Abstract: A system for monitored additive manufacturing of an object, comprising a manufacturing unit], designed for additive manufacturing of the object based on metal-containing manufacturing material in a manufacturing volume, wherein the object is built up by repeated layer-by-layer provision of the manufacturing material in defined quantity and accurately-positioned forming of the provided manufacturing material. The system moreover comprises an optical checking unit having at least one projector and two cameras and a control and processing unit. The manufacturing volume comprises an optical transmission region, the projector and cameras—are arranged outside the manufacturing volume in a fixed position relationship and are aligned in such a way that respective optical axes extend through a respective transmission region, by means of the projector, a projection can be generated on a manufacturing area and at least a common part of the manufacturing area on which the projection can be overlaid can be captured.

Abstract: A reflector arrangement for position determination and/or marking of target points, comprising a retroreflector and a first sensor arrangement, by means of which the orientation measurement radiation passing through the retroreflector is acquirable. The first sensor arrangement comprises a first optical assembly providing a fisheye lens, and a first sensor, wherein the retroreflector and the first sensor arrangement are arranged in such a way that orientation measurement radiation passing through the retroreflector is projectable onto the detection surface of the first sensor by means of the first optical assembly.

Abstract: A triangulation scanner having a projection unit, at least one first image acquisition unit and one second image acquisition unit and a control and processing unit for deriving distance measured values from image information. The scanner comprises a third image acquisition unit and a fourth image acquisition unit and an acquisition zoom functionality for activating or reading out the sensors such that a respective first acquisition state and a respective second acquisition state can be provided for each sensor. The acquisition of an image corresponding to a field of view defined by the respective acquisition zoom level is provided by each such acquisition zoom level thus definable, wherein the fields of view are each different.

Abstract: A measuring system for acquiring three-dimensional measuring points, comprising a base unit, a support unit mounted on the base unit and rotatable relative to the base unit around an azimuth axis, an emitting unit, a receiving unit, a directing unit mounted in the support unit, and configured for directing a transmission beam from the emitting unit towards a scene, directing a reception beam from the scene to the receiving unit, a first actuator configured for rotating the support unit relative to the base unit around the azimuth axis, a second actuator configured for rotating the directing unit relative to the support unit around the elevation axis, a first angle encoder configured for measuring a rotatory position of the support unit, a second angle encoder configured for measuring a rotatory position of the directing unit, a camera comprising an image sensor.

Abstract: Surveying device comprising a base defining a base axis (A), a support structure arranged to be rotatable around the base axis (A) and defining a rotation axis (B), a light emitting unit for emitting measuring signal and a light receiving unit comprising a detector for detecting reflected measuring signal. A rotation unit is mounted on the support structure for providing emission and reception of measuring light in defined directions, wherein the rotation unit comprises a rotation body which is mounted rotatable around the rotation axis (B) and the rotation body comprises a scanning mirror which is arranged tilted relative to the rotation axis (B). The device comprises at least one projector fixedly arranged with the support structure, defining a particular optical axis and configured to direct a light pattern at a scene, wherein position and shape of the pattern are controllable by the controlling and processing unit.

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PH F) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: A triangulation device for measuring a measurement object by a projection of a structured light pattern onto the measurement object. The triangulation device includes a projector projecting the structured light pattern decomposable into different spatial frequencies onto the measurement object. The projector comprises a matrix of pixel elements and a lens system which determines a wavefront with a wavefront aberration from a reference wavefront, and a camera including a lens system and an imaging sensor, the camera being configured to receive the structured light pattern projected by the projector onto the measurement object, and a processing unit configured to provide distance information by evaluating imaging information provided by the camera. The wavefront aberration comprises a primary spherical aberration coefficient Z9, wherein the primary spherical aberration coefficient Z9 is larger than 0.5?, wherein ? is a wavelength of the projected structured light pattern.

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: An optical system comprising an optical coherence tomography (OCT) measuring device and a beam deflection unit for laterally deflecting the position or angle of a beam path of the OCT measuring device. There is an optical component in the beam path, said optical component being embodied in such a way that a back-reflection of the optical component has a different configuration in terms of its longitudinal location along the beam path depending on the lateral position of the deflected beam path on the optical component. The optical system comprises an evaluation unit which is embodied in such a way that a value of the lateral position or angle deflection of the beam deflection unit is determinable on the basis of a longitudinal location of the back-reflection at the optical component determined by the OCT measuring device.

Abstract: A method for measurement of a surface, in particular according to the principle of Optical Coherence Tomography, whereby distances to points of the surface are measured based on interferograms and classifying of measurements as non-valid or valid based on evaluation of phase change or amplitude change of a respective interferogram.

Abstract: Disclosed herein are methods and compositions for treating nonalcoholic fatty liver disease. Specifically exemplified herein is administration of compositions comprising a V1b inhibitor or V1a agonist or V1a stabilizer.

Abstract: A surveying device including a base defining a base axis, a support structure rotatable around the base axis and defining a rotation axis, a light emitting unit emitting light and a light receiving unit for detecting reflected light. A rotation unit is mounted on the support structure for emitting and receiving light in defined directions, wherein the rotation unit comprises a rotation body rotatable around the rotation axis including a scanning mirror arranged tilted relative to the rotation axis. An imaging unit for capturing an image of a scanning region is provided. The imaging unit comprises a camera fixedly arranged on the support structure, the rotation body comprises at least one reflecting deflecting surface assigned to the camera. The imaging unit and the rotation body are arranged so that the field of view comprises a defined field angle around the rotation axis.

Abstract: A triangulation scanner having a projection unit, at least one first image acquisition unit and one second image acquisition unit and a control and processing unit for deriving distance measured values from image information. The scanner comprises a third image acquisition unit and a fourth image acquisition unit and an acquisition zoom functionality for activating or reading out the sensors such that a respective first acquisition state and a respective second acquisition state can be provided for each sensor. The acquisition of an image corresponding to a field of view defined by the respective acquisition zoom level is provided by each such acquisition zoom level thus definable, wherein the fields of view are each different.

Abstract: A machine state monitoring system for recurrently determining a change in static or dynamic properties of a geometry of a machine with positional encoders to derive a coordinate information of at least a first machine portion with respect to a second machine portion, which are movable with respect to one another. The monitoring system includes one calibration-monitoring-unit with an optical, at least two-dimensional measuring location sensing unit which is fixed to the first machine portion and configured to optically sense an at least two dimensional location information of an artifact which is provided at the second machine portion, and temporarily moved into a sensing range for determining the change in the static or dynamic properties of the geometry of the machine by a comparison of multiple of such sensings, the compensation parameters are then updated and is used to derive the coordinate information from the encoders.

Abstract: A reflector arrangement for determining the position or marking of target points, having at least one retroreflector, and a beam detection unit, by means of which the orientation measurement radiation passing through the retroreflector is acquirable. The beam detection unit comprises a first sensor for generating a signal in dependence on an acquisition of orientation measurement radiation and a first beam guiding unit. The first sensor and the first beam guiding unit are arranged such that a detection field of view for acquiring the orientation measurement radiation is defined, an alignment of the detection field of view around the yaw axis is variable and orientation measurement radiation passing through the retroreflector is acquirable in dependence on the alignment of the detection field of view with the first sensor.

Abstract: Light emitting unit, in particular of or for a triangulation-based distance measuring device, for providing defined measuring light, in particular laser light, is disclosed. The light emitting unit comprising a light source for emitting light, in particular a laser light source for emitting laser light, and a beam forming assembly for shaping the light by affecting propagation of the light emitted by the light source, wherein the beam forming assembly is arranged and designed so that measuring light is provided in form of a light line having a midpoint and two opposite ends. The beam forming assembly comprises at least one micro-lens array, the at least one micro-lens array comprises a plurality of micro-lenses, wherein the micro-lenses are designed and arranged in joint manner next to each other with algebraic signs for curvatures of successive micro-lenses being opposite and so that a periodic structure is provided.

Abstract: Some embodiments of the invention include a probe body of an optical probe assembly. The probe assembly may be designed for measuring a surface of an object while being carried by a probe head of a coordinate measuring machine. The probe body comprising a coupling unit at a first end of the probe body designed for providing coupling of the probe body to the probe head of a coordinate measuring machine and a light guiding element for transmitting original source light supplied by the probe head from the coupling unit to a second end of the probe body.

Abstract: The invention relates to an optical sensor element for a measuring machine, comprising a coupling element on the sensor element side for mechanically and optically connecting to a coupling element on the measuring machine side. An optical fiber is arranged in the coupling element on the sensor element side, wherein said optical fiber comprises an optical interface for connecting to an optical machine contact element of the measuring machine, wherein said optical interface is formed by an optical sensor contact element having a self-centering ferrule that encloses the end of the optical fiber. The ferrule is supported in the coupling element on the sensor element side in a floating manner.

Abstract: A measuring device for measuring an object. The measuring device includes a distance measuring unit having a beam emission unit generating a measurement radiation having a defined wavelength spectrum and a detector detecting the measurement radiation reflected on the object surface, the detector having at least one first sensor. The distance measuring unit generates distance measured data and reflection measured data as first distance measured data by emitting the measurement radiation and detecting the reflected measurement radiation according to the principle of triangulation. The measurement radiation is generated using a wavelength spectrum such that a fluorescence is excitable by an interaction of the measurement radiation with the object material to emit fluorescent light, wherein a spectrum of the fluorescent light and the wavelength spectrum of the measurement radiation are different.

Abstract: An optical roughness sensor for a coordinate measuring machine, comprising a beam coupling unit for coupling and decoupling optical radiation, a local reference oscillator element for providing a reference path and an interferometric reference signal by means of a reference radiation component of the radiation, a first decoupling path comprising a first beam passage window for bidirectional transmission of a measuring radiation component of the radiation such that the measuring radiation component is aligned onto an object surface to be measured and a reflection of the measuring radiation component is acquired and a surface signal is provided by the reflected measuring radiation component. The reference path and the decoupling path interact such that the reference signal and the surface signal interfere and a roughness signal is derivable.