nutrient medium. The nutrient medium has a fluidity such that at least some of the flowable or semi-solid component containing the carbohydrate nutrient remains in contact with the embryo or germinant at least until the embryo or germinant establishes vigorous growth under environmental conditions effective for such growth.

Abstract: The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

Abstract: An adaptive use of recessed lights cans for retrofitting various types of light fixtures. For example, a recessed light could be retrofitted as a junction box. In other embodiments, the recessed light could supply power for a speaker that includes a threaded power. Other electronic devices are contemplated that could be installed in a recessed light housing, including a battery backup light, a wireless repeater, a surveillance camera, a cellular phone booster, an infrared repeater, a fan, a wireless perimeter barrier, an alarm system, a sound machine, a web cam, an electronic pest control, a smoke detector, a carbon monoxide detector, an air purifier, a HVAC repeater control, a temperature monitor, a humidity monitor, a sound monitor, a photoelectric motion detector light, a photoelectric light sensor, and a hanging mobile.

Abstract: Disclosed is a mobile marketing and advertising based system comprised of a database, a mobile device, a trigger location (primary physical location), a secondary location in a favorable proximity to the trigger location and a means for providing multimedia content from the database to the mobile device.

Abstract: This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

Abstract: Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

Abstract: Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

Abstract: This invention relates to novel pharmaceutical compositions comprising therapeutically effective combination of a positive allosteric modulator of nicotine receptors; and a cognitive enhancer selected from the group consisting of a nicotine acetylcholine receptor agonist, an acetylcholine esterase inhibitor, a positive AMPA receptor modulator, an antipsychotic drug, an antidepressant drug and an anti Parkinson drug. The pharmaceutical compositions for use according to the invention are contemplated particularly useful for combating cognitive disorders.

Abstract: A method of sowing a somatic plant embryo or germinant of a conifer species to facilitate subsequent development of the embryo or germinant into an autotrophic seedling. The method involves the following steps carried out ex vitro in non-sterile conditions: providing a nutrient medium comprising particles of a solid component present within a flowable or semi-solid component containing water and a carbohydrate nutrient for the embryo or germinant, dispensing a quantity of the nutrient medium onto a surface of a porous solid growth substrate for the somatic plant embryo or germinant, and contacting the plant embryo or germinant with the nutrient medium. The nutrient medium has a fluidity such that at least some of the flowable or semi-solid component containing the carbohydrate nutrient remains in contact with the embryo or germinant at least until the embryo or germinant establishes vigorous growth under environmental conditions effective for such growth.

Abstract: A machine and method for applying braid by means of a braiding machine to a mandrel, where the mandrel has a shape that approximates a wheel but has an irregularly varying radius of curvature. The machine includes drive/positioning wheel assemblies that are used to continuously reposition a cross-section of the mandrel relative to the braiding machine such that a center point of cross-section of the mandrel is maintained to be coaxial with a braiding point of the braiding machine as the mandrel 18 is rotationally advanced by the drive/positioning wheel assemblies. Repositioning of the drive/positioning wheel assemblies is controlled by a computer numerical control (CNC) controller, based on information describing one or more radiuses of curvature for sections of the mandrel and a current position of the mandrel relative to the drive/positioning wheel assemblies.

Abstract: This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

Abstract: A nasal cannula arrangement for use as part of systems for delivery respiratory gases to a patient is disclosed. The nasal cannula arrangement includes a manifold part adapted to receive gases from a delivery conduit. The manifold includes one but preferably a pair of prongs extending upward and curving towards the rear of the manifold. The prongs are inserted into the nostrils of the patient and deliver gases to a patient. The prongs have a cut out on the rear side of the prongs. The cut out forms a gases outlet in the prongs and are shaped such that the area of the cut out area is greater than the cross sectional area of the prongs at the entry point to the prongs.

Abstract: A catalyst composition for producing polyesters comprises: a) an organometallic compound obtained by reacting an orthoester or condensed orthoester of titanium, zirconium or aluminum, an alcohol containing at least two hydroxyl groups, a 2-hydroxy carboxylic acid and a base; and b) at least one compound comprising germanium, antimony or tin. Polyesters obtained by esterification reaction in the presence of the catalyst compositions according to the present invention exhibit improved melt properties and are particularly suitable for production of textile and commercial fibers, films and rigid packaging.

Abstract: An ultrasound probe comprises a probe housing that has an inner surface and an outer surface. An array of transducer elements are within the probe housing. At least one sensor is formed between the inner and outer surfaces of the probe housing. The at least one sensor is configured to detect at least one parameter associated with an object in contact with the outer surface proximate the at least one sensor.

Abstract: A white light LED-based lighting device configured for direct form, fit, and function replacement of existing incandescent and fluorescent devices is provided. The white light LED-based lighting device comprises a group of solid state light emitting diodes, electronics to activate the light emitting diodes, and an encapsulating housing configured for direct form, fit, and function replacement of existing fluorescent devices.

Abstract: The present invention is directed to a test probe having an indexable probe tip. In one embodiment, an insulative sleeve extends from the test probe and surrounds a portion of the exposed probe tip. The insulative sleeve is moveable relative to the probe tip and may be indexable to at least two positions. For instance, the insulative sleeve locks into a first position to provide a first length of the probe tip exposed from the insulative sleeve, and the insulative sleeve locks into a second position to provide a second length of the probe tip exposed from the insulative sleeve.

Abstract: A method for correcting a time delay between at least two signals in ultrasound systems is provided. The ultrasound system comprises a beamformer processor comprising a summer coupled to the transducer array and configured for performing a complex operation on a first plurality of receive signals to generate a beamsum signal; wherein each of the receive signals comprise a corresponding beamforming delay and a complex filter coupled to the summer and configured to transform the beamsum signal to an analytical signal. The beamformer processor further comprises a plurality of correlator processors coupled to at least one respective transducer element and the complex filter, each correlator processor configured to calculate a correlation sum for at least one receive signal and at least one time delay estimator adapted to receive the correlation sum of at least one receive signal and configured to estimate the corresponding time delay using the correlation sum.

Abstract: An electrical connector assembly for a cable having a plurality of insulated conductors comprises a body having a respective recess for receiving a terminating pin each of the conductors. A respective spigot sealingly engages within each of the recesses and has a passage for receiving an associated one of the terminating pins. Furthermore a seal is associated with each of the spigots for sealing the spigot relative to the associated terminating pin. The provision of a separate spigot for each of the conductors and for sealing engagement within a respective recess in the body enables the spigots to be sealingly fitted to the conductors prior to each spigot being introduced into its recess and sealingly engaged therein. This provides improved insulation of the conductor and increased creepage distance between the mating electrical parts and the outer surface of the housing of the assembly.