Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens.

Abstract: Devices and methods may allow for the removal of material from a remote location in the vasculature. In an example of such a remote location, the device may be used in the vasculature of a lower extremity in combination with an external cuff. The external cuff may create a dam preventing material from flowing throughout the body. With the external cuff in place, the device of the present disclosure may be utilized to suction the material from the vasculature while rotating the catheter to assist in the removal of the material.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, to share information in a community of robots and users to perform tasks. In one aspect, a method includes registering a plurality of robots in a system including creating for each robot a robot profile; publishing the robot profile; collecting operational data related to performance of tasks, the operational data including situational awareness information from at least a first of the plurality of registered robots; evaluating the collected operational data including performing statistical analysis, modeling, and extrapolation using the collected operational data; and in response to a request to transfer relevant data to at least a second of the plurality of registered robots, determining relevant data from the evaluated collected operational data, the relevant data including at least a portion of the situational awareness information; and sending the relevant data to at least the second registered robot.

Abstract: Devices and methods may allow for the removal of material from a remote location in the vasculature. In an example of such a remote location, the device may be used in the vasculature of a lower extremity in combination with an external cuff. The external cuff may create a dam preventing material from flowing throughout the body. With the external cuff in place, the device of the present disclosure may be utilized to suction the material from the vasculature while rotating the catheter to assist in the removal of the material.

Abstract: In various embodiments, a stylization subsystem automatically modifies a three-dimensional (3D) object design. In operation, the stylization subsystem generates a simplified quad mesh based on an input triangle mesh that represents the 3D object design, a preferred orientation associated with at least a portion of the input triangle mesh, and mesh complexity constraint(s). The stylization subsystem then converts the simplified quad mesh to a simplified T-spline. Subsequently, the stylization subsystem creases one or more of edges included in the simplified T-spline to generate a stylized T-spline. Notably, the stylized T-spline represents a stylized design that is more convergent with the preferred orientation(s) than the 3D object design. Advantageously, relative to prior art approaches, the stylization subsystem can more efficiently modify the 3D object design to improve overall aesthetics and manufacturability.

Abstract: The present invention relates to methods for modulating endosomal GPCR signaling. In particular, the present invention relates to use of polymeric nanoparticles for the targeted delivery of hydrophobic modulators of endosomal GPCRs and their use in the treatment of associated diseases and disorder.

Abstract: In various embodiments, a stylization subsystem automatically modifies a three-dimensional (3D) object design. In operation, the stylization subsystem generates a simplified quad mesh based on an input triangle mesh that represents the 3D object design, a preferred orientation associated with at least a portion of the input triangle mesh, and mesh complexity constraint(s). The stylization subsystem then converts the simplified quad mesh to a simplified T-spline. Subsequently, the stylization subsystem creases one or more of edges included in the simplified T-spline to generate a stylized T-spline. Notably, the stylized T-spline represents a stylized design that is more convergent with the preferred orientation(s) than the 3D object design. Advantageously, relative to prior art approaches, the stylization subsystem can more efficiently modify the 3D object design to improve overall aesthetics and manufacturability.

Abstract: An automatic card shuffler to shuffle eight decks of cards (or less) and deal a round of Baccarat. The automatic shuffler comprises two pre-shuffle bins, each receiving approximately four decks of cards wherein the pre-shuffle bins are spaced apart from one another with card slides directing to a card-receiving area. Cards are randomly selected from the cards in each of the pre-shuffle bins and propelled onto the card slides directing the cards to the card-receiving area. Once a sufficient number of buffer cards (e.g., seven) have been deposited into the card-receiving area, a card flipper moves the seven cards against a face plate of an integral dealing shoe. A buffer-holder member maintains the buffer cards against the face plate for dealing as the card flipper returns to a home position to receive more shuffled cards while buffer cards are being dealt in a round of Baccarat.

Abstract: In one aspect, a handheld lighting system is disclosed, which comprises a handheld housing extending from a proximal end to a distal end, and a light module disposed at least partially in the housing. The handheld lighting system further includes a removable and replaceable power module that is coupled to the housing (e.g., it is at least partially disposed within the housing) and is electrically coupled to the light module, e.g., through a pair of electrical leads, for providing electrical power thereto. Light intensity from the light module may be controlled from a knob on the power module. Various adapters can allow the lighting system to attach to a multitude of medical, industrial, dental or veterinary endoscopes or other instruments.

Abstract: A design application generates feasible engineering designs that satisfy criteria associated with a particular engineering problem. The design application receives input that outlines a specific engineering problem to be solved, and then synthesizes a problem specification based on this input. The design application then searches a database to identify different classes of approaches to solving the design problem set forth in the problem specification. The design application then selects one or more such classes of approaches, and generates a spectrum of potential design solutions for each such approach. The generated solutions may then be evaluated to determine the degree to which the problems specification has been met.

Abstract: An automatic card shuffler to shuffle eight decks of cards (or less) and deal a round of Baccarat. The automatic shuffler comprises two pre-shuffle bins, each receiving approximately four decks of cards wherein the pre-shuffle bins are spaced apart from one another with card slides directing to a card-receiving area. Cards are randomly selected from the cards in each of the pre-shuffle bins and propelled onto the card slides directing the cards to the card-receiving area. Once a sufficient number of buffer cards (e.g., seven) have been deposited into the card-receiving area, a card flipper moves the seven cards against a face plate of an integral dealing shoe. A buffer-holder member maintains the buffer cards against the face plate for dealing as the card flipper returns to a home position to receive more shuffled cards while buffer cards are being dealt in a round of Baccarat.

Abstract: An iterative design environment performs an iterative design process of a product by implementing usage feedback of the product when utilized under real-world conditions. Sensors are installed on the physical product and collect data about the behavior of the product under real-world conditions. The sensor data comprise usage feedback implemented to inform and produce a design problem statement and one or more design solutions. The sensor data is received by a problem statement engine to produce a problem statement based, at least in part, on the sensor data. A design engine then produces one or more design solutions for the problem statement and one of the design solutions is fabricated to produce a new physical product. Sensors are then installed onto the new physical product and the iterative design process may be performed again. The iterative design process may be performed multiple times until a satisfactory physical product is achieved.

Abstract: In one aspect, a handheld lighting system is disclosed, which comprises a handheld housing extending from a proximal end to a distal end, and a light module disposed at least partially in the housing. The handheld lighting system further includes a removable and replaceable power module that is coupled to the housing (e.g., it is at least partially disposed within the housing) and is electrically coupled to the light module, e.g., through a pair of electrical leads, for providing electrical power thereto. Light intensity from the light module may be controlled from a knob on the power module. Various adapters can allow the lighting system to attach to a multitude of medical, industrial, dental or veterinary endoscopes or other instruments.

Abstract: A wakeboat includes a hull; a thruster associated with the hull of the wakeboat, the thruster configured to selectively impart lateral force to the hull; an operator control in the wakeboat configured to control a parameter of the wakeboat other than the thruster; a thruster control associated with the operator control, the thruster control selectively receiving input from the operator to control the thruster, the thruster control positioned to be operable with at least the same hand and/or fingers already operating the operator control. Other systems and methods for controlling a wakeboat are also provided.

Abstract: This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.

Abstract: A design application is configured to determine design problem geometry and design criteria associated with a design problem to be solved. Based on this information, the design application identifies one or more design approaches to creating a custom material having specific material attributes needed to solve the design problem. The design application then executes the design approaches to create material designs that reflect one or more custom materials. With these designs as input, a manufacturing machine may then construct physical instances of those custom materials. A given custom material may have a unique combination of material attributes potentially not found among existing materials. Additionally, a design fabricated from a custom material may better satisfy the design criteria than a design fabricated from a known material.

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens.

Abstract: A design application interacts with an end-user to generate design problem geometry that reflects a design problem to be solved. Various design objectives, design constraints, boundary conditions, and other design criteria may be associated with the design problem geometry via the design application. When the design problem is sufficiently well defined, a client-side solver generates a solution approximation using a coarse multi-objective solver. The client-side solver favors speed over accuracy, and so the solution approximation provides only a rough representation of various attributes of potentially feasible design solutions. Based on the solution approximation, the end-user may correct any omissions, mistakes, and so forth, before executing pay-per-service cloud-based parallel solver.

Abstract: An embodiment of the invention provides a method for determining a patient-specific probability of disease. The method collects clinical parameters from a plurality of patients to create a training database. A fully unsupervised Bayesian Belief Network model is created using data from the training database; and, the fully unsupervised Bayesian Belief Network is validated. Clinical parameters are collected from an individual patient; and, such clinical parameters are input into the fully unsupervised Bayesian Belief Network model via a graphical user interface. The patient-specific probability of the healing rate of an acute traumatic wound is output from the fully unsupervised Bayesian Belief Network model and sent to the graphical user interface for use by a clinician in pre-operative planning. The fully unsupervised Bayesian Belief Network model is updated using the clinical parameters from the individual patient and the patient-specific probability of the healing rate of an acute traumatic wound.

Abstract: A design application includes a design engine and a tracking engine. The design engine allows end-users to create and modify a design space. The design space includes a spectrum of possible design options, as well as other information related to the process of creating designs. When changes are applied to the design space, the design engine transmits event data to the tracking engine that reflects those changes. The tracking engine, based on the event data, updates a design space timeline. The design space timeline illustrates the evolution of the design space over time.