Abstract: The invention relates to an interferometric distance measuring arrangement for measuring surfaces, using at least one laser which can be tuned for generating measurement radiation modulated by a wave length ramp, an optical beam path with an optical transmitting system for emitting the measurement radiation to the surface and an optical capturing system for capturing the measurement radiation back-scattered by the surface, comprising a measuring arm and a reference arm and a radiation detector and an evaluation unit for determining the distance from a reference point of the distance measuring device to the surface. Channels are defined by at least one beamsplitter n?2 for the parallel emission of measurement radiation, respectively, one different sub area of the wave length ramp is allocated to said channels at a predetermined emission time point.

Abstract: Surveying device comprising a base defining a base axis (A), a support structure arranged to be rotatable around the base axis (A) and defining a rotation axis (B), a light emitting unit for emitting measuring signal and a light receiving unit comprising a detector for detecting reflected measuring signal. A rotation unit is mounted on the support structure for providing emission and reception of measuring light in defined directions, wherein the rotation unit comprises a rotation body which is mounted rotatable around the rotation axis (B) and the rotation body comprises a scanning mirror which is arranged tilted relative to the rotation axis (B). The device comprises at least one projector fixedly arranged with the support structure, defining a particular optical axis and configured to direct a light pattern at a scene, wherein position and shape of the pattern are controllable by the controlling and processing unit.

Abstract: An optical roughness sensor for a coordinate measuring machine, comprising a beam coupling unit for coupling and decoupling optical radiation, a local reference oscillator element for providing a reference path and an interferometric reference signal by means of a reference radiation component of the radiation, a first decoupling path comprising a first beam passage window for bidirectional transmission of a measuring radiation component of the radiation such that the measuring radiation component is aligned onto an object surface to be measured and a reflection of the measuring radiation component is acquired and a surface signal is provided by the reflected measuring radiation component. The reference path and the decoupling path interact such that the reference signal and the surface signal interfere and a roughness signal is derivable.

Abstract: A ratcheting spanner which can be installed on a rotatable body along a vector substantially perpendicular to an axis of rotation. The ratcheting spanner comprising a spanner body, a ratchet ring, and a plurality of pawls. The pawls can rotationally couple the spanner body to the ratchet ring in one or both directions relative to the axis of rotation. The ratcheting spanner can have a home key to facilitate the alignment of the openings in the spanner body and the ratchet ring. The direction of rotational coupling of the pawls and the action of the home key can be controlled by one or more selector controls. A driven ratcheting spanner can be constructed to further allow transmission of torque to the ratchet ring without movement of the spanner body. A method of using a ratcheting spanner to rotate a rotatable body.

Abstract: A surveying device including a base defining a base axis, a support structure rotatable around the base axis and defining a rotation axis, a light emitting unit emitting light and a light receiving unit for detecting reflected light. A rotation unit is mounted on the support structure for emitting and receiving light in defined directions, wherein the rotation unit comprises a rotation body rotatable around the rotation axis including a scanning mirror arranged tilted relative to the rotation axis. An imaging unit for capturing an image of a scanning region is provided. The imaging unit comprises a camera fixedly arranged on the support structure, the rotation body comprises at least one reflecting deflecting surface assigned to the camera. The imaging unit and the rotation body are arranged so that the field of view comprises a defined field angle around the rotation axis.

Abstract: Reflector arrangement for position determination and/or marking of target points, in particular for industrial or geodetic surveying, having a retroreflector for position determination for the reflector arrangement using parallel, in particular coaxial, beam reflection, and a sensor arrangement. According to the invention, the sensor arrangement has a lens and a sensor which is sensitive with respect to at least one wavelength range, with a reception direction that is orthogonal to the detection surface thereof, wherein the lens and the sensor are rigidly connected such that it is possible using the sensor to determine a location, which is incidence-angle-dependent with respect to the reception direction, of an illumination cross section defined by the lens on the detection surface.

Abstract: A distance measuring method for a point on an object is performed by emitting measurement radiation. When an optical measurement axis of the measurement radiation is aligned with the point to be measured, an optical measurement point region is defined by the beam cross section of the radiation on the object. The beam cross section may be, for example, a maximum of eight times the standard deviation of a Gaussian steel profile of the measurement radiation. The the distance to the point on the object is determined by receiving measurement radiation reflected from the object. The method includes altering, at least once, a measurement direction as emission direction of the measurement radiation with respective emission and reception of the measurement radiation. Altering the measurement direction is carried out such that respective area centroids defined by the beam cross section on the object lie within the measurement point region.

Abstract: In one aspect of the present technique, a method for selecting between a plurality of electromagnetic sensors to correct for one or more field distortions includes, in the presence of an electromagnetic field, acquiring signals representative of the location of a plurality of electromagnetic sensors. The method further includes selecting between the signals from the plurality of electromagnetic sensors based on one or more quality metrics. In another aspect of the present technique, a system for selecting an optimum EM sensor to correct for one or more field distortions includes a plurality of EM sensors and an additional EM sensor for transmitting or receiving signals representative of the location of each of the plurality of EM sensors. The system further includes a controller configured to acquire signals representative of the location of the plurality of EM sensors, and select between the signals from the plurality of EM sensors based on one or more quality metrics.

Abstract: The present invention is directed to the combined use of BACE1 inhibitor of Formula I and a compound useful in active or passive Tau immunotherapy, a compound useful in active or passive A? peptide immunotherapy, an NMDA receptor antagonists, an acetylcholine esterase inhibitor, an antiepileptic, an anti-inflammatory drug, a Tau aggregation inhibitor or an SSRI for the treatment of neurodegenerative or cognitive disorders.

Abstract: Optical sensors are adapted for distance measurement by emission and capture of measuring radiation reflected from an object to be measured. The optical sensors can be used with measuring devices, including coordinate measuring machines. The optical sensors have an optomechanical coupling unit, configured for automated coupling of the optical sensor to the measuring device and for bidirectional measuring radiation transmission between measuring device and optical sensor. The optical sensors have a first optical measuring channel, by which bidirectional measuring radiation transmission is provided between the measuring device and a first exit window of the optical sensor.

Abstract: The invention relates to an interferometric distance measuring arrangement for measuring surfaces, with at least one laser source, which can be tuned, with a coherence length for generating measurement radiation modulated by a wave length ramp, an optical beam path with an optical transmitting system for emitting the measurement radiation to the surface and an optical capturing system for capturing the measurement radiation back-scattered by the surface, comprising a measuring arm and a reference arm and a radiation detector and an evaluation unit for determining the distance from a reference point of the distance measuring device to the surface. Channels are defined by at least one beamsplitter n?2 for the parallel emission of measurement radiation, respectively one different sub area of the measurement range defined by the coherence length is allocated to the channels.

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: A method of identifying a surface point or region of an object to be measured by means of an optical sensor providing defined measuring conditions regarding emission of measuring light and reception of reflected measuring light in a defined spatial relationship. The method comprises defining a point or region of interest of the object, determining an optical property of the defined point or of the defined region and deriving an object information base on the optical property. The determination of the optical property is performed by optically pre-measuring the point or region using the optical sensor by illuminating the point or the region with the measuring light, capturing at least one image by means of the optical sensor of at least one illumination (Lr,Li) at the object and analysing respective illuminations (Lr,Li) regarding position or appearance plausibility with respect to the measuring conditions of the optical sensor.

Abstract: In some implementations, a computing device can be configured to present a graphical user interface that enables the dynamic authoring of music by a user of the computing device. The computing device can present a grid of cells, where each cell represents a music segment. The cells can be configured to playback the music segment once or playback the music segment in a repeating loop. The user can select (e.g., touch) one or more cells in the grid to cause the corresponding music segment to play. While playing selected cells, the user can provide input selecting various musical effects to apply to the playing music. The user can record a dynamically selected sequence of cells and musical effects to create an original musical product.

Abstract: Some embodiments of the invention include a probe body of an optical probe assembly. The probe assembly may be designed for measuring a surface of an object while being carried by a probe head of a coordinate measuring machine. The probe body comprising a coupling unit at a first end of the probe body designed for providing coupling of the probe body to the probe head of a coordinate measuring machine and a light guiding element for transmitting original source light supplied by the probe head from the coupling unit to a second end of the probe body.

Abstract: Some embodiments include a measuring probe adapted to be attached to a probe head of a coordinate measuring machine for determination of at least one spatial coordinate of a measurement point on an object to be measured, the measuring probe comprising an optical measuring unit adapted to provide distance measurements of measuring points at the object and a probe interface which provides modular mounting of the measuring probe to a probe head of the coordinate measuring machine and transmission, in particular bidirectional transmission, of optical signals between the probe and the coordinate measuring machine. The probe interface is designed as an integrally formed module providing a reproducible mountability of the measuring probe at the probe head and comprising a one-sided component of a ball bearing.

Abstract: A distance measuring method for measuring surfaces uses a laser source having a frequency that can be modulated to tune a wavelength of a laser beam in a wavelength range. The laser beam is generated with a coherence length to provide a measuring beam and is emitted at the surface, located within a specified distance range, as a measuring beam. The measuring beam is back-scattered by the surface and is received again and used to interferometrically measure the distance from a reference point to the surface. The specified distance range lies at least partly outside of the coherence length. One portion of the laser beam is temporally delayed with respect to another portion, such that the one optical path difference caused by the delay matches the optical path difference that corresponds to a distance in the specified distance range plus or minus the coherence length of the laser.

Abstract: Embodiments described herein relate to a measuring device, comprising a base that defines a vertical axis, an assembly that can be pivoted about the vertical axis relative to the base, and a beam deflecting unit for varying the orientation of a measurement axis, wherein the beam deflecting unit can be rotated about a horizontal axis relative to the assembly. The measuring device further has a distance measurement functionality for measuring distance by means of the measurement radiation, an angle measurement functionality for determining an orientation of the measurement axis relative to the base, a control and processing unit for processing data and for controlling the measuring device, and a scanning functionality, wherein when the scanning functionality is executed, a scan is performed, and a point cloud comprising the scan points is produced. The assembly also has an imaging system. The measuring device may have a single-point measurement mode.

Abstract: Light emitting unit, in particular of or for a triangulation-based distance measuring device, for providing defined measuring light, in particular laser light, is disclosed. The light emitting unit comprising a light source for emitting light, in particular a laser light source for emitting laser light, and a beam forming assembly for shaping the light by affecting propagation of the light emitted by the light source, wherein the beam forming assembly is arranged and designed so that measuring light is provided in form of a light line having a midpoint and two opposite ends. The beam forming assembly comprises at least one micro-lens array, the at least one micro-lens array comprises a plurality of micro-lenses, wherein the micro-lenses are designed and arranged in joint manner next to each other with algebraic signs for curvatures of successive micro-lenses being opposite and so that a periodic structure is provided.

Abstract: Method of providing measuring light for triangulation-based distance measurement to an object to be measured, wherein distance information is derivable by detecting at least portions of the measuring light reflected at the object. The method comprises emitting light and shaping the light so that the measuring light is provided in form of a line having a midpoint and two opposite ends. The intensity distribution of the light across the line is adjusted so that a respective light intensity at the ends of the line is at least 10% higher than light intensity around the midpoint.