Patents by Inventor Werner Mederski

Werner Mederski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMIDAZO 1, 2-A PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS DIABETES
    Publication number: 20100249151
    Abstract: Novel compounds of the formula (I), in which W, T, R1, R2, R3, R4, R5, R6 and X7 have the meanings indicated in Patent Claim 1, are suitable as antidiabetics.
    Type: Application
    Filed: September 13, 2008
    Publication date: September 30, 2010
    Applicant: MERCK PATENT GESELLSCHAFT BESCHRANKTER HAFTUNG
    Inventors: Markus Klein, Werner Mederski, Christos Tsaklakidis, Norbert Beier
  • PROCESS FOR THE PREPARATION OF N-ARYLMORPHOLINONES
    Publication number: 20100210864
    Abstract: Process for the preparation of compounds of the formula (I) in which X has the meaning indicated in Patent Claim 1, and precursors thereof.
    Type: Application
    Filed: February 16, 2010
    Publication date: August 19, 2010
    Inventors: Dieter DORSCH, Bertram Cezanne, Werner Mederski, Christos Tsaklakidis, Hanns Wurziger
  • Mandelic hydrazides
    Patent number: 7776920
    Abstract: Novel mandelic hydrazides of the formula (I), in which R1-R11 have the meanings indicated in claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and complaints, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in fibroses and inflammatory processes of any type.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: August 17, 2010
    Assignee: Merck Patent GmbH
    Inventors: Rolf Gericke, Markus Klein, Werner Mederski, Norbert Beier, Florian Lang
  • Acyl hydrazines as kinase inhibitors, in particular for SGK
    Patent number: 7767716
    Abstract: Novel acyl hydrazides of the formula (I), in which R1-R9 have the meanings indicated in claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and complaints, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, generally in fibroses and inflammatory processes of any type.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: August 3, 2010
    Assignee: Merck Patent GmbH
    Inventors: Rolf Gericke, Dieter Dorsch, Werner Mederski, Markus Klein, Norbert Beier, Florian Lang
  • Aroylsemicarbazide derivatives against thromboembolic diseases
    Patent number: 7763611
    Abstract: Novel compounds of the formula (I) in which Het, R1, R2 and R3 have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: July 27, 2010
    Assignee: Merck Patent GmbH
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz
  • Prolinylarylacetamides
    Patent number: 7732481
    Abstract: Novel compounds of the formula (I), in which R, R1, R2, R3, X, X? and Y have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
    Type: Grant
    Filed: November 26, 2004
    Date of Patent: June 8, 2010
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz
  • Process for the production of N-arylmorpholinones
    Patent number: 7687624
    Abstract: The invention relates to a method for production of compounds of formula (I), where X has the meaning given in claim 1 and precursors for the same.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: March 30, 2010
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Bertram Cezanne, Werner Mederski, Christos Tsaklakidis, Hanns Wurziger
  • Prolinyl derivatives for the treatment of thrombosis
    Patent number: 7683093
    Abstract: Novel compounds of the formula (I), in which R, R1, R2, R3 and R4 have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: March 23, 2010
    Assignee: Merck Patent GmbH
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz
  • INDOLIZINE DERIVATIVES AND THE USE THEREOF AS ANTIDIABETICS
    Publication number: 20100035915
    Abstract: Novel compounds of the formula (I), in which X, Y, R, R1, R1, R1?, R2, R2?, R3, R4, R4?, R5 and n have the meanings indicated in patent claim 1, are suitable as antidiabetics.
    Type: Application
    Filed: November 17, 2007
    Publication date: February 11, 2010
    Applicant: Merck Patent Gesellschaft
    Inventors: Werner Mederski, Norbert Beier, Lars Thore Burgdorf, Rolf Gericke, Markus Klein, Christos Tsaklakidis
  • Benzimidazole Derivatives
    Publication number: 20100016372
    Abstract: Novel compounds of the formula I (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R, Q, W, X and Z have the meanings indicated in Patent Claim 1, are suitable as antidiabetics.
    Type: Application
    Filed: January 28, 2008
    Publication date: January 21, 2010
    Applicant: Merck Patent GmbH
    Inventors: Lars Thore Burgdorf, Bertram Cezanne, Markus Klein, Rolf Gericke, Christos Tsaklakidis, Werner Mederski, Norbert Beier
  • Ortho-substituted N'-benzylidene-(3-hydroxyphenyl)acethydrazides
    Patent number: 7619115
    Abstract: Novel ortho-substituted N?-benzylidene-(3-hydroxyphenyl)acetohydrazides of the formula (I), in which R1-R9 have the meanings indicated in claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and conditions, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in fibroses and inflammatory processes of any type.
    Type: Grant
    Filed: June 6, 2005
    Date of Patent: November 17, 2009
    Assignee: Merck Patent GmbH
    Inventors: Rolf Gericke, Dieter Dorsch, Werner Mederski, Norbert Beier, Florian Lang
  • Carboxamide derivatives and their use as factor Xa inhibitors
    Patent number: 7598241
    Abstract: Novel compounds of the formula (I) in which R1, D, X, W, Y and T have the meaning indicated in Patent Claim (1), e.g. (II), are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
    Type: Grant
    Filed: January 8, 2004
    Date of Patent: October 6, 2009
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Bertram Cezanne, Werner Mederski, Christos Tsaklakidis, Johannes Gleitz, Christoph van Amsterdam
  • MANDELIC HYDRAZIDES
    Publication number: 20090221712
    Abstract: Novel mandelic hydrazides of the formula (I), in which R1-R11 have the meanings indicated in claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and complaints, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in fibroses and inflammatory processes of any type.
    Type: Application
    Filed: January 18, 2007
    Publication date: September 3, 2009
    Inventors: Rolf Gericke, Markus Klein, Werner Mederski, Norbert Beier, Florian Lang
  • Carboxamides
    Patent number: 7579346
    Abstract: Novel compounds of the formula (I), in which D, W, X, Y, T, m and R1 have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: August 25, 2009
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Bertram Cezanne, Werner Mederski, Christos Tsaklakidis, Hanns Wurziger, Johannes Gleitz, Christoph van Amsterdam
  • Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor Xa inhibitors for the treatment of thromboses
    Patent number: 7557102
    Abstract: Novel compounds of the formula (I), in which R, R1, R2 and R3 have the meanings indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: July 7, 2009
    Assignee: Merck Patent GmbH
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz
  • 1-[(4-Ethynylphenyl)]-2-[(phenyl)]-pyrrolidine-1,2-dicarboxamide derivatives as inhibitors of coagulation factors Xa and VIIa for the treatment of thrombosis
    Patent number: 7557222
    Abstract: Novel compounds of the formula (I), in which R, R1, R2 and R3 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: July 7, 2009
    Assignee: Merck Patent GmbH
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz
  • 4-amino-quinazolines
    Patent number: 7547702
    Abstract: Quinazolines of the formula (I) in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein 1bIX antagonists.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: June 16, 2009
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Werner Mederski, Maria Devant, legal representative, Gerhard Barnickel, Sabine Bernotat-Danielowski, James Vickers, Bertram Cezanne, Daljit Dhanoa, Bao-Ping Zhao, James Rinker, Mark R. Player, Edward Jaegar, Richard Soll, Ralf Devant
  • INDAZOLE-HETEROARYL DERIVATIVES
    Publication number: 20090076091
    Abstract: The invention relates to novel indazole derivatives as cited in claim 1, which are inhibitors of CHK1, CHK2 and SGK kinases and can be used to treat cancer and other diseases.
    Type: Application
    Filed: January 10, 2007
    Publication date: March 19, 2009
    Applicant: MERCK PATENT GMBH
    Inventors: Markus Klein, Rolf Gericke, Werner Mederski, Norbert Beier, Florian Lang
  • Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products
    Patent number: 7504500
    Abstract: Process for the preparation of compounds of the formula I in which R, R1, R2 and R3 are as defined in Patent claim 1, and compounds of the formula IV in which R and R1 are as defined in Patent claim 1, are intermediates for the preparation of the compounds of the formula I.
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: March 17, 2009
    Assignee: Merck Patent GmbH
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz
  • Indazolesquaric Acid Derivatives as Chk1, Chk2 and Sgk Inhibitors
    Publication number: 20090036449
    Abstract: Novel squaric acid compounds of the formula (I), in which R, R1, R2, R2?, R2?, R3, B, B? and X have the meanings indicated in Claim 1, are inhibitors of CHK1 CHK2 and SGK kinases and can be used for the treatment of diseases and complaints such as cancer, diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, generally in fibroses and inflammatory processes of any type.
    Type: Application
    Filed: March 21, 2006
    Publication date: February 5, 2009
    Inventors: Werner Mederski, Rolf Gericke, Markus Klein, Dieter Dorsch, Norbert Beier, Florian Lang