Abstract: The invention is directed to a device and method to prevent migration of Human Mesenchymal Stem Cells (hMSCs) from a delivery site while allowing communication between the stem cells and native cardiomyocytes. The device is characterized by scaffold pore size, fiber diameter and biomaterial selection. The invention includes a two part polyurethane scaffold that prevents migration of stem cells, allows gap junction formation through pores and is packaged for minimally invasive delivery.

Abstract: The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphthoquinone derivatives of the present invention are related to the compound known as ?-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione).

Abstract: Embodiments of this invention relate to a composition and a method for tailoring the rheology of a fluid for use in the oil field services industry including forming a fluid comprising a tetrakis(hydroxyalkyl) phosphonium salt and a polymer, and exposing the fluid to a temperature of about 20° C. to about 200° C., wherein a viscosity is observed that is at least about 5 percent different than if no salt were present. Embodiments of this invention also relate to a composition and a method for tailoring the rheology of a fluid for use in the oil field services industry including forming a fluid comprising a tetrakis(hydroxyalkyl) phosphonium salt and diutan and/or guar and/or guar derivatives and/or a combination thereof, and exposing the fluid to a temperature of about 20° C. to about 163° C., wherein a viscosity is observed that is at least about 5 percent lower than if no salt were present.

Abstract: The invention provides an environmentally friendly composition including a friction reducer, a biocide, a scale inhibitor, and optionally a clay stabilizer.

Abstract: A method of treating a subterranean formation penetrated by a wellbore of a well having iron-containing components is carried out by introducing a treatment fluid into the wellbore of the well. The treatment fluid is formed from an aqueous solution, a mineral acid, a viscoelastic surfactant gelling agent and corrosion inhibitor system containing at least one of an alkyl, alkenyl, alicyclic or aromatic substituted aliphatic ketone and aliphatic or aromatic aldehyde. The treatment fluid is substantially free of any formic acid or precursor formic acid. In certain embodiments, the corrosion inhibitor system comprises a mixture of at least one of an alkenyl phenone or ?,?-unsaturated aldehyde, an unsaturated ketone or unsaturated aldehyde other than the alkenyl phenone and ?,?-unsaturated aldehyde, a dispersing agent, an extender and an alcohol solvent. A corrosion inhibitor intensifier may also be used in certain embodiments, which may include a mixture of cuprous iodide and cuprous chloride.

Abstract: In general, the present invention relates to compounds capable of inhibiting p38, methods for inhibiting p38 in vivo or in vitro, and methods for treating conditions associated with p38 activity or cytokine activity.

Abstract: The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphthoquinone derivatives of the present invention are related to the compound known as ?-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione).

Abstract: A well treatment microemulsion for use in a subterranean formation is disclosed, the microemulsion comprises a solvent blend comprising a solvent and a co-solvent; a surfactant blend comprising a surfactant, wherein the surfactant blend is able to give formation intermediate wettability properties; an alcohol; and a carrier fluid; wherein the alcohol, the solvent and surfactant blends are combined with the carrier fluid to produce the well treatment microemulsion. By intermediate wettability it is meant that the water has an advancing contact angle on the surface between 62 and 133 degrees. The associate method of treating a subterranean formation of a well with the microemulsion and the associate method of modifying the wettability of the formation with the microemulsion are also disclosed.

Abstract: Embodiments of this invention relate to an apparatus and a method for treating a subterranean formation permeated by a wellbore including forming a fluid comprising a reverse emulsion and a degradable material, introducing the fluid into a wellbore, and allowing the degradable material to degrade. Embodiments of this invention relate to an apparatus and a method for treating a subterranean formation permeated by a wellbore including forming a fluid comprising a reverse emulsion and a fluid loss additive, introducing the fluid into a wellbore, and allowing the fluid loss additive to degrade.

Abstract: The invention provides a method of forming a gelled liquid hydrocarbon treatment fluid, comprising: combining a liquid hydrocarbon, a phosphoric acid ester and a pre-mixed solution comprising water, ferrous ion (Fe2+) and an amine; and forming the gelled liquid hydrocarbon treatment fluid. A method of treating a portion of a subterranean formation is also disclosed and comprises: providing a gelled liquid hydrocarbon treatment fluid, by combining a liquid hydrocarbon, a phosphoric acid ester and a pre-mixed solution comprising water, ferrous ion and an amine, and treating the portion of the subterranean formation with the gelled liquid hydrocarbon treatment fluid.

Abstract: Embodiments of this invention relate to a composition and a method for tailoring the rheology of a fluid for use in the oil field services industry including forming a fluid comprising a tetrakis(hydroxyalkyl) phosphonium salt and a polymer, and exposing the fluid to a temperature of about 20° C. to about 200° C., wherein a viscosity is observed that is at least about 5 percent different than if no salt were present. Embodiments of this invention also relate to a composition and a method for tailoring the rheology of a fluid for use in the oil field services industry including forming a fluid comprising a tetrakis(hydroxyalkyl) phosphonium salt and diutan and/or guar and/or guar derivatives and/or a combination thereof, and exposing the fluid to a temperature of about 20° C. to about 163° C., wherein a viscosity is observed that is at least about 5 percent lower than if no salt were present.

Abstract: The invention provides a method for treating tight gas sand and shale subterranean formations, the method comprising: forming a solvent-surfactant blend by combining a solvent, a surfactant and a co-surfactant; adding a diluent to the solvent-surfactant blend to form a micro emulsion; wherein the wettability of the formation altered from water-wet to gas-wet, and the amount of water imbibed into the formation is reduced.

Abstract: Embodiments of this invention relate to a method of removing debris from a wellbore including contacting debris in a wellbore with a treatment fluid, wherein the fluid contains degradable fibers, collecting at least a portion of the treatment fluid, and allowing the degradable fibers to degrade. Embodiments of this invention also relate to a method of removing debris from a wellbore including contacting debris in a wellbore with a treatment fluid, wherein the fluid contains degradable fibers, collecting the treatment fluid, and exposing the fluid to a composition to encourage the degradable fibers to degrade.

Abstract: The invention discloses method of treating a subterranean formation of a well bore, the method comprising: providing a treatment fluid comprising: an aqueous base fluid; a viscosity enhancer; and a viscoelastic surfactant, wherein the enhancer is acid in the aqueous base fluid and co-operates with the viscoelastic surfactant to enhance viscosity compared to viscoelastic surfactant alone in the aqueous base fluid; and introducing the treatment fluid into the well bore.

Abstract: A method of treating a subterranean formation includes pumping into a cased, perforated wellbore that intersects the formation an invert emulsion kill fluid, the invert emulsion kill fluid comprising: an oleaginous continuous phase; a non-oleaginous discontinuous phase; an emulsifier; at least one degradable material; and at least one bridging material; contacting the formation with the kill fluid; and allowing the degradable material to at least partially degrade.

Abstract: A method of treating a subterranean formation including emplacing in a wellbore a fluid, comprising an oleaginous continuous phase, a non-oleaginous discontinuous phase, an emulsifier, at least one degradable material, and at least one bridging material, and contacting the formation with the fluid. A method and apparatus related to an invert emulsion fluid loss pill including an oleaginous continuous phase, a non-oleaginous discontinuous phase, an emulsifier, at least one degradable material, wherein the degradable material hydrolyzes to release an organic acid, and at least one bridging material.

Abstract: A method is disclosed where introducing into a wellbore a degradable material stabilized in a non-aqueous based fluid.

Abstract: The current disclosure describes a multifunctional fluid that addresses a new concept in the removal of filter cake. A composition is disclosed comprising: a carrier fluid, a surfactant, a fluorine source and an organic stabilizer able to minimize precipitation of fluorine The associated method to remove the filter cake is also described.

Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.

Abstract: This invention relates to compositions and methods of removing an organic deposit including introducing a fluid, wherein the fluid comprises at least two non-polar organic solvents and at least two polar organic solvents; allowing the fluid to dissolve at least a portion of the organic deposit; and removing at least a portion of the fluid. This invention relates to compositions and methods of removing an organic deposit including introducing a fluid, wherein the fluid comprises at least two non-polar organic solvents and at least two polar organic solvents, wherein the non-polar organic solvents comprise aromatic naphtha, terpenes, kerosene, and combination thereof, and wherein the polar solvents comprise heavy aromatic naphtha, cyclohexanone, N-2-methyl pyrrolidone, N-ethyl-2-pyrrolidone, and combination thereof, allowing the fluid to dissolve at least a portion of the organic deposit, and removing at least a portion of the fluid.