Abstract: A method for measurement of a surface, in particular according to the principle of Optical Coherence Tomography, whereby distances to points of the surface are measured based on interferograms and classifying of measurements as non-valid or valid based on evaluation of phase change or amplitude change of a respective interferogram.

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: A ratcheting spanner which can be installed on a rotatable body along a vector substantially perpendicular to an axis of rotation. The ratcheting spanner comprising a spanner body, a ratchet ring, and a plurality of pawls. The pawls can rotationally couple the spanner body to the ratchet ring in one or both directions relative to the axis of rotation. The ratcheting spanner can have a home key to facilitate the alignment of the openings in the spanner body and the ratchet ring. The direction of rotational coupling of the pawls and the action of the home key can be controlled by one or more selector controls. A driven ratcheting spanner can be constructed to further allow transmission of torque to the ratchet ring without movement of the spanner body. A method of using a ratcheting spanner to rotate a rotatable body.

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PH F) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: A reflector arrangement having at least one retroreflector and at least one sensor arrangement arranged downstream of the retroreflector in relation to a beam incidence direction, having a sensor. The sensor arrangement comprises a code element—having a code pattern, and the retroreflector, the code element—and the sensor are arranged in such a way that the code element—is arranged between the retroreflector and the sensor and an angle-dependent position with respect to the optical axis of a projection of the code pattern onto the detection surface can be determined by means of the sensor.

Abstract: A reflector arrangement for position determination and/or marking of target points, comprising a retroreflector and a first sensor arrangement, by means of which the orientation measurement radiation passing through the retroreflector is acquirable. The first sensor arrangement comprises a first optical assembly providing a fisheye lens, and a first sensor, wherein the retroreflector and the first sensor arrangement are arranged in such a way that orientation measurement radiation passing through the retroreflector is projectable onto the detection surface of the first sensor by means of the first optical assembly.

Abstract: An optical system comprising an optical coherence tomography (OCT) measuring device and a beam deflection unit for laterally deflecting the position or angle of a beam path of the OCT measuring device. There is an optical component in the beam path, said optical component being embodied in such a way that a back-reflection of the optical component has a different configuration in terms of its longitudinal location along the beam path depending on the lateral position of the deflected beam path on the optical component. The optical system comprises an evaluation unit which is embodied in such a way that a value of the lateral position or angle deflection of the beam deflection unit is determinable on the basis of a longitudinal location of the back-reflection at the optical component determined by the OCT measuring device.

Abstract: A system for monitored additive manufacturing of an object, comprising a manufacturing unit], designed for additive manufacturing of the object based on metal-containing manufacturing material in a manufacturing volume, wherein the object is built up by repeated layer-by-layer provision of the manufacturing material in defined quantity and accurately-positioned forming of the provided manufacturing material. The system moreover comprises an optical checking unit having at least one projector and two cameras and a control and processing unit. The manufacturing volume comprises an optical transmission region, the projector and cameras-are arranged outside the manufacturing volume in a fixed position relationship and are aligned in such a way that respective optical axes extend through a respective transmission region, by means of the projector, a projection can be generated on a manufacturing area and at least a common part of the manufacturing area on which the projection can be overlaid can be captured.

Abstract: A measuring device for measuring an object. The measuring device includes a distance measuring unit having a beam emission unit generating a measurement radiation having a defined wavelength spectrum and a detector detecting the measurement radiation reflected on the object surface, the detector having at least one first sensor. The distance measuring unit generates distance measured data and reflection measured data as first distance measured data by emitting the measurement radiation and detecting the reflected measurement radiation according to the principle of triangulation. The measurement radiation is generated using a wavelength spectrum such that a fluorescence is excitable by an interaction of the measurement radiation with the object material to emit fluorescent light, wherein a spectrum of the fluorescent light and the wavelength spectrum of the measurement radiation are different.

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: A machine state monitoring system for recurrently determining a change in static or dynamic properties of a geometry of a machine with positional encoders to derive a coordinate information of at least a first machine portion with respect to a second machine portion, which are movable with respect to one another. The monitoring system includes one calibration-monitoring-unit with an optical, at least two-dimensional measuring location sensing unit which is fixed to the first machine portion and configured to optically sense an at least two dimensional location information of an artifact which is provided at the second machine portion, and temporarily moved into a sensing range for determining the change in the static or dynamic properties of the geometry of the machine by a comparison of multiple of such sensings, the compensation parameters are then updated and is used to derive the coordinate information from the encoders.

Abstract: Method of providing measuring light for triangulation-based distance measurement to an object to be measured, wherein distance information is derivable by detecting at least portions of the measuring light reflected at the object. The method comprises emitting light and shaping the light so that the measuring light is provided in form of a line having a midpoint and two opposite ends. The intensity distribution of the light across the line is adjusted so that a respective light intensity at the ends of the line is at least 10% higher than light intensity around the midpoint.

Abstract: Some embodiments of the invention include a method for determining distances to an object to be measured based on the principle of triangulation, comprising generating and emitting a measuring light beam, directing the measuring light beam to the object to be measured, detecting a reflection of the measuring light from the object with respective pixels of an image sensor during a defined detection sequence (t0-te) and deriving distance information based on the detected reflection. The detection sequence (t0-te) comprises a number of at least two exposure sub-sequences each defining a particular exposure period and saturation limit for the pixels of the sensor, wherein a successive exposure sub-sequence comprises a higher saturation limit than its prior exposure sub-sequence and each saturation limit defines a maximum charging level of the pixels for the respective exposure sub-sequence.

Abstract: A method of identifying a surface point or region of an object to be measured by means of an optical sensor providing defined measuring conditions regarding emission of measuring light and reception of reflected measuring light in a defined spatial relationship. The method comprises defining a point or region of interest of the object, determining an optical property of the defined point or of the defined region and deriving an object information base on the optical property. The determination of the optical property is performed by optically pre-measuring the point or region using the optical sensor by illuminating the point or the region with the measuring light, capturing at least one image by means of the optical sensor of at least one illumination (Lr,Li) at the object and analyzing respective illuminations (Lr,Li) regarding position or appearance plausibility with respect to the measuring conditions of the optical sensor.

Abstract: Some embodiments include a measuring probe adapted to be attached to a probe head of a coordinate measuring machine for determination of at least one spatial coordinate of a measurement point on an object to be measured, the measuring probe comprising an optical measuring unit adapted to provide distance measurements of measuring points at the object and a probe interface which provides modular mounting of the measuring probe to a probe head of the coordinate measuring machine and transmission, in particular bidirectional transmission, of optical signals between the probe and the coordinate measuring machine. The probe interface is designed as an integrally formed module providing a reproducible mountability of the measuring probe at the probe head and comprising a one-sided component of a ball bearing.

Abstract: Disclosed herein are methods and compositions for treating nonalcoholic fatty liver disease. Specifically exemplified herein is administration of compositions comprising a V1b inhibitor or V1a agonist or V1a stabilizer.

Abstract: Optical sensors are adapted for distance measurement by emission and capture of measuring radiation reflected from an object to be measured. The optical sensors can be used with measuring devices, including coordinate measuring machines. The optical sensors have an optomechanical coupling unit, configured for automated coupling of the optical sensor to the measuring device and for bidirectional measuring radiation transmission between measuring device and optical sensor. The optical sensors have a first optical measuring channel, by which bidirectional measuring radiation transmission is provided between the measuring device and a first exit window of the optical sensor.