Publication number: 20220249594
Abstract: A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, ----, R1, R2, R3, R4, R1, R6, R7, R1, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
Type:
Application
Filed:
February 18, 2020
Publication date:
August 11, 2022
Applicant:
HANGZHOU DAC BIOTECH CO., LTD
Inventors:
Robert ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Hangbo YE, Linyao ZHAO, Huihui GUO, Lu BAI, Wenjun LI, Junxiang JIA, Zhixiang GUO, Jun ZHENG, Xiaoxiao CHEN, Xiangfei KONG, Chen LIN, Yong DU, Yu ZHANG, Lei ZHOU, Xiuzhen ZHANG, Xiuhong ZHENG, Binbin CHEN, Yanlei YANG, Meng DAI, Yifang XU, Zhongliang FAN, Xiaomai ZHOU, Xingyan JIANG, Miaomiao CHEN, Lingli ZHANG, Yanhua LI
Publication number: 20210393790
Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.
Type:
Application
Filed:
July 30, 2021
Publication date:
December 23, 2021
Applicant:
Hangzhou DAC Biotech Co., Ltd.
Inventors:
Robert Yongxin ZHAO, Yuanyuan HUANG, Qingliang YANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Yifang XU, Huihui GUO, Minjun CHAO, Qianqian TONG, Wenjun LI, Xiang CAI, Xiaomai ZHOU, Hongsheng XIE, Junxiang JIA, Haifeng ZHU, Zhixiang GUO, Shuihong GAO, Chunyan WANG, Chen LIN, Yanlei YANG, Zhicang YE, Jie PENG, Jun XU, Xiaotao ZUO, Qingyu SU
Publication number: 20210369855
Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.
Type:
Application
Filed:
July 28, 2021
Publication date:
December 2, 2021
Applicant:
Hangzhou DAC Biotech Co., Ltd.
Inventors:
Robert Yongxin ZHAO, Yuanyuan HUANG, Qingliang YANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Yifang XU, Huihui GUO, Minjun CHAO, Qianqian TONG, Wenjun LI, Xiang CAI, Xiaomai ZHOU, Hongsheng XIE, Junxiang JIA, Haifeng ZHU, Zhixiang GUO, Shuihong GAO, Chunyan WANG, Chen LIN, Yanlei YANG, Zhicang YE, Jie PENG, Jun XU, Xiaotao ZUO, Qingyu SU