Abstract: A self-managed DRAM module configured to reduce energy consumption. A module is described that includes a plurality of DRAM chips and a management engine configured to read and write data blocks to the DRAM chips, wherein a write operation is implemented according to a process that includes: allocating a sequential region of memory space in the DRAM chips; collecting sequential data in a write buffer; compressing a data chunk of sequential data from the write buffer to form a compressed data chunk; and writing the compressed data chunk to the sequential region.

Abstract: A model training method and apparatus for image recognition, and a non-transitory storage medium are provided. The model training method includes: obtaining a multi-label image training set including a plurality of training images each annotated with a plurality of sample labels; selecting target training images from the multi-label image training set for training a current model; performing label prediction on each target training image using the current model, to obtain a plurality of predicted labels of the each target training image; obtaining a cross-entropy loss function corresponding to the plurality of sample labels of the each target training image, a positive label loss being greater than a negative label loss and having a weight greater than 1; converging the predicted labels and the sample labels of the each target training image according to the cross-entropy loss function, and updating parameters of the current model, to obtain a trained model.

Abstract: This disclosure relates to IL-2 variants and methods of use thereof, including methods of treating or inhibiting a cancer or tumor. The IL-2 variants may have reduced ability in binding to or activating IL-2R?. The IL-2 variants may retain the ability in binding to or activating IL-2R? and/or IL-2R?. In addition, the IL-2 variants may have decreased Treg activity but maintain the capacity to activate NK cells and T effector cells.

Abstract: The present invention belongs to the technical field of membrane-based water treatment and relates to a novel guanidine-based composite nanofiltration (NF) flat-sheet membrane, and a preparation method and application thereof. The present invention provides a method for preparing a guanidine-based composite NF flat-sheet membrane, where a dense separation layer is formed on the surface of a polyethersulfone ultrafiltration membrane through polymerization reaction between the amino group of 1,3-diaminoguanidine and the acyl chloride group of trimesoyl chloride. Under suitable reaction conditions, the guanidine-based composite NF membrane obtained according to the present invention enables effective separation of multivalent ions over a wide pH range, with a rejection rate of over 96% for 1000 ppm of MgSO4 solution, and can operate continuously and stably in a mixed ions solution with a wide pH.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind to human OX40 (ACT35, CD134, or TNFRSF4), a pharmaceutical composition comprising said antibody, and use of the antibody or the composition for treating a disease, such as cancer. In particular, the anti-OX40 antibody of the present invention does not interfere with the binding of OX40-ligand to its receptor.

Abstract: Provided is a method for data storage, the method including receiving a first request at a storage device, the first request being associated with a first protocol that is a memory protocol, converting address information associated with the first request to logical block address (LBA) information, determining, by the storage device, a first group of contiguous physical block addresses associated with the first request and associated with a first application, based on a data placement configuration of the storage device, and performing a first memory operation at the first group, based on the first request.

Abstract: An online system matches source and target entities using multiple queues. The online system receives information identifying a plurality of source entities and a plurality of target entities. The online system maintains a plurality of queues, each queue associated with a source entity. Each queue comprises one or more target entities. A target entity is included in a queue based on matching of the target entity with a source entity. The online system may perform matching using a machine learning model. The online system selects a particular target entity for a particular source entity from the queue corresponding to the source entity. The online system schedules an interaction between the particular source entity and the particular target entity.

Abstract: An online system matches source and target entities using multiple queues. The online system performs clustering of target entities to generate a plurality of clusters based on vector distances between pairs of target entities. Each cluster comprises target entities that are close to other target entities within the cluster compared to target entities of remaining clusters. The online system optimizes an aggregate score across the plurality of entities using a plurality of queues. Each queue is associated with a source entity and includes one or more target entities. The online system identifies a cluster of target entities based on a distance between the source entities and entities of the cluster of target entities. The online system selects a subset of target entities from the identified cluster using a machine learning based model trained to determine a score between an input source entity and target entity.

Abstract: A device may include a storage medium, a cache medium, a buffer medium, and at least one control circuit configured to perform one or more operations including receiving a first request to access the storage medium, accessing, based on the first request, the cache medium, copying, from a portion of the storage medium to the buffer medium, data, modifying, based on the copying, an availability of the at least a portion of the storage medium, receiving a second request to access the storage medium, and accessing, based on the second request, the buffer medium. The one or more operations may include determining a location of data associated with the second request, and accessing, based on the determining, the buffer medium. The one or more operations may include receiving information about a location of data associated with the second request, and accessing, based on the information, the buffer medium.

Abstract: A device may include a first memory media, a second memory media, and at least one control circuit configured to receive placement information for data, store, in a portion of the first memory media, based on the placement information, the data, and store, in a portion of the second memory media, based on the placement information, the data. The at least one control circuit may be configured to receive a request to access, from the portion of the first memory media, the data, and access, based on the request, from the portion of the second memory media, the data. The at least one control circuit may be configured to modify, based on an allocation status, the portion of the first memory media to an available state.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: Antibodies and antigen-binding fragments thereof that bind to human NKp30, multispecific antibodies that recognize NKp30 as one antigen and at least one other antigen, a pharmaceutical composition comprising NKp30 antibodies, and use of the antibody, multispecific antibody or the composition for treating a disease, such as cancer.

Abstract: Systems and methods for prefetching data are disclosed. A processor executes a first command for moving first data stored in a storage device. Based on the first command, the processor stores, into a first queue of the storage device, a first address associated with the first data. The storage device further retrieves the first address from the first queue, retrieves the first data from the first storage medium based on the first address, and stores the first data to the second storage medium. In some embodiments, a process for prefetch optimization is also disclosed. A processor identifies a value for prefetching data. The processor runs an application, measures performance of the application, modifies the value based on the performance, and determines that the performance satisfies a criterion.

Abstract: Systems and methods for prefetching data are disclosed. A processor in communication with a storage device identifies a first address. The processor identifies a first setting associated with the first address. The processor issues a first command to a first storage medium of the storage device based on the first setting. The first command is for performing a first type of memory read. The storage device is configured to retrieve first data associated with the first address in the first storage medium, to a second storage medium of the storage device, based on the first command.

Abstract: The present disclosure provides interferon (IFN) receptor antagonists. IFN receptor antagonists disclosed herein comprise an anchoring moiety, an IFN masking moiety, an IFN moiety, and a separator moiety, e.g., a targeting moiety that recognizes an antigen associated with cells expressing Type 1 interferon receptors and anchors the IFN receptor antagonist to such cells. The disclosure further provides pharmaceutical compositions comprising the IFN receptor antagonists, and methods of use of the IFN receptor antagonists in IFN signaling inhibition, including treatment methods. Also disclosed are nucleic acids encoding the IFN receptor antagonists, recombinant cells that express the IFN receptor antagonists, and methods of producing the IFN receptor antagonists.

Abstract: Systems and methods for cache management of a storage device are disclosed. The storage device is configured to receive a first code provided by a computing device; execute the first code; perform a first update of the first storage medium based on the first code; receive a second code provided by the computing device; execute the second code; and perform a second update of the first storage medium based on the second code.

Abstract: A device may include cache media, storage media, a communication interface configured to communicate with the cache media and the storage media, and at least one control circuit to configure a portion of the storage media as visible memory, and configure a portion of the cache media as a cache for the portion of the storage media. The portion of the storage media may be a first portion of the storage media, and the at least one control circuit may be to configure a second portion of the storage media to persist the portion of the cache media. The portion of the storage media may be a first portion of the storage media, and the at least one control circuit may be to configure a second portion of the storage media as visible storage.

Abstract: A self-managed DRAM module configured to reduce energy consumption. A module is described that includes a plurality of DDR channels and a management engine configured to read and write data blocks to DDR channels according to a process that includes: allocating a set of sub-channels for each DDR channel, wherein each sub-channel includes a subset of the set of DRAM chips; wherein a write operation of a data block includes: encoding the data block to generate an ECC codeword; and writing the ECC codeword into the subset of DRAM chips of a specified sub-channel; and wherein a read operation of the data block includes: reading the ECC codeword from the subset of DRAM chips of the specified sub-channel; and decoding the ECC codeword to obtain the data block.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind to human OX40 (ACT35, CD134, or TNFRSF4), a pharmaceutical composition comprising said antibody, and use of the antibody or the composition for treating a disease, such as cancer. In particular, the anti-OX40 antibody of the present invention does not interfere with the binding of OX40-ligand to its receptor.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.