Abstract: The present disclosure provides a switching device for shower system and a shower system including same. The switching device for shower system includes a shell main body, a valve, a handle kit, and a sealing cover. The shell main body is internally provided with a partition, the partition is provided with a plurality of water passing holes, and a side of the partition is provided with a plurality of water chambers. The valve is located inside the shell main body, and a first end of the valve abuts on a side of the partition and communicates with the water passing holes. The handle kit is connected to a second end of the valve. The sealing cover is configured to block the water chambers at an outer end.

Abstract: A method for manufacturing and a Super Junction MOSFET are disclosed. The Super Junction MOSFET comprises a lightly doped epitaxial layer of a first conductivity type on a heavily doped substrate of the first conductivity type. A deep trench is formed in the epitaxial layer. The deep trench having an insulating layer with a thickness gradient formed on surfaces of the deep trench. One or more regions of the epitaxial layer proximate to sidewalls of the deep trench is doped of a second conductivity type, wherein the second conductivity type is opposite the first conductivity type. Finally, MOSFET device structures are formed in the epitaxial layer.

Abstract: The present disclosure provides a shower system including a valve, a connection tube, a hand shower, and a holder. The connection tube includes a first connection tube, a second connection tube, and a third connection tube that are connected in sequence. The first connection tube is connected to the valve, the third connection tube is connected to the hand shower, the second connection tube is inserted into the holder, and holder is attached on a wall to hang the second connection tube on the wall. The shower system with flexible connection tube of the present disclosure can adjust the height of the connection tube, so as to adjust the height of the hand shower, which is practical and convenient.

Abstract: The present invention relates to the conjugates of Tubulysin derivatives (anologs) and cell-binding molecules using branched (side-chain) linkers, and the resulting conjugates have better pharmacokinetic properties, and thus can more accurately target and kill abnormal cells. The invention also relates to the conjugation methods of the Tubulysin derivatives (anologs) to cell-binding molecules, and methods for synthesizing the small molecules, and methods of using the conjugates for targeted therapy for cancers, infections and autoimmune diseases. The conjugates of Tubulysin derivatives with long branched linkers demonstrated increased half-life, minimal exposure to non-targeted cells, tissues or organs in system circulation, leading to reduced off-target toxicity.

Abstract: A switching device for shower system includes a housing; a valve core main body, wherein the valve core main body includes a first valve core and a second valve core, a first end of the first valve core is provided with a plurality of water passing holes in different positions, and a second end of the first valve core is slidably connected to the second valve core; a push rod, wherein the push rod is located inside the valve core main body, and an end of the push rod is inserted into the second valve core; and a switching assembly, wherein a first end of the switching assembly is slidably connected to the housing and a second end of the switching assembly is connected to the second valve core, when the switching assembly is pressed, the push rod is pushed to switch the water passing holes in different positions.

Abstract: The present disclosure provides a structure for aligning handle and mounting base of faucet and a widespread faucet including same. The structure for aligning handle and mounting base of a faucet includes: a water access main body, a cartridge, a mounting base, a handle, a first connecting element, and a second connecting element. A water inlet end of the cartridge is mounted in the water access main body. The mounting base is arranged around the water access main body and is provided with a first mounting hole. The handle is mounted on the cartridge and is provided with a second mounting hole. The first connecting element is inserted in the second mounting hole to fix the handle with a top end of the cartridge. The second connecting element is inserted in the first mounting hole to fix the mounting base with the water access main body.

Abstract: The present invention relates to a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (a dual-linker) containing a 2,3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.

Abstract: The present disclosure provides a luminous water outlet device, which includes a hydroelectric power generation module, a waterway separation body, a waterway switching module, a water outlet panel, and a light board. The hydroelectric power generation module is arranged at a water inlet, the waterway separation body has two waterways, the waterway switching module is used to switch a flow of water in the two waterways, and the water outlet panel is correspondingly arranged below the two waterways, the light board is electrically connected with the hydroelectric power generation module. Compared with the prior art, the hydroelectric power generation module is arranged in the water inlet to ensure that the light board works no matter which waterway is opened and allows water to flow through. Further, the present disclosure has simpler installation, smaller volume, and simpler waterway structure.

Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.

Abstract: An integrated circuit (IC) structure includes a semiconductor fin having a first longitudinal extent and a second longitudinal extent. The semiconductor fin has an upper fin portion having a uniform lateral dimension in the first longitudinal extent and the second longitudinal extent, a first subfin portion under the upper fin portion in the first longitudinal extent having a first lateral dimension, and a second subfin portion under the upper fin portion in the second longitudinal extent having a second lateral dimension different than the first lateral dimension. The second subfin may be used in a drain extension region of a laterally-diffused metal-oxide semiconductor (LDMOS) device. The second subfin reduces subfin current and improves HCI reliability, regardless of the type of LDMOS device.

Abstract: Integrated circuit (IC) structures including asymmetric, recessed source and drain regions and methods for forming are provided. In an example, the IC structure includes a substrate, a gate structure over the substrate, first and second spacers contacting respective, opposite sidewalls of the gate structure, and source and drain regions on opposite sides of the gate structure. In one configuration, the source region includes an upper source portion having a first lateral width, and a lower source portion having a second lateral width greater than the first lateral width, and the drain region includes an upper drain portion having a third lateral width, and a lower drain portion having a fourth lateral width that is substantially the same as the third lateral width.

Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.

Abstract: A backlight source module and a display device are provided. The backlight source module includes a back plate structure and a rubber member. The back plate structure includes a bottom plate, and a first side plate and a second side plate respectively connected with the bottom plate, and the first side plate and the second side plate oppose each other. A light-emitting portion, a light-guiding component and the rubber member are sequentially disposed on the bottom plate along a first direction pointing from the first side plate to the second side plate. The rubber member is only disposed at the second side plate.

Abstract: Provided are an asynchronous heating and calendering device, a large wide ultra-thin lithium metal foil, and preparation method and use thereof, wherein the asynchronous heating and calendering device comprises: a pulling-substrate unwinding unit (E) for unwinding a pulling-substrate (P); a lithium strip unwinding unit (D) for unwinding a lithium strip (S); an asynchronous heating and calendering unit (H) which comprises: a first calendering roller (B), a second calendering roller (A) and a heating box (C), wherein the heating box (C) is used to heat the first calendering roller (B), the first calendering roller (B) heats the pulling-substrate (P), and the first calendering roller (B) and the second calendering roller (A) have parallel axes and are arranged opposite to each other, so that the pulling-substrate (P) and the lithium strip (S) are combined into a composite strip (Z); and a winding unit (G) for winding the composite strip (Z).

Abstract: Transistor device and method of making thereof comprising a substrate heavily doped with a first conductivity type and an epitaxial layer lightly doped with the first conductivity type on top of the substrate. A body region doped with a second conductivity type is formed in the epitaxial layer wherein the second conductivity type is opposite the first conductivity type and a source region doped with the first conductivity type is formed in the body region of the epitaxial layer. An integrated planar-trench gate having a planar gate portion is formed on the surface of the epitaxial layer that is contiguous with a gate trench portion formed in the epitaxial layer.

Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.