Abstract: This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts.

Abstract: Hybrid additive manufacturing methods include building a green state additive structure, wherein building the green state additive structure comprises iteratively binding together a plurality of layers of additive material using a binder, and joining the green state additive structure to a base structure to form a hybrid article.

Abstract: Creating and processing a natural language grammar set of data based on an input text string are disclosed. The method may include tagging the input text string, and examining, via a processor, the input text string for at least one first set of substitutions based on content of the input text string. The method may also include determining whether the input text string is a substring of a previously tagged input text string by comparing the input text string to a previously tagged input text string, such that the substring determination operation determines whether the input text string is wholly included in the previously tagged input text string.

Abstract: A paintball transfer apparatus and method for operating the apparatus to move a paintball enable a user to load a paintball into a paintball marker. The apparatus has an housing forming a cavity for storing paintballs, a path around the wall of the cavity that is shaped to guide paintballs, and a driver that rotates a roller within the cavity. Rotation of the roller moves paintballs along the path. The path may have one of a variety of shapes, such as circular or helical. The surface speed of the roller may be greater than the speed of the paintballs along the path. The roller may be made of a high friction material, and also may be a brush. The apparatus may be used to move paintballs within and about a marker, such as vertically upwards or downwards, or horizontally left or right.

Abstract: In some aspects, finer grained parallelism is achieved by segmenting programmatic workloads into smaller discretized portions, where a first element can be indicative both of a configuration or program to be executed, and a first data set to be used in such execution, while a second element can be indicative of a second data element or group. The discretized portions can cause program execute on distributed processors. Approaches to selecting processors, and allocating local memory associated with those processors are disclosed. In one example, discretized portions that share a program have an anti-affinity to cause dispersion, for initial execution assignment. Flags, such as programmer and compiler generated flags can be used in determining such allocations. Workloads can be grouped according to compatibility of memory usage requirements.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: In one aspect, an aircraft instrumentation system for a cockpit instrument panel of an aircraft is provided. The system includes a first display operable to display at least one of flight mission data or aircraft systems monitoring data, and a second display operable to control a plurality of display options of the first display. The first display and the second display are positioned outside an ejection envelope of the aircraft.

Abstract: Some embodiments include a method of making available a synthetic variable interest rate to a borrower under a loan and a fixed interest rate to a lender of the loan. The method includes generating a settlement notice and sending the settlement notice. The settlement notice includes one of a notice of a first interest payment amount or a notice of a second interest payment amount. Further, when the settlement notice comprises the notice of the first interest payment amount, the method includes sending the first interest payment amount, and when the settlement notice comprises the notice of the second interest payment amount, the method includes receiving the second interest payment amount. Further still, the method includes receiving from the borrower a shared security interest in collateral securing the loan, and the shared security interest is shared with the lender. Other embodiments of related methods and systems are also provided.

Abstract: Some embodiments include a method of making available a synthetic fixed interest rate to a borrower under a loan and a variable interest rate to a lender of the loan. The method includes generating a settlement notice and sending the settlement notice. The settlement notice includes one of a notice of a first interest payment amount or a notice of a second interest payment amount. Further, when the settlement notice comprises the notice of the first interest payment amount, the method includes sending the first interest payment amount, and when the settlement notice comprises the notice of the second interest payment amount, the method includes receiving the second interest payment amount. Further still, the method includes receiving from the borrower a shared security interest in collateral securing the loan, and the shared security interest is shared with the lender. Other embodiments of related methods and systems are also provided.

Abstract: A method for notifying a plurality of User Equipment (UE) operating under a power saving setting of system information changes to a wireless communication system serving the plurality of UEs, is disclosed. The method includes grouping the plurality of UEs according to a power saving scheme having a plurality of sleep intervals, wherein each UE is activated at the end of each sleep interval for receiving pages; and transmitting a group paging indication to the plurality of UEs at the end of a sleep interval, the group paging indication indicative of SI changes to the wireless communication system.

Abstract: The present invention concerns Capsicum annuum plants producing pepper fruits, exhibiting new physicochemical characteristics of the pepper fruit in relation with chlorophyll A & B, lutein as well as violaxanthin. The pepper fruits of the plants according to the present invention also exhibit a characteristic extreme dark green color at immature stage which color is linked to the content in pigment of the said fruit. The present invention also relates to QTL alleles directing the expression of the pigment content of those pepper fruits as well as molecular markers associated with these QTL alleles.

Abstract: This invention is directed toward a beverage dispensing module and flexible pouch. The beverage dispensing module is suitable for alcoholic beverages. The beverage dispensing module includes an outlet arrangement for selectively dispensing beverage, a pressurizing arrangement including resilient bias means connected to a roller and a beverage pouch fluidly connected to the outlet arrangement and mounted with the roller. The resilient bias means, outlet arrangement and roller are configured to form an overpressure, relative to atmospheric pressure, within the pouch.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention are represented by formula I-A and formula I-B: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: A capacitive fluid sensor is provided that utilizes a flexible substrate. It has a plurality of conductive members supported on it which are connected to a connecting end. The conductive members are arranged in an array and are aligned with a longitudinal axis of the substrate and the members are separated by intervening spaces. The intervening spaces are arranged so that they cross the longitudinal axis at an angle such that adjacent conductive members overlap each other when viewed from a side edge of the sensor. Such an arrangement provide more accurate measurement of fluid levels within containers.

Abstract: Adsorbent compositions useful in adsorption and separation processes are made using silicone-derived binding agents. The adsorbent compositions are made from crystallite aluminosilicate particles bound with silicone-derived binding agents, and optionally small amounts of a clay binder, to form agglomerated crystallite particles and are calcined to volatilize the organic components associated with the silicone-derived binding agents. The agglomerated crystallite particles have superior pore structures and superior crush strengths at low binder concentrations and exhibit enhanced N2 adsorption rates and capacities when used in air separation processes.

Abstract: Additive manufacturing methods include iteratively fusing together a plurality of layers of additive material to build a turbine component comprising an intermediate portion that extends from a first surface to a second surface, wherein a cross section of at least portion of the intermediate portion of the turbine component comprises a plurality of walls disposed in a cellular configuration.

Abstract: A system and method are disclosed for detecting and handling resource contention in a cluster file system. In one implementation, a processing device determines a measure of congestion for a resource that is shared by a first node of a cluster file system and a second node of the cluster file system, where the first node has a first local queue for lock requests for the resource, and wherein the second node has a second local queue for lock requests for the resource. The processing device adjusts a parameter for a node of the cluster file system in view of the measure of congestion.

Abstract: A patient interface for delivering breathable gas to a patient includes a nasal prong assembly including a pair of nasal prongs structured to sealingly communicate with nasal passages of a patient's nose in use and headgear to maintain the nasal prong assembly in a desired position on the patient's face. The headgear includes side straps and rigidizers provided to respective side straps. Each rigidizer includes a first end portion that provides a connector structured to engage a respective end of the nasal prong assembly and an inwardly curved protrusion in the form of a cheek support that curves inwardly of the connector. The cheek support is adapted to follow the contour of the patient's cheek and guide a respective end portion of the side strap into engagement with the patient's cheek to provide a stable cheek support.

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.