Abstract: Monte Carlo and quasi-Monte Carlo integration are simple numerical recipes for solving complicated integration problems, such as valuating financial derivatives or synthesizing photorealistic images by light transport simulation. A drawback of a straightforward application of (quasi-)Monte Carlo integration is the relatively slow convergence rate that manifests as high error of Monte Carlo estimators. Neural control variates may be used to reduce error in parametric (quasi-)Monte Carlo integration—providing more accurate solutions in less time. A neural network system has sufficient approximation power for estimating integrals and is efficient to evaluate. The efficiency results from the use of a first neural network that infers the integral of the control variate and using normalizing flows to model a shape of the control variate.

Abstract: A control valve for applying a spring-loaded brake pressure to spring-loaded parts of a rear-axle wheel brake is pneumatically activated as a function of a parking-brake braking demand and a service-brake braking demand. A first control chamber is connected via a first control piston to a control arrangement in the control valve. During an adjustment of the first control chamber via the service-brake control pressure, the spring-loaded brake pressure at the working output is a function of the service-brake control pressure or of the parking-brake control pressure. The first control piston is connected to a third control chamber, wherein the pressure in the first control chamber acts on the first control piston in one direction, and the pressure in the third control chamber acts on the first control piston in the opposite direction. The first control chamber is selectively connectable to the third control chamber via a switchable bypass valve.

Abstract: The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

Abstract: A flexible, scalable, and fast query system for a distributed execution environment is provided. An example method includes receiving a plurality of processor summaries, each including a list of job digests, each job digest including a job identifier for a job running on a job processor and a payload portion. The method can also include, for each job digest, determining a location in a probabilistic payload data structure for the job digest and storing the payload portion and a fingerprint portion generated from a portion of a hash of the job identifier in an entry at the location as a job summary and responding to queries using the probabilistic payload data structure. Responding to a particular query may include identifying job properties corresponding to parameters of the particular query, updating job property statistics, and using the job property statistics to change the job properties represented in the payload portion.

Abstract: A device for controlling a fluid flow in an array of fluid pathways on a microfluidic chip is provided. The device comprising: two or more resistors provided upstream of the chip wherein each upstream resistor is configured to provide a resistance at an upstream end of a fluid pathway; two or more resistors provided downstream of the chip wherein each downstream resistor is configured to provide a resistance at a downstream end of a fluid pathway, wherein the values of the resistances are selected in order to control a proportion of fluid that flows through each fluid pathway.

Abstract: A single-layer valve is provided. The valve comprises a microfluidic pathway at least partially defined by a flexible membrane which is configured to deform when subjected to an actuation torque, and a discontinuity bounded by a first surface. The length of the discontinuity is constant across the full width of the first surface. The valve is configured such that the actuation torque on the membrane is larger in a first direction than a second direction substantially opposite to the first direction.

Abstract: Sampling a function is used for many applications, such as rendering images. The challenge is how to select the best samples to minimize computations and produce accurate results. An alternative is to use a larger number of samples that may not be carefully selected in an attempt to increase accuracy. For a function that is an integral, such as functions used to render images, a sample distribution may be computed by inverting the integral. Unfortunately, for many integrals, it is neither easy nor practical to compute the inverted integral. Instead, warp functions may be combined to provide a sample distribution that accurately approximates the factors of the product being integrated. Each warp function approximates an inverted term of the product while accounting for the effects of warp functions approximating other factors in the product. The selected warp functions are customized or “fitted” to implement importance sampling for the approximated product.

Abstract: A relay valve module for an electronically controllable pneumatic brake system for actuating wheel brakes of a utility vehicle includes: a reservoir connection for receiving a reservoir pressure; a brake control pressure connection for receiving a brake control pressure; at least one first service brake connection for outputting a service brake pressure; a relay valve with a relay valve reservoir connection, which is connected to the reservoir connection, a relay valve working connection, which is connected to the first service brake connection, a relay valve ventilation connection, and a relay valve control connection; an electropneumatic pilot control unit, which is connected to the reservoir connection, the electropneumatic pilot control unit providing a pilot control pressure; and a shuttle valve with a first shuttle valve inlet, a second shuttle valve inlet, and a shuttle valve outlet. The first shuttle valve inlet is connected to the brake control pressure connection.

Abstract: In order to be able to detect a possible loss of cut during the thermal separation of a workpiece as early as during the separation, the invention proposes a method for detecting an impending loss of cut or a loss of cut that has already occurred, in which energy is input into a cutting region and which comprises the following method steps: a) applying a first alternating signal to the workpiece, b) identifying a second alternating signal caused by the first alternating signal in a measurement electrode spaced apart from the workpiece, c) ascertaining the phase shift between the first and second alternating signal by outputting a phase shift signal, d) comparing the phase shift signal with a prescribed upper limit value and a prescribed lower limit value for the phase shift signal, wherein, when the phase shift signal exceeds the upper limit value or undershoots the lower limit value, the energy input is changed, for example, by stopping the thermal separation of the workpiece.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present disclosure relates to an inductive angle and/or position sensor comprising a first sensor component and a second sensor component, which is movable relative thereto, wherein the first sensor component comprises an excitation coil and a receiving coil arrangement having two or more individual receiving coils, and wherein the second sensor component comprises an inductive target. The first sensor component comprises a semiconductor chip having an integrated circuit. The sensor comprises a housing, in which the semiconductor chip is arranged. The individual receiving coils of the receiving coil arrangement are configured in at least two structured metallization layers spaced apart from one another, which are arranged within the housing and/or outside on an outer surface of the housing.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: A fluidic system is provided. The system comprises: a rigid housing (12), a plurality of flexible reagent containers (14) contained within the housing (12); wherein each reagent container (14) has a connection port (16) through which a reagent can flow, in use, on the application of pressure. The system further comprises a single pressure source (18) configured to apply pressure to the interior of the rigid housing (12); a microfluidic device configured to analyse one or more fluids provided from the plurality of reagent containers; and a plurality of channels (20) configured to transfer fluid from the plurality of reagent containers (14) to the microfluidic device. The ratio of resistances provided by a combination of the connection ports and the plurality of channels dictates the ratio of flow rates of the reagents. The claimed system allows for an accurate control of the various reagent flow rates while minimizing fluctuations in the relative flow rates.

Abstract: Oxathiazin-like compounds, processes for making new oxathiazin-like compounds, compounds useful for making oxathiazin-like compounds, and their uses are disclosed. Processes of treating patients suffering from cancers, bacterial infections, fungal infections and/or viral infections by administering oxathiazin-like compounds are also disclosed. These compounds were found to have significantly longer half-life compared to taurolidine and taurultam.

Abstract: Data transformation and access generation for data sets is provided herein. Access generation for a data set can include generating one or more new access modes for the data set. An access mode can include a transformed data set and one or more search definitions or a search model for the transformed data set. Transforming the data set can include transforming a linear data set to a relational data set by determining structural information for the linear data, generating a relational schema based on the structural information, and loading data from the linear data set into the generated relational data structure. Transforming the data set can include sanitizing the data, restructuring the relational data set based on functional dependencies, and reformatting the data set. One or more search definitions can be generated for the relational data. A search model can be generated based on the search definitions.

Abstract: A digital broadcast receiver includes a first receiving module tunable to a foreground broadcast service to extract a program information, a first decoder module coupled to the first receiving module and decoding the program information, an output module switchably coupled to the first decoder module and adapted to output the program information, at least one second decoder module coupled to the first receiving module and tunable to a background broadcast service to decode a program information associated with the background broadcast service, and a control unit adapted to tune the first receiving module and the first decoder module to the foreground broadcast service and to tune each of the at least one second decoder modules to a background broadcast service. The control unit determines the foreground broadcast service based on a user input and determines the background broadcast services based on the foreground broadcast service and a predefined rule.

Abstract: Crux detection in search definition sets is provided herein. Crux detection can include generating a hierarchical representation of a search definition set. The hierarchical representation can be reduced by removing search definitions unrelated to a target search definition. The search definitions in the reduced hierarchical representation can be focused by removing inapplicable elements or operations in the search definitions. Focusing the search definitions in the reduced hierarchical representation can include removing context-irrelevant elements and/or removing search-definition-irrelevant elements. The focused reduced hierarchical representation can be analyzed to identify implementation cruxes in the search definitions. Cruxes can include performance-impacting elements of the search definitions. The cruxes can be tagged and provided for redevelopment or analysis.

Abstract: A mixer device for an exhaust system of an internal combustion engine includes a tubular carrier (30) enclosing a mixer longitudinal axis (A) in a ring shape configuration and a mixer insert (28) carried at the carrier (30). The mixer insert (28) has a plurality of connection attachments (52, 54, 56) located at spaced locations from one another in relation to the mixer longitudinal axis (A) radially on the outside. The carrier (30) has a plurality of connection recesses (60, 62) for the permanent connection of the mixer insert (28) to the carrier (30).

Abstract: A fiber cement material formulation comprising a cementitious binder, a siliceous material, fiber, alumina trihydrate and a bifunctional low density additive wherein the bifunctional low density additive comprises any one or more of diatomaceous earth, recycled autoclave fiber cement dust or cellulose dust. The fiber cement material formulation optionally further comprises a secondary low density additive which may be perlite. In some embodiments, a fiber cement article manufactured from the fiber cement material formulation comprises a density of approximately 1.1 g/cm3 or below.