Abstract: An irrigation device includes a body defining a fluid passage; a slider movably coupled to the body, wherein the slider includes a body defining a plurality of apertures and a plurality of projections extending away from the body; a plurality of flexible jets coupled longitudinally to the body, wherein the plurality of flexible jets receive fluid from the fluid passage, and wherein each jet is received by an aperture in the plurality of apertures of the slider; and a toggle rotatably coupled to the body and to the slider, wherein the toggle is rotatably coupled to the body in substantial alignment with the plurality of jets, and wherein rotation of the toggle in a first direction moves the slider to cause at least one projection of the slider to engage with at least one jet to adjust a position of the at least one jet.

Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: A lighting system and related methods are disclosed herein. The lighting system may have a mounting fixture and a light fixture. The mounting fixture is configured to engage a mounting surface. The light fixture is configured to engage the mounting fixture and has a driver configured to drive a light source. A first fastener having a movable elongated member is configured to removably couple the light fixture to the mounting fixture in an extended configuration. A second fastener having a quick connect feature is configured to removably couple the light fixture to the mounting fixture in a retracted configuration.

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

Abstract: Invention provided for efficiently transmitting energy to a target for producing an overall effective result for applications comprising power transmission and communications. Wherein, first, a source of electromagnetically intense coherent radiation and an interferometer produce a beam of electromagnetically neutralized radiation. The neutralized beam comprises forward propagating photons or forward propagating electrically charged particles which have associated forward traveling waves which superimpose and destructively interfere to an extent, and have oscillatorily time-varying electromagnetic fields which cancel to a corresponding extent. Then, second, the electromagnetically neutralized beam is coherently transmitted through transmission apparatus to a target which then, third, utilizes the transmitted beam.

Abstract: Pilots suitable for use in MIMO systems and capable of supporting various functions are described. The various types of pilot include—a beacon pilot, a MIMO pilot, a steered reference or steered pilot, and a carrier pilot. The beacon pilot is transmitted from all transmit antennas and may be used for timing and frequency acquisition. The MIMO pilot is transmitted from all transmit antennas but is covered with different orthogonal codes assigned to the transmit antennas. The MIMO pilot may be used for channel estimation. The steered reference is transmitted on specific eigenmodes of a MIMO channel and is user terminal specific. The steered reference may be used for channel estimation. The carrier pilot may be transmitted on designated subbands/antennas and may be used for phase tracking of a carrier signal. Various pilot transmission schemes may be devised based on different combinations of these various types of pilot.

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: An actuator assembly for actuating electrical switches housed in an electrical enclosure is disclosed. The assembly includes at least one handle assembly including a handle positioned above a cover of the enclosure, a trip bracket positioned below the cover and a shaft connecting the handle to the trip bracket. At least one slider actuator is slidably mounted over the electrical switch and coupled to a toggle of the electrical switch. The slider actuator has a drive link which is adapted to be engaged with the trip bracket such that rotation of the handle causes the drive link to slide which in turn causes a linear movement of the slider actuator to toggle the electrical switch. The use of the slider actuator allows a higher density of electrical switches to be stacked inside the enclosure.

Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: A low electrical and thermal resistance FinFET device includes a semiconductor body, a fin body on the substrate wafer, an isolation structure forming a fin connecting region, a gate dielectric on the fin body extending above the isolation structure, a FinFET gate electrode on the gate dielectric, a heavily-doped buried layer in the semiconductor body extending under said fin, and a vertical conductive region extending from the semiconductor body surface to the heavily-doped buried layer. Additionally, a fin body-to-buried layer implanted region disposed in the fin connecting region provides a low electrical and thermal resistance shunt from the fin body to the heavily-doped buried layer.

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

Abstract: In various embodiments, a downlight illumination device is upgraded to an illumination device based on one or more light-emitting diodes (LEDs) via a retrofit kit that includes (i) a lighting module comprising one or more LEDs, (ii) a driver module comprising circuitry for receiving power from the power source and supplying compatible power to the one or more LEDs, (iii) a flexible conduit connecting the lighting module to the driver module and containing therewithin a plurality of wires electrically connecting the lighting module to the driver module, and (iv) an alignment bracket for attachment within the housing and configured to receive the lighting module.

Abstract: A system and method for manufacturing a set of cast stones includes a set of spray stations, a set of fill stations, a set of vibration tables, a drying rack, and a demolder connected to the drying rack. A controller is connected to each of the set of spray stations, the set of fill stations, the set of vibration tables, the drying rack, and the demolder, each of which has a set of sensors connected to the controller. The set of spray stations include a set of release stations and a set of color stations. A mold is sprayed with a release product, a set of colors, and then filled with a cementitious material. Once vibrated, the cementitious material is dried to form the set of cast stones, which is then automatically released from the mold utilizing the demolder.

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: Invention for producing an orderly aligned horizontally planar array of nanowires comprising: step 1) providing a template for producing nanowires in which the template comprises an alternating multilayer stack of substrate and inert insulating thin film layers; and step 2) fabricating an orderly aligned, horizontally planar array of nanowires by depositing atoms and/or molecules along the outer edges of the thin film substrate layers on at least one side of the template with the use of atomic layer deposition.

Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: An electrical connection system connecting a flexible conduit to electrical conductors, comprising a conduit portion and a removably attachable base portion. The conduit portion retains an end of the conduit, via a retention mechanism within a first housing at a first end. The conduit portion comprises a first electrical connector housing and electrical terminals within a second end of the first housing. The base portion comprises a base mount and a second housing having a first end pivotably connected to the base mount, the second housing being pivotable at a joint. The base portion may also comprise a second electrical connector housing and electrical terminals within a second end of the second housing for electrical connection to the conduit portion. Mechanical fastening components of the base portion and the conduit portion enable a mechanical connection between the base portion and the conduit portion.

Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: In various embodiments, a downlight illumination device is upgraded to an illumination device based on one or more light-emitting diodes (LEDs) via a retrofit kit that includes (i) a lighting module comprising one or more LEDs, (ii) a driver module comprising circuitry for receiving power from the power source and supplying compatible power to the one or more LEDs, (iii) a flexible conduit connecting the lighting module to the driver module and containing therewithin a plurality of wires electrically connecting the lighting module to the driver module, and (iv) an alignment bracket for attachment within the housing and configured to receive the lighting module.