Abstract: The disclosure is directed to an antibody and an antibody-drug conjugate (ADC) including a monoclonal antibody, or an antigen-binding fragment thereof, conjugated to a cytotoxin, directed against B-cell maturation antigen (BCMA). The BCMA antibody and its ADCs are useful for treatment of multiple myeloma cells, B-cell mediated or plasma cell mediated disease, and immune disorders as well as for detecting BCMA. Further disclosed are pharmaceutical compositions and medical treatment methods.

Abstract: Provided herein is a process for preparing a homogeneous conjugate of an antibody or antibody-like protein via linkage of cysteine sites between heavy-light chains in the IgG antibody or antibody-like protein. It also relates to method of making the conjugates in a specific manner including either generation of specific thiols of an antibody or antibody-like protein agent, followed by reaction with drug/linker complexes, or generation of specific thiols of an antibody or antibody-like protein agent and conjugation of a synthetic linker-drug assembly with the thiols simultaneously in one pot reaction, to provide conjugates with over 75%, in most cases more than 80% of payloads linked at the specific cysteine sites between heavy-light chains of the IgG antibody or antibody-like protein. It also relates to methods of using the homogeneous conjugate in targeted prophylaxis or treatment of cancer, infection and immunological disorders.

Abstract: A communication method includes receiving a Wi-Fi data frame from a transmitter; obtaining interference information of the Wi-Fi data frame, where the interference information comprises a proportion of interfered orthogonal frequency-division multiplexing (OFDM) symbols or a first quantity of interfered medium access control (MAC) protocol data units (MPDUs); and sending the block acknowledgment frame to the transmitter, where the block acknowledgment frame includes interference information.

Abstract: Dynamic coverage optimization for network energy savings is described. An apparatus is configured to receive or retrieve first information indicative of a coverage region. The coverage region has a common definition common for both the first network device and a set of second network devices that is independent of cells, beams, and/or SSBs of the network devices. The apparatus is also configured to provide, to the set of second network devices, second information associated with a coverage state for the coverage region having the common definition.

Abstract: A bioactive peptide PCT-1, and preparation method and application thereof are provided. The amino acid sequence of the bioactive peptide PCT-1 is LNRTFE, as shown in SEQ ID NO: 1, and the bioactive peptide PCT-1 has antioxidant and intestinal flora-regulating functions. Extracted from spirulina protein peptides, the bioactive peptide PCT-1 can significantly increase the activities of SOD and GSH-Px in serum, and significantly reduce the content of MDA in serum; its in vivo antioxidant activity is comparable to that of the positive control Trolox. Meanwhile, compared with the blank control group, the bioactive peptide PCT-1 can also reduce the ?-diversity index of intestinal flora, change the overall structure of intestinal flora, regulate the abundance of intestinal flora at various taxonomic levels, and significantly increase the contents of acetic acid and butyric acid. Therefore, the bioactive peptide PCT-1 can be applied in functional foods for antioxidation and intestinal flora regulation.

Abstract: An integrated wall-mounted base includes a wall-mounted base body which is provided with a water inlet connection part, a water outlet connection part, a upright column installation part, press-button switches, and a shower holder installation part. The water inlet connection part is connected to one water inlet pipe, the water outlet connection part is respectively connected to two water outlet pipes, the water inlet connection part is communicated with the water outlet connection part, and the press-button switches control opening and closing of flow passages of the two water outlet pipes. The upright column installation part is internally configured with a upright column for connecting and supporting a top shower, and an adjusting component is configured to fasten or release the upright column, as so to freely adjust a height of the upright column. The shower holder installation part is provided with a rotatable shower holder.

Abstract: A semiconductor device comprising a substrate comprised of a semiconductor material having a drift region lightly doped with ions of a first conductivity type and a body region formed the substrate doped with ions of the second conductivity type. A dummy trench may be formed in the drift region. The dummy trench is formed to a depth in the substrate deeper than a bottom depth of the body region. An insulation layer formed over the substrate in the dummy trench. A dummy electrode is formed over the insulation layer in the dummy trench. The top of the dummy electrode is at a depth in the dummy trench below the bottom of the body region and a gate electrode formed in the active gate trench wherein the gate electrode extends from a portion of the body region to below the bottom of the body region in the active gate trench.

Abstract: A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, , R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

Abstract: A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, ----, R1, R2, R3, R4, R1, R6, R7, R1, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

Abstract: An apparatus, at a network entity, for scheduling multi-user multiple-input multiple-output (MU-MIMO) transmissions to a co-scheduled set of user equipment (UEs) from an antenna array comprising multiple panels is disclosed. The apparatus comprises: a processor; a memory communicatively coupled to the processor; and executable instructions code stored in the memory, which when executed by the processor, cause the processor to: determine a reduced set of entries of panel-to-UE assignment from among multiple combinations of panel-to-UE assignment; and select, from within the reduced set, an entry of the panel-to-UE assignment for scheduling, based on a proportionately fair (PF) metric, wherein a panel-to-UE assignment is a mapping of the panels assigned to transmit to a selection of the UEs using associated serving beams configured for transmission to the respective UEs.

Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.

Abstract: The present invention relates to an antibody-drug conjugate containing two or more functional small molecules for enhancement of targeted treatment of cancers and refractory diseases. The invention also relates to preparation of such conjugate, pharmaceutical compositions, and methods in treatment of cancers and refractory diseases.

Abstract: An antenna pairing method and an apparatus are provided. A first communication apparatus may send a measurement frame. After receiving the measurement frame, a second communication apparatus obtains, based on the measurement frame, channel information of an antenna combination corresponding to the measurement frame. Therefore, the second communication apparatus may send a feedback frame based on the channel information. After receiving the feedback frame, the first communication apparatus may learn of an antenna pairing result based on the feedback frame, and perform communication based on the antenna pairing result. This effectively reduces an increase in system overheads.

Abstract: Disclosed in the invention is a lithium battery production process, which comprises: through sequentially implemented processes of pre-compounding, winding for lamination, cutting, reclaiming material, continuously processing and assembling finished products, each electrode and separator are laminated, processed and formed, and finally assembled into a battery prefabricated product. The lithium battery production process is simple and efficient to implement, and it may realize continuous production of lithium battery products, thereby greatly improving battery production efficiency, and correspondingly simplifying the entire process flow to reduce the labor intensity of the staff. Also disclosed is a lithium battery production equipment for the above lithium battery production process.

Abstract: In a multi-link concurrent connection method, a first device establishes a multi-link connection to a second device via a first link set, where the first link set includes a first link and a second link. The first device establishes a multi-link connection to a third device via a second link set, where the second link set includes a third link and a fourth link, and operating frequencies of the third link and the first link are the same. Alternatively, operating frequencies of the third link, the first link, and the second link are all different.

Abstract: A semiconductor package comprises a lead frame, a chip, and a molding encapsulation. The lead frame comprises one or more die paddles and a plurality of leads. Each of the plurality of leads comprises a base member and a protrusion member. A width of an end surface of the protrusion member of each of the plurality of leads is less than 50% of a width of a corresponding base member so as to improve solderability. A method, for fabricating semiconductor packages, comprises the steps of providing a lead frame array, mounting a chip, forming a molding encapsulation, applying a cutting process or a punching process, applying a plating process, and applying a singulation process.

Abstract: A system used to supplement an electrode with lithium or sodium, includes an electrode treatment unit including metal source-unwinding shafts (1, 3), an electrode-unwinding shaft (2), and press roller devices (7, 8) configured to allow physically adhesive contact of the electrode with the metal source, so that the electrode (5) is supplemented with the metal from metal sources (4, 6); a temperature control treatment device (20a) configured to improve the quality and uniformity of metal supplement; and a stripping unit configured to peel off the metal source that has been rolled by the press roller devices (7, 8), wherein the metal sources (4, 6) are a ribbon-shaped lithium source or a ribbon-shaped sodium source. This system and the method using the system can produce an electrode having high cycle efficiency.

Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

Abstract: Disclosed is a sediment classification method and system based on bottom echo information of a deep-sea multibeam water column, falling within the technical field of seabed sediment classification. Multidimensional features of seabed multibeam time series are extracted by using multibeam water column data, and multidimensional features of seabed spots are constructed by fusing an angle response curve; double-waveform spectrum comparison of original sample point waveform with seabed measured point waveform is performed, and two groups of corresponding waveforms are matched by using Cosine Similarity to expand original sample points; and the reliability of classification results is improved. In the present disclosure, the transformation from hard to soft classification is realized, and the seabed habitat inversion of complex mixed sediment in a deep sea is further realized.