Abstract: Described herein are integrated circuit devices that include conductive structures formed by direct bonding of different components, e.g., direct bonding of two dies, or of a die to a wafer. The conductive structures are formed from a top metallization layer of each of the components. For example, elongated conductive structures at the top metallization layer may be patterned and bonded to form large interconnects for high-frequency and/or high-power signals. In another example, the bonded conductive structures may form radio frequency passive devices, such as inductors or transformers.

Abstract: A coordinate measuring machine for measuring a number of measuring points on a surface, the coordinate measuring machine comprising a base, a probe head with an optical probe, a machine structure for linking the probe head to the base, at least one drive mechanism for providing movability of the probe head relative to the base, at least one encoding unit, an optical overview sensor unit arranged at the machine structure and a controlling and processing unit adapted at least for controlling the drive mechanism. The optical probe comprises an optical detection unit, in particular a sensor, a variable focal length lens capable of modifying its focal length and an actuating unit configured and arranged relative to the variable focal length lens so that the actuating unit provides setting and varying the focal length as a function of a controlling signal.

Abstract: The invention relates to a centrifugal pump assembly having an electric drive motor (2), at least one impeller (14) driven by said electric drive motor (2) and a valve element (24; 24?) rotatable between two 5 valve positions driven by a fluid flow produced by said impeller (14), wherein the valve element (24; 24?) has a cover plate (104; 104?) extending transverse to the rotational axis (X) of the impeller (14) and facing the impeller (14), wherein the valve element (24; 24?) having protrusions (102, 102?) arranged on an outer surface side facing away 10 from the impeller (14) such that a flow can act on them for driving the valve element (24; 24?).

Abstract: A smoking substitute device having: a control unit; a battery configured to supply power to the smoking substitute device; a movement sensing component configured to sense movement of the smoking substitute device; and a battery level indicator configured to, when activated, provide an indication of charge remaining in the battery. The control unit is configured to activate the battery level indicator when a predetermined movement of the smoking substitute device is detected using the movement sensing component.

Abstract: A hydraulic valve device includes a first inlet port (20) and a second inlet port (22) and a valve element (24) for selectively closing one of the first and the second inlet port. The valve element (24; 24?) is rotatable between two valve positions such that a surface of the valve element is moved in a direction parallel to openings of the inlet ports. The valve element includes two separate sealing portions (72, 74), a first sealing portion (72) for closing the first inlet port and a second sealing portion (74) for closing the second inlet port. The two sealing portions are arranged such that in a first valve position a first sealing portion closes the first inlet port and in a second valve position a second sealing portion closes the second inlet port. A centrifugal pump device includes such hydraulic valve device.

Abstract: A wearable, open and pliable conforming MRI receiver coil system having an assembly of MRI imaging coils, each configured in a framework to simultaneously apply or position MRI receiver antennae and medical implements such as ultrasound transducers against the skull or skin of a patient. The system is configured to perform an MRI imaging and operation of the one or more medical implements simultaneously.

Abstract: This disclosure relates generally to generating reports for patient encounters or visits with a clinician. Disclosed are systems and methods of use thereof regarding generation of variable entries for a clinical or encounter statement. In some embodiments, disclosed methods include preparing a customized user interface; conducting a series of randomization algorithms for randomizing one or more sentence structures of a clinical statement, one or more clinical finding values, and one or more structures of a patient name; and/or one or more structures of a clinician name. The method can also include receiving a first input via the customized user interface; and generating the clinical statement based on the received first input. The clinical statement may include at least one variable entry that corresponds to one or more of the randomized sentence structures resulting from the series of randomization algorithms.

Abstract: A hearing device comprises an input transducer comprising a microphone for providing an electric input signal representative of sound in the environment of the hearing device, a pre-processor for processing electric input signal and providing a multitude of feature vectors, each being representative of a time segment thereof, a neural network processor adapted to implement a neural network for implementing a detector configured to provide an output indicative of a characteristic property of the at least one electric input signal, the neural network being configured to receive said multitude of feature vectors as input vectors and to provide corresponding output vectors representative of said output of said detector in dependence of said input vectors.

Abstract: The present invention relates a pharmaceutical formulation comprising a long-acting growth hormone for use in a method of treating growth hormone deficiency, wherein the long-acting growth hormone formulation is administered to a patient in a bracketed dosage regimen, to a multitude of unit dosage forms comprising a long-acting growth hormone formulation, wherein the unit dosage forms comprise increasing amounts of growth hormone equivalents and wherein the amount of growth hormone equivalents increases by at least 10% between one unit dosage form and the next higher dosage form; their use in a method of treating growth hormone deficiency and method of treating growth hormone deficiency in a bracketed dosing regimen.

Abstract: The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulation comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: The present invention is directed to compounds of formula IIa These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease. Furthermore, the invention relates to pharmaceutical compositions comprising said compounds.

Abstract: A hearing aid system comprises a hearing aid, and a portable auxiliary device’ adapted to establish a communication link between them. The hearing aid comprises a microphone providing an electric input signal, a signal processor, and an output unit. The auxiliary device comprises a microphone providing an auxiliary electric input signal, and a user control interface allowing a user to initiate a specific calibration mode of operation of the hearing aid system. The signal processor of the hearing aid is configured to receive corresponding time segments of said electric input signal and said auxiliary electric input signal to provide an estimate of an acoustic transfer function from said microphone of said auxiliary device to said microphone of said hearing aid. A method of operating a hearing aid system is further disclosed. The invention may e.g. be used in various applications related to own voice detection and estimation.

Abstract: A wearable, open and adjustable MRI head coil system having an assembly of support members, panels, or portions defining one or more access openings. The support members, panels, or portions can support, house, or otherwise include radiofrequency receiver antennae or imaging coils such that the assembly is positionable or wearable by a patient for MRI scanning. The radiofrequency receiver antennae or imaging coils, and other devices can be simultaneously in contact with a patient's head, thereby enabling use during diagnostic, therapeutic, surgical or other interventional procedures.

Abstract: A hearing aid with a low-latency filter and a method of operating such a hearing aid (500).

Abstract: A triangulation device for measuring a measurement object by a projection of a structured light pattern onto the measurement object. The triangulation device includes a projector projecting the structured light pattern decomposable into different spatial frequencies onto the measurement object. The projector comprises a matrix of pixel elements and a lens system which determines a wavefront with a wavefront aberration from a reference wavefront, and a camera including a lens system and an imaging sensor, the camera being configured to receive the structured light pattern projected by the projector onto the measurement object, and a processing unit configured to provide distance information by evaluating imaging information provided by the camera. The wavefront aberration comprises a primary spherical aberration coefficient Z9, wherein the primary spherical aberration coefficient Z9 is larger than 0.5?, wherein ? is a wavelength of the projected structured light pattern.

Abstract: A measuring system for measuring an object, the measuring system comprising a measuring device and a controlling and processing unit. The measuring device comprises at least one camera, a first optical sensor and a second optical sensor, the first optical sensor provides a first field of view and is configured for collecting first measuring data representing a first part of the object, the second optical sensor provides a second field of view and is configured for collecting second measuring data representing a second part of the object. The second optical sensor comprises at least three light sources configured for illuminating the object from at least three different poses. The controlling and processing unit comprises a second capturing mode.

Abstract: The present invention is directed to compounds of formula I The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Parkinson's disease.

Abstract: A sensor device comprising a retro-reflecting element having a front boundary surface configured for entry of measuring light into the retro-reflecting element and a back boundary surface configured for reflecting a first part of the measuring light as reflected measuring light and configured for transmitting a second part of the measuring light as transmitted measuring light, wherein the front boundary surface and the back boundary surface are arranged on opposite sides of the retro-reflecting element, and a sensor unit configured and arranged so that the transmitted measuring light is detectable by the sensor unit. The front boundary surface and the back boundary surface are of curved shape.

Abstract: The present invention is directed to compounds of formula IIa These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease. Furthermore, the invention relates to pharmaceutical compositions comprising said compounds.