Abstract: A PEG linker as represented by formula (I), wherein n and m are respectively an integer from 1 to 7, providing the PEG linker with 1 to 49 linking sites. A ligand drug conjugate as represented by formula (II). The conjugate uses the PEG linker to increase a drug loading capacity and drug loading diversity, thereby improving pharmaceutical efficacy.

Abstract: The present invention discloses a preparation method for water-soluble potassium polymetaphosphate, and relates to the technical field of potassium polymetaphosphate production and preparation. In the present invention, potassium dihydrogen phosphate is mixed with a divalent cationic metal oxide at a mixing mass ratio of 70-90:5-18 to obtained a mixture, wherein the divalent cationic metal oxide is one or more of calcia, magnesia and zinc oxide in the field of food processing; then the mixture is heated and melted, and the temperature is kept constant for 1-3 h at a temperature of 600-700° C.; and after temperature keeping, the melted mixture is cooled naturally to obtain a product. The water-soluble potassium polymetaphosphate prepared by the present invention has a high water solubility and effectively solves the application defect of a traditional potassium polymetaphosphate product which is insoluble in water.

Abstract: Methods, systems, apparatuses, and computer program products are provided for enabling devices to determine the time zone in which they are located. A mobile device may receive location information from one or more sources. Based thereon, the current location of the mobile device may be determined in terms of latitude and longitude. The indication of the current location may be converted to an index value according to a Hilbert curve (or other space-filling curve), and the index value applied to a time zone index file to determine the local time zone. A time zone setting of the mobile device may be updated accordingly. Furthermore, “geofencing” may be used by the mobile device to detect movement towards and through a time zone boundary, leading to a new time zone determination being initiated.

Abstract: To provide a technique capable of measuring high-frequency electrical noise in a charged particle beam device. A charged particle beam device 100 includes an electron source 2 for generating an electron beam EB1, a stage 4 for mounting a sample 10, a detector 5 for detecting secondary electrons EB2 emitted from the sample 10, and a control unit 7 electrically connected to the electron source 2, the stage 4, and the detector 5 and can control the electron source 2, the stage 4, and the detector 5. Here, when the sample 10 is mounted on the stage 4, and a specific portion 11 of the sample 10 is continuously irradiated with the electron beam EB1 from the electron source 2, the control unit 7 can calculate a time-series change in irradiation position of the electron beam EB1 based on an amount of the secondary electrons EB2 emitted from the specific portion 11, and can calculate a feature quantity for a shake of the electron beam EB1 based on the time-series change in irradiation position.

Abstract: A method of determining an aim point of a firearm or simulated firearm at a time of firing by continuously pulsing a laser coaxially aligned with a barrel of the firearm or simulated firearm. The aim point is then continuously detected by a camera system observing the target. A shot firing event is detected and the last detected laser pulse location on the target prior to the shot firing event is determined. The aim point of the firearm or simulated firearm at the time of firing is extrapolated from the last detected laser pulse location and at least one laser pulse location prior to the last laser pulse location.

Abstract: Methods are provided for treating disorders associated with default mode network (DMN) dysfunction in a patient, where the methods include administering alpha-frequency transcranial alternating current stimulation (?-tACS) to the brain of the patient via at least one electrode, and where the ?-tACS is effective to regulate DMN dysfunction and treat disorders associated therewith. Diseases and disorders associated with DMN dysfunction include normal or abnormal aging, cognitive impairment, or neuropsychiatric disorders such as Alzheimer's disease, schizophrenia, autism, or posttraumatic stress disorder (PTSD).

Abstract: The present disclosure describes various processes of forming an electrochromic stack using at most one metallic lithium deposition station. In some aspects, a process may include depositing metallic lithium only within an electrochromic counter-electrode of an electrochromic stack. In some aspects, a process may include using a lithium-containing ceramic counter-electrode target to form an electrochromic counter-electrode and depositing metallic lithium only within or above an electrochromic electrode of the electrochromic stack. In some embodiments, a process may include using a lithium-containing ceramic electrode target, and optionally additionally depositing metallic lithium to add mobile lithium to the electrochromic stack. In some embodiments, a process may include using a single metallic lithium deposition station to deposit metallic lithium between an ion-conducting layer and an electrochromic electrode of the electrochromic stack.

Abstract: Provided is a charged particle beam device capable of improving the accuracy of measurement and processing. The charged particle beam device includes an electrostatic chuck that adsorbs an inspection object, a voltage generation unit that generates a voltage to be supplied to the electrostatic chuck, and a state determination unit that determines a state of the inspection object.

Abstract: A mixer for generating particles, comprising a first mixing unit, wherein the first mixing unit comprises a first channel (702) and a second channel (701), the first channel (702) comprises a rectilinear channel, the second channel (701) comprises a curvilinear channel. The mixer is particularly suitable for producing nanoparticles, and the mixing efficiency can be improved. A microfluidic hybrid chip cartridge prepared by the mixer is also provided.

Abstract: A plurality of switching units are provided, and a controller performs control in an antiphase manner to approximately synchronize a rise of a control signal applied to one of the switching units with a fall of a control signal for switching applied to any one of the other switching units and synchronize a fall of the control signal applied to the one of the switching units with a rise of the control signal for switching applied to the any one of the other switching units. When control in an antiphase manner is disabled, control is performed to prevent rises or falls from coinciding with each other between the switching units. Output signals from the switching units are input to rectifiers and are combined by a combiner to become an output signal.

Abstract: Various embodiments disclosed herein relate to techniques for simultaneously designing optical and electrical properties of an electrochromic device by tuning specific parameters of the electrochromic device. One or more models representing respective relationships of the optical and electrical properties with respect to the individual ones of the parameters of the device may be obtained. Given specific values of the optical and/or electrical properties, at least one of the parameters may be adjusted to simultaneously control the optical and electrical properties according to the given specific values.

Abstract: A high-nitrogen nickel-free austenitic stainless steel seamless thin-walled tube, a high-safety nickel-free metal-based drug-eluting vascular stent manufactured therefrom, and manufacturing methods therefor. In the process of manufacturing a stent tube, the nitrogen content of a material is further increased by means of stage-by-stage nitriding, so as to obtain a high-nitrogen nickel-free austenitic stainless steel seamless thin-walled tube having the nitrogen content of 0.8-1.2% as a metal stent platform material. By using rolling line contact type electrochemical polishing, the surface of the stent forms a micron-scale protrusion-recess structure by means of crystal grains having different orientations, thus improving a binding force between a metal stent material and a drug coating. The vascular stent has the characteristics of high fatigue life, high biological safety, and a high binding force between the drug coating and a substrate.

Abstract: A remote rendering system based on a virtual mobile architecture, including a client and a server is provided. The client includes a central processing unit (CPU) for executing a remote rendering service receiver (RRS receiver) and applications, a graphics processing unit (GPU), and a display. The server is configured to execute a QEMU pipe and a remote rendering service sender (RRS sender). OpenGL commands are transmitted to the RRS sender through the QEMU pipe, and the RRS sender transmits the OpenGL commands to the client. The CPU executes the RRS receiver to receive the OpenGL commands. After a connection between the RRS receiver and the applications is established, the GPU draws a screen corresponding to the applications according to the OpenGL commands, and displays the screen through the monitor.

Abstract: A verification method and a verification system for an information and communication safety protection mechanism are provided. The verification methods includes: selecting a target malicious program, and collecting at least one behavioral trace of the target malicious program; providing a target machine and deploying a protection mechanism to be tested for the target machine; configuring the target machine to reproduce the at least one behavioral trace; and determining whether the protection mechanism to be tested detects an abnormal event, so as to verify an effectiveness of the protection mechanism to be tested.

Abstract: An error calibration apparatus and method are provided. The method is adapted for calibrating a machine learning (ML) accelerator. The ML accelerator achieves computation by using an analog circuit. An error between an output value of one or more computing layers of a neural network and a corresponding corrected value is determined. The computation of the computing layers is achieved by the analog circuit. A calibration node is generated according to the error. The calibration node is located at the next layer of the computing layers. The calibration node is used to minimize the error. The calibration node is achieved by a digital circuit. Accordingly, error and distortion of the analog circuit could be reduced.

Abstract: The present disclosure provides a structural engineering dominated geotechnical structured permanent supporting system and a design method, and belongs to the technical field of underground structures. Through the technical solutions, the structural engineering dominated geotechnical structured permanent supporting system comprises a supporting structure designed on the basis of the partial coefficient of a permanent load, the supporting structure is connected to frame columns of a main structure through a plurality of connecting members arranged at intervals, and a partition wall for blocking soil mass is arranged between every two adjacent frame columns to form a permanent supporting system only bearing soil pressure in the horizontal direction of the supporting structure. When the system is designed, the combined action generated after the main structure and the supporting structure are connected is considered, so that the use of materials is reduced, and the cost is reduced.

Abstract: A method and system for of treating type 1 includes implanting genetically modified islet cells under a capsule of or within an organ, implanting a microsystem adjacent the islet cells, said microsystem, comprising a light emitting diode stimulator comprising a plurality of light emitting diodes, determining a glucose level in a body and controlling the microsystem to selectively illuminate the islet cells to secrete insulin or glucagon or both based on the glucose level.

Abstract: The present invention provides a two-way soil clearing device for single-ridge grapevine and a construction machine for mounting the device, comprising a frame part, a soil clearing mechanism, a distance measuring sensor, an expansion and contraction device and a control unit; the frame comprises a left side frame and a right side frame; the left side frame and the right side frame are connected by a connecting device; the left side frame and the right side frame are provided with a soil clearing mechanism respectively; the distance measuring sensor is provided in front of the soil clearing mechanism; the left side frame and the right side frame are respectively provided with expansion and contraction devices, and the control unit is respectively connected with the distance measuring sensor and the expansion and contraction device.

Abstract: A data processing circuit and a fault mitigating method are provided. The method is adapted for a memory having at least one fault bit. The memory provides a block for data storage. A difference between an output of a value of a plurality of bits input to at least one computing layer in a neural network and a correct value is determined. The bits are respectively considered the at least one fault bit. A repair condition is determined based on the difference. The repair condition includes a correspondence between a position where the fault bit is located in the block and at least one non-fault bit in the memory. A value of at least one non-fault bit of the memory replaces a value of the fault bit based on the repair condition.

Abstract: The color of an electrochromic stack in a tinted state may be modified to achieve a desired color target by utilizing various techniques alone or in combination. A first approach generally involves changing a coloration efficiency of a WOx electrochromic (EC) layer by lowering a sputter temperature to achieve a WOx microstructural change in the EC layer. A second approach generally involves utilizing a dopant (e.g., Mo, Nb, or V) to improve the neutrality of the tinted state of WOx (coloration efficiency changes). A third approach generally involves tailoring a thickness of the WOx layer to tune the color of the tinted stack.