Abstract: An antibody-drug conjugate containing a side chain of a functional small molecule for enhancement of targeted treatment of cancers and refractory diseases is provided. The preparation of such conjugate, pharmaceutical compositions, and methods in treatment of refractory diseases are also provided.

Abstract: A communication apparatus includes a multiplexer and a plurality of antenna structures. The multiplexer includes a common terminal and a plurality of selection terminals. The common terminal of the multiplexer is configured to switchably connect to different selection terminals of the plurality of selection terminals to form a plurality of paths. The plurality of antenna structures include a phased array antenna. The plurality of selection terminals include a first selection terminal. The phased array antenna is coupled to the first selection terminal.

Abstract: The present invention relates to the technical field of medical rehabilitation and discloses a three-degree-of-freedom wearable upper limb rehabilitation exoskeleton mechanism, including: a shoulder joint mechanism and an elbow joint mechanism. Two ends of the shoulder joint mechanism are fastened to a human shoulder and a human upper arm, respectively, and the shoulder joint mechanism is configured to drive the human upper arm to implement flexion, extension, abduction, and adduction movements. Two ends of the elbow joint mechanism are fastened to the human upper arm and a human forearm, respectively, and the elbow joint mechanism is configured to drive the human forearm to implement flexion and extension movements.

Abstract: The present disclosure relates to the field of finger rehabilitation and provides a nested elastic member-driven finger rehabilitation device and hand rehabilitation device. The nested elastic member-driven finger rehabilitation device includes: an elastic driving member disposed on one side close to the back of a hand and capable of telescopic and flexion-extension movements, a palm connection assembly configured to be connected to a palm and the elastic driving member, and a finger joint connection assembly configured to be connected to a finger joint and the elastic driving member, where the elastic driving member has the following working states: a bending state and an extension state. In the bending state, the elastic driving member extends and bends toward the palm. In the extension state, the elastic driving member retracts and extends away from the palm.

Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.

Abstract: The present disclosure provides methods, systems, devices, and media for data processing. The method may include obtaining information of one or more hard disks of each of one or more data nodes, the information of the one or more hard disks at least including type information, capacity information, and location information of each of the one or more hard disks; determining, based on a data processing instruction and the information of the one or more hard disks, target information of a target hard disk among the one or more hard disks; and transmitting the data processing instruction including the target information of the target hard disk to a target data node corresponding to the target hard disk.

Abstract: Embodiment herein relate to logic gates. An example of a logic gate includes a semiconductor material, source regions having a first width, drain regions having a second width that is different than the first width, transistor gates, and electrical contacts coupled to the source regions and the drain regions.

Abstract: A second AP receives a first frame from a first AP, where the first frame includes first indication information and second indication information, the first indication information indicates whether the first AP allows another AP to perform data transmission simultaneously with the first AP, the second indication information indicates a first bandwidth, and the first bandwidth is used by the first AP to receive a first acknowledgment frame; and when the first AP separately sends data to at least one first STA, the second AP separately sends data to K second STAs, where K is a positive integer. The second AP receives a second acknowledgment frame by using a bandwidth other than the first bandwidth.

Abstract: A method of wireless communication at a first network node, comprising: providing a request for an energy cost associated with one or more attributes of a second network node, wherein the request indicates the one or more attributes, and wherein the one or more attributes include one or more of a beam, a group of beams, a coverage state for one or more beams or cells, a cell activation, a cell deactivation, a beam activation, a beam deactivation, a beam reconfiguration, a cell reconfiguration, a power reconfiguration, a periodicity, a system information activation, a system information deactivation, a synchronization signal block (SSB) activation, an SSB deactivation, discontinuous transmission (DTX), discontinuous reception (DRX), a random access configuration, a paging configuration, or a group handover of multiple UEs and receiving a response indicating energy cost information of the second network node associated with the one or more attributes indicated in the request.

Abstract: The disclosure is directed to an antibody and an antibody-drug conjugate (ADC) including a monoclonal antibody, or an antigen-binding fragment thereof, conjugated to a cytotoxin, directed against B-cell maturation antigen (BCMA). The BCMA antibody and its ADCs are useful for treatment of multiple myeloma cells, B-cell mediated or plasma cell mediated disease, and immune disorders as well as for detecting BCMA. Further disclosed are pharmaceutical compositions and medical treatment methods.

Abstract: Provided herein is a process for preparing a homogeneous conjugate of an antibody or antibody-like protein via linkage of cysteine sites between heavy-light chains in the IgG antibody or antibody-like protein. It also relates to method of making the conjugates in a specific manner including either generation of specific thiols of an antibody or antibody-like protein agent, followed by reaction with drug/linker complexes, or generation of specific thiols of an antibody or antibody-like protein agent and conjugation of a synthetic linker-drug assembly with the thiols simultaneously in one pot reaction, to provide conjugates with over 75%, in most cases more than 80% of payloads linked at the specific cysteine sites between heavy-light chains of the IgG antibody or antibody-like protein. It also relates to methods of using the homogeneous conjugate in targeted prophylaxis or treatment of cancer, infection and immunological disorders.

Abstract: A communication method includes receiving a Wi-Fi data frame from a transmitter; obtaining interference information of the Wi-Fi data frame, where the interference information comprises a proportion of interfered orthogonal frequency-division multiplexing (OFDM) symbols or a first quantity of interfered medium access control (MAC) protocol data units (MPDUs); and sending the block acknowledgment frame to the transmitter, where the block acknowledgment frame includes interference information.

Abstract: Dynamic coverage optimization for network energy savings is described. An apparatus is configured to receive or retrieve first information indicative of a coverage region. The coverage region has a common definition common for both the first network device and a set of second network devices that is independent of cells, beams, and/or SSBs of the network devices. The apparatus is also configured to provide, to the set of second network devices, second information associated with a coverage state for the coverage region having the common definition.

Abstract: A bioactive peptide PCT-1, and preparation method and application thereof are provided. The amino acid sequence of the bioactive peptide PCT-1 is LNRTFE, as shown in SEQ ID NO: 1, and the bioactive peptide PCT-1 has antioxidant and intestinal flora-regulating functions. Extracted from spirulina protein peptides, the bioactive peptide PCT-1 can significantly increase the activities of SOD and GSH-Px in serum, and significantly reduce the content of MDA in serum; its in vivo antioxidant activity is comparable to that of the positive control Trolox. Meanwhile, compared with the blank control group, the bioactive peptide PCT-1 can also reduce the ?-diversity index of intestinal flora, change the overall structure of intestinal flora, regulate the abundance of intestinal flora at various taxonomic levels, and significantly increase the contents of acetic acid and butyric acid. Therefore, the bioactive peptide PCT-1 can be applied in functional foods for antioxidation and intestinal flora regulation.

Abstract: An integrated wall-mounted base includes a wall-mounted base body which is provided with a water inlet connection part, a water outlet connection part, a upright column installation part, press-button switches, and a shower holder installation part. The water inlet connection part is connected to one water inlet pipe, the water outlet connection part is respectively connected to two water outlet pipes, the water inlet connection part is communicated with the water outlet connection part, and the press-button switches control opening and closing of flow passages of the two water outlet pipes. The upright column installation part is internally configured with a upright column for connecting and supporting a top shower, and an adjusting component is configured to fasten or release the upright column, as so to freely adjust a height of the upright column. The shower holder installation part is provided with a rotatable shower holder.

Abstract: A semiconductor device comprising a substrate comprised of a semiconductor material having a drift region lightly doped with ions of a first conductivity type and a body region formed the substrate doped with ions of the second conductivity type. A dummy trench may be formed in the drift region. The dummy trench is formed to a depth in the substrate deeper than a bottom depth of the body region. An insulation layer formed over the substrate in the dummy trench. A dummy electrode is formed over the insulation layer in the dummy trench. The top of the dummy electrode is at a depth in the dummy trench below the bottom of the body region and a gate electrode formed in the active gate trench wherein the gate electrode extends from a portion of the body region to below the bottom of the body region in the active gate trench.

Abstract: A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, , R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

Abstract: A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, ----, R1, R2, R3, R4, R1, R6, R7, R1, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

Abstract: An apparatus, at a network entity, for scheduling multi-user multiple-input multiple-output (MU-MIMO) transmissions to a co-scheduled set of user equipment (UEs) from an antenna array comprising multiple panels is disclosed. The apparatus comprises: a processor; a memory communicatively coupled to the processor; and executable instructions code stored in the memory, which when executed by the processor, cause the processor to: determine a reduced set of entries of panel-to-UE assignment from among multiple combinations of panel-to-UE assignment; and select, from within the reduced set, an entry of the panel-to-UE assignment for scheduling, based on a proportionately fair (PF) metric, wherein a panel-to-UE assignment is a mapping of the panels assigned to transmit to a selection of the UEs using associated serving beams configured for transmission to the respective UEs.