Abstract: The present disclosure relates to the technical field of biotechnology, in particular to carbonyl reductase mutant and its application. Specifically, the present disclosure provides a carbonyl reductase mutant for catalyzing the preparation of (R)-8-chloro-6-hydroxyoctanoic acid ethyl ester from 8-chloro-6-oxooctanoic acid ethyl ester. The mutant protein is a non natural protein and undergoes mutations in three core amino acids related to enzyme catalytic activity in the initial carbonyl reductase. The advantageous effect of the present disclosure is that the carbonyl reductase mutant provided by the present disclosure has the characteristic of efficiently catalyzing the preparation of the precursor substance (R)-8-chloro-6-hydroxyoctanoic acid from 8-chloro-6-oxooctanoic acid ethyl ester, and can efficiently catalyze the oxidation-reduction reaction of 8-chloro-6-oxooctanoic acid, with a product space-time yield of 99.9 g·L?1·h?1 or more.

Abstract: A method for memory access may include receiving, at a device, a first memory access request for a parallel workload, receiving, at the device, a second memory access request for the parallel workload, processing, by a first logical device of the device, the first memory access request, and processing, by a second logical device of the device, the second memory access request. Processing the first memory access request and processing the second memory access request may include parallel processing the first and second memory access requests. The first logical device may include one or more first resources. The method may further include configuring the first logical device based on one or more first parameters of the parallel workload. The method may further include allocating one or more first resources to the first logical device based on at least one of the one or more first parameters of the parallel workload.

Abstract: A display panel, including an active area and a peripheral area, which is located outside of the active area, wherein the active area comprises a base substrate, and a display structure layer and a touch structure layer sequentially arranged on the base substrate; the peripheral area includes an isolation dam, a first ground trace and a second ground trace arranged on the base substrate; and the first ground trace is located at a side of the isolation dam close to the active area, and the second ground trace is located at a side of the isolation dam away from the active area.

Abstract: A device may include memory media; storage media; a buffer; and at least one circuit configured to perform one or more operations including receiving memory address information; storing the memory address information in the buffer; determining that data may be loaded to the memory media; and loading data to the memory media, from the storage media, corresponding to the memory address information in the buffer. In some aspects, the memory address information is first memory address information; the data is first data; and the at least one circuit is further configured to perform one or more operations including receiving a memory access request including second memory address information; determining to load second data based on the memory access request; and loading the second data to the memory media, from the storage media, based on the second memory address information.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: The present disclosure provides a multi-antenna single-station stereoscopic-arrangement ultra-short baseline lightning location method and related devices.

Abstract: The first circuit board is a flexible printed circuit, and a stiffener and one or more first pads are disposed on a first surface of the first circuit board. The stiffener is provided with first through holes, at least one first pad is located in one first through hole of the the first through holes, and hardness of the stiffener is greater than hardness of the first circuit board. In addition, second pads are disposed on the second circuit board, and the at least one first pad is soldered to the second pad, to implement an electrical connection between the first circuit board and the second circuit board.

Abstract: Systems and methods for buffer data preservation. In some embodiments, the method includes: receiving, by a persistent storage device including non-volatile memory and a buffer storing data, a first memory-addressed instruction; and copying a portion of the data in the buffer of the persistent storage device to the non-volatile memory, based on receiving the first memory-addressed instruction.

Abstract: The invention discloses a convenient human and animal power drive permanent magnet power generation and storage system, comprising a grip power drive power generation system; the grip power drive power generation system is a dumbbell-shaped grip power generation device, comprising a grip handle and power generation devices provided at both ends of the grip handle; the power generation device is composed of a permanent magnet generator, a tensioning wheel, a spring sheet, a winder ratchet device, and a battery; folding buckles are provided between the power generation devices at both ends and the grip handle so as to be folded inward. The invention solves the problem of continuous power guarantee of wearable intelligent device; in the invention, the grip-type slow gear is designed as a spring tensioning device similar to a mechanical watch; the stress generated during the grip tightens the spring.

Abstract: The present invention belongs to the technical field in sodium ion battery, which includes material synthesis, and discloses a high-entropy cathode material with a chemical formula of Na1-xKxNiyFezMndTimZn1-y-z-d-mO2, wherein 0<x?0.1, 0<y, z, d, and m?1. Its crystallographic structure is a hexagonal system with a space group of R-3m, where the arrangement subsequence of transition metal layers is ABCABC. Ni, Fe, Zn, Mn and Ti elements occupy in a transition metal layer and are arranged in a disordered subsequence; Na and K elements sit in an alkali metal layer and are arranged in a disordered subsequence. The cathode material of this present invention exhibits excellent electrochemical performance with a high specific capacity of 150 mAhg?1 at a high cut-off charge voltage of 4.3V, and the capacity retention of this pouch cell does not decay after 200 cycles.

Abstract: The present disclosure relates to IL 12 receptor agonists with improved therapeutic profiles.

Abstract: Provided are antibodies that specifically bind to TIGIT (T cell immunoreceptor with Ig and ITIM domains, WUCAM or Vstm3) and inhibit Tigit-mediated cellular signaling and activities in immune cells. The anti-TIGIT antibodies can be used to treat or diagnose cancer, infectious diseases or other pathological disorders that may be modulated by Tigit-mediated functions.

Abstract: Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) and inhibit PD1-mediated cellular signaling and activities in immune cells, antibodies binding to a set of amino acid residues required for its ligand binding, and uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders modulated by PD1-mediated functions.

Abstract: A display panel, including an active area and a peripheral area, which is located outside of the active area, wherein the active area comprises a base substrate, and a display structure layer and a touch structure layer sequentially arranged on the base substrate; the peripheral area includes an isolation dam, a first ground trace and a second ground trace arranged on the base substrate; and the first ground trace is located at a side of the isolation dam close to the active area, and the second ground trace is located at a side of the isolation dam away from the active area.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: Antibodies, chimeric antigen receptors, and bispecific T-cell engagers having specificity for B7-H6 and methods for using the same in the diagnosis and treatment of disorders associated with B7-H6 expression are provided.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: A self-managed DRAM module configured to reduce energy consumption. A module is described that includes a plurality of DDR channels, each DDR channel having a set of DRAM chips; and a management engine configured to read and write data blocks to DDR channels, wherein a write operation of a data block in a DDR channel is implemented according to a process that includes: compressing the data block to generate a compressed data block; encoding the compressed data block to obtain a punctured ECC codeword; determining a reduced number of DRAM chips in the DDR channel required to store the punctured ECC codeword; storing metadata indicative of the reduced number; and writing the punctured ECC codeword to the reduced number of DRAM chips in the DDR channel.