Abstract: A sensor device comprising a retro-reflecting element having a front boundary surface configured for entry of measuring light into the retro-reflecting element and a back boundary surface configured for reflecting a first part of the measuring light as reflected measuring light and configured for transmitting a second part of the measuring light as transmitted measuring light, wherein the front boundary surface and the back boundary surface are arranged on opposite sides of the retro-reflecting element, and a sensor unit configured and arranged so that the transmitted measuring light is detectable by the sensor unit. The front boundary surface and the back boundary surface are of curved shape.

Abstract: The present invention is directed to compounds of formula IIa These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease. Furthermore, the invention relates to pharmaceutical compositions comprising said compounds.

Abstract: An ear-worn electronic device comprises a housing configured to be supported by, at, in or on an ear of a wearer. Electronic circuitry is disposed in the housing and comprises a processor. A power source and a receiver or a speaker are respectively disposed in or on the housing. A microphone array is disposed in or on the housing and operatively coupled to the electronic circuitry. The microphone array comprises a plurality of microphones. The processor is configured to operate a set of two or more of the microphones in a directional mode, detect degradation in performance of any microphone of the microphone set, and switch microphone operation from the directional mode to a safe mode using at least one non-degraded microphone of the microphone set in response to detecting the microphone performance degradation.

Abstract: An optical detection unit comprising a retro-reflecting element which provides a reflection surface configured for retro-reflecting a first part of measuring light as reflected measuring light for providing determination of a position of the optical detection unit and a passage surface configured for transmitting a second part of the measuring light as transmitted measuring light, further comprising a sensor arrangement with a sensor configured and arranged behind of the retro-reflecting element so that the transmitted measuring light is detectable by the sensor. The optical detection unit comprises a referencing assembly with at least one illumination unit configured to emit reference illumination light. The at least one illumination unit is arranged with fixed positional relationship to the retro-reflecting element and/or the sensor arrangement and the referencing assembly is configured and arranged to direct the reference illumination light onto the sensor.

Abstract: A measuring device for acquiring a three-dimensional measuring point related to a target in a scene, the measuring device comprises a base unit, a support unit mounted on the base unit, a distance measuring unit comprising an emitting unit configured for emitting measuring radiation and a receiving unit configured for detecting at least a part of the measuring radiation reflected by the target and a directing unit mounted in the support unit configured for directing the measuring radiation towards the scene. The measuring device comprises a capturing unit, wherein the capturing unit is configured for capturing at least a scene image of at least part of the scene, the scene image is generated by the detection of visual-spectrum light, and a controlling and processing unit, wherein the controlling and processing unit is configured for aligning the directing unit.

Abstract: A measuring device for acquiring a three-dimensional measuring point related to a target in a scene, the measuring device comprises a distance measuring unit comprising an emitting unit configured for emitting collimated measuring radiation (T) and a receiving unit configured for detecting at least a part of the collimated measuring radiation reflected (R) by the target, a directing unit rotatable around an elevation axis and configured for directing the measuring radiation towards the scene, a capturing unit, wherein the capturing unit comprises an image sensor and is configured to capture at least a scene image of at least part of the scene, and a controlling and processing unit configured at least for aligning the directing unit.

Abstract: Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidin-1 -yl)-[1,2,4]triazolo[4,3-b]pyridazine of formula (Ib), which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: The present invention is directed to compounds of formula I The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Parkinson's disease.

Abstract: The present invention is directed to compounds of formula I The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Parkinson's disease.

Abstract: Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b] [1,4]dioxin-6-yl)oxy)piperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine, i.e. 7-(4-((phenyl or pyridin-3-yl)oxy)piperidin-1-yl)-4H-pyrimido[1,2-b]pyridazin-4-one derivatives of formula (I) which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: An opto-electronic dual-comb interferometric distance measuring method and device wherein a signal comb is chromatically divided into a target signal comb and a non-target signal comb at a emission position, preferably by an optical interleaver in a measurement probe of the device. Only the target signal comb serves as a free beam emitted to the target. The non-target signal comb serves for generation of additional or compensation internal phase differences. Thus, the distance to the target is based on first, target related phase differences and on the second, internal compensation phase differences.

Abstract: A metrology system comprising a target object, a metrology instrument and a control unit configured for controlling an alignment of the targeting unit and for deriving an orientation of the target object. The metrology instrument comprises a zoom objective, an illumination unit and a time-of-flight sensor comprising an array of pixels and capable of providing range data for each pixel of the array as point cloud data, the time-of-flight sensor provides the distance measuring device. The control unit comprises an object determination functionality which provides receiving the point cloud data provided by the time-of-flight sensor, deriving a digital representation of the target object by processing the point cloud data, comparing the digital representation of the target object with a reference pattern of the target object, and determining the orientation of the target object based on the comparison of the digital representation of the target object with the reference pattern.

Abstract: Optical assembly comprising a variable focal length lens assembly comprising a variable focal length lens and an actuating unit, wherein an energy absorption rate of energy absorbed by the variable focal length lens assembly depends on the applied controlling signal. The optical assembly comprises a controlling unit configured to control focal length settings of the variable focal length lens by providing respective controlling signals and to apply a default controlling signal for providing a default focal length and default energy absorption rate. The controlling unit provides a thermal stabilisation functionality, the thermal stabilisation functionality is defined by applying a varying controlling signal related to a varying focal length and applying a compensation controlling signal related to a compensating focal length.

Abstract: A reflector arrangement having at least one retroreflector and at least one sensor arrangement arranged downstream of the retroreflector in relation to a beam incidence direction, having a sensor. The sensor arrangement comprises a code element—having a code pattern, and the retroreflector, the code element—and the sensor are arranged in such a way that the code element—is arranged between the retroreflector and the sensor and an angle-dependent position with respect to the optical axis of a projection of the code pattern onto the detection surface can be determined by means of the sensor.

Abstract: The present invention is directed to compounds of formula I The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Parkinson's disease.

Abstract: A reflector arrangement for determining the position or marking of target points, having at least one retroreflector, and a beam detection unit, by means of which the orientation measurement radiation passing through the retroreflector is acquirable. The beam detection unit comprises a first sensor for generating a signal in dependence on an acquisition of orientation measurement radiation and a first beam guiding unit. The first sensor and the first beam guiding unit are arranged such that a detection field of view for acquiring the orientation measurement radiation is defined, an alignment of the detection field of view around the yaw axis is variable and orientation measurement radiation passing through the retroreflector is acquirable in dependence on the alignment of the detection field of view with the first sensor.

Abstract: A hearing aid configured to be worn by a user, the hearing aid comprising a user interface allowing the user to control functionality of the hearing aid, and a feedback sensor for repeatedly providing a feedback signal indicative of a current estimate of feedback from an output transducer to an input transducer of the hearing aid, wherein the user interface is based on changes to the current estimate of the feedback path, e.g. provided by the user. A method of operating a hearing aid is further disclosed. Thereby an alternative user interface for a hearing aid may be provided. The invention may e.g. be used in hearing aids or headsets, or a combination thereof.

Abstract: A spherically mounted retroreflector comprising an optic inlay, the optic inlay comprising a retroreflector having a vertex and an axis of symmetry, and a carrier having an at least partly spherical outer surface and a cavity, wherein the optic inlay is arranged in the cavity, and wherein the at least partly spherical outer surface has a sphere center, which sphere center coincides with the vertex, wherein the optic inlay is connected to the carrier. The optic inlay comprises a coupling portion, and the spherically mounted retroreflector comprises a coupling element arranged between the optic inlay and the carrier.

Abstract: A system for monitored additive manufacturing of an object, comprising a manufacturing unit], designed for additive manufacturing of the object based on metal-containing manufacturing material in a manufacturing volume, wherein the object is built up by repeated layer-by-layer provision of the manufacturing material in defined quantity and accurately-positioned forming of the provided manufacturing material. The system moreover comprises an optical checking unit having at least one projector and two cameras and a control and processing unit. The manufacturing volume comprises an optical transmission region, the projector and cameras—are arranged outside the manufacturing volume in a fixed position relationship and are aligned in such a way that respective optical axes extend through a respective transmission region, by means of the projector, a projection can be generated on a manufacturing area and at least a common part of the manufacturing area on which the projection can be overlaid can be captured.