Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2, R3, A, W, U and V are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: In various embodiments, a downlight illumination device is upgraded to an illumination device based on one or more light-emitting diodes (LEDs) via a retrofit kit that includes (i) a lighting module comprising one or more LEDs, (ii) a driver module comprising circuitry for receiving power from the power source and supplying compatible power to the one or more LEDs, (iii) a flexible conduit connecting the lighting module to the driver module and containing therewithin a plurality of wires electrically connecting the lighting module to the driver module, and (iv) an alignment bracket for attachment within the housing and configured to receive the lighting module.

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: Devices and methods are disclosed for treating the vertebral column. One embodiment provides a transverse connector for vertebral fixation systems comprising a first connector body comprising a first engaging member for engaging a first elongate member and a first locking member, a second connector body comprising a second engaging member for engaging a second elongate member, and a transverse rod coupled to the first connector body and the second connector body, thereby forming an articulation between a first end of the transverse rod and the first connector body, wherein the first locking member is configured to secure both the articulation and the first elongate member to the first connector body.

Abstract: A framework is provided for building a visual representation of a product concept including a textual component and/or a graphical component. A first element within one of the textual component and the graphical components is designated as a first dynamic element. A second element within one of the textual component and the graphical component is designated as a second dynamic element. The first dynamic element is associated with a first variant list. The second dynamic element is associated with a second variant list. A constraint is associated between at least a first element variant and at least a second element variant. A selection of a first element variant from the first variant list and a second element variant from the second variant list are received. A first instantiation of the visual representation is generated including the first element variant and the second element variant based upon the constraint.

Abstract: Invention for producing a relatively large uniformly aligned planar array of nanowires comprising: step 1) fabricating a template for producing nanowires in which the template comprises an alternating multilayer stack of thin film substrate layers and inert insulating thin film layers using atomic layer deposition; and step 2) fabricating a relatively large uniformly aligned planar array of nanowires by depositing atoms or molecules along the thin film substrate layers on at least one side of the template with the use of atomic layer deposition.

Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: Devices and methods are disclosed for treating the vertebral column. One embodiment provides a transverse connector for vertebral fixation systems comprising a first connector body comprising a first engaging member for engaging a first elongate member and a first locking member, a second connector body comprising a second engaging member for engaging a second elongate member, and a transverse rod coupled to the first connector body and the second connector body, thereby forming an articulation between a first end of the transverse rod and the first connector body, wherein the first locking member is configured to secure both the articulation and the first elongate member to the first connector body.

Abstract: Invention for pattern recognition and artificial intelligence comprising: 1) storing data in parallel by applying a logic level (1) input or a logic level (0) input to one input of each of at least two exclusive-nor logic gates; 2) comparing data in parallel by applying a logic level (1) input or a logic level (0) input to the other input of each of the exclusive-nor gates, wherein each exclusive-nor gate produces a logic level (1) output when both inputs have the same datum input, and each exclusive-nor gate produces a logic level (0) output when both inputs have different datum input; and 3) measuring the outputs of the exclusive-nor logic gates collectively with a measuring apparatus, wherein the percentage of the pattern input for comparison which matches the pattern of data stored in the exclusive-nor gates is directly proportional to the magnitude of the collective output of the exclusive-nor gates.

Abstract: A computer implemented method, system, and computer program product include one or more processors identifying a dynamic element within framework for building a visual representation of a product concept, the visual representation including one or more of a textual component and a graphical component, the dynamic element associated with a variant list including one or more variant elements; one or more processors identifying one of a longest variant element and a shortest variant element from within the variant list; and one or more processors generating a first instantiation of a visual representation of a product concept including the one of the longest variant element and the shortest variant element as the dynamic element.

Abstract: Embodiments described herein provide a chip, comprising a first device on a substrate and a second device on the substrate. The chip further comprises a heat distribution structure in thermal proximity to the first device and the second device, wherein the heat distribution structure is thermally isolated and reduces a thermal gradient between the first device and the second device.

Abstract: An isolated epitaxial modulation device comprises a substrate; a barrier structure formed on the substrate; an isolated epitaxial region formed above the substrate and electrically isolated from the substrate by the barrier structure; a semiconductor device, the semiconductor device located in the isolated epitaxial region; and a modulation network formed on the substrate and electrically coupled to the semiconductor device. The device also comprises a bond pad and a ground pad. The isolated epitaxial region is electrically coupled to at least one of the bond pad and the ground pad. The semiconductor device and the epitaxial modulation network are configured to modulate an input voltage.

Abstract: Devices and methods are disclosed for treating the vertebral column. One embodiment provides a transverse connector for vertebral fixation systems comprising a first connector body comprising a first engaging member for engaging a first elongate member and a first locking member, a second connector body comprising a second engaging member for engaging a second elongate member, and a transverse rod coupled to the first connector body and the second connector body, thereby forming an articulation between a first end of the transverse rod and the first connector body, wherein the first locking member is configured to secure both the articulation and the first elongate member to the first connector body.

Abstract: Integrated solar modules are provided. In one example, a corner cap for coupling to a solar module is described. The solar module has a solar panel and a frame circumscribing the solar panel. The corner cap includes a first wall and a second wall. The first wall and the second wall define a corner angle substantially the same as an angle defined by a corner of the solar module. The corner cap includes a flange extending from the corner cap. The flange is configured for coupling the corner cap to a solar module.

Abstract: A mounting bracket for use with a solar module is disclosed. The mounting bracket includes a foot including a first wall and a second wall oriented substantially orthogonal to the first wall, the first wall including serrations configured to engage serrations on a rail to adjust a height of the rail with respect to the foot. The mounting bracket further includes a backing configured to be coupled to the foot and secure the mounting bracket to the rail.

Abstract: The invention provides a compound of the formula (I): or a salt, solvate, tautomer or N-oxide thereof, wherein M is selected from a group D1 and a group D2: and R?, E, A and X are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds, processes for making the compounds and the use of the compounds in the prophylaxis or treatment of a disease state mediated by a CDK kinase, GSK-3 kinase or Aurora kinase.

Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: In various embodiments, a system for providing an LED illumination source on a surface includes a light module comprising (i) an illumination area for receiving one or more light-emitting diodes (LEDs) and (ii) slip joints at first and second ends of the light module, each slip joint comprising a slip joint slot, and at least one bracket for mounting the light module to the surface, the at least one bracket having (i) a fitting frictionally receivable within one of the slip joint slots and (ii) a mounting region engageable to the surface.