Abstract: The present invention relates to the conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.

Abstract: A waterway switching structure for a multifunctional shower head includes a water diversion seat, a water outlet body, a switching assembly, and a driving assembly. The driving assembly includes a rotating shaft, a driving wheel, a master wheel, and a slave wheel. The driving wheel is rotatably connected to the rotating shaft, the master wheel and the slave wheel are linked to the rotating shaft. A first end of the driving wheel is movably provided with a driving detent which fits into the notch of the master wheel, the slave wheel is provided with water inlet holes. The switching assembly is rotatably connected to the driving wheel. A second end of the driving wheel is connected to a resetting member to move the driving wheel backward. The slave wheel is driven to enable the water inlet holes selectively switch on the water diversion holes communicating with the respective waterway.

Abstract: A gas phase rust-resisting material for various metals includes, calculated in parts by weight, following components of: 78.5 to 95.5 parts of benzotriazole, 78.5 to 95.5 parts of dicycloethylamine nitrite, 500 to 800 parts of octadecylamine, 9000 to 11000 parts of ethanol, 33.5 to 38.5 parts of a reinforcing agent and 23.5 to 25.5 parts of a rust-resistant microcapsule. Further disclosed is a method for preparing the gas phase rust-resisting material which is suitable for various metals.

Abstract: The present invention relates to linkers having a group of propioloyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

Abstract: Provided herein is the conjugation of an amanita toxin compound to a cell-binding molecule with branched linkers for having better targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of an amanita molecule to a cell-binding ligand, as well as methods of using the conjugate in targets treatment of cancer, infection and autoimmune disease.

Abstract: A watchband assembly and a wrist-worn device having the same are provided. The watchband assembly includes a watch buckle, a watchband, a buckle tongue, and a rotating shaft for mounting the buckle tongue to the watch buckle, wherein the watch buckle includes a watch buckle upper cover and a watch buckle lower cover, the watchband and the rotating shaft are both arranged between the watch buckle upper cover and the watch buckle lower cover, and a fastener penetrates the watchband and is fixedly connected to the watch buckle to press and fix the watchband to the watch buckle. The lower surface of the watch buckle upper cover and/or the watch buckle lower cover is in contact with a human body when worn, such that the surface in contact with the human body when worn is smooth.

Abstract: The present disclosure provides a switching device for shower system and a shower system including same. The switching device for shower system includes a shell main body, a valve, a handle kit, and a sealing cover. The shell main body is internally provided with a partition, the partition is provided with a plurality of water passing holes, and a side of the partition is provided with a plurality of water chambers. The valve is located inside the shell main body, and a first end of the valve abuts on a side of the partition and communicates with the water passing holes. The handle kit is connected to a second end of the valve. The sealing cover is configured to block the water chambers at an outer end.

Abstract: A method for manufacturing and a Super Junction MOSFET are disclosed. The Super Junction MOSFET comprises a lightly doped epitaxial layer of a first conductivity type on a heavily doped substrate of the first conductivity type. A deep trench is formed in the epitaxial layer. The deep trench having an insulating layer with a thickness gradient formed on surfaces of the deep trench. One or more regions of the epitaxial layer proximate to sidewalls of the deep trench is doped of a second conductivity type, wherein the second conductivity type is opposite the first conductivity type. Finally, MOSFET device structures are formed in the epitaxial layer.

Abstract: The present invention relates to the conjugates of Tubulysin derivatives (anologs) and cell-binding molecules using branched (side-chain) linkers, and the resulting conjugates have better pharmacokinetic properties, and thus can more accurately target and kill abnormal cells. The invention also relates to the conjugation methods of the Tubulysin derivatives (anologs) to cell-binding molecules, and methods for synthesizing the small molecules, and methods of using the conjugates for targeted therapy for cancers, infections and autoimmune diseases. The conjugates of Tubulysin derivatives with long branched linkers demonstrated increased half-life, minimal exposure to non-targeted cells, tissues or organs in system circulation, leading to reduced off-target toxicity.

Abstract: The present disclosure provides a shower system including a valve, a connection tube, a hand shower, and a holder. The connection tube includes a first connection tube, a second connection tube, and a third connection tube that are connected in sequence. The first connection tube is connected to the valve, the third connection tube is connected to the hand shower, the second connection tube is inserted into the holder, and holder is attached on a wall to hang the second connection tube on the wall. The shower system with flexible connection tube of the present disclosure can adjust the height of the connection tube, so as to adjust the height of the hand shower, which is practical and convenient.

Abstract: The present disclosure provides a structure for aligning handle and mounting base of faucet and a widespread faucet including same. The structure for aligning handle and mounting base of a faucet includes: a water access main body, a cartridge, a mounting base, a handle, a first connecting element, and a second connecting element. A water inlet end of the cartridge is mounted in the water access main body. The mounting base is arranged around the water access main body and is provided with a first mounting hole. The handle is mounted on the cartridge and is provided with a second mounting hole. The first connecting element is inserted in the second mounting hole to fix the handle with a top end of the cartridge. The second connecting element is inserted in the first mounting hole to fix the mounting base with the water access main body.

Abstract: A switching device for shower system includes a housing; a valve core main body, wherein the valve core main body includes a first valve core and a second valve core, a first end of the first valve core is provided with a plurality of water passing holes in different positions, and a second end of the first valve core is slidably connected to the second valve core; a push rod, wherein the push rod is located inside the valve core main body, and an end of the push rod is inserted into the second valve core; and a switching assembly, wherein a first end of the switching assembly is slidably connected to the housing and a second end of the switching assembly is connected to the second valve core, when the switching assembly is pressed, the push rod is pushed to switch the water passing holes in different positions.

Abstract: The present invention relates to a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (a dual-linker) containing a 2,3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.

Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.

Abstract: The present disclosure provides a luminous water outlet device, which includes a hydroelectric power generation module, a waterway separation body, a waterway switching module, a water outlet panel, and a light board. The hydroelectric power generation module is arranged at a water inlet, the waterway separation body has two waterways, the waterway switching module is used to switch a flow of water in the two waterways, and the water outlet panel is correspondingly arranged below the two waterways, the light board is electrically connected with the hydroelectric power generation module. Compared with the prior art, the hydroelectric power generation module is arranged in the water inlet to ensure that the light board works no matter which waterway is opened and allows water to flow through. Further, the present disclosure has simpler installation, smaller volume, and simpler waterway structure.

Abstract: An integrated circuit (IC) structure includes a semiconductor fin having a first longitudinal extent and a second longitudinal extent. The semiconductor fin has an upper fin portion having a uniform lateral dimension in the first longitudinal extent and the second longitudinal extent, a first subfin portion under the upper fin portion in the first longitudinal extent having a first lateral dimension, and a second subfin portion under the upper fin portion in the second longitudinal extent having a second lateral dimension different than the first lateral dimension. The second subfin may be used in a drain extension region of a laterally-diffused metal-oxide semiconductor (LDMOS) device. The second subfin reduces subfin current and improves HCI reliability, regardless of the type of LDMOS device.

Abstract: Integrated circuit (IC) structures including asymmetric, recessed source and drain regions and methods for forming are provided. In an example, the IC structure includes a substrate, a gate structure over the substrate, first and second spacers contacting respective, opposite sidewalls of the gate structure, and source and drain regions on opposite sides of the gate structure. In one configuration, the source region includes an upper source portion having a first lateral width, and a lower source portion having a second lateral width greater than the first lateral width, and the drain region includes an upper drain portion having a third lateral width, and a lower drain portion having a fourth lateral width that is substantially the same as the third lateral width.