Abstract: A knotless suture anchor assembly for engaging a bone tunnel and holding suture therein to knotlessly secure said suture to soft tissue including an elongated generally cylindrical hollow outer member having an axial lumen, an outer surface with projections for engaging the wall of the bone tunnel, a distal end and a proximal end; and an elongated, generally cylindrical inner member having an axis, a proximal end and a distal end, the distal end having a transverse passage for receiving suture therethrough, the transverse passage having a proximal and distal end and adapted to receive a plurality of sutures in said eyelet, the inner member adapted to move coaxially relative to the outer member between a distal, suture-unlocked position and a proximal, suture-locked position.

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Abstract: A computer system for dynamically switching modes within a magnetic sensor device communicates through a secondary communication channel with a first magnetic sensor device and a second magnetic sensor device. The first magnetic sensor device includes at least a magnetic signal receiving functionality. The computer system determines that the second magnetic sensor device includes magnetic signal transmitting functionality and magnetic signal receiving functionality. After determining that the second magnetic sensor device includes magnetic signal transmitting functionality, the computer system causes the second magnetic sensor device to begin transmitting a first magnetic field signal.

Abstract: A seed treatment composition which efficiently applies a seed treatment material such as a bacterium or plant protein to a seed by using a talc-based carrier material. The seed treatment composition generally includes a carrier material which is mixed with a seed treatment material and applied to a seed such that the carrier material and seed treatment material both adhere to and uniformly coat the exterior surface of the seed. The carrier material will generally include talc which mixes with the seed treatment material and adheres to the exterior of the seed. The seed treatment material may comprise any solid, particulate material which would benefit a seed, such as an inoculant, bacterium, plant proteins, insecticide, and/or fungicide.

Abstract: A zone control panel that is easy and intuitive to use and to program. In some embodiments, a zone control panel may be configured to have an easy to use, single level menu structure with, for example, a configuration mode and/or a checkout mode. The configuration mode may, if present, include a number of menu screens sometimes without any sub-menu levels. Likewise, the checkout mode may, if present, include a number of menu screens sometimes without any sub-menu levels. A mode selector may be provided to select a particular mode, after which, the menu screens that correspond to the selected mode may be sequentially displayed to the user. Other features and aspects are also disclosed.

Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.

Abstract: The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express 158P1D7 and variants thereof.

Abstract: A method of making a piston for an opposed-piston engine comprises providing a piston. The piston comprises a substantially cylindrical portion including a sidewall and a piston crown located at an end of the piston. The piston crown comprises an end surface structured to form a combustion chamber when disposed within a cylinder bore in cooperation with an end surface of a cooperating opposing piston. A bonding layer including a bonding material is deposited on the end surface of the piston crown using a high velocity oxy-fuel spray process. At least one thermal barrier layer comprising ceramic material is deposited above the bonding layer.

Abstract: A non-sliding, non-sutured hands-free contact lens assembly for ophthalmic procedures utilizes a number of microstructures strategically placed on the bottom of either the contact lens or the bottom of a contact lens holder ring. After the contact lens, or the contact lens assembled with the contact lens holder ring, is placed on the cornea of the eye and centered, a surgeon applies downward pressure either on the contact lens itself or on the lens holder ring. This secures the lens assembly to the cornea due to increased friction between the microstructures and the tissues of the eye when the microstructures penetrate through the tear film and, optionally, viscous solution film and into the contact with superficial layer of cornea or other parts of the eye, thus temporarily anchoring the contact lens, or lens holder, to the desired surgical site.

Abstract: The present invention provides a novel electrochemical cell that comprises a cathode, an anode, and an electrolyte, where an ion species present in the electrolyte intercalates into the cathode upon discharge of the electrochemical cell.

Abstract: A sterilization mechanism for a shopping cart is described. The shopping cart includes a frame, a basket portion mounted to the frame, and a handle portion mounted to the frame and including a top and bottom section. The shopping cart includes a cleanliness sensor configured to detect a cleanliness level of the handle portion. The shopping cart includes a sterilization mechanism for killing microorganisms on the handle portion detachably mounted to the handle portion. The sterilization mechanism includes an ultraviolet light source disposed within the body of the sterilization mechanism and configured to be actuated into a light-emitting position when the cleanliness level is detected to be equal to or above a predetermined cleanliness threshold. In the light-emitting position, the ultraviolet light source is configured to emit ultraviolet light onto the handle portion to sterilize both the top and bottom sections of the handle portion from a mounted position.

Abstract: A bucket level indicator mechanism for use with work machine with a front mounted loader implement includes a carriage assembly having a carriage frame comprising a carriage back and first and second carriage endplates at longitudinal ends of the carriage back, a first end of the carriage assembly being pivotably connected to one of the masts, wherein the carriage back has a slot formed therein along a portion of its longitudinal length. At least one guide rod extends between the carriage endplates. A boom height compensating link is mounted on the upper arm section. The boom height compensating link has at least one fixed traveler configured to be received in the slot in the carriage back, the carriage assembly being mounted so as to slide relative the traveler, wherein as the loader boom is raised and lowered by extension or retraction of the lift actuator, the carriage assembly rotates relative the mast about a pivot as the traveler slides in the slot in the carriage back.

Abstract: A system determines the transmission strength of the magnetic field signal. The magnetic field signal is transmitted from a first magnetic-sensor device to a second magnetic-sensor device. The system then determines a first projected distance between the first magnetic-sensor device and the second magnetic-sensor device. Based at least in part on the first projected distance, the system calculates an adjusted transmission strength for the magnetic field signal. The system then causes the first magnetic-sensor device to transmit an adjusted magnetic field signal. The adjusted magnetic field signal comprises the adjusted transmission strength. The system receives, from the second magnetic-field device, the adjusted magnetic field signal. Based at least in part upon the received adjusted magnetic field signal, the system, computes a first pose of the first magnetic-sensor device in relation to the second magnetic-sensor device.

Abstract: A screw guide includes a first end, a second end spaced from the first end, a guide body that extends from the first end to the second end, and a guide hole that extends through the guide body. The guide body includes a first guide surface and a second guide surface, the first guide surface defines a first opening of the guide hole, and the second guide surface is spaced from the first guide surface in a first guide direction. The second guide surface defines a second opening of the guide hole, the guide body includes a leg portion that extends from the second guide surface in the first guide direction such that the leg portion is spaced from the second opening in a second guide direction that is perpendicular to the first guide direction.

Abstract: A mixed-reality system for augmenting spatial sensor device readings comprises a first magnetic sensor device configured to transmit a magnetic field signal at a reduced rate relative to a previous transmission rate. The system also comprises a second magnetic sensor device configured to determine a measurement of the magnetic field signal. The measurement indicates a pose estimation of the first magnetic sensor device. Additionally, the system comprises a third spatial input device configured to acquire pose data of the first spatial input device through means other than the magnetic field signal. Further, the system comprises one or more processors configured to compute a pose of the first magnetic sensor device by at least augmenting the measurement of the magnetic field signal with the pose data acquired by the other spatial input device.

Abstract: Provided herein are compounds of the General Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.

Abstract: Techniques are provided that involve employing artificial intelligence (AI) to facilitate reducing adverse outcomes associated with healthcare delivery. In one embodiment, a computer implemented method comprises monitoring live feedback received over a course of care of a patient, wherein the live feedback comprises physiological information regarding a physiological state of the patient. The method further comprises employing AI to identify, based on the live feedback information, an event or condition associated with the course of care of the patient that warrants clinical attention or a clinical response. The method further comprises generating a response, based on the identification of the event or condition, that facilitates reducing an adverse outcome of the course of care, wherein the response varies based on a type of the event or condition, and providing the response to a device associated with an entity involved with treating the patient in association with the course of care.

Abstract: Novel glycopyrronium fatty acid salts have been developed. Bi-phasic reaction conditions enable the desired counterion exchange reactions between glycopyrronium bromide and fatty acid salts of alkali metals and alkaline earth metals in methods to form glycopyrronium fatty acid salts. In preferred embodiments, an excess of the free fatty acid in the reaction mixture stabilizes the glycopyrronium fatty acid salt and reduces the formation of the impurity, Acid A. In some preferred embodiments, between 0.2 and 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture. In another embodiment, approximately 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture.

Abstract: A system for implementing an electrical rotary joint in a large-diameter system using relatively small-diameter capsule slip rings is described herein. The system includes a system rotor that rotates about a system axis of rotation, and a system stator that is stationary with respect to the system rotor. The system also includes at least one conductive contact channel disposed on one of the system rotor and the system stator. The system further includes at least one capsule slip ring (CSR) coupled to the other of the system rotor and the system stator. The at least one CSR has a conductive annular element coupled thereto, the conductive annular element in mechanical contact with the at least one conductive contact channel such that the at least one CSR forms an electrical rotary joint between the system rotor and the system stator.

Abstract: A method for X2 interface communication is disclosed, comprising: at an X2 gateway for communicating with, and coupled to, a first and a second radio access network (RAN), receiving messages from the first RAN according to a first X2 protocol and mapping the received messages to a second X2 protocol for transmission to the second RAN; maintaining state of one of the first RAN or the second RAN at the X2 gateway; executing executable code received at an interpreter at the X2 gateway as part of the received messages; altering the maintained state based on the executed executable code; and receiving and decoding an initial X2 message from the first RAN; identifying specific strings in the initial X2 message; matching the identified specific strings in a database of stored scripts; and performing a transformation on the initial X2 message, the transformation being retrieved from the database for stored scripts, the stored scripts being transformations.