Abstract: The invention provides lapachone analogs and derivatives as well as methods of use thereof. These compounds can be used in pharmaceutical compositions for the treatment or prevention of cell proliferation disorders. These compounds can also be used in the treatment or prevention of cancer or precancerous conditions.

Abstract: A worm propagation modeling system for use with a mobile ad-hoc network (MANET) includes an infection detection module receiving temporal dynamics information relating to temporal dynamics of worm spread in the MANET and spatial dynamics information relating to spatiality of nodes in the MANET. The infection detection module detects infection in a network segment of the MANET based on the temporal dynamics information and the spatial dynamics information.

Abstract: The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphthoquinone derivatives of the present invention are related to the compound known as ?-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione).

Abstract: A pulse charging profile for a vehicle battery is synchronized with driver or vehicle demanded current disturbances by phase tracking the fundamental frequency of the desired pulse charging profile to those driver or vehicle demanded current disturbances. When these driver or vehicle demanded disturbances are not active, the tracked charging profile is honored.

Abstract: A treatment fluid for treating a subterranean formation penetrated by a wellbore is formed from an aqueous medium, a diutan heteropolysaccharide having a tetrasaccharide repeating unit in the polymer backbone and a peroxide breaker. A method of treating a subterranean formation penetrated by a wellbore may be carried out by introducing the treatment fluid into the formation through the wellbore. Breaking aids or catalysts may also be used with the treatment fluid.

Abstract: A treatment fluid for treating a subterranean formation penetrated by a wellbore is formed from an aqueous medium, a diutan heteropolysaccharide having a tetrasaccharide repeating unit in the polymer backbone and a peroxide breaker. A method of treating a subterranean formation penetrated by a wellbore may be carried out by introducing the treatment fluid into the formation through the wellbore. Breaking aids or catalysts may also be used with the treatment fluid.

Abstract: In general, the present invention relates to compounds capable of inhibiting P38, methods for inhibiting P38 in vivo or in vitro, diagnostics for determining activity in the treatment of P38 and/or cytokine-associated conditions and methods for treating conditions associated with P38 activity or cytokine activity.

Abstract: The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.

Abstract: In general, the present invention relates to compounds capable of inhibiting p38, methods for inhibiting p38 in vivo or in vitro, and methods for treating conditions associated with p38 activity or cytokine activity.

Abstract: Disclosed herein are antibacterial compounds that inhibit fabl, a NADH-dependent enoyl [acyl carrier protein] reductase enzyme in the fatty acid biosynthesis pathway. The compounds are represented by structural formulas Ia and Ib: R1 and R2 are independently monocyclic aryl or heteroaryl groups, wherein the groups represented by R1 and R2 are optionally substituted with one or more acyclic substituents; R3 is —H or an optionally substituted C1-C8 aliphatic, C3-C8 cycloaliphatic, aryl, or heteroaryl group. X1 is a bond or a C1-C3 alkylene chain that is optionally substituted with a C1-C4 alkyl or an acidic group. X2 is an aryl, heteroaryl or C3-C8 cycloaliphatic ring, wherein the group represented by X2 is optionally substituted with triazole, tetrazole, and/or one or more acyclic substituents.

Abstract: Disclosed are tetrahydro-?-carboline derivatives such as structural formula I, pharmaceutical compositions comprising them and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatment and prevention of diseases caused by bacteria, particularly bacteria dependent on PPAT, for example, species such Escherichia coli, Helicobacter pylori, Staphyloccocus aureus, and the like. Description of the variables in structural formula I are provided herein.

Abstract: A method for analyzing a target system that includes obtaining a plurality of characteristics from the target system using a characteristics extractor, wherein the plurality of characteristics is associated with a characteristics model, storing each of the plurality of characteristics in a characteristics store, and analyzing the target system by issuing at least one query to the characteristics store to obtain an analysis result.

Abstract: A method for analyzing a target system that includes obtaining a characteristics model, generating at least one selected from the group consisting of a schema, characteristics store API, and a characteristics extractor, using the characteristics model, obtaining a plurality of characteristics from the target system using characteristics extractor, wherein each of the plurality of characteristics is associated with the characteristics model, storing each of the plurality of characteristics in the characteristics store using the schema, and analyzing the target system by issuing at least one query to the characteristics store to obtain an analysis result.

Abstract: A method for analyzing a target system that includes obtaining a characteristics model, loading the characteristics model into a meta model, obtaining a plurality of characteristics from the target system using a characteristics extractor, wherein each of the plurality of characteristics is associated with the characteristics model, storing each of the plurality of characteristics obtained from the target system in a characteristics store, and analyzing the target system by issuing at least one query to the characteristics store to obtain an analysis result, wherein the issuing the at least one query comprises verifying the at least one query using the meta model.

Abstract: A method for analyzing a target system that includes obtaining a plurality of characteristics from the target system using a characteristics extractor, wherein the plurality of characteristics is associated with a characteristics model, storing each of the plurality of characteristics in a characteristics store using a tracking mechanism, and analyzing the target system by issuing a query to the characteristics store to obtain an analysis result, wherein the query uses tracking information associated with the tracking mechanism.

Abstract: A method for analyzing a target system, that includes obtaining a plurality of characteristics from the target system using a characteristics extractor, wherein the plurality of characteristics is defined in a characteristics model and each of the plurality of characteristics is associated with one of a plurality of artifacts defined in the characteristics model, storing each of the plurality of characteristics in a characteristics store, and analyzing the target system by issuing a query to the characteristics store to obtain an analysis result, wherein the query is used to determine the presence of a first pattern in the target system.

Abstract: The process for preparation of hypoglycemic foods and formulations thereof, useful as snacks, wholesome or supplementary foods, especially to the Type II diabetics, and a hypoglycemic foods and formulations product of composition with concentration of toasted cereals is ranging between 50-60%, concentration of toasted legumes is ranging between 6-12%, concentration of soy is ranging between 7-15%, concentration of fenugreek is ranging between 2-6%, concentration of spice mix is ranging between 3-7%, concentration of amla fruit pulp is ranging between 0.5-2%, concentration of Garcinia combogia rinds is ranging between 1.5 to 3%, concentration of dry skimmed milk is ranging between 3-6%, concentration of edible oil is ranging between 2-6%, and concentration of vitamin and mineral premix is ranging between 1-3%.

Abstract: A mold pin is formed of a longitudinally extending rod-like body with a collar extending laterally or transversely from the body. The collar is of peripheral and longitudinal dimensions similar to those of a protrusion extending from the surface of a mold tray (mold casting or half), such that when the mold pin seats in the protrusion, the protrusion and the collar define a boss in the mold tray.

Abstract: Pesticidal compositions comprising a pesticidally effective amount of an N-substituted azacyclic derivative of the formula (I); wherein R, an N-substituted azacycle, and V, Q, X, T and U are defined, as well as their agriculturally acceptable salts, in admixture with at least one agriculturally acceptable extender or adjuvant are disclosed. In addition, methods of controlling pests such as insects and acarids comprising applying said compositions to a locus of crops where control is desired are disclosed.

Abstract: Insecticidal and acaricidal compositions comprising an insecticidally or acaricidally effective amount of a 1,2,5-thiadiazole of the formula (I); wherein R, Q and m are as defined in admixture with at least one agriculturally acceptable extender or adjuvant are disclosed. In addition, methods of controlling insects and acarids comprising applying said compositions to a locus of crops where control is desired are disclosed.