Abstract: A retro-reflector comprising a front boundary surface configured for entry of measuring light into the retro-reflector and a back boundary surface configured for reflecting the measuring light as reflected measuring light. The front boundary surface and the back boundary surface are arranged on opposite sides of the retro-reflector, and an optical axis is defined by the arrangement of the front boundary surface and/or the back boundary surface of the retro-reflector, wherein an incidence angle of the measuring light relative to the optical axis is equal to an exit angle of the reflected measuring light relative to the optical axis. A first optical element is provided comprising the front boundary surface, and a second optical element is provided comprising the back boundary surface.

Abstract: A coordinate measuring machine for measuring a number of measuring points on a surface, the coordinate measuring machine comprising a base, a probe head with an optical probe, a machine structure for linking the probe head to the base, at least one drive mechanism for providing movability of the probe head relative to the base, at least one encoding unit, an optical overview sensor unit arranged at the machine structure and a controlling and processing unit adapted at least for controlling the drive mechanism. The optical probe comprises an optical detection unit, in particular a sensor, a variable focal length lens capable of modifying its focal length and an actuating unit configured and arranged relative to the variable focal length lens so that the actuating unit provides setting and varying the focal length as a function of a controlling signal.

Abstract: A laser line module for projecting a laser line onto a surface of a distant target object, the projected laser line having a laser line length, the laser line module comprising: a laser diode configured to emit radiation in the form of a laser beam; a beam-shaping optical arrangement; a micro-lens array comprising a multitude of microlenses and having a surface with a height profile, each point on the surface having a distance from an average height of the height profile and providing a divergence for radiation passing through the micro-lens array at the respective point, which divergence depends on the relative height of the respective point; and a spatial light modulator that is provided between the beam-shaping optical arrangement and the micro-lens array.

Abstract: A measuring system for measuring an object, the measuring system comprising a measuring device and a controlling and processing unit. The measuring device comprises at least one camera, a first optical sensor and a second optical sensor, the first optical sensor provides a first field of view and is configured for collecting first measuring data representing a first part of the object, the second optical sensor provides a second field of view and is configured for collecting second measuring data representing a second part of the object. The second optical sensor comprises at least three light sources configured for illuminating the object from at least three different poses. The controlling and processing unit comprises a second capturing mode.

Abstract: An opto-electronic dual-comb interferometric distance measuring method and device wherein a signal comb is chromatically divided into a target signal comb and a non-target signal comb at a emission position, preferably by an optical interleaver in a measurement probe of the device. Only the target signal comb serves as a free beam emitted to the target. The non-target signal comb serves for generation of additional or compensation internal phase differences. Thus, the distance to the target is based on first, target related phase differences and on the second, internal compensation phase differences.

Abstract: Optical assembly comprising a variable focal length lens assembly comprising a variable focal length lens and an actuating unit, wherein an energy absorption rate of energy absorbed by the variable focal length lens assembly depends on the applied controlling signal. The optical assembly comprises a controlling unit configured to control focal length settings of the variable focal length lens by providing respective controlling signals and to apply a default controlling signal for providing a default focal length and default energy absorption rate. The controlling unit provides a thermal stabilisation functionality, the thermal stabilisation functionality is defined by applying a varying controlling signal related to a varying focal length and applying a compensation controlling signal related to a compensating focal length.

Abstract: A laser line module LLM for projecting a laser line onto a surface of a distant target object comprising a light emitting assembly configured to emit measuring radiation, the light emitting assembly comprising a laser diode and a beam shaping assembly, wherein the laser diode and the beam shaping assembly are arranged and configured to guide the measuring radiation along an optical axis of the laser line module. The LLM comprises a line adjusting unit successively arranged to be irradiated by the measuring radiation of the light emitting assembly and configured to manipulate the measuring radiation to provide the laser line with a defined laser line length, the line adjusting unit comprising a first micro-lens array having a first beam-manipulation surface having a multitude of first microlenses which define a first periodic height profile and providing a first refractive power.

Abstract: Disclosed herein are embodiments of a hearing aid configured to be worn by a user. The hearing aid can include a user interface allowing the user to control functionality of the hearing aid, and a feedback sensor for repeatedly providing a feedback signal indicative of a current estimate of feedback from an output transducer to an input transducer of the hearing aid, wherein the user interface is based on changes to the current estimate of the feedback path, e.g. provided by the user.

Abstract: A spherically mounted retroreflector comprising an optic inlay, the optic inlay comprising a retroreflector having a vertex and an axis of symmetry, and a carrier having an at least partly spherical outer surface and a cavity, wherein the optic inlay is arranged in the cavity, and wherein the at least partly spherical outer surface has a sphere center, which sphere center coincides with the vertex, wherein the optic inlay is connected to the carrier. The optic inlay comprises a coupling portion, and the spherically mounted retroreflector comprises a coupling element arranged between the optic inlay and the carrier.

Abstract: Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy) piperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine of formula (Ib), which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: A hearing aid configured to be worn by a user, the hearing aid comprising a user interface allowing the user to control functionality of the hearing aid, and a feedback sensor for repeatedly providing a feedback signal indicative of a current estimate of feedback from an output transducer to an input transducer of the hearing aid, wherein the user interface is based on changes to the current estimate of the feedback path, e.g. provided by the user. A method of operating a hearing aid is further disclosed. Thereby an alternative user interface for a hearing aid may be provided. The invention may e.g. be used in hearing aids or headsets, or a combination thereof.

Abstract: A measuring system for acquiring three-dimensional measuring points, comprising a base unit, a support unit mounted on the base unit and rotatable relative to the base unit around an azimuth axis, an emitting unit, a receiving unit, a directing unit mounted in the support unit, and configured for directing a transmission beam from the emitting unit towards a scene, directing a reception beam from the scene to the receiving unit, a first actuator configured for rotating the support unit relative to the base unit around the azimuth axis, a second actuator configured for rotating the directing unit relative to the support unit around the elevation axis, a first angle encoder configured for measuring a rotatory position of the support unit, a second angle encoder configured for measuring a rotatory position of the directing unit, a camera comprising an image sensor.

Abstract: A reflector arrangement for determining a position and/or for marking a target point having at least two retro-reflecting elements, each of the at least two retro-reflecting elements comprises a respective front boundary surface configured for entry of measuring light into the respective retro-reflecting element and a respective back boundary surface configured for reflecting the measuring light as reflected measuring light, wherein the front boundary surface and the back boundary surface are arranged on opposite sides of the respective retro-reflecting element, and a respective optical axis defined by the arrangement of the front boundary surface and/or the back boundary surface of the respective retro-reflecting element. The front boundary surface and the back boundary surface of each of the at least two retro-reflecting elements are of curved shape.

Abstract: Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine, i.e. 7-(4-((phenyl or pyridin-3-yl)oxy)piperidin-1-yl)-4H-pyrimido[1,2-b]pyridazin-4-one derivatives of formula (I) which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: A measuring device for imaging an object, including a light emitting unit configured to emit polarised measuring light, a light receiving unit configured to receive and detect reflected measuring light, and a support structure which comprises a retro-reflective layer and a polarisation state manipulation layer. The support structure provides retro-reflecting of the measuring light and changing a polarisation state of the measuring light such that the polarisation state of incident measuring light is different relative to the polarisation state of retro-reflected measuring light. The measuring device comprises a polarisation selecting unit configured to provide selecting either reflected measuring light with a first polarisation state or with a second polarisation state.

Abstract: A metrology system comprising a target object, a metrology instrument and a control unit configured for controlling an alignment of the targeting unit and for deriving an orientation of the target object. The metrology instrument comprises a zoom objective, an illumination unit and a time-of-flight sensor comprising an array of pixels and capable of providing range data for each pixel of the array as point cloud data, the time-of-flight sensor provides the distance measuring device. The control unit comprises an object determination functionality which provides receiving the point cloud data provided by the time-of-flight sensor, deriving a digital representation of the target object by processing the point cloud data, comparing the digital representation of the target object with a reference pattern of the target object, and determining the orientation of the target object based on the comparison of the digital representation of the target object with the reference pattern.

Abstract: A coordinate measuring machine for measuring a number of measuring points on a surface, the coordinate measuring machine comprising a base, a probe head with an optical probe, a machine structure for linking the probe head to the base, at least one drive mechanism for providing movability of the probe head relative to the base, at least one encoding unit, an optical overview sensor unit arranged at the machine structure and a controlling and processing unit adapted at least for controlling the drive mechanism. The optical probe comprises an optical detection unit, in particular a sensor, a variable focal length lens capable of modifying its focal length and an actuating unit configured and arranged relative to the variable focal length lens so that the actuating unit provides setting and varying the focal length as a function of a controlling signal.

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: The present invention is directed to compounds of formula IIa These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease. Furthermore, the invention relates to pharmaceutical compositions comprising said compounds.