Abstract: Some embodiments of the invention include a method for determining distances to an object to be measured based on the principle of triangulation, comprising generating and emitting a measuring light beam, directing the measuring light beam to the object to be measured, detecting a reflection of the measuring light from the object with respective pixels of an image sensor during a defined detection sequence (t0-te) and deriving distance information based on the detected reflection. The detection sequence (t0-te) comprises a number of at least two exposure sub-sequences each defining a particular exposure period and saturation limit for the pixels of the sensor, wherein a successive exposure sub-sequence comprises a higher saturation limit than its prior exposure sub-sequence and each saturation limit defines a maximum charging level of the pixels for the respective exposure sub-sequence.

Abstract: The present invention is directed to novel inhibitors of the BACE1 enzyme. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders for which the reduction of A? deposits is beneficial such as Alzheimer's disease.

Abstract: Some embodiments of the invention relate to a coordinate measuring method for detecting an object surface by means of a coordinate measuring machine, comprising a measuring head for accommodating a sensor, a guiding unit for producing a relative movement of the measuring head in relation to the object surface in at least one direction, an optical sensor for detecting the object surface, and a control unit, the object surface being optically detected by the optical sensor during the coordinate measuring method, and a data set representing a surface profile in an object profile domain being generated. The data set is filtered by simulating contact of the surface profile represented by the data set with a virtual tactile sensor, and a tactile data set is derived from the simulated contact such that the tactile data set represents a virtual tactile surface profile in a virtual sensor domain.

Abstract: The present invention is directed to the combined use of BACE1 inhibitor of Formula I and a compound useful in active or passive Tau immunotherapy, a compound useful in active or passive A? peptide immunotherapy, an NMDA receptor antagonists, an acetylcholine esterase inhibitor, an antiepileptic, an anti-inflammatory drug, a Tau aggregation inhibitor or an SSRI for the treatment of neurodegenerative or cognitive disorders.

Abstract: The invention relates to an optical sensor element for a measuring machine, comprising a coupling element on the sensor element side for mechanically and optically connecting to a coupling element on the measuring machine side. An optical fiber is arranged in the coupling element on the sensor element side, wherein said optical fiber comprises an optical interface for connecting to an optical machine contact element of the measuring machine, wherein said optical interface is formed by an optical sensor contact element having a self-centering ferrule that encloses the end of the optical fiber. The ferrule is supported in the coupling element on the sensor element side in a floating manner.

Abstract: The invention relates to a sensor element for a measuring machine, having a sensing component with a sensing element for optically measuring a surface; a sensing element receiving portion with a plate-shaped base; and a sensor housing with a sensing component receiving portion comprising at least one bearing which contacts the base, which has at least one defined bearing point, and via which the sensing component is connected in a movable manner relative to the sensing component receiving portion. The sensor housing has a coupling on a housing coupling side for connecting to the measuring machine and at least partly surrounds the sensing component at the base, and a force directed in the direction of the sensing element is applied to the base. The sensing component receiving portion lies in the sensor housing opposite the coupling side and has the at a least one bearing.

Abstract: The present invention is directed to novel inhibitors of the BACE1 enzyme. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders for which the reduction of A? deposits is beneficial such as Alzheimer's disease.

Abstract: A surface sensing device comprising an optical monitoring system for measuring a displacement of the tip a hollow stylus with respect to a stylus carrier. According to the invention, the light emitting means of the optical monitoring system are built in such a way that the beam has at least two distinguishable light characteristics with a given characteristics distribution. The optical monitoring system further comprises an optically encoding component positioned in the stylus carrier in the optical return path and designed to transform the information of an impinging position of the returned beam upon the optical encoding component into a change of the characteristics distribution of the returned beam, and the detector means is sensitive for the at least two distinguishable light characteristics and built for generating the electrical output signal dependent on the changed characteristics distribution of the returned beam.

Abstract: Embodiments of the invention include a sensor arrangement for inclination determination with respect to at least one axis. The sensor arrangement may include a code element having a code pattern and a line sensor, which is sensitive at least with respect to one wavelength range, having a reception direction orthogonal to its extension direction. In some embodiments the code element and the line sensor are arranged such that the extension direction of the line sensor and an extension direction of the code element are oriented in the same direction. The code element and the line sensor may be rigidly connected at a spacing of at least 1 mm and at most 10 mm such that a location, which is angle-dependent with respect to the reception direction, of a projection of the code pattern onto the line sensor can be determined by means of the line sensor.

Abstract: Embodiments of the invention include a sensor arrangement for inclination determination with respect to at least one axis. The sensor arrangement may include a code element having a code pattern and a line sensor, which is sensitive at least with respect to one wavelength range, having a reception direction orthogonal to its extension direction. In some embodiments the code element and the line sensor are arranged such that the extension direction of the line sensor and an extension direction of the code element are oriented in the same direction. The code element and the line sensor may be rigidly connected at a spacing of at least 1 mm and at most 10 mm such that a location, which is angle-dependent with respect to the reception direction, of a projection of the code pattern onto the line sensor can be determined by means of the line sensor.

Abstract: Reflector arrangement for position determination and/or marking of target points, in particular for industrial or geodetic surveying, having a retroreflector for position determination for the reflector arrangement using parallel, in particular coaxial, beam reflection, and a sensor arrangement. According to the invention, the sensor arrangement has a lens and a sensor which is sensitive with respect to at least one wavelength range, with a reception direction that is orthogonal to the detection surface thereof, wherein the lens and the sensor are rigidly connected such that it is possible using the sensor to determine a location, which is incidence-angle-dependent with respect to the reception direction, of an illumination cross section defined by the lens on the detection surface.

Abstract: In a method for gauging surfaces (7?), in which a frequency-modulated laser beam is generated, the laser beam is emitted onto the surface as measuring radiation (MS), the measuring radiation (MS) backscattered from the surface (7?) is received and the distance between a reference point and the surface (7?) is measured interferometrically, wherein the measuring radiation (MS) is emitted and received while the surface to be gauged is being scanned, and a measuring arm and a reference interferometer arm with a partially common beam path are used, deviations from the essentially perpendicular impingement of the measuring radiation (MS) on the surface (7?) are taken into account algorithmically during distance measurement and/or are avoided or reduced during scanning by controlling the emission of the measuring radiation (MS).

Abstract: The present invention is directed to novel inhibitors of the BACE1 enzyme. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders for which the reduction of A? deposits is beneficial such as Alzheimer's disease.

Abstract: Some embodiments of the invention relate to a coordinate measuring method for detecting an object surface by means of a coordinate measuring machine, comprising a measuring head for accommodating a sensor, a guiding unit for producing a relative movement of the measuring head in relation to the object surface in at least one direction, an optical sensor for detecting the object surface, and a control unit, the object surface being optically detected by the optical sensor during the coordinate measuring method, and a data set representing a surface profile in an object profile domain being generated. The data set is filtered by simulating contact of the surface profile represented by the data set with a virtual tactile sensor, and a tactile data set is derived from the simulated contact such that the tactile data set represents a virtual tactile surface profile in a virtual sensor domain.

Abstract: The invention relates to an interferometric distance measuring arrangement for measuring surfaces, using at least one laser which can be tuned for generating measurement radiation modulated by a wave length ramp, an optical beam path with an optical transmitting system for emitting the measurement radiation to the surface and an optical capturing system for capturing the measurement radiation back-scattered by the surface, comprising a measuring arm and a reference arm and a radiation detector and an evaluation unit for determining the distance from a reference point of the distance measuring device to the surface. Channels are defined by at least one beamsplitter n?2 for the parallel emission of measurement radiation, respectively, one different sub area of the wave length ramp is allocated to said channels at a predetermined emission time point.

Abstract: The invention relates to an interferometric distance measuring arrangement for measuring surfaces, with at least one laser source, which can be tuned, with a coherence length for generating measurement radiation modulated by a wave length ramp, an optical beam path with an optical transmitting system for emitting the measurement radiation to the surface and an optical capturing system for capturing the measurement radiation back-scattered by the surface, comprising a measuring arm and a reference arm and a radiation detector and an evaluation unit for determining the distance from a reference point of the distance measuring device to the surface. Channels are defined by at least one beamsplitter n?2 for the parallel emission of measurement radiation, respectively one different sub area of the measurement range defined by the coherence length is allocated to the channels.

Abstract: The invention relates to a sensor element for a measuring machine, having a sensing component with a sensing element for optically measuring a surface; a sensing element receiving portion with a plate-shaped base; and a sensor housing with a sensing component receiving portion comprising at least one bearing which contacts the base, which has at least one defined bearing point, and via which the sensing component is connected in a movable manner relative to the sensing component receiving portion. The sensor housing has a coupling on a housing coupling side for connecting to the measuring machine and at least partly surrounds the sensing component at the base, and a force directed in the direction of the sensing element is applied to the base. The sensing component receiving portion lies in the sensor housing opposite the coupling side and has the at a least one bearing.

Abstract: Embodiments described herein relate to a measuring device, comprising a base that defines a vertical axis, an assembly that can be pivoted about the vertical axis relative to the base, and a beam deflecting unit for varying the orientation of a measurement axis, wherein the beam deflecting unit can be rotated about a horizontal axis relative to the assembly. The measuring device further has a distance measurement functionality for measuring distance by means of the measurement radiation, an angle measurement functionality for determining an orientation of the measurement axis relative to the base, a control and processing unit for processing data and for controlling the measuring device, and a scanning functionality, wherein when the scanning functionality is executed, a scan is performed, and a point cloud comprising the scan points is produced. The assembly also has an imaging system. The measuring device may have a single-point measurement mode.

Abstract: A distance measuring method for a point on an object is performed by emitting measurement radiation. When an optical measurement axis of the measurement radiation is aligned with the point to be measured, an optical measurement point region is defined by the beam cross section of the radiation on the object. The beam cross section may be, for example, a maximum of eight times the standard deviation of a Gaussian steel profile of the measurement radiation. The distance to the point on the object is determined by receiving measurement radiation reflected from the object. The method includes altering, at least once, a measurement direction as emission direction of the measurement radiation with respective emission and reception of the measurement radiation. Altering the measurement direction is carried out such that respective area centroids defined by the beam cross section on the object lie within the measurement point region.

Abstract: A system of separating oil and water from produced or fracturing water with an intended separation direction, the system includes: a unit for feeding the produced or fracturing water to a solid-fluid separator; a membrane system configured to output clean water; and a decanter configured to output solids, wherein the decanter or the membrane system is coupled to an output of the solid-fluid separator; wherein the membrane system or the decanter is configured to feed remaining fluid from the membrane system or decanter to an oil extractor system configured to output oil; and wherein the oil extractor system comprises a high speed separator configured to output the oil, and has a feedback conduit for feeding a remaining water containing fluid back to the membrane system.