Abstract: Provided herein are compositions and methods of using prime editing systems comprising prime editors and prime editing guide RNAs for treatment of genetic disorders.

Abstract: A voltage detection device includes a voltage divider circuit, a comparator circuit and a switch control circuit. The voltage divider circuit operates in a first mode based on a switching signal and divides a power voltage to generate an input voltage. The comparator circuit compares the input voltage with a set of reference voltages to generate a detection signal. The switch control circuit selectively adjusts a switching signal according to the detection signal after a predetermined period has elapsed from power-on of the power voltage so as to control the voltage divider circuit to switch from operating in the first mode to operating in a second mode. The first mode corresponds to a first target level of the power voltage, the second mode corresponds to a second target level of the power voltage, and the first target level is higher than the second target level.

Abstract: A light-emitting unit, having a substrate; a first light-emitting body formed on the substrate, and having a first longer side and a first shorter side; a second light-emitting body formed on the substrate, and having a second longer side and a second shorter side which is parallel to the first longer side; a third light-emitting body formed on the substrate, having a third longer side and a third shorter side which is parallel to the first longer side, and electrically connected to the first light-emitting body and the second light-emitting body; a first electrode covering the first light-emitting body and the second light-emitting body, and electrically connecting to the first light-emitting body; a second electrode separated from the first electrode, and covering the second light-emitting body without covering the first light-emitting body; and a transparent element enclosing the first light-emitting body, the second light-emitting body, and the third light-emitting body.

Abstract: The present application provides a powder sample adding device and a powder sample adding system. The powder sample adding device includes a first bracket and a sample adding mechanism. The first bracket includes a powder adding substrate and a powder bucket carrying member, the powder adding substrate is connected to the powder bucket carrying member. The sample adding mechanism is connected to the powder adding substrate. The sample adding mechanism includes a powder adding member, a stirring driving member, and a pressing-down driving member. The stirring driving member is connected to the powder adding member in a transmission way and configured to drive the powder adding member to rotate. The pressing-down driving member is rotatably connected to the powder adding member and configured to drive the powder adding member to rise and fall relative to the powder adding substrate.

Abstract: Disclosed are a processing apparatus, a corrugated plate, and a storage container. The processing apparatus includes a pair of slide plates, a pair of press plates, a shaping block, and a driving mechanism. The driving mechanism includes a slide plate driving portion linked to a shaping block driving portion, allowing the slide plate driving portion drives the pair of slide plates to approach each other at a first predetermined speed, the shaping block driving portion moves the shaping block downward at a second predetermined speed, and the first and second predetermined speed are specifically correlated with respect to a predetermined forming profile of an intersection portion. The processing apparatus of the present disclosure causes running speeds of various portions that move in different directions to extrude a blank plate to be specifically associated, so that the formation process is particularly applicable to a corrugated plate having the predetermined corrugated shape.

Abstract: A sheet detection device includes: a magnetic sensing element disposed on a sheet guide, wherein the sheet guide brings the magnetic sensing element to move to a first position or a second position; a first magnetic element disposed on a sheet tray corresponding to the first position; a second magnetic element disposed on the sheet tray corresponding to the second position and in spaced with the first magnetic element; a processing element electrically connected with the magnetic sensing element. When the magnetic sensing element outputs a first voltage signal, the processing element determines the sheet guide is located at the first position according to the first voltage signal. When the magnetic sensing element outputs a second voltage signal, the processing element determines the sheet guide is located at the second position according to the second voltage signal. The first voltage signal is different from the second voltage signal.

Abstract: A system for monitoring and/or controlling a treatment process includes a treatment apparatus for carrying out the treatment process. The treatment apparatus includes a vibratory trough for receiving and retaining treatment media and a component support fixedly attached to the vibratory trough. The system includes a plurality of sensor devices respectively and fixedly disposed at a plurality of heights relative to the vibratory trough and configured to respectively measure a plurality of movement parameters of the treatment media at the plurality of heights and generate a plurality of movement signals corresponding to the plurality of movement parameters. The system includes a central controller configured to determine a plurality of process variables corresponding to the plurality of movement signals and control the treatment apparatus based at least on the plurality of process variables.

Abstract: A chromatic, confocal measuring device uses a broadband, high-intensity light source implemented by optically pumping a luminophore. The illumination of the luminophore is selected so that the properties of the luminophore are exploited to maximize the optical output power of the light source.

Abstract: A method for storing metadata and a configuration schema for each of a plurality of capabilities, and storing a plurality of catalogs, each catalog identifying the metadata and configuration schema associated with at least one of the plurality of capabilities. The method also includes receiving a request for implementation of one of the plurality of capabilities on a pluggable system, and associating, by a lifecycle manager and based on a catalog of the plurality of catalogs related to the request, the metadata and configuration schema related to the requested one of the plurality of capabilities with a domain specific capabilities controller compatible with the pluggable system.

Abstract: A photographing system lens assembly includes, in order from an object side to an image side: a first lens element, a second lens element, a third lens element and a fourth lens element. Each of the four lens elements has an object-side surface facing toward the object side and an image-side surface facing toward the image side. At least one surface of at least one lens element in the photographing system lens assembly has at least one inflection point. The first lens element has positive refractive power, the object-side surface of the first lens element is convex in a paraxial region thereof, and the image-side surface of the first lens element is convex in a paraxial region thereof. The object-side surface of the second lens element is concave in a paraxial region thereof. The image-side surface of the third lens element is concave in a paraxial region thereof.

Abstract: An optical element driving mechanism is provided, including a fixed portion and a movable portion. The movable portion moves relative to the fixed portion. The movable portion includes a first movable assembly and a second movable assembly. The first movable assembly is connected to a first optical element. The second movable assembly is connected to a second optical element. The first movable assembly and the second movable assembly are movable relative to each other. The fixed portion further includes a first guiding element and a second guiding element. The first guiding element guides the first movable assembly and the second movable assembly to move in a first dimension. The second guiding element guides the first movable assembly and the second movable assembly to move in the first dimension. The first guiding element and the second guiding element are located at opposite corners of the fixed portion.

Abstract: An optical path folding element includes an optical portion, a connection portion, matte structures and a light blocking layer. The optical portion has an optical surface and two reflective surfaces. A light beam enters into the optical path folding element via the optical surface and is reflected inside the optical path folding element through the optical surface. Each reflective surface is configured to reflect the light beam again inside the optical path folding element. The connection portion has connection surfaces connected to the optical surface and the reflective surfaces. The matte structures are at least disposed on and integrally formed with the connection portion. Each unitary structure of the matte structures is tapered off and recessed from the connection portion, such that the outer surface of the connection portion has an undulating shape. The light blocking layer is at least disposed on the connection portion for blocking light.

Abstract: A decoration panel includes a first substrate, a first transparent conductive element, a transparent structure, a second substrate, a second transparent conductive element, and a first cholesteric liquid crystal layer. The first transparent conductive element is disposed on the first substrate. The transparent structure is disposed on the first substrate. The second substrate is disposed opposite to the first substrate. The second transparent conductive element is disposed on the second substrate. The first cholesteric liquid crystal layer is disposed between the first transparent conductive element and the second transparent conductive element. A display apparatus is adapted to render a decoration pattern, and the decoration pattern corresponds to the transparent structure. Moreover, a display apparatus including the decoration panel is also provided.

Abstract: An augmented reality display device includes a display, a polarizing beam splitter, and a reflective liquid crystal panel. The display is configured to provide an image beam. The polarizing beam splitter is disposed on a path of the image beam. The reflective liquid crystal panel is disposed on a path of the image beam from the polarizing beam splitter. The reflective liquid crystal panel is configured to form a plurality of modulating and reflecting regions separate from each other. The modulating and reflecting regions are configured to modulate a polarized direction of the image beam and reflect the image beam back to the polarizing beam splitter. The polarizing beam splitter is configured to make the modulated image beam travel to an eye of the user. The reflective liquid crystal panel is configured to vary a pitch of the modulating and reflecting regions.

Abstract: A hard disk failure prediction method, a hard disk failure prediction system, a device and a medium are provided. The method includes: acquiring SMART attribute values of a hard disk; performing data standardization processing on the SMART attribute values, and filtering the processed SMART attribute values to obtain filtered SMART attribute values; constructing a hard disk failure prediction key database according to the filtered SMART attribute values, a warning value and a rating value corresponding to the filtered SMART attribute values; optimizing a decision tree-based hard disk failure prediction model by using the hard disk failure prediction key database to obtain an optimized decision tree-based hard disk failure prediction model; and acquiring SMART attribute values of a target hard disk hard disk, and predicting a health of the target hard disk to obtain a prediction result. The present disclosure improves the accuracy of failure prediction.

Abstract: An objective of the present disclosure is to provide a domain adaptation method and system for gesture recognition, which relates to the field of gesture recognition technologies. The domain adaptation method for gesture recognition includes: obtaining a to-be-recognized target domain surface electromyography signal of a user; separately inputting the to-be-recognized target domain surface electromyography signal into multiple target domain gesture recognition models, to obtain target domain gesture recognition results under multiple source-specific views, where source domains of training data used by different target domain gesture recognition models are different; and determining a gesture category of the to-be-recognized target domain surface electromyography signal according to the gesture recognition results under multiple source-specific views and a weight under each source-specific view.

Abstract: An optical film, an optical film set, a backlight module and a display device are provided. The optical film includes a main body, plural first prism structures and plural second prism structures. The main body has a first optical surface and a second optical surface. The first prism structures are disposed on the first optical surface. Each of the first prism structures extends along a first direction. The second prism structures are disposed on the second optical surface. Each of the second prism structures extends along a second direction. The first direction is different from the second direction.

Abstract: An electronic device includes an image capturing module and a processing module. The image capturing module is configured to capture a hand to obtain a first hand image. The processing module is configured to receive the first hand image, process the first hand image through an artificial intelligence model to generate a first hand landmark, and control the electronic device to enter the unlock mode according to a first gesture corresponding to the first hand landmark.

Abstract: The present disclosure provides a driving assembly, a LiDAR, and a carrier system. The driving assembly comprises: a shaft comprising a first end and a second end; a first bearing sleeved on an outer side of the shaft and located close to the first end; a second bearing sleeved on the outer side of the shaft and located close to the second end; a stator sleeved on the outer side of the shaft and located between the first bearing and the second bearing; and a rotor assembly fixedly connected to an outer ring of the first bearing and an outer ring of the second bearing and arranged corresponding to the stator, the rotor assembly being configured to be connected to the optical assembly. The spatial arrangement of the driving assembly of the LiDAR improves the stability of the LiDAR during rotation, and reduces the wear of parts and components.

Abstract: The concepts and technologies disclosed herein are directed to providing a split ledger for securing extended reality (“XR”) environments. According to one aspect, an XR server computer can create an XR environment. The XR server computer can cause a passed ledger to be populated with an environment ID associated with the XR environment. The XR server computer can cause a hash ledger to be populated with a first hash of the environment ID. The XR server computer can register a user for participating in the XR environment and can cause the passed ledger to be populated with a user-created block associated with the user. The XR server computer can cause the hash ledger to be further populated with a second hash of the user-created block. The XR server computer can allow a user avatar associated with the user to join the XR environment.