Abstract: An application search system may maintain an index of applications available from multiple different application stores, and includes parameters, such as features and/or content of the applications. When a user submits a query, the system may derive contextual information pertaining to a user device used to submit the query, applications installed on a particular user device and/or usage information for installed applications. The system then may, in one example, determine one or more applications relevant to the search query and, depending on the contextual information derived, may provide an entry point to access a particular application at a task level, may prompt the user to install the application, or may provide a web result related to the particular application.

Abstract: Embodiments of the invention relate to a computer-implemented method and system for generating personalized recommendations for a target user based at least on stored data about the target user. The method comprises obtaining, at the server computer, data from a plurality of data sources, including entity data associated with a plurality of entities, stored in an entity database, or personal data associated with a plurality of users, stored in a user database. The personalized recommendations system then merges the entity data or personal data and maps the entity or personal data to a corresponding entity or target user, respectively. The entity or personal data is differentiated, a relevance is determined, a weight is assigned to the data and corresponding source to canonicalize the data, the respective databases are updated with the corresponding data, and then a set of personalized recommendations to the target user is generated using the updated databases.

Abstract: This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

Abstract: This invention relates to a novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its use in the manufacture of pharmaceutical compositions. The compound of the invention is found to be a cholinergic ligand at the nicotinic acetylcholine receptors. Due to its pharmacological profile the compound of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

Abstract: A water flush mechanism has a plunger having a plug and a stem connected to the plug. There is a lower float located around a lower portion of the stem and a middle float located around the stem. There is an upper float located around the stem. The float is connected to an upper portion of the stem so lifting of the float causes the plunger to rise.

Abstract: A power source with multiple cells connected in parallel to a common node or power supply point. The individual cells within the power source may also have a dedicated controller for each of the individual cells such that the dedicated controllers are connected on a one to one basis with each of the respective individual cells.

Abstract: An electronic device comprises an array of electro wetting cells, each cell comprising first and second liquids (14,18) which are immiscible in each other. An electrode arrangement (60a,60b) is used to control the position of the interface between the first and second liquids, and comprises a first electrode and a second electrode. Each cell comprises a first switching device (64a) for applying a cell drive voltage to the first electrode (60a), and a second switching device (64b) for simultaneously applying the same cell drive voltage to the second electrode (60b). The cell circuit can be produced without requiring any additional control lines to those required for a single electrode and associated switching device, but the use of two switching devices enables the ultimate signal applied to each electrode to be different as a result of different capacitive effects. This then enables control over the way the liquid interface moves in response to control voltages.

Abstract: This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

Abstract: The present invention relates to methods for treating bowel disorders using calcimimetics.

Abstract: In one implementation, a conference bridge or a multipoint conference unit (MCU) receives media streams from the endpoints in the conference. The media stream may contain at least one of audio, video, file sharing, or collaboration data. The MCU measures a characteristic in each of a plurality of media streams and calculates statistics based on the individual participation levels of the endpoints. A dynamic participation indicator displayed at the endpoints shows the relative participation levels of the endpoints. For example, the dynamic participation indicator may show the names of the users in a font that changes size and/or location as the participation level changes. In another example, the dynamic participation indicator may show respective videos of the endpoints in a format and/or size that changes as the participation level changes.

Abstract: The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.

Abstract: An ultrasound probe and an ultrasound imaging system include a plurality of transducer elements arranged in an array. The plurality of transducer elements are organized to form a transmit aperture and a receive aperture. The ultrasound probe and ultrasound imaging system include a plurality of summing nodes. The ultrasound probe and ultrasound imaging system include a set of receive switches associated with each of the transducer elements in the receive aperture. Each set of receive switches is configured to selectively connect the associated transducer element to any one of the plurality of summing nodes.

Abstract: A system and method of ultrasound imaging includes a beamformer including a plurality of channels, a two-dimensional transducer array including a plurality of elements, and a plurality of signal pathways linking the plurality of elements to the plurality of channels. The system and method also include a plurality of switches positioned along the plurality of signal pathways. The plurality of switches being configured to actively connect a subset of the plurality of elements to the plurality of channels in order to form a receive aperture. The plurality of switches are further configured to control an aspect ratio of the receive aperture by changing which of the plurality of elements are actively connected to the plurality of channels.

Abstract: A method for applying a braided fabric over a mandrel using a braiding apparatus having a central axis and providing braiding yarns drawn toward a braiding point where a braid is formed on the mandrel, the method comprising the steps of advancing the mandrel through the braiding point of the braiding apparatus, determining a current position of the mandrel; and controlling the position of the mandrel transversely to the central axis of the braiding apparatus responsive to the current position such that a center point of a mandrel cross-section passing through the braiding apparatus is coincident with the braiding point.

Abstract: The electrical properties of particle solutions can be investigated on a single particle basis by using micro fluidic channels. The impedance can be measured across the channel using at least one pair of conductive electrodes, at least one electrode of a pair being a fingered electrode having a plurality of fingers. The pattern of fingered electrodes creates a longer and more complicated measurement signal shape which leads to a significant improvement of measurement sensitivity. An application for the proposed technology is to significantly improve the measurement sensitivity of impedance measurements on blood cells, leading to a better differentiation between different types of white blood cells. Better measurement sensitivity also enables the measurement of smaller particles and higher throughput.

Abstract: In a digital system with a processor coupled to a paged memory system, the memory system may be dynamically configured using a memory compaction manager in order to allow portions of the memory to be placed in a low power mode. As applications are executed by the processor, program instructions are copied from a non-volatile memory coupled to the processor into pages of the paged memory system under control of an operating system. Pages in the paged memory system that are not being used by the processor are periodically identified. The paged memory system is compacted by copying pages that are being used by the processor from a second region of the paged memory into a first region of the paged memory. The second region may be placed in a low power mode when it contains no pages that are being used by the processor.

Abstract: Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

Abstract: An integral tab system for a 2-D or 3-D tab for a folder, and a method of making same is disclosed. The integral 2-D (flat) tab (20) is provided in the hanging folder itself without the need for additional tabs being affixed. The 3-D tab version (120) is created by an extension which is folded onto itself so that one edge surface is at an angle relative to the panels of the file folder allowing it to be read from the side. These tabs may also be supplied in a detachable form.

Abstract: A compound according to Formula I or II: wherein R1, R1b, R2, L1, and L2 and L2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: The present invention facilitates the sharing of resources among multiple applications hosted on a server using shared resource providers. A shared resource provider is a logical grouping of shared services and resources to support the shared services, and is associated with one or more applications hosted on a computing device. The server fulfills requests for the shared services from the shared resource provider with which the requesting application is associated. Shared resource providers may be associated with many different applications, but each application may be associated with only one shared resource provider. The shared services may be configured for consumption by the applications at the server level, at the level of the shared resource provider, and the level of the application.