Abstract: A door includes a door frame, first and second door skins having rectangular outer peripheries and inner openings, and a frameless glazed unit received at the openings. The door skins include exterior surfaces facing away from the door frame and opposite interior surfaces facing and secured to opposite sides of the door frame. The exterior and interior surfaces of the first and second door skins establish integral lips and grooves of the first and second door skins. Opposite sides of the frameless glazed unit directly contact and are sealed by the integral lips and sealant and/or adhesive contained in the grooves of the first and second door skins.

Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with psoriasis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, such as a haplotype, a diplotype, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

Abstract: A controller for use in a power converter includes a control circuit coupled to generate a low side drive signal to control switching of a low side switch, and generate an ON signal and an OFF signal in response to a feedback signal representative of an output of the power converter. A high side signal interface circuit is coupled to generate a high side drive signal in response to the ON signal and the OFF signal to control switching of a high side switch. The ON signal and the OFF signal are coupled to be pulled up in response to a bypass voltage during an initial state. The high side signal is coupled to turn on the high side switch in response to the control circuit pulling the ON signal low, and turn off the high side switch in response to the control circuit pulling the OFF signal low.

Abstract: A method and system provide a storage device. A plurality of read sensor stacks for each reader of the storage device are provided. The read sensor stacks are distributed along a down track direction and offset in a cross-track direction. A plurality of electronic lapping guides (ELGs) are provided for the read sensor stacks. The read sensor stacks are lapped. Lapping is terminated based on signal(s) from the ELG(s).

Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)-N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.

Abstract: A device and a method for establishing a target design are disclosed. A generator generates a graphical representation of a starting target design and displays it on a display. A user directly manipulates a graphical representation of the starting target design displayed on the display through the graphical user interface. The graphical representation of the manipulated starting target design is updated and displayed on the display.

Abstract: A self-aligning interface (6300) is attached to a robotic carton unloader (6100) and provides an interface between an extendable conveyor (6200) and the robotic carton unloader (6100). The self-aligning interface (6300) can include a positional measurement device (6320, 6320b, 6320c) mounted on the robotic carton unloader (6100) and operatively engaged with the extendable conveyor (6200) to provide positional information about the location of the extendable nose conveyor (6220) relative to the positional measurement device (6320, 6320b, 6320c). A control unit (6180) is attached to the robotic carton unloader (6100) for full robotic control of robotic carton unloader (6100) and the unloading process. The control unit (6180) is connected to the positional measurement device (6320, 6320b, 6320c) and the extendable conveyor (6200).

Abstract: The invention relates to a RNA interference triggers for inhibiting the expression of an AAT gene through the mechanism of RNA interference. The invention also relates to a pharmaceutical composition comprising the AAT RNAi trigger together with an excipient capable of improving delivery of the RNAi trigger to a liver cell in vivo. Delivery of the AAT RNAi trigger to liver cells in vivo provides for inhibition of AAT gene expression and treatment of alpha 1-antitrypsin deficiency and associated diseases.

Abstract: A self-contained mobile surveillance apparatus has applicability in a variety of short or long term settings where security and documentation of activities are needed. Integral to the apparatus is a gas shock assisted swing arm lift assembly and a removable quick connect pod platform system for use in acquiring, recording, storing, and transmitting data to one or more receive locations.

Abstract: Forces in a vehicle interface between the suspension and a body are identified. Rather than using many or all strain gauges, some more easily and rapidly installed acceleration sensors are instead used to measure local deformation. To remove or reduce the effects of rigid-body motion captured by accelerometers, an inertial measurement unit is also used. The forces are estimated from a behavior model accounting for both rigid and flexible motions.

Abstract: A storage device includes a storage controller configured to operate a heat-assisted magnetic recording head to write data to a band of consecutive data tracks in a consecutive track order while selectively alternating a power level of the heat source when writing to some data tracks of the band.

Abstract: A system for protecting a surface of an electronic device includes a protective film and a liner. The protective film includes an adhesive-coated surface. The liner, which covers the adhesive-coated surface until the protective film is secured to the surface of an electronic device, includes a main element that covers a majority of the adhesive-coated surface and a strip element that covers a smaller strip of the adhesive-coated surface, which strip is located adjacent to an edge of the adhesive-coated surface. One or both of the strip element and the main element of the liner may also include a tab for facilitating their removal from the adhesive-coated surface of the protective film. Methods for using the system to apply a protective film to a surface, such as a surface of a display screen, of an electronic device are also disclosed.

Abstract: A catheter adapted or high density mapping and/or ablation of tissue surface has a distal electrode array with offset spine loops, each spine loop having at least a pair of linear portions and a distal portion connecting the pair of linear portions, and one or more electrodes on each linear portion. The linear portions of the plurality of offset spine loops are arranged in-plane a single common plane, and the distal portions of the plurality of offset spine loops are arranged off-plane from the single common plane.

Abstract: Provided are techniques for dynamically maintaining data structures driven by heterogeneous clients in a distributed data collection system. In response to determining that a client-specific data structure has been modified in a source coupled to each of a plurality of clients, a metadata specification is generated, at each of the plurality of clients, from data structure metadata that includes attributes of the client-specific data structure; and data driven structure definitions are generated, at each of the plurality of clients, from the metadata specification, wherein the data driven structure definitions from each of the plurality of clients are to be aggregated to form a common data model in a central server.

Abstract: A regenerative drive device and a method for configuring the DC link of a regenerative drive device are disclosed. The multilevel regenerative drive device may include an inverter having a plurality of power components and a converter having a plurality of power components. The multilevel regenerative drive device may also include a direct current (DC) link bridging the inverter and the converter, the DC link including a capacitor, an inverter neutral point, and a converter neutral point independent of the inverter neutral point. Alternatively, the inverter neutral point and the converter neutral point may be connected.

Abstract: One embodiment of the present invention sets forth a technique for processing load instructions for parallel threads of a thread group when a sub-set of the parallel threads request the same memory address. The load/store unit determines if the memory addresses for each sub-set of parallel threads match based on one or more uniform patterns. When a match is achieved for at least one of the uniform patterns, the load/store unit transmits a read request to retrieve data for the sub-set of parallel threads. The number of read requests transmitted is reduced compared with performing a separate read request for each thread in the sub-set. A variety of uniform patterns may be defined based on common access patterns present in program instructions. A variety of uniform patterns may also be defined based on interconnect constraints between the load/store unit and the memory when a full crossbar interconnect is not available.

Abstract: Embodiments of a method to determine airspeed for aircraft include determining critical air data parameters without the use of pitot-static systems. Airspeed may be determined by iteratively repeating the method until converging on a stable airspeed value that differs from a previous airspeed value by less than a predetermined threshold. Airspeed may be determined by modeling aircraft lift and repeatedly updating dynamic pressure to converge on an airspeed based on the balance between aircraft lift and weight. Airspeed may be determined based on predetermined relationships between a horizontal control surface position and dynamic pressure. A voting logic method validates or invalidates airspeeds from dissimilar sources, including airspeeds determined using the methods described herein and conventional pitot-static systems.

Abstract: In an example embodiment, a WDM array includes an optical filter, N common ports, N reflection ports, and N pass ports. The N common ports may be positioned to a first side of the optical filter. N may be greater than or equal to two. The N reflection ports may be positioned to the first side of the optical filter. The N pass ports may be positioned to a second side of the optical filter opposite the first side.

Abstract: A method of increasing the density and reducing the bulk of multi-ply paper products allowing one to reduce the roll size or increase the roll content, while minimizing the destruction of favorable product attributes.

Abstract: A sensor manager provides dynamic input fusion using thermal imaging to identify and segment a region of interest. Thermal overlay is used to focus heterogeneous sensors on regions of interest according to optimal sensor ranges and to reduce ambiguity of objects of interest. In one implementation, a thermal imaging sensor locates a region of interest that includes an object of interest within predetermined wavelengths. Based on the thermal imaging sensor input, the regions each of the plurality of sensors are focused on and the parameters each sensor employs to capture data from a region of interest are dynamically adjusted. The thermal imaging sensor input may be used during data pre-processing to dynamically eliminate or reduce unnecessary data and to dynamically focus data processing on sensor input corresponding to a region of interest.