Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: The application relates to a dynamic visualization method and device for earthquake disasters. The method comprises: acquiring initial point cloud data of buildings and scenes in a target area; acquiring shake displacement data varying with time of the buildings by simulating an earthquake excitation on the buildings and the scenes; performing voxel downsampling and point cloud segmentation and extraction on the initial point cloud data to determine a ground point cloud and a point cloud of each building; updating in real time coordinates of each point of the point cloud of each building according to the shake displacement data; and rendering in real time the ground point cloud and the coordinates of each point of the point cloud of each building to generate a dynamic visual image for displaying. Accordingly, seismic scenes of regional buildings are presented more truly and visually, thus improving the visualization effect.

Abstract: The disclosure provides techniques for peer to peer communication of a remote display protocol via a real-time communication session between a client device and a remote device. Embodiments include receiving, at a remote device configured to execute a virtual desktop, a request to join a real-time communication (RTC) session with a client device. Embodiments include joining the RTC session with the client device in response to receiving the request. Embodiments include receiving, at the remote device and via the RTC session, data indicative of a remote display protocol for rendering the virtual desktop on a display of the client device. Embodiments include performing, at the remote device, one or more actions based, at least in part, on receiving the data indicative of the remote display protocol.

Abstract: Dialogue skeleton assisted prompt transfer for dialogue summarization techniques are described that support training of a language model to perform dialogue summarization in a few-shot scenario. A processing device, for instance, receives a training dataset that includes training dialogues. The processing device then generates dialogue skeletons based on the training dialogues using one or more perturbation-based probes. The processing device trains a language model using prompt transfer between a source task, e.g., dialogue state tracking, and a target task, e.g., dialogue summarization, using the dialogue skeletons as supervision. The processing device then receives an input dialogue and uses the trained language model to generate a summary of the input dialogue.

Abstract: An aging drawer and refrigeration apparatus with the same. The aging drawer comprises a shell, at least one air duct board provided within the shell and a circulation fan. The shell and the at least one air duct board define a aging chamber and at least one air supply duct, the aging chamber is connected to the air supply duct through multiple air outlet supply ports arranged along the direction of airflow within the air supply duct; and at least an air supply section of the air supply duct, which is directly connected to the multiple air outlets, is configured to gradually taper along the direction of airflow therein, thereby ensuring the airflow passes through the air supply section at a uniform speed at different positions, and improving the aging effect.

Abstract: Antibodies, chimeric antigen receptors, and bispecific T-cell engagers having specificity for B7-H6 and methods for using the same in the diagnosis and treatment of disorders associated with B7-H6 expression are provided.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: A self-managed DRAM module configured to reduce energy consumption. A module is described that includes a plurality of DRAM chips and a management engine configured to read and write data blocks to the DRAM chips, wherein a write operation is implemented according to a process that includes: allocating a sequential region of memory space in the DRAM chips; collecting sequential data in a write buffer; compressing a data chunk of sequential data from the write buffer to form a compressed data chunk; and writing the compressed data chunk to the sequential region.

Abstract: A self-managed DRAM module configured to reduce energy consumption. A module is described that includes a plurality of DDR channels, each DDR channel having a set of DRAM chips; and a management engine configured to read and write data blocks to DDR channels, wherein a write operation of a data block in a DDR channel is implemented according to a process that includes: compressing the data block to generate a compressed data block; encoding the compressed data block to obtain a punctured ECC codeword; determining a reduced number of DRAM chips in the DDR channel required to store the punctured ECC codeword; storing metadata indicative of the reduced number; and writing the punctured ECC codeword to the reduced number of DRAM chips in the DDR channel.

Abstract: This disclosure relates to IL-2 variants and methods of use thereof, including methods of treating or inhibiting a cancer or tumor. The IL-2 variants may have reduced ability in binding to or activating IL-2R?. The IL-2 variants may retain the ability in binding to or activating IL-2R? and/or IL-2R?. In addition, the IL-2 variants may have decreased Treg activity but maintain the capacity to activate NK cells and T effector cells.

Abstract: A model training method and apparatus for image recognition, and a non-transitory storage medium are provided. The model training method includes: obtaining a multi-label image training set including a plurality of training images each annotated with a plurality of sample labels; selecting target training images from the multi-label image training set for training a current model; performing label prediction on each target training image using the current model, to obtain a plurality of predicted labels of the each target training image; obtaining a cross-entropy loss function corresponding to the plurality of sample labels of the each target training image, a positive label loss being greater than a negative label loss and having a weight greater than 1; converging the predicted labels and the sample labels of the each target training image according to the cross-entropy loss function, and updating parameters of the current model, to obtain a trained model.

Abstract: Provided is a method for data storage, the method including receiving a first request at a storage device, the first request being associated with a first protocol that is a memory protocol, converting address information associated with the first request to logical block address (LBA) information, determining, by the storage device, a first group of contiguous physical block addresses associated with the first request and associated with a first application, based on a data placement configuration of the storage device, and performing a first memory operation at the first group, based on the first request.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind to human OX40 (ACT35, CD134, or TNFRSF4), a pharmaceutical composition comprising said antibody, and use of the antibody or the composition for treating a disease, such as cancer. In particular, the anti-OX40 antibody of the present invention does not interfere with the binding of OX40-ligand to its receptor.

Abstract: The present invention belongs to the technical field of membrane-based water treatment and relates to a novel guanidine-based composite nanofiltration (NF) flat-sheet membrane, and a preparation method and application thereof. The present invention provides a method for preparing a guanidine-based composite NF flat-sheet membrane, where a dense separation layer is formed on the surface of a polyethersulfone ultrafiltration membrane through polymerization reaction between the amino group of 1,3-diaminoguanidine and the acyl chloride group of trimesoyl chloride. Under suitable reaction conditions, the guanidine-based composite NF membrane obtained according to the present invention enables effective separation of multivalent ions over a wide pH range, with a rejection rate of over 96% for 1000 ppm of MgSO4 solution, and can operate continuously and stably in a mixed ions solution with a wide pH.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: An online system matches source and target entities using multiple queues. The online system performs clustering of target entities to generate a plurality of clusters based on vector distances between pairs of target entities. Each cluster comprises target entities that are close to other target entities within the cluster compared to target entities of remaining clusters. The online system optimizes an aggregate score across the plurality of entities using a plurality of queues. Each queue is associated with a source entity and includes one or more target entities. The online system identifies a cluster of target entities based on a distance between the source entities and entities of the cluster of target entities. The online system selects a subset of target entities from the identified cluster using a machine learning based model trained to determine a score between an input source entity and target entity.

Abstract: An online system matches source and target entities using multiple queues. The online system receives information identifying a plurality of source entities and a plurality of target entities. The online system maintains a plurality of queues, each queue associated with a source entity. Each queue comprises one or more target entities. A target entity is included in a queue based on matching of the target entity with a source entity. The online system may perform matching using a machine learning model. The online system selects a particular target entity for a particular source entity from the queue corresponding to the source entity. The online system schedules an interaction between the particular source entity and the particular target entity.

Abstract: A device may include a storage medium, a cache medium, a buffer medium, and at least one control circuit configured to perform one or more operations including receiving a first request to access the storage medium, accessing, based on the first request, the cache medium, copying, from a portion of the storage medium to the buffer medium, data, modifying, based on the copying, an availability of the at least a portion of the storage medium, receiving a second request to access the storage medium, and accessing, based on the second request, the buffer medium. The one or more operations may include determining a location of data associated with the second request, and accessing, based on the determining, the buffer medium. The one or more operations may include receiving information about a location of data associated with the second request, and accessing, based on the information, the buffer medium.