Abstract: A vaporizer tank unit for an inhaler, preferably an electronic cigarette product comprises at least an electric vaporizer for vaporizing liquid fed to the vaporizer, a liquid reservoir for storing liquid, and a capillary wick structure, wherein the liquid is feedable by capillary forces from the liquid reservoir to an inlet side of the vaporizer. The wick structure is one-piece and contacts and/or forms the liquid reservoir over at least one circumferential section.

Abstract: A microfluidic device (11) is provided for separation and analysis of microfluidic samples. The device comprises: a separation channel (10); a first electrolyte channel (12) configured to provide a flow of high conductivity electrolyte solution, in use; and provided with a positive electrode (13) at a downstream outlet of the channel; a second electrolyte channel (14) configured to provide a flow of high conductivity electrolyte solution, in use, and provided with a negative electrode (15) at a downstream outlet of the channel; and wherein the flow of electrolyte through the first and second electrolyte channels removes electrophoresis products and gas bubbles from the device; and wherein the presence of the electrolyte provides a substantially homogenous electric field across the separation channel.

Abstract: A fluid flow controller for introducing fluids into a microfluidic device is provided. The fluid flow controller comprising, at least one high resistance fluid pathway provided between an inlet port and a connection port; at least one low resistance fluid pathway between the inlet and connection port; and at least one valve configured to enable fluid flow through the high resistance fluid pathway, the low resistance fluid pathway or both.

Abstract: A cable connector arrangement includes a cable connector and an electrical cable with a plurality of individual lines each having a respective insulation and electrical conductor. The connector may include a front section configured for connection to a mating connector, a rear section in which the individual lines are surrounded by a cable sheath, and a central section. The electrical conductors of two individual lines have a first mutual distance in the rear section and a greater, second mutual distance in the front section with the mutual distance being increased in the central section. At least one pressing means in the central section may press at least the two individual lines together such that their insulations undergo mechanical deformation in a region of common contact.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: Data transformation and access generation for data sets is provided herein. Access generation for a data set can include generating one or more new access modes for the data set. An access mode can include a transformed data set and one or more search definitions or a search model for the transformed data set. Transforming the data set can include transforming a linear data set to a relational data set by determining structural information for the linear data, generating a relational schema based on the structural information, and loading data from the linear data set into the generated relational data structure. Transforming the data set can include sanitizing the data, restructuring the relational data set based on functional dependencies, and reformatting the data set. One or more search definitions can be generated for the relational data. A search model can be generated based on the search definitions.

Abstract: A method of providing pest control service to a customer includes signing up the customer for a pest monitoring service. A pest sensor or multiple pest sensors are set up to monitor a pest monitoring site designated by the customer. The pest sensor determines that there is a need for pest control service within the pest monitoring site. A pest control technician and the customer are alerted that pest control services are needed at the pest monitoring site without additional intervention by the customer. The pest control technician and the customer to make an appointment for the technician to provide pest control service, and the pest control technician provides the necessary pest control service at the pest monitoring site.

Abstract: A device and a method is provided for profiling particles such as proteins. The device comprises: a liquid chromatography column (16) in a mixture separation module (10); a fractionation device (22, 24) and a plurality of microfluidic analysis modules (26, 28) in a microfluidic network (14). The microfluidic analysis modules are configured to provide multi-dimensional analysis of the particles. Furthermore, a fluidic flow adaptor (20) allows for controlled flow between separator (16) and the microfluidic network to provide a continuous fluid flow.

Abstract: The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

Abstract: A flow apparatus for detecting a component on a surface is provided. The flow apparatus, comprising an inlet for receiving a solution of the components to be detected; a detection chamber in fluid connection with and downstream from the inlet, and in fluid connection with a downstream outlet, wherein the internal surface of the detection chamber comprises a plurality of detection zones and the detection zones are configured to adhere to the component to be detected such that the component is immobilised in the detection zones; a detector for detecting components immobilised on each of the detection zones; and a director for directing the flow of the solution of the components to each of the detection zones in sequence, wherein the director is provided by flow rates.

Abstract: The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

Abstract: The present application relates to novel imidazopyridinyl- or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives of formula (I), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring. Formula (I) in which the ring Q represents a bridged 1,4-diazepane cycle.

Abstract: A cyclic chromatographic purification method for the isolation of a product from a feed mixture consisting of the product and at least one further component representing impurities, which impurities bind stronger to the chromatographic stationary phase than the product is given. The method uses at least two chromatographic adsorbers as chromatographic stationary phase, grouped into only one first adsorber section (1) and one second adsorber section (2), wherein if an adsorber section comprises more than one chromatographic adsorber these are permanently connected in series, wherein the first adsorber section (1) has a first adsorber section inlet and a first adsorber section outlet, and the second adsorber section (1) has a second adsorber section inlet and a second adsorber section outlet.

Abstract: The present invention relates to nanoparticles based on optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity, a method for preparing such nanoparticles, compositions comprising such nanoparticles and medical uses thereof. The invention further relates to the use of optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity for preparing nanoparticles as well as to a method for preparing such polymers.

Abstract: A process for manufacturing an exhaust system, especially for an internal combustion engine of a vehicle, includes providing an exhaust gas-guiding component (26) with a wall (38) made of a metallic material and providing a sensor-mounting connector (22), to be fixed at the wall. The sensor-mounting connector includes a sensor-mounting area (28) to be positioned outside the exhaust gas-guiding component, and a connection area (34), which is to be positioned such that the connection area meshes with the wall. The connection area is pressed against an outer surface (40) of the wall of the exhaust gas-guiding component in a fastening area (39) of the wall, and at the same time rotated about a longitudinal axis (A) of the connector to penetrate into the material forming the wall and a connection in substance is established between the metallic material of the wall and the metallic material of the sensor-mounting connector.

Abstract: A foot brake valve (2?) of a pneumatic brake system in a motor vehicle has an installation plate (4?), on which a brake pedal (14) is pivotably mounted and to which a housing (18?) of a control unit (16, 26) is fastened. A spring-loaded plunger piston (36) in actuating contact with the brake pedal (14) is guided axially movably in an annular collar (50) projecting upward out of the installation plate (4?). For fastening the housing (18?) of the control unit (16, 26) to the installation plate (4?), the housing (18?) has an intermediate flange (48) which is screw-connected to the main part of the housing (18?) and has the annular collar (50). The intermediate flange (48) is coaxially rotatably about a vertical central axis (32), and is connectable in non-positively locking fashion to the installation plate (4?) via a releasable clamping connection (62).

Abstract: The assembly comprises a semiconductor device with an active-pixel array, a readout circuit chip or plurality of readout circuit chips mounted outside the active-pixel array, the readout circuit chip or plurality of readout circuit chips being configured to read out voltages or currents provided by the active-pixel array, and electric connections between the active-pixel array and the readout circuit chip or plurality of readout circuit chips.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: A process for producing doped nanoparticles, in particular for N-doped nanoparticles, includes a hydrothermal process using an organic nitrogen-containing compound or a mineral acid having at least one nitrogen atom. In particular, the photocatalytically active particles produced are characterized by a particularly high activity even in visible light.