Patents by Inventor Tong Zhang

Tong Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250145970
    Abstract: The present disclosure relates to the technical field of biotechnology, in particular to carbonyl reductase mutant and its application. Specifically, the present disclosure provides a carbonyl reductase mutant for catalyzing the preparation of (R)-8-chloro-6-hydroxyoctanoic acid ethyl ester from 8-chloro-6-oxooctanoic acid ethyl ester. The mutant protein is a non natural protein and undergoes mutations in three core amino acids related to enzyme catalytic activity in the initial carbonyl reductase. The advantageous effect of the present disclosure is that the carbonyl reductase mutant provided by the present disclosure has the characteristic of efficiently catalyzing the preparation of the precursor substance (R)-8-chloro-6-hydroxyoctanoic acid from 8-chloro-6-oxooctanoic acid ethyl ester, and can efficiently catalyze the oxidation-reduction reaction of 8-chloro-6-oxooctanoic acid, with a product space-time yield of 99.9 g·L?1·h?1 or more.
    Type: Application
    Filed: October 31, 2024
    Publication date: May 8, 2025
    Inventors: Xiuzhen Gao, Qinyuan Ma, Yanmiao Yin, Yanling Zhao, Zhixin Ma, Tong Zhang
  • Patent number: 12287985
    Abstract: A method for memory access may include receiving, at a device, a first memory access request for a parallel workload, receiving, at the device, a second memory access request for the parallel workload, processing, by a first logical device of the device, the first memory access request, and processing, by a second logical device of the device, the second memory access request. Processing the first memory access request and processing the second memory access request may include parallel processing the first and second memory access requests. The first logical device may include one or more first resources. The method may further include configuring the first logical device based on one or more first parameters of the parallel workload. The method may further include allocating one or more first resources to the first logical device based on at least one of the one or more first parameters of the parallel workload.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: April 29, 2025
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Zongwang Li, Tong Zhang, Rekha Pitchumani, Yang Seok Ki
  • Publication number: 20250130661
    Abstract: A display panel, including an active area and a peripheral area, which is located outside of the active area, wherein the active area comprises a base substrate, and a display structure layer and a touch structure layer sequentially arranged on the base substrate; the peripheral area includes an isolation dam, a first ground trace and a second ground trace arranged on the base substrate; and the first ground trace is located at a side of the isolation dam close to the active area, and the second ground trace is located at a side of the isolation dam away from the active area.
    Type: Application
    Filed: January 2, 2025
    Publication date: April 24, 2025
    Inventors: Chang LUO, Xiping LI, Hongwei MA, Ming HU, Wei HE, Youngyik KO, Haijun QIU, Yi ZHANG, Taofeng XIE, Tianci CHEN, Qun MA, Xinghua LI, Ping WEN, Yang ZHOU, Yuanqi ZHANG, Xiaoyan YANG, Shun ZHANG, Pandeng TANG, Yang ZENG, Tong ZHANG, Xiaofei HOU, Zhidong WANG, Haoyuan FAN, Jinhwan HWANG
  • Publication number: 20250123968
    Abstract: A device may include memory media; storage media; a buffer; and at least one circuit configured to perform one or more operations including receiving memory address information; storing the memory address information in the buffer; determining that data may be loaded to the memory media; and loading data to the memory media, from the storage media, corresponding to the memory address information in the buffer. In some aspects, the memory address information is first memory address information; the data is first data; and the at least one circuit is further configured to perform one or more operations including receiving a memory access request including second memory address information; determining to load second data based on the memory access request; and loading the second data to the memory media, from the storage media, based on the second memory address information.
    Type: Application
    Filed: August 13, 2024
    Publication date: April 17, 2025
    Inventors: Zongwang LI, Shuyi PEI, Tong ZHANG, Rekha PITCHUMANI, Yang Seok KI
  • Publication number: 20250109194
    Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
    Type: Application
    Filed: December 11, 2024
    Publication date: April 3, 2025
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Tong ZHANG, Samuel DAVIS, Chia-Yang LIN, Eric SMITH, Erica PYLES, Michael ROSCONI, Nina LIU, Supriya PATEL, Andrew J. MURPHY
  • Patent number: 12259490
    Abstract: The present disclosure provides a multi-antenna single-station stereoscopic-arrangement ultra-short baseline lightning location method and related devices.
    Type: Grant
    Filed: July 18, 2024
    Date of Patent: March 25, 2025
    Assignees: Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Hexi University
    Inventors: Xiangpeng Fan, Yijun Zhang, Yajun Li, Yuhui Zhang, Guo Zhao, Tong Zhang
  • Publication number: 20250098070
    Abstract: The first circuit board is a flexible printed circuit, and a stiffener and one or more first pads are disposed on a first surface of the first circuit board. The stiffener is provided with first through holes, at least one first pad is located in one first through hole of the the first through holes, and hardness of the stiffener is greater than hardness of the first circuit board. In addition, second pads are disposed on the second circuit board, and the at least one first pad is soldered to the second pad, to implement an electrical connection between the first circuit board and the second circuit board.
    Type: Application
    Filed: December 5, 2022
    Publication date: March 20, 2025
    Inventors: Tong ZHANG, Fan JIANG, Heyujia TANG, Haisheng ZHOU, Dan WEI, Kelin LI, Jiguang LI, Hao WANG
  • Publication number: 20250077092
    Abstract: Systems and methods for buffer data preservation. In some embodiments, the method includes: receiving, by a persistent storage device including non-volatile memory and a buffer storing data, a first memory-addressed instruction; and copying a portion of the data in the buffer of the persistent storage device to the non-volatile memory, based on receiving the first memory-addressed instruction.
    Type: Application
    Filed: November 16, 2023
    Publication date: March 6, 2025
    Inventors: Byung CHOI, Tong ZHANG, Changho CHOI
  • Patent number: 12244210
    Abstract: The invention discloses a convenient human and animal power drive permanent magnet power generation and storage system, comprising a grip power drive power generation system; the grip power drive power generation system is a dumbbell-shaped grip power generation device, comprising a grip handle and power generation devices provided at both ends of the grip handle; the power generation device is composed of a permanent magnet generator, a tensioning wheel, a spring sheet, a winder ratchet device, and a battery; folding buckles are provided between the power generation devices at both ends and the grip handle so as to be folded inward. The invention solves the problem of continuous power guarantee of wearable intelligent device; in the invention, the grip-type slow gear is designed as a spring tensioning device similar to a mechanical watch; the stress generated during the grip tightens the spring.
    Type: Grant
    Filed: November 29, 2022
    Date of Patent: March 4, 2025
    Inventors: Yifei Lu, Feng Lu, Hao Wei, Tong Zhang, Yuanzhe Ge
  • Publication number: 20250066220
    Abstract: The present invention belongs to the technical field in sodium ion battery, which includes material synthesis, and discloses a high-entropy cathode material with a chemical formula of Na1-xKxNiyFezMndTimZn1-y-z-d-mO2, wherein 0<x?0.1, 0<y, z, d, and m?1. Its crystallographic structure is a hexagonal system with a space group of R-3m, where the arrangement subsequence of transition metal layers is ABCABC. Ni, Fe, Zn, Mn and Ti elements occupy in a transition metal layer and are arranged in a disordered subsequence; Na and K elements sit in an alkali metal layer and are arranged in a disordered subsequence. The cathode material of this present invention exhibits excellent electrochemical performance with a high specific capacity of 150 mAhg?1 at a high cut-off charge voltage of 4.3V, and the capacity retention of this pouch cell does not decay after 200 cycles.
    Type: Application
    Filed: January 22, 2024
    Publication date: February 27, 2025
    Inventors: Fujun Li, Suning Gao, Tong Zhang, Xiangshuai Wei, Wei Hu
  • Publication number: 20250066441
    Abstract: The present disclosure relates to IL 12 receptor agonists with improved therapeutic profiles.
    Type: Application
    Filed: July 18, 2022
    Publication date: February 27, 2025
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Aaron CHANG, Jiaxi WU, Tong ZHANG, Nicolin BLOCH, Erica ULLMAN, Eric SMITH, Chia-Yang LIN, Samuel DAVIS
  • Patent number: 12234286
    Abstract: Provided are antibodies that specifically bind to TIGIT (T cell immunoreceptor with Ig and ITIM domains, WUCAM or Vstm3) and inhibit Tigit-mediated cellular signaling and activities in immune cells. The anti-TIGIT antibodies can be used to treat or diagnose cancer, infectious diseases or other pathological disorders that may be modulated by Tigit-mediated functions.
    Type: Grant
    Filed: November 24, 2021
    Date of Patent: February 25, 2025
    Assignee: BEIGENE SWITZERLAND GMBH
    Inventors: Tong Zhang, Liu Xue, Qi Liu, Min Wei, Kang Li
  • Publication number: 20250059277
    Abstract: Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) and inhibit PD1-mediated cellular signaling and activities in immune cells, antibodies binding to a set of amino acid residues required for its ligand binding, and uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders modulated by PD1-mediated functions.
    Type: Application
    Filed: November 4, 2024
    Publication date: February 20, 2025
    Applicant: BeiGene Switzerland GmbH
    Inventors: Kang LI, Tong ZHANG, Jing SONG, Lanlan XU, Qi LIU, Hao PENG
  • Patent number: 12229360
    Abstract: A display panel, including an active area and a peripheral area, which is located outside of the active area, wherein the active area comprises a base substrate, and a display structure layer and a touch structure layer sequentially arranged on the base substrate; the peripheral area includes an isolation dam, a first ground trace and a second ground trace arranged on the base substrate; and the first ground trace is located at a side of the isolation dam close to the active area, and the second ground trace is located at a side of the isolation dam away from the active area.
    Type: Grant
    Filed: January 9, 2023
    Date of Patent: February 18, 2025
    Assignees: Chengdu BOE Optoelectronics Technology Co., Ltd., BOE Technology Group Co., Ltd.
    Inventors: Chang Luo, Xiping Li, Hongwei Ma, Ming Hu, Wei He, Youngyik Ko, Haijun Qiu, Yi Zhang, Taofeng Xie, Tianci Chen, Qun Ma, Xinghua Li, Ping Wen, Yang Zhou, Yuanqi Zhang, Xiaoyan Yang, Shun Zhang, Pandeng Tang, Yang Zeng, Tong Zhang, Xiaofei Hou, Zhidong Wang, Haoyuan Fan, Jinhwan Hwang
  • Patent number: 12215131
    Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.
    Type: Grant
    Filed: May 9, 2023
    Date of Patent: February 4, 2025
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Jiaxi Wu, Tong Zhang, Maria del Pilar Molina-Portela, Eric Smith, Chia-Yang Lin, Thomas Craig Meagher
  • Patent number: 12215148
    Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: February 4, 2025
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chiayang Lin, Samuel Davis
  • Publication number: 20250034224
    Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.
    Type: Application
    Filed: April 5, 2024
    Publication date: January 30, 2025
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Jiaxi WU, Tong ZHANG, Maria del Pilar MOLINA-PORTELA, Eric Smith, Chia-Yang LIN, Thomas Craig Meagher
  • Publication number: 20250002584
    Abstract: Antibodies, chimeric antigen receptors, and bispecific T-cell engagers having specificity for B7-H6 and methods for using the same in the diagnosis and treatment of disorders associated with B7-H6 expression are provided.
    Type: Application
    Filed: July 9, 2024
    Publication date: January 2, 2025
    Inventors: Charles L. SENTMAN, Tong ZHANG
  • Patent number: 12180272
    Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: December 31, 2024
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chia-Yang Lin, Samuel Davis
  • Publication number: 20240427505
    Abstract: A self-managed DRAM module configured to reduce energy consumption. A module is described that includes a plurality of DDR channels, each DDR channel having a set of DRAM chips; and a management engine configured to read and write data blocks to DDR channels, wherein a write operation of a data block in a DDR channel is implemented according to a process that includes: compressing the data block to generate a compressed data block; encoding the compressed data block to obtain a punctured ECC codeword; determining a reduced number of DRAM chips in the DDR channel required to store the punctured ECC codeword; storing metadata indicative of the reduced number; and writing the punctured ECC codeword to the reduced number of DRAM chips in the DDR channel.
    Type: Application
    Filed: September 3, 2024
    Publication date: December 26, 2024
    Inventors: Kelly Fitzpatrick, Yang Liu, Tong Zhang